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http://dx.doi.org/10.5657/FAS.2014.0013

Arousal Inhibitory Effect of Phlorotannins on Caffeine in Pentobarbital-Induced Mice  

Cho, Suengmok (Korea Food Research Institute)
Yang, Hyejin (Korea Food Research Institute)
Yoon, Minseok (Korea Food Research Institute)
Kim, Jiyoung (Korea Food Research Institute)
Kim, Dongsoo (Korea Food Research Institute)
Kim, Jinkyung (KGC Lifengin)
Kim, Seon-Bong (Department of Food Science and Technology, Pukyong National University)
Publication Information
Fisheries and Aquatic Sciences / v.17, no.1, 2014 , pp. 13-18 More about this Journal
Abstract
Sleep is vital to maintain health and well-being; however, insomnia is currently a widespread health complaint worldwide. In particular, caffeine, a psychoactive component of coffee, tea, and caffeine beverages may lead to sleep disorders such as insomnia. In this study, our primary objective was to investigate the inhibitory effect of high-purity phlorotannin preparation (HP-PRT) on caffeine-induced wakefulness. The sleep test of pentobarbital-induced mice was used as an in vivo animal model. Caffeine (50 and 100 mg/kg) showed significant arousal effects (an increase in sleep latency and a decrease in sleep duration). Co-administration of caffeine (50 mg/kg) and the sedative-hypnotic diazepam (DZP, 1 mg/kg) did not result in similar arousal activity. HP-PRT (500 mg/kg) also inhibited caffeine-induced wakefulness. Our results suggest that HP-PRT would be a useful additive for developing coffee products without the arousal effect.
Keywords
Phlorotannins; Somnogenic effect; Caffeine; Arousal effect; Pentobarbital-induced sleep test;
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