• 한국재료학회:학술대회논문집
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• 한국재료학회 1998년도 IUMRS-ICEM ABSTRACT BOOK
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• pp.101.4-101
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• 1998

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 2019년도 정기학술대회 발표논문집
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• pp.58-58
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• 2019

• 동의생리병리학회지
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• 제28권6호
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• pp.614-620
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• 2014

Kainic acid (KA) is a excitatory agonist causing epileptic seizure and excitotoxicity in the hippocampus. Gastrodia Elata (GE) is known to have anti-convulsant and anti-oxidant effects. This study was investigated a possible role of GE in suppressing epileptic seizure using KA-induced epilepsy mouse model. Eight-week-old male C57BL/6 mice were administrated GE (50 or 500 mg/kg) once a day for 5 days, and then injected KA (30 mg/kg) intraperitoneally. Behavioral changes in mice by KA were evaluated for 90 minutes immediately after the KA administration. Six hours after the KA administration, their brains were harvested and the expressions of glutamate decarboxylase 67 (GAD-67) and K+-Cl- cotransporter 2 (KCC2) in the hippocampus of the mice were measured by immunohistochemistry.GE delayed the onset of epileptic seizure after KA administration, suppressed the severity of the seizure and decreased the number of severe seizures dose dependently. Moreover, GAD-67 and KCC2 expressions in the cornu ammonis (CA) 1 and CA3 of 500 mg/kg GE administrated mice were significantly increased compared to those in KA-treated mice.GAD-67 and KCC2 play an important role in regulating GABAergic system. Our results suggest that GE has anti-convulsant effect against KA-induced epileptic seizure through enhancing GABAergic system.

• 한국식품저장유통학회지
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• 제12권6호
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• pp.565-571
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• 2005

본 연구는 품질특성과 기능성이 우수한 고추장을 제조하기 위해서, 고춧가루, 찹쌀, 메주, 엿기름, 소금, 물과 3종류의 한약재(당귀,목통,골담초)의 물추출물을 첨가하여 재래식 방법으로 한방고추장을 제조한 후, $5^{\circ}C$와 $20^{\circ}C$에서 90일간 저장하면서 고추장의 품질특성을 수분함량, 색도, 관능검사로서 조사하였다. 고추장의 수분함량은 저장 초기에 $33\~38\%$였으며 저장기간이 길어질수록 증가하여 저장 90일후에는 $48\~51\%$까지 증가하였다. 고추장의 색도는 명도(L), 적색도(a), 황색도(a) 모두 저장기간의 경과에 따라 감소하는 경향을 나타내었으며 $20^{\circ}C$에 저장한 경우가 $5^{\circ}C$에 저장한 경우보다 감소의 폭이 컸다. 고추장의 명도는 $5^{\circ}C$와 $20^{\circ}C$ 모두 대조군과 한약재 첨가군 간에 유의적인 차이를 나타내지 않았으나, 적색도는 $20^{\circ}C$에 저장했을때 목통과 골담초 첨가 고추장이 유의적으로 낮았으며 황색도는 $5^{\circ}C$에 저장한 골담초 첨가 고추장이 대조군보다 유의적으로 낮았다(p<0.05). 한방고추장의 관능검사 결과, $5^{\circ}C$와 $20^{\circ}C$ 모두 90일간 저장한 고추장이 60일간 저장한 경우보다 기호도가 높았으며 한약재 첨가군이 대조군보다 기호도가 높은 편이었고 특히 목통을 첨가한 고추장이 색상, 단맛, 종합평가에서 유의적으로 높은 기호도를 나타내었다(p<0.05).

• 과학과기술
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• 제32권1호통권356호
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• pp.74-77
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• 1999

북한의 정보화는 어디까지 와 있는가. 한마디로 북한의 정보화는 경제사정 악화와 심각한 식량난으로 어려움을 겪고 있다. 하드웨어부문은 자본부족과 외자유치 부진으로 위축되어 있으나 소프트웨어부문은 계속 발전을 보이고 있다. KCC(조선콤퓨터쎈터), PIC, 은별 콤퓨터기술연구소의 제품과 실태를 살펴본다.

• Spatial Information Research
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• 제19권4호
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• pp.33-43
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• 2011

세계 여러나라들은 자국의 업체와 소비자 보호를 목적으로 다양한 인증제도를 운영하고 있으며, 이는 상대국으로 하여금 무역장벽으로 작용하고 있다. 또한, 기존에 시행되고 있는 KS, KCC등 품질인증 관련 제도가 공간정보 분야의 특성을 충분히 반영하지 못하고 있다. 따라서 본 연구는 기존의 품질 인증제도와 사례분석을 통하여 공간정보 기기 품질인증(안)을 마련하고자 하였다. 본 연구에서는 첫째, 공간정보 기기 품질인증에 필요한 기본개념을 정립하였고 둘째, 공간정보 기기의 품질인증 범위와 내용 및 절차를 세부항목으로 분류하여 설정하였으며, 마지막으로 국내외 유사인증제도의 특성과 비교하여 실증적인 품질인증제도 도입을 위한 기본방향을 제시하였다.

• Biomolecules & Therapeutics
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• 제17권4호
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• pp.379-387
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• 2009

We have previously reported that N-ethylmaleimide (NEM) induces apoptosis through activation of $K^+$, $Cl^-$-cotransport (KCC) in HepG2 human hepatoblastoma cells. In this study we investigated the possible role of phospholipase $A_2$ ($PLA_2$)-arachidonic acid (AA) signals in the mechanism of the NEM-induced apoptosis. In these experiments we used arachidonyl trifluoromethylketone ($AACOCF_3$), bromoenol lactone (BEL) and p-bromophenacyl bromide (BPB) as inhibitors of the calcium-dependent cytosolic $PLA_2$ ($cPLA_2$), the calcium-independent $PLA_2$ ($iPLA_2$) and the secretory $PLA_2$ ($sPLA_2$), respectively. BEL significantly inhibited the NEM-induced apoptosis, whereas $AACOCF_3$ and BPB did not. NEM increased AA liberation in a dose-dependent manner, which was markedly prevented only by BEL. In addition AA by itself induced $K^+$ efflux, a hallmark of KCC activation, which was comparable to that of NEM. The NEM-induced apoptosis was not significantly altered by treatment with indomethacin (Indo) and nordihydroguaiaretic acid (NDGA), selective inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX), respectively. Treatment with AA or 5,8,11,14-eicosatetraynoic acid (ETYA), a non-metabolizable analogue of AA, significantly induced apoptosis. Collectively, these results suggest that AA liberated through activation of $iPLA_2$ may mediate the NEMinduced apoptosis in HepG2 cells.

• ETRI Journal
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• 제30권6호
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• pp.871-873
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• 2008

In this letter, we investigate the spectral efficiency of IEEE 802.22 wireless regional area network (WRAN) spectrum overlay when it is used in TV white space. Since 2004, when the FCC published the notice of proposed rule making 04-186 to make use of unused TV spectrum, the IEEE 802.22 working group has been standardizing specifications for WRAN operations. There have been a few papers investigating the spectral efficiency of this, but their analyses were limited to the cases for various guard distances between WRAN base stations. Since WRAN base station (BS) power for WRAN service may differ from country to country, it is important to analyze the spectral efficiency for various WRAN BS powers. In this letter, we analyze the spectral efficiency of WRAN spectrum overlay as a function of the power of WRAN BSs. The simulation results show that spectral efficiency decreases as the power of WRAN BSs and guard distances increase.

• 디지털산업정보학회논문지
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• 제16권3호
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• pp.13-23
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• 2020

Currently, online means of replacing resident registration numbers(RRN) include I-Pin, mobile phone, credit card, MyPin, and general-purpose certificate. In order to issue alternative means based on the RRN, it must be designated through the designation review by the Korea Communications Commission(KCC) through a designation review by personal proofing agency and be subject to annual management. However, the criteria for designation and follow-up of the designation of the personal proofing agency carried out by KCC have been used in 2010 without revision, and there are problems that do not conform to the evaluation standards of various alternative means. Therefore, in this paper, we propose a method for improving the designation criteria and management system of the personal proofing service agency. The proposed method analyzes the characteristics of the alternative identification-based personal proofing service and proposes a follow-up management standard that can appropriately evaluate the analyzed characteristics and improves the designation criteria according to the emergence of new alternatives. Through the proposed method, it can be seen that it is possible to strengthen the safety of the personal proofing service based on the alternative means of RRN provided online and face-to-face and to protect the user's personal information.

• Journal of Microbiology and Biotechnology
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• 제5권1호
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• pp.18-21
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• 1995

Endoglucanase gene of Pseudomonas sp. LBC505 was previously cloned in pUCl9 to yield plasmid pLC1. overproduction of endoglucanase was attempted by following ways. First, the endoglucanase gene of Pseudomonas sp. LBC505 cloned in pUCl9(pLC1) was tandemly inserted, step by step, into a expression vector pKK223-3 in a directly repeated form to enhance productivity of endoglucanase. Escherichia coli containing pKCC30 among the resulting plasm ids showed the higher yield of the endoglucanase. Ecoli harboring pKCC30 which had three inserted endoglucanase genes expressed about 12.3 times as much CMCase activity as Ecoli harboring pLCl. Second, the endoglucanase gene was subcloned into Bacillus subtilis expression vector pgnt41 for both overproduction and extracellular secretion of the endoglucanase. A resulting plasmid pgntc15 in Bacillus subtilis expressed 4.3-fold higher levels of CMCase activity than that of E.coli harboring pLCl and the endoglucanase produced was entirely secreted into the culture medium.