• Proceedings of the PSK Conference
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• 2003.10b
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• pp.99.1-99.1
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• 2003

Cinnamaldehyde is the main component of cinnamon bark oil and show several biological activities such as anti-tumor, anti-fungal, anti-mutagenic and anti-inflammatory effects. A couple of studies have investigated how the natural compound exerts its anti-inflammatory effect. In despite of numerous investigations, the biological mechanism of effects belong to cinnamaldehyde remain unclear. We isolated 2-hydroxycinnamaldehyde(HCA) from the bark of Cinnamomun cassia Blume and reported a various of biological activities of HCA. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.93.1-93.1
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• 2003

Bee Venom (BV) has been treated in inflammatory diseases such as rheumatoid arthritis (RA). Bee venom contains several biologically active non-peptide substances as well as two major known peptides; the hemolytic peptide melittin (50%) and the neurotoxic peptide apamin, and a number of minor peptides. Previous our study showed that BV blocked LPS and SNP-induced production of NO and PG through inactivation of NF-kB which regulates expression of COX-2 and iNOS. (omitted)

• Journal of Plant Biotechnology
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• v.1 no.2
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• pp.85-90
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• 1999

In order to protect fungal diseases, leaf disc explants of Solanum tuberosum cultivar, Belchip, was infected with an Agrobacterium MP90 strain containing chimeric gene construct, consisting of antibiotic resistance and chitinase gene driven by the CaMV 35S promoter, for transformation. Regenerated multiple shoots were selected on a medium containing kanamycin and carbenicillin after exposure to Agrobacterium. The presence and integration of the npt II and chitinase gene were confirmed by polymerase chain reaction(PCR). Northern blot analysis indicated that the genes coding for the enzyme could be expressed in potato plants. The chitinase activity of transgenic potato plants was higher than the control potato.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.94.3-95
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• 2003

Familial form of Alzheimer's disease (FAD) is caused by mutations in presenilin-l (PS-1) and presenilin-2 (PS-2). PS1 and PS2 mutation are known to similar effects on the production of amyloid peptide (A ) and cause of neuronal cell dath in the brain of patient of Alzheimer's disease. The importance of the alternation of cellular calcium homeostasis in the neuronal cell death by PS1 mutation in a variety of experimental systems has been demonstrated. However, no studies on the effect of PS2 of mutant PS2 on cellular calcium homeostasis, and relevance of its change to neuronal cell vulnerability against neurotoxins have been reported. (omitted)

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.207.3-208
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• 2003

Peroxisome proliferator-activated receptor (PPAR), a member of the nuclear hormone receptor superfamily, is a transcription factor activated by specific natural or synthetic ligands. It is involved in various cellular processes including adipogenesis, inflammation, cell cycle progression and carcinogenesis. Here, we report the production and characterization of a PPARgamma subtype-specific monoclonal antibody P${\gamma}$ 48.34A, which was raised against full-length human PPARgamma protein. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.173.1-173.1
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• 2003

One of attractive target for Rheumatoid Arthritis (RA) therapy is the cytokine, tumor necrosis factor-alpha (TNF-$\alpha$), which has been shown to be overproduced in the joint of RA patients. The clinical success of anti- TNFR biologics has validated TNF-$\alpha$ as a drug discovery target. Thus, inhibiting of formation of TNF-$\alpha$ has been emerged to an intriguing approach for RA therapy. TNF-$\alpha$ is processed from its membrane bound precursor by the metalloprotease TNF-$\alpha$ converting enzyme (TACE), Here, biological evaluation, mode of action of natural TACE inhibitor, Gelastatin hydroxamate, are addressed. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.98.1-98.1
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• 2003

Bee venom (BY) has been utilized to relieve pain and to treat inflammatory diseases such as rheumatoid arthritis (RA). However, the molecular mechanism by which BV-induced anti-arthritis effect has been not reported yet. Therefore, in the present study we investigated anti-inflammatory effect of BV in a murine marcrophage cell line Raw 264.7 cell and synoviocyte obtained from RA patients. The present data showed that BV has a preventive effect on lipopolysaccharide (LPS) and sodium nitroprusside (SNP) induced induction of COX-2, cPLA2 and iNOS. (omitted)

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.42-42
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• 2019

한국생명공학연구원은 1985년 설립된 이후로 현재까지 국가적 연구개발 수요에 대응하여 바이오 분야의 기초 원천 연구, 인프라 구축 및 운영을 통하여 우리나라 생명과학기술 발전에 힘써왔다. 특히 2006년부터는 해외생물자원의 중요성에 주목하여 차세대 국가 핵심 전략 BT산업의 필수 원자재인 생물소재의 범지구적 확보, 보존 및 관리를 위하여 해외생물소재센터를 설치하였다. 이후 차례로 중국, 코스타리카, 인도네시아, 베트남의 4개 거점 센터를 개소 및 운영하여 권역별 해외생물소재의 공동연구 및 국제협력 네트워크를 구축하고 효과적인 소재 확보 및 관리를 도모하고 있다. 이와 같이 확보된 소재는 36개국에서 채집된 약 318과 3,406속의 36,500여점 (2019년 9월 기준)에 달하고 소재의 확증표본은 해외생물소재센터 식물표본관(KRIB)에 보관 중이다. KRIB표본관은 2000년 Index Herbariorum에 등록되었으며, 약 80,000여점의 건조표본을 소장하고 있다. 분류군수는 과별로 콩과>국화과>꼭두서니과 순으로 많았으며, 국가별로는 중국>베트남>코스타리카 순으로 조사되었다. 한국생명공학연구원 해외생물소재센터 및 식물표본관은 소재의 정확한 동정을 위한 분류학적 시설로서의 역할뿐 아니라 누구에게나 개방된 홈페이지를 통하여 해외소재의 표본정보, 표본이미지 및 민속학적 정보와 활성 등 가치 있는 정보를 제공하여 연구자들에게 다양한 활용지원 서비스를 제공하고 있다.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.325.3-326
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• 2002

An imbalance between matrix metalloproteinase (MMP)-2 and its endogenous inhibitor. tissue inhibitor of metalloproteinase (TIMP)-2 causes the degradation of the extracellular matrix associated with pathological events including invasion. metastasis and angiogenesis. Since TIMPs are secreted molecules. they have the potential to be used for gene therapy of certain tumors. (omitted)

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.79-80
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• 2003

A lot of polyketide antibiotics have been isolated from natural sources like microorganism, fungi and plant. The polyketide natural products have biologically and medically important activities, including antibacterial, anticancer, antiparasitic, and immunosuppressant properties. The diversified activities of polyketides are originated from their structural variety of which have been took advantage by several research groups for development of new drugs. (omitted)