• 지구물리와물리탐사
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• 제9권1호
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• pp.102-107
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• 2006

최근 급속히 발전하는 하드웨어로 인해 역시간 구조보정을 다양한 현장자료의 영상화에 적용할 수 있게 되었다. 양방향 파동방정식을 이용하는 파동방정식 구조보정 방법으로, 역시간 구조보정은 다중 도달파 뿐 아니라 급경사 및 수직 이상의 경사를 갖는 반사면도 영상화가 가능하다. 그러나 쌍곡선 파동방정식의 양방향 전파라는 성질로 인해 역시간 구조보정은 잡음을 발생시킨다. 연속적으로 입사각이 증가하여 지표로 전파되는 파, 선두 파, 역 산란 파 등과의 영 지연 상호상관은 의사영상을 만든다. 이러한 큰 진폭의 의사영상은, 상호상관되는 각 점에서 볼 때, 순 전파 및 역전파되는 두 파동장들이 거의 정 반대방향으로 전파한다는 공통점을 갖고 있다. 이는 순 전파하는 파동장과 역 전파하는 파동장의 두 전파경로가 거의 일치함으로써 발생한다. 본 논문에서는 음원 모음 역시간 구조보정에서의 의사영상을 제거하는 몇 가지 시도들을 소개하고자 한다. 구조보정 전에 실시하는 음원모음자료의 간단한 뮤팅 또는 초동 주시 이후의 시간 창 이내에서만 상호상관을 실시하는 파면 구조보정은 이러한 의사영상을 제거하는데 효과적이다. 포인팅벡터로부터 계산한 파동방정식의 전파방향을 이용하면 큰 진폭의 의상영상을 제거할 수 있는 새로운 영상화 조건을 적용할 수 있고 반사각에 따른 공통영상모음을 구할 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4115-4119
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• 2013

Background: Previous reports have shown that human epidermal receptor (HER)-3 overexpression may be associated with poor prognosis in patients with breast cancer, but results have been conflicting. In this study, we sought to investigate the prognostic significance of HER-3 immunohistochemical expression in patients with metastatic breast cancer. Methods: We retrospectively analyzed HER-3 immunohistochemical expression profiles in 45 paraffin-embedded specimens from patients who had been treated between 1996 and 2006 in the Department of Oncology of the Uludag University School of Medicine, Bursa, Turkey. Membranous or cytoplasmic dominant expression patterns of HER-3 were analyzed using the Rajkumar score and a cytoplasmic 4-point scoring system, respectively. Progression-free survival (PFS) and overall survival (OS) served as the main outcome measures. Results: The median PFS in the study participants was 9 months (interquartile range: 4.5-13 months), whereas the median OS was 20 months (interquartile range: 7.5-28 months). Categorization of the patient population according to HER-3 positive immunohistochemical expression did not reveal any statistically significant difference in terms of both PFS (p=0.70) and OS (p=0.81). The results of multivariable Cox regression analysis indicated that tumor size was the only independent predictor of PFS, whereas estrogen and progesterone receptor status was independently associated with OS. Conclusions: HER-3 immunohistochemical expression did not correlate with outcomes in Turkish patients with metastatic breast cancer. Although our results suggest that HER-3 expression in cancer specimens is not of prognostic significance, further prospective studies are warranted to confirm these results.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5487-5492
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• 2014

Ultrasonography is non-invasive and can give useful clues in the diagnosis of cervical lymphadenopathy, However, differential diagnosis is difficult in some situations even combined with color Doppler imaging. The present study was conducted to evaluate the clinical value of real time elastography in patients with unexplained cervical lymphadenopathy using a quantitative method. From May 2011 to February 2012, 39 enlarged lymph nodes from 39 patients with unexplained cervical lymphadenopathy were assessed. All the patients were examined by both B-mode ultrasound, color Doppler flow imaging and elastography. The method of analyzing elasto-graphic data was the calculation of the 10 parametres ("mean", "sd", "area%", "com", "kur", "ske", "con", "ent", "idm", "asm") offered by the software integrated into the Hitachi system. The findings were then correlated with the definitive tissue diagnosis obtained by lymph node dissection or biopsy. Final histology revealed 10 cases of metastatic lymph nodes, 11 cases of lymphoma, 12 cases of tuberculosis and 6 cases of nonspecific lymphadenitis. The significant distinguishing features for conventional ultrasound were the maximum short diameter (p=0.007) and absent of echogenic hilum (p=0.0293). The diagnostic accuracy was 43.6% (17/39 cases) and there were 17 patients with equivocal diagnosis. For elastography, "mean" (p=0.003), "area%" (p=0.009), "kurt" (p=0.0291), "skew" (p=0.014) and "cont" (p=0.012) demonstrated significant differences between groups. With 9 of the 17 patients with previous equivocal diagnoses (52.9%) definite and correct diagnoses could be obtained. The diagnostic accuracy for conventional ultrasound combined elastography was 69.2% (27/39 cases). There were differences in the diagnostic sensitivity of the two methods (p=0.0224). Ultrasound combined with elastography demonstrated higher rates of conclusive and accurate diagnoses in patients with unexplained cervical lymphadenopathy than conventional ultrasound. The quantitative program showed good correlation with the pathology of different lymph node diseases.