• 한국식물병리학회지
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• 제14권4호
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• pp.345-349
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• 1998

Fifty isolates of myxobacteria were isolated from soils from several areas in Korea during 1996-1997 and bioactivity against plant pathogenic fungi of these isolates was examined. A myxobacterial isolate KR025 showed good antifungal activities against Pyricularia oryzae, Cryphonectria parasitica, Colletotrichum lagenarium, and C. gloeosporioides but did not against Rhizoctonia solani, Fusarium oxysporum and Pythium ultimum. The bacterium was identified as Myxococcus fulvus based on morphological and physiological characteristics. Antifungal substances were extracted from culture broth and bacterial cell of Myxococcus fulvus KR025 by ethyl acetate. Antifungal substance of Myxothiazole (100 ${\mu}{\textrm}{m}$/ml) produced by Myxococcus fulvus KR 025 controlled 97.0% rice blast, tomato late blight, wheat leaf rust, and barley powdery mildew and showed 45.0 and 82.6% disease control of rice sheath blight and cucumber gray model, respectively.

• 한국미생물·생명공학회지
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• 제30권2호
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• pp.162-166
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• 2002

제주도 서귀포의 해변에서 채집한 해양퇴적물로부터 Myxococcus속의 점액세균 JW154를 분리하여 그 대사산물로부터 강한 항균활성을 나타내는 두 개의 bithiazole계 화합물을 분리하고 각종 기기분석을 통하여 구조를 확인한 바, 이들은 각각 KR025와 melithiazole F로 보고된 화합물임을 밝혔다. 유묘 검정법으로 조사된 이 화합물의 주요 식물병원균에 대한 in vivo 항균활성은 토마토 역병과 밀 녹병 및 보리 흰가루병에 대해 높게 나타났는데, 20$\mu\textrm{g}$/m1 수준으로 처리하였을 때 80% 이상의 높은 방제가를 보였다.

• Ocean and Polar Research
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• 제36권4호
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• pp.373-381
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• 2014

Korea contract Mn-nodule field in the NE equatorial Pacific is composed of seven sectors with average water depths of 4,513-5,025 m. Of the various factors controlling the properties of Mn-nodule, it seems that water depth is likely connected to the chemical composition and occurrence of nodules. To test whether such an assumption held in each sector, we reviewed previous research data accumulated since 1994 for one of the northern sectors (hereafter KR1) where there are stark contrasts in water depth. High-resolution seabed mapping clearly separates a northern part (KR1N) from a deeper southern part (KR1S), cutting across in the middle of the KR1. In addition, significant volcanic activities forming numerous seamounts are distinctive especially in KR1N. In terms of nodule occurrence, manganese nodules in KR1S are comparatively larger (2-4 cm) with a discoidal shape, while those in KR1N are generally small (<2 cm) with poly-lobate and irregular shapes. Nodules in KR1N also have lower Co, Cu, Mn and Ni, and higher Fe contents. The spatial separation in nodule characteristics might be caused by volcanic activities in KR1N rather than water depth contrast. During the formation of the seamounts in KR1N, rock fragments and volcanic ashes as new nuclei of the nodules would have been continuously generated. As a result, the nodules could not grow larger than 2 cm and display the shapes of a newbie (i.e., irregular and poly-lobate shapes). Moreover, significant Fe supply from volcanic activities probably decreases the Mn/Fe ratio, which may lead to the KR1 nodules being misinterpreted as a hydrogenic in origin compared to other sectors where a high Mn/Fe ratio is present.

• 한국식품위생안전성학회지
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• 제9권3호
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• pp.163-168
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• 1994

In the present study we investigated the peripheral function of capsaicin and KR-25018, a newly synthesized capsaicin derivative, which was demonstrated to have a potent analgesic activity through different mechanism from morphine and nonsteroidal antiinflammatory drugs. Capsaicin (10-8~10-5 M) and KR-25018 (10-8~10-5 M) produced concentration-dependent contractions of the isolated guinea pig bronchi. There were no significant differences in the maximum response and the EC50 values (EC50: 0.137$\pm$0.025 $\mu$M and 0.097$\pm$0.031 $\mu$M for capsaicin and KR-25018, respectively, P>0.05). Phosphoramidon (10 $\mu$M) and indomethacin (10 $\mu$M) had no significant effect on contractile response to the submaximal concentration range of capsaicin and KR-25018 (3$\times$10-9~3$\times$10-7 M). The response to KR-25018, like that to capsaicin, was significantly inhibited by ruthenium red with reduction in the maximum response, which is indicative of non-competitive antagonism. A further common feature of the responses to capsaicin and KR-25018 in the guinea pig bronchi was their sensitivity to capsazepine. Capsazepine caused a rightward parallel shift in concentration-response curves obtained by capsaicin and KR-25018. the pA2 values of capsazepine were 5.90 and 5.99 against capsaicin and KR-25018 response, respectively. In conclusion, KR-25018 and capsaicin exert their contractile effects in the isolated guinea pig bronchial muscle by common mechanisms, probably via the activation of a specific receptor.

• 대한한방소아과학회지
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• 제31권1호
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• pp.25-42
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• 2017

Objectives The goal of this review was to investigate clinical, experimental and literature studies of Korean medicine on atopic dermatitis (AD) of Korean children in Korean medicine literature, seeking for the better research methods for more effective treatments. Methods Electronic investigations were practiced on AKOP (The Association of Korean Oriental Pediatrics, http://www.akop.or.kr) to collect theses which were published by J Pediatr Korean Med. The key word 'Atopy' was used for searching to ensure that every related thesis was collected. The publication date was limited from 1996 to 2016. The selected literatures were assessed mainly according to distributions of study type, publication year, scale, treatment and its efficacy. Results 55 papers were selected from 59 studies. In these collected 55 related theses, there were 29 experimental studies (52.73%), 18 clinical studies (32.73%), 8 review studies (14.55%). In the 29 experimental studies, there were 20 studies (68.97%) using NC/Nga mouse as subjects. The mite antigen was used to trigger AD by 8 studies (27.59%). The studies have been utilizing DNCB and DNFB instead of mite antigen since 2011. All the experimental studies showed that the Korean medicine was effective in AD. In total 18 clinical studies, 3 studies (16.67%) were case reports, only 1 thesis (5.56%) was conducted by case control study and the rest were case series studies. 7 studies (38.89%) of 18 studies diagnosed AD according to Hanifin and Rajka's diagnostic criteria (1980), only 1 study (5.56%) according to the Korean standard and the rest 10 studies (55.56%) didn't mention diagnostic criteria. 12 clinical studies (66.67%) showed efficacy in treating AD. There were 10 studies (55.56%) only employing internal treatments and 1 thesis (5.56%) didn't mention the exact prescription. Naesowhajungtang-kamibang, Saenghyeoryunbue-um were used 3 times (16.67%) as the internal medicine respectively. 5 theses (27.78%) were combined with acupuncture therapy. Hegu (LI4), Sanyinjiao (SP6) were used in 4 theses, and Taichong (LR3), Quchi (LI11), Zusanli (ST36) in 3 theses. The number of acupoints chosen from The Spleen meridian of Foot-Taiyin was the largest. There were 8 review theses. 2 were about the foreign oriental medicine, 3 were about the external medicine or external treatment methods, and 3 other studies were about severity scoring systems, the methodological study in the latest clinical study, overview for pattern and results of herbal medicine-derived AD clinical researches. Conclusions The experimental studies and clinical studies showed the effectiveness of Korean medicine treatments. However, this study still needs improving by conducting more comparative studies and using better research methods, in order to find more effective treatments to improve clinical efficacy.