• Journal of Ginseng Research
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• v.37 no.4
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• pp.389-400
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• 2013

Korean Red Ginseng (KRG) has been reported to exert anticancer, anti-oxidant, and anti-inflammatory effects. However, there has been no report on the effect of KRG on skin pigmentation. In this study, we investigated the inhibitory effect of KRG on melanocyte proliferation. KRG extract (KRGE) at different concentrations had no effect on melanin synthesis in melan-A melanocytes. Saponin of KRG (SKRG) inhibited melanin content to 80% of the control at 100 ppm. Keratinocyte-derived factors induced by UV-irradiation were reported to stimulate melanogenesis, differentiation, proliferation, and dendrite formation. In this study, treatment of melan-A melanocytes with conditioned media from UV-irradiated SP-1 keratinocytes increased melanocyte proliferation. When UV-irradiated SP-1 keratinocytes were treated with KRGE or SKRG, the increase of melanocyte proliferation by the conditioned media was blocked. Granulocyte-macrophage colony-stimulating factor (GM-CSF) was produced and released from UV-irradiated keratinocytes. This factor has been reported to be involved in regulating the proliferation and differentiation of epidermal melanocytes. In this study, GM-CSF was significantly increased in SP-1 keratinocytes by UVB irradiation ($30mJ/cm^2$), and the proliferation of melan-A melanocytes increased significantly by GM-CSF treatment. In addition, the proliferative effect of keratinocyte-conditioned media on melan-A melanocytes was blocked by anti-GM-CSF treatment. KRGE or SKRG treatment decreased the expression of GM-CSF in SP-1 keratinocytes induced by UVB irradiation. These results demonstrate that UV irradiation induced GM-CSF expression in keratinocytes and KRGE or SKRG inhibited its expression. Therefore, KRG could be a good candidate for regulating UV-induced melanocyte proliferation.

• Journal of Communications and Networks
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• v.10 no.1
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• pp.18-27
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• 2008

This paper is to study a subclass of group-oriented cryptographic scheme: Many-to-one encryption and authentication scheme. The many-to-one encryption and authentication scheme is to solve a practical problem, i.e., the scenario that the number of the receivers is very small compared with the number of the senders and a receiver may serve millions of senders. Compared with the traditional methods, the burdens of the receiver and the KGC are reduced greatly. How to revoke a sender from his receiver's legitimate sender group is also proposed and it is efficient compared with some traditional methods. The proposed scheme is proven in the random oracle models. The computational complexity of our scheme is independent of the number of the senders. At the end of the paper, an example is given to show how to use our scheme in online software registration and update.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.9
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• pp.4527-4547
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• 2018

Signcryption is a cryptographic primitive that provides authentication (signing) and confidentiality (encrypting) simultaneously at a lower computational cost and communication overhead. With the proposition of certificateless public key cryptography (CLPKC), certificateless signcryption (CLSC) scheme has gradually become a research hotspot and attracted extensive attentions. However, many of previous CLSC schemes are constructed based on time-consuming pairing operation, which is impractical for mobile devices with limited computation ability and battery capacity. Although researchers have proposed pairing-free CLSC schemes to solve the issue of efficiency, many of them are in fact still insecure. Therefore, the challenging problem is to keep the balance between efficiency and security in CLSC schemes. In this paper, several existing CLSC schemes are cryptanalyzed and a new CLSC scheme without pairing based on elliptic curve cryptosystem (ECC) is presented. The proposed CLSC scheme is provably secure against indistinguishability under adaptive chosen-ciphertext attack (IND-CCA2) and existential unforgeability under adaptive chosen-message attack (EUF-CMA) resting on Gap Diffie-Hellman (GDH) assumption and discrete logarithm problem in the random oracle model. Furthermore, the proposed scheme resists the ephemeral secret leakage (ESL) attack, public key replacement (PKR) attack, malicious but passive KGC (MPK) attack, and presents efficient computational overhead compared with the existing related CLSC schemes.

• Fisheries and Aquatic Sciences
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• v.17 no.1
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• pp.13-18
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• 2014

Sleep is vital to maintain health and well-being; however, insomnia is currently a widespread health complaint worldwide. In particular, caffeine, a psychoactive component of coffee, tea, and caffeine beverages may lead to sleep disorders such as insomnia. In this study, our primary objective was to investigate the inhibitory effect of high-purity phlorotannin preparation (HP-PRT) on caffeine-induced wakefulness. The sleep test of pentobarbital-induced mice was used as an in vivo animal model. Caffeine (50 and 100 mg/kg) showed significant arousal effects (an increase in sleep latency and a decrease in sleep duration). Co-administration of caffeine (50 mg/kg) and the sedative-hypnotic diazepam (DZP, 1 mg/kg) did not result in similar arousal activity. HP-PRT (500 mg/kg) also inhibited caffeine-induced wakefulness. Our results suggest that HP-PRT would be a useful additive for developing coffee products without the arousal effect.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.17 no.1
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• pp.3-10
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• 2007

In this paper, we show that the status certificate-based encryption(SCBE) scheme proposed at ICISC 2004 and the certificateless signature(CLS) scheme proposed at EUC workshops 2006 are insecure. Both schemes are claimed that an adversary has no advantage if it controls only one of two participants making a cryptographic key such as a decryption key in SCBE or a signing key in CLS. But we will show that an adversary considered in the security model of each scheme can generate a valid cryptographic key by replacing the public key of a user.

• Journal of Ginseng Research
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• v.39 no.2
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• pp.94-104
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• 2015

Background: Ginseng (Panax ginseng Meyer) is an important medicinal herbs in Asia. However, ginseng varieties are less developed. Method: To developed ginseng varieties, a pure line selection method was applied in this study. Results: Gumpoong was testing of 4-yr-old specimens in 2002, the proportions of the below-ground roots that were rusty colored for Gumpoong was 1.29 in Daejeon and 1.45 in Eumseong, whereas the proportions for its yellow berry variant were 2.60 and 2.45 in the two regions, respectively. Thus the Gumpoong was resistant to root rust. Sunpoong has a high yielding property. Its average root weight is 70.6 g for 6-yr-old roots. Its yield is 2.9 kg/$1.62m^2$ and the rate of heaven- and earth-grade product is 20.9%, which is very high compared to 9.4% for Yunpoong. Sunone is resistance to root rot and the survival rate of 4-yr-old roots was 44.4% in 1997, whereas that of the violet-stem variant landrace was 21.7%. Sunhyang has content of arginyl-fructosyl-glucose (AFG), which produces the unique scent of red ginseng, is $95.1{\mu}mol/g$ and greater than the $30.8{\mu}mol/g$ of Chunpoong in 6-yr-old plants. Sunun and Cheongsun are being nurtured to protect genetic resources. Conclusion: Developed ginsneg varieties will be used as the basis for the protection of genetic resources and breeding.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.13 no.4
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• pp.71-84
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• 2003

Self-certified public keys need not be accompanied with a separate certificate to be authenticated by other users because the public keys are computed by both the authority and the user. At this point, verifiable self-certified public keys are proposed that can determine which is wrong signatures or public keys if public keys are used in signature scheme and then verification of signatures does not succeed. To verify these public keys, key generation center's public key trusted by users is required. If all users trust same key generation center, public keys can be verified simply. But among users in different domains, rusty relationship between two key generation centers must be accomplished. In this paper we propose inter-domain verifiable self-certified public keys that can be verified without certificate between users under key generation centers whose trusty relationship is accomplished. Also we present the execution of signature and key distribution between users under key generation centers use different public key parameters.

• Journal of Ginseng Culture
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• v.4
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• pp.1-12
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• 2022

Ginseng and ginseng products are distributed in approximately 190 countries around the world. The size of the ginseng market varies by country and there are no accurate statistics on production and distribution amounts per country. Therefore, it is difficult to make predictions about the global ginseng market. Governments and ginseng trading companies are in need of comprehensive data that shows the current status of the ginseng market to help them establish effective import, export, and sales and marketing policies. To addressthis need, this study examines the approximate size of the world ginseng market based on estimates of recent quantities of ginseng distributed in specific country as well as production by major ginseng producing countries. In 2018, global ginseng production was about 86,223 tons based on fresh ginseng. China produced 50,164 tons, South Korea 23,265 tons, Canada 11,367 tons, the US 1,285 tons, Japan 30 tons, and other countries a combined 112 tons. The value of global ginseng production is estimated to be approximately $5,900 million, with $2,870 million (48.6%) in China, $2,489 million (42.2%) in South Korea, $478 million (8.1%) in Canada, $54 million (0.9%) in the USA, $4 million (0.1%) in Japan, and $5 million (0.1%) in other countries. The value of ginseng products consumed for the last five yearsin South Korea was $1,162 million in 2014, $1,280 million in 2015, $1,548 million in 2016, $1,638 million in 2017, and $1,762 million in 2018, showing that the market has been increasing in recent years. In particular, the Korea Ginseng Corporation (KGC), the biggest global ginseng company in South Korea, recorded sales of $1,207 million in 2018. This represents about 69% of the South Korean ginseng market, and about 20% of global production. Since interest in alternative medicine and health food among consumers is increasing globally, the market for ginseng is expected to expand into the future.

• Korean Journal of Breeding Science
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• v.42 no.5
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• pp.555-564
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• 2010

Aphid and mite are the major insects that harm corn. These insects are difficult to control because they are very sensitive to environmental conditions. The purpose of this experiment was to information the loss in quantity of corn and to select inbred lines with resistance after exposing corn to aphid and mite. When exposed to aphid, the average loss in grain yield, ear length, ear diameter, 100 kernel weight, kernel length, kernel width, and kernel thickness were 18.4, 10.9, 1.7, 5.4, 2.3, 1.5 and -0.2%, respectively. When exposed to mite, the average loss in grain yield, ear length, ear diameter, 100 kernel weight, kernel length, kernel width, and kernel thickness were 49.7, 16.5, 20.7, 18.9, 9.5, and -3.4, respectively. Mite had more significant impact on the loss than aphid. Among these factors, grain yield and ear dimater were most significantly correlated on the loss to aphid ($r=0.83^{**}$), while kernel length and thickness were most significantly correlated on the loss to mite ($r=0.83^{**}$). However, ear length was not related to loss to the two insects. The inbred lines that were often used for $F_1$ hybrid which was lower than the average loss by aphid, were KS7, B68, 61B3, 70A1, and KS5, while the inbred lines that were often used for $F_1$ hybrid which was lower than the average decrease by mite, were KS7, B68, 61B3, 66B2-4, 70A1, 72B2, and KS5. These inbred lines could be used to breed inbred lines, hybrid, and open pollination variety that confer resistant to aphid and mite.

• Korean Journal of Medicinal Crop Science
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• v.25 no.5
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• pp.269-281
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• 2017

Background: Small particles increase airway inflammation upon reaching the alveoli. Here, we investigated the protective or therapeutic effects of Salvia plebeia R. Br. (SP_R) extracts on airway inflammation. Methods and Results: To investigate the anti-inflammatory activity of SP_R extracts, we measured their inhibitory effect on the production of reactive oxygen species (ROS) expression of inflammatory mediators, and immune cell infiltration in MH-S alveolar macrophage cells and in the ambient particulate matter (APM)-exposed airway inflammation mice model. The SP_R extracts inhibited the production of ROS and expression of IL-4, IL-10, IL-15, and IL-17A mRNA in APM-stimulated MH-S cells. Oral administration of SP_R extracts suppressed APM-induced inflammatory symptoms, such as high alveolar wall thickness, excess collagen fibers, decreased mRNA expression of chemokines (Ccr9, Ccl5, Ccr3), inflammatory cytokines (IL-15, TNF-${\alpha}$), and IL-4 Th2 cytokine in the lung. The SP_R extracts also inhibited ROS production, granulocyte ($CD11b^+Gr-1^+$) infiltration, IL-17A, TNF-${\alpha}$, macrophage inflammatory protein (Mip-2), and chemokine (C-X-C motif) ligand 1 (Cxcl-1) production in the airway. The specific compounds in the SR-R extracts that mediate the anti-inflammatory effects were identified. Conclusions: In this study, SP_R extracts effectively inhibited airway inflammatory responses, such as ROS production and granulocyte infiltration into the airway, by regulating the expression of chemokines and inflammatory cytokines.