• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2002년도 학술대회지
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• pp.522-530
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• 2002

We have already known, neural progenitor cells exist not only in the developing brain, but in certain spots in adult CNS in mammals, so it will be of great value to find out some compounds which can interfere these cells proliferation ability. In this research, we observed that ginsenoside $Rg_1$ can not only enhance neural progenitors' proliferation ability in vitro, but increase neurogenesis in adult mouse dentate gyrus in vivo. Firstly, we set up neural progenitor cells' culture system from embryonic rats' hippocampus and prove their feature through immunocytochemistry. Then by using MTT assay, we found that when growing with ginsenoside $Rg_1(0.5\~2.5{\mu}mol/l)$, the progenitor cells' survival rate nearly doubled, furthermore, we proved that this increase was due to the increment of cell proliferation through $^3H-thimidine$ incorporation assay, hence, we drew the first conclusion: ginsenoside Rg1 has the ability to stimulate neural progenitor cells' proliferation in vitro; in order to observe this compound's effect in vivo, we devised the following experiment: after administering ginsenoside Rg1 (5, 10 mg/kg, once a day) intraperitoneally for two weeks, we examine the number of BrdU positive cells in the dentate gyrus of mice, and found that Rg1 could increase the number of proliferation cells significantly in vivo. From these studies, we are quite sure about Rg1's effects on the proliferation ability of neural progenitor cells both in vitro and in vivo, certain targets of the compound and its underlying mechanisms are in progress.

• 한방재활의학과학회지
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• 제24권4호
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• pp.155-162
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• 2014

Objectives Advanced researches on the relationship between obesity and heart rate variability (HRV), heretofore, focused on characteristics of HRV depending on the state of obesity. However, the previous researches have not quantified predictive power of HRV toward the obesity-related variables, which is rather more meaningful for clinicians who regularly treat obese patients. Hence, we designed a research to investigate whether HRV could predict serum levels of obesity-related metabolites. Methods Ninety obese premenopausal women meeting the inclusion criteria were recruited. The HRV test, blood sampling, and measurement of physical traits were conducted. Multiple regression analysis of the measurement data was carried out, putting obesity-related metabolites (insulin, glucose, triglyceride, hs-CRP, HDL, LDL, total cholesterol) as outcome variables and the others as predictors. To select appropriate predictive variables, the Akaike's Information Criterion (AIC) was applied. Normality and homoskedasticity of residuals for each model were tested to identify if there were any violations of the regression analysis's basic assumption. Logarithm transformation was used for the values of the concentration of metabolites and the HRV. Results The regression model including Total Power (TP) value and BMI had significant predictive power for serum insulin concentration (F(2, 88)=835.7, p<0.001, $R^2=0.95$). The regression coefficient of ln (TP) was -0.1002. However, it was not sure if the HRV could predict concentrations of other metabolites. Conclusions The results suggest that the Total Power (TP) value of the HRV can predict the level of serum insulin. If the BMI could be assumed as being constant, when the TP value is multiplied by n, the predicted change of insulin could be drawn by multiplying $n^{-0.1002}$. The uncertainty of this model can be assumed as approximately 5%.

• 약학회지
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• 제53권5호
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• pp.293-297
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• 2009

The abuse of methamphetamine (MA) is one of the most serious drug abuses in Asia. And, the prevention of precursor production for abuse drug is one of the most effective drug control system. Isotope ratio analysis at natural abundance levels have been used to establish the environmental source or the geographic origin of various biological and nonbiological materials. Ephedrine, the precursor of MA, is produced by one of three methods; extraction from Ephedra plants, full chemical synthesis or via a semi-synthetic process involving the fermentation of sugar, followed by amination. We investigated the origin of ephedrine and pseudoephedrine based on the carbon and nitrogen values for nineteen pharmaceutical powder materials (PPMs) obtained from pharmaceutical company in Korea by stable isotope ratio mass spectrometry coupled to an elemental analyser (EA-IRMS). The carbon delta values for the ephedrine and pseudoephedrine were -24.21~-22.72 (mean=-23.72) $^{\cir}/_{\circ\circ}$ and -23.79~-22.71 (mean=-23.48) $^{\cir}/_{\circ\circ}$. The nitrogen delta values were 3.51~5.55 (4.43) $^{\cir}/_{\circ\circ}$ and 2.24~8.22 (5.42) $^{\cir}/_{\circ\circ}$. These results indicate that PPMs are semi-synthetic products. Therefore the origins of ephedrine(natural, semi-synthetic or synthetic) could be discriminated by using carbon and nitrogen stable isotope ratios. we are sure tat this stable isotope ratio analysis can discriminate the origins of precursors of methamphetamine.

• Journal of Chest Surgery
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• 제38권12호
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• pp.866-869
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• 2005

랑게르한스 세포 조직구증(Langerhans Cell Histiocytosis)은 병적인 랑게르한스 세포의 과도한 증식과 침윤으로 생기는 병으로 병태 생리가 확실하게 밝혀져 있지 않다. 소아에서 백만명 당 3$\∼$4명의 발생률을 보이나 성인의 경우 그 발생빈도가 확실치 않다. 피부, 귀, 골수, 간, 비장, 폐, 뇌하수체-시상하부, 위장관 등 거의 모든 장기가 침범되며 뇌하수체-시상하부 축이 침범되면 요붕증이 발생한다. 원발성 폐 랑게르한스 세포 조직구증이 타장기의 침범과 동반되는 경우는 드물며, 요붕증을 동반한 경우는 더욱 드물다. 국내에서 랑게르한스 세포 조직구증 중 요붕증을 동반한 예는 다수의 보고가 있었으나 중추신경계 등 폐 이외의 장기침범이었으며 원발성 폐 랑게르한스 세포 조직구증과 동반된 중추성 요붕증은 1예가 보고되었다. 저자는 중추성 요붕증을 동반한 폐 랑게르한스 세포 조직구증을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Childhood Kidney Diseases
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• 제21권2호
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• pp.142-146
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• 2017

Purpose: To evaluate changes in quality of life (QoL) in patients with neurogenic bladder treated with clean intermittent catheterization (CIC), who changed from a multiple use catheter (MUC) to single use catheter (SUC). Methods: The Modified Intermittent Self-Catheterization Questionnaire (mISC-Q) was used to determine potential changes in patients' QoL as a result of switching from MUC to SUC. The mISC-Q consists of questions within four categories: ease of use, convenience, discreetness, and symptomatic benefit. Answers were graded as Strongly agree (+2), Agree (+1), Not sure (0), Disagree (-1), and Strongly disagree (-2). Overall patient QoL, as well as by sex, disease (presence of augmentation cystoplasty), and catheterization route (via urethra or urinary diversion), were analyzed. Results: Thirty-eight patients (21M:17F; mean age: $21.7{\pm}5.3y$) submitted questionnaires. For ease of use, SUC was significantly better than MUC (score: 0.364, P=0.002) in all patients. Patients with catheterization via the urethra showed significant favor for SUC in ease of use (score: 0.512, P<0.001) and convenience (score: 0.714, P=0.011), but patients with catheterization via the abdominal stoma of urinary diversion gave negative scores in all categories, though no categories were significant. Conclusion: This study suggested that changing from MUC to SUC may lead to improvements in QoL, especially regarding ease of use. This benefit was clearly found in patients with catheterization via urethra rather than abdominal stoma of urinary diversion.

• 대한임상검사과학회지
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• 제37권1호
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• pp.1-7
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• 2005

The purpose of this study was to verify (i) a consistent calibration verification for the assessment of method linearity and (ii) calibration agreement with calibration settings. We validated calibration verification through method linearity with different lot number of individual calibrators that span the working range for 9 tests except salicylate with control sample in test. We evaluated that it covered broad analyte range to assay from near zero to the top of the measuring range with 5 or 6 points every three times for 10 analytes in TDM test. Target values were plotted on X-axis with assigned or observed values on the Y-axis. Working range were as follows. Calibration verification of the measuring range (maximum to minimum values) has been validated asetaminophen 0.1 to $304.6_{\mu}g/mL$, salicylate 0 to $1005_{\mu}g/mL$, valproic acid 3.2 to $154.19_{\mu}g/mL$, digoxin 0.17 to 5.65 ng/mL, vancomycine 1.3 to $80.51_{\mu}g/mL$, carbarmazepine 0.1 to $22.3_{\mu}g/mL$, phenytonin 0.6 to $40.21_{\mu}g/mL$, theophyline 0.2 to $40.21_{\mu}g/mL$, primidone 0 to $24.07_{\mu}g/mL$, phenobarbital 0.6 to $60.0_{\mu}g/mL$. Drawing a straight line through five or six points of these data showed good linearity. We are sure that it is important to assess the calibration verification of a test method to ascertain the lowest and highest test results that are reliable.

• 한국식품위생안전성학회지
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• 제20권3호
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• pp.179-184
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• 2005

시중에 유통되는 과자류 3,716건에 대해 각각의 규격검사를 실시하였으며 그중 36건이 부적합하였다. 부적내역을 보면 빵류가 2건, 건과류가 33건, 사탕류가 1건이먼으며 가장 부적이 많은 건과류는 33건의 부적합 중에서 32건이 유처리 스낵이었다. 유처리 스낵 중 전통한과가 전체 한과의 $8.9\%$에 해당하는 부적률을 보였으며, 부적항목이 튀김유의 산패와 관련된 산가와 과산화물가이어서 유처리 제품의 철저한 위생관리가 이루어져야 할 것이다. 빵류의 영양성분 표시사항은 표시제품 20건 중 18건이 부적절한 것으로 나타나 심각한 수준인 것으로 측정되었다. 빵류에는 영양성분을 반드시 표시하게 되어있으나 표시되지 않은 제품들이 시중에 많이 유통되고 있어 이에 대한 규제가 강화되어야 할 것이다. 결과적으로 과자류 중에서 변질되기 쉬운 유처리 스낵의 철저한 품질관리와 지속적인 주의가 절실히 필요하며, 영양성분 표시에 대한 집중적인 점검과 관리가 요구된다.

• 동의생리병리학회지
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• 제30권6호
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• pp.458-465
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• 2016

The information relating to the health of person has been increasing. The information is such as medical information and personal health record and the information collected by utilization and dissemination of mobile devices. Therefore, the interest and demand for systems that can integrate and manage the Personal Health Record(PHR) is increasing. Quantity and quality of information that is collected from the patient can have a major impact on the diagnosis and treatment of Korean Medicine(KM) in clinical practice. Because closely observe the usual clinical symptoms of patients to utilize the treatment. But if the interview when memories are not sure of the correct answer does not get much easier to find exactly the symptoms. So when recording original symptom(素證) and daily subjective symptom can be helpful for care. Therefore, the personal health care services that can record and manage and own is necessary based on KM. In this paper, we propose Korean Medicine Personal Health Record Platform(KM PHR Platform). We have selected the significant symptoms that mean to the personal records from symptom information required for diagnosis in KM. And classifying and scoring as the symptoms were used as personal health care indicators. And significant symptoms were easily configure a screen that can be recorded. simple operation is recorded as a symptom. It was designed to reflect these functions. So KM PHR Platform helps to Personal health care. Doctor may be able to help in the diagnosis and prognosis observation by reference to shared symptom. We look forward to a variety of health services based on KM using a symptom, a medical record, personal health device information.

• 전자공학회논문지
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• 제50권9호
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• pp.201-208
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• 2013

본 논문에서는 USB(Universal Serial Bus) 케이블 전원선에서의 방사성 EMI(Electro-Magnetci Interference) 개선 방안을 제시한다. 케이블 전원선에서의 EMI 방사현상을 확인하기 위해 무선 비디오 액세스 시스템을 이용하여, 방사성 EMI 결과를 분석하고 초기 측정 결과 규제치 대비 약 3 [dBuV/m]~15 [dBuV/m]를 초과함을 확인한다. 방사성 EMI 원인 분석을 위해, 먼저 USB 케이블 전원선에서의 S-파라미터 측정을 수행하여 케이블의 고주파수 대역에서의 규칙적인 공진현상과 방사성 EMI 주파수의 연관성을 분석한다. 그리고, 전원 회로 임피던스 관리 기법을 응용하여 캐패시터의 개수 선정, 비드를 이용한 저역통과 대역 필터를 구성을 통해 케이블 전원선의 공진현상을 저감하는 개선방법을 적용한다. 결론적으로 개선된 회로를 시스템에 적용하여 케이블의 규칙적 공진의 저감방법을 제시하여, 방사성 EMI 테스트 결과 규제치 대비 약 3 [dBuV/m]~20 [dBuV/m] 마진의 마진을 확보하여 제시한 방법의 적합성 확인한다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 춘계학술대회
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• pp.519-522
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• 2017

본 논문에서는 개개인의 사용자 상황인식 정보추출을 위해 구분이 필요한 시스템에서의 클러스터링 알고리즘을 이용한 대체 방법에 대한 알고리즘을 제안한다. 기존의 사용자 구분 시스템에서는 사용자가 직접 자신의 정보를 입력해야 하는 번거로움이 있었다. 본 논문에서는 이러한 사용자 관리기반에 있어 개선된 알고리즘을 연구 적용한 상용자 인식정보 추출이 가능한 클러스터링 알고리즘을 적용한 시스템을 연구 개발하고자 한다. 일반적으로 같은 데이터를 가진 사용자들을 구분하는 알고리즘은 기록된 정보와 새로 입력된 정보가 일치하는지 확인 후 그에 따라 적절한 대처를 해준다. 하지만 그 새로 입력된 정보가 어떤 사용자의 정보인지를 직접 입력해줘야 하는 번거로움이 발생한다. 따라서 본 논문에서는 사용자 정보를 직접 입력하지 않아도 누적된 시스템 내의 워킹 메모리로부터 분석된 데이터를 바탕으로 시스템 스스로 클러스터링 알고리즘을 이용하여 사용자를 구분하는 방법을 제안한다. 연구 적용된 알고리즘을 적용한 시스템의 관리 기법이 기존의 시스템보다 인원 구성이 다양한 환경에서 적응성이 더 높음을 보여주었다(주관적 관찰자 실험방법으로 증빙).