• Journal of The Korean Society of Integrative Medicine
• /
• v.3 no.4
• /
• pp.69-78
• /
• 2015

Purpose: The purpose of this study was to identify whether inclined treadmill gait training with rhythmic auditory simulation (RAS) could improve on balance and gait in stroke patients. Method: Fifteen stroke patients who had agreed with the study were allocated to the group 1(n=5), group 2(n=5), or group 3(n=5). The group 1, group 2 and group 3 performed RAS with inclined treadmill gait training, inclined treadmill gait training and treadmill without incline gait training respectively for 3 weeks (30 minutes per session, 5 times in a week). The balance was assessed using Timed Up & Go (TUG) and Berg Balance Sale (BBS), and the gait was evaluated using 6 Minutes Walking Test (6MWT) and spatio-temporal walking variables as walking speed, cadence, Single Limb Support of affected side(SLS) and Symmetric Index(SI) before and after training. Result: Both the group 1 and group 2 showed significant improvement after training in all variables of balance and gait. The group 3 showed significant improvement in TUG values, 6MWT values, walking speed, cadence and SI. The changes in the group 1 were significantly greater in all dependent variables of balance and gait than those of the group 2 and group 3. The changes in the group 2 were significantly greater in TUG values, BBS scores, 6MWT values, walking speed, and cadence than those of the group 3. Conclusion: The result of this study show inclined treadmill gait training with RAS is more effective to improve balance and gait in stoke patients than inclined treadmill or general treadmill gait training without RAS.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.10 no.6
• /
• pp.1361-1368
• /
• 2009

This study attempts to present investment priorities and select industry for regional economic reinvigorating by analysing regional inter-industry of Chungchong area(including Chungnam and Chungbuk region) After the regional inter-industry table of Chungchong area has been made using a location quotient(LQ) method based on national inter-industry table of 2006 derived from national inter-industry table of 2003 using RAS method, various kind of impacts to Chungchong area are analysed. Manufacturing has the highest result in the result of production-inducing effect and value-added-inducing effect and hotels and restaurants has the highest result in employ-inducing effect. Sensitivity coefficient is highly analysed in mining and quarrying and influential coefficient is highly analysed in manufacturing.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.11
• /
• pp.6653-6656
• /
• 2013

Background: The single most common proto-oncogene change in human neoplasms is a point mutation in RAS genes. A wide range of variation in frequency of KRAS mutations has been seen in hematologic malignancies. Despite this, RAS roles in leukemogenesis remain unclear. The frequency of KRAS mutations in CML has been reported to be between zero an 10%. Many attempts have been done to develop an anti-RAS drug as a therapeutic target. Materials and Methods: This cross sectional study was performed in Mashhad University of Medical Sciences, Mashhad, Iran from 2010-2012. In 78 CML patients (diagnosed according to WHO 2008 criteria) in chronic or accelerated phases, KRAS mutations in codons 12 and 13 were analyzed using a modified PCR-restriction fragment length polymorphism (RFLP) method. Results: We did not detect any KRAS mutations in this study. Conclusions: KRAS mutations are overall rare in early phase CML and might be secondary events happening late in leukemogenesis cooperating with initial genetic lesions.

• Journal of Korea Water Resources Association
• /
• v.34 no.5
• /
• pp.561-566
• /
• 2001

This study is the analysis of hydraulic characteristic for stream diversion reach by numerical model test. Through it we can provide the basis data in flood, and in grasping stream flow characteristics. Analysis of hydraulic characteristics in Seoknam stream were implemented by using computer model HEC-RAS(one-dimensional model) and RMA2(two-dimensional finite element model). As a result we became to known that RMA2 to simulate left, main channel, right in stream is more effective method in analysing flow in channel bends, steep slope, complex bed form effect stream flow characteristics, than HEC-RAS.

• Korean Journal of Clinical Laboratory Science
• /
• v.50 no.4
• /
• pp.457-461
• /
• 2018

Corpus luteum (CL) is a transient endocrinal tissue that undergoes repeated formation and regression during the estrous cycle. In this study, we hypothesized that the functional and structural mechanism of angiogenesis is similar between CL and tumor formation. First, we measured mRNA and protein expression of angiogenic receptors (vascular endothelial growth factor receptor-2, VEGFR2; Tie 2) in the early, middle, and late phase CL tissues during the estrous cycle. Ral-interacting protein of 76 kDa (RLIP76) and H-ras mRNA and protein were also expressed in the CL tissues. VEGFR2 and Tie 2 mRNA and protein were expressed in the early and middle phase CLs and decreased in the late phase. H-ras mRNA and protein were expressed in the early and middle phase CLs, but not in the late phase. RLIP76 mRNA was expressed in all phase CLs, and the protein expression was highest in early phase CLs. We suggest that RLIP76 and H-ras, an oncogenic gene, regulate the function of the CL during the estrous cycle, and the proteins will play an important role in the angiogenic mechanism of the CL.

• Natural Product Sciences
• /
• v.12 no.4
• /
• pp.214-216
• /
• 2006

Isorhamnetin from the aerial parts of Persicaria thunbergii has been reported to have anti-tumor activity mediated by the inhibition of farnesyl protein transferase. In this study, we investigated the anti-proliferation effects of isorhamnetin on NIH3T3, K-RAS, H-RAS and SW620 cells, and it showed anti-proliferative effects in a dose-dependent manner with $IC_{50}$ value 4.1, 7.9, 20.2, and $22.4{\mu}g/ml$, repectively.

• Radiation Oncology Journal
• /
• v.15 no.2
• /
• pp.79-95
• /
• 1997

Purpose : Phospholipase C(PLC) isozymes play significant roles in signal transduction mechanism. $PLC-\gamma$ 1 is one of the key regulatory enzymes in signal transduction for cellular proliferation and differentiation. Ras oncoprotein, EGFR, and PKC are also known to be involved in cell growth. The exact mechanisms of these signal transduction following irradiation, however, were not clearly documented Thus, this study was Planned to determine the biological significance of PLC, ras oncoprotein, EGFR, and PKC in damage and regeneration of rat intestinal mucosa following irradiation. Material and Method : Sixty Sprague-Dawley rats were irradiated to entire body with a single dose of 8Gy. The rats were divided into S groups according to the sacrifice days after irradiation. The expression of PLC, ras oncoprotein, EGFR and PKC in each group were examined by the immunoblotting and immunohistochemistry. The histopathologic findings were observed using H&I stain, and the mitoses for the evidence of regeneration were counted using the light microscopy & PCNA kit. The Phosphoinositide(PI) hydrolyzing activity assay was also done for the indirect evaluation of $PLC-\gamma$ 1 activity. Results: In the immunohistochemistry , the expression of $PLC-{\beta}$ was negative for all grøups. The expression of $PLC-{\gamma}1$ was highest in the group III followed by group II in the proliferative zone of mucosa. The expression of $PKC-{\delta}1$ was strongly positive in group 1 followed by group II in the damaged surface epithelium. The above findings were also confirttled in the immunoblotting study. In the immunoblotting study, the expressions of $PLC-{\beta}$, $PLC-{\gamma}1$, and $PKC-{\delta}1$ were the same as the results of immunohis-tochemistry. The expression of ras oncoprctein was weakly positive in groups II, III and IV. The of EGFR was the highest in the group II, III, follwed by group IV and the expression of PKC was weakly positive in the group II and III. Conclusion: $PLC-{\gamma}1$ mediated signal transduction including ras oncoprotein, EGFR, and PKC play a significant role in mucosal regeneration after irradiation. $PLC-{\delta}1$ mediated signal transduction might have an important role in mucosal damage after irradiation. Further studies will be necessary to confirm the signal transduction mediating the $PKC-{\delta}1$.

• Journal of Korea Water Resources Association
• /
• v.41 no.9
• /
• pp.929-941
• /
• 2008

The objectives of this study are to propose a system for combined use of a hydrologic and a hydraulic model for urban flood forecast model and to evaluate the system on the $300km^2$ Jungrang urban watershed area, which is relatively large area as an urban watershed and consequently composed of very complex drainage pipes and streams with different land uses. In this study, SWMM for hydrologic model and HEC-RAS for hydraulic model are used and the study area is divided into 25 subbasins. The SWMM model is used for sewer drainage analysis within each subbasin, while HEC-RAS for unstready flow analysis in the channel streams. Also, this study develops a GUI system composed of mean areal precipitation input component, hydrologic runoff analysis component, stream channel routing component, and graphical representation of model output. The proposed system was calibrated for the model parameters and verified for the model applicability by using the observation data. The correlation coefficients between simulated and observed flows at the 2 important locations were ranged on 0.83-0.98, while the coefficients of model efficiency on 0.60-0.92 for the verification periods. This study also provided the possibilities of manhole overflows and channel bank inundation through the calculated water profile of longitudinal and channel sections, respectively. It can be concluded that the proposed system can be used as a surface runoff and channel routing models for urban flood forecast over the large watershed area.

• Journal of Korea Water Resources Association
• /
• v.40 no.6 s.179
• /
• pp.447-458
• /
• 2007

In this study, the coastal urban flood prediction and warning system based on HEC-RAS and SWMM were investigated to evaluate a watershed of On-Cheon stream in Busan which has characteristics of costal area cased by flooding of coastal urban areas. The basis of this study is a selection of various geological data from the numerical map that is a watershed of On-Cheon stream and computation of hydrologic GIS data. Thiessen method was used for analyzing of rainfall on the On-Cheon stream and 6th regression equation, which is Huff's Type II was time-distribution of rainfall. To evaluate the deployment of flood prediction and warning system, risk depth was used on the 3 selected areas. To find the threshold runoff for hydraulic analysis of stream, HEC-RAS was used and flood depth and threshold runoff was considered with the effect of tidal water level. To estimate urban flash flood trigger rainfall, PCSWMM 2002 was introduced for hydrologic analysis. Consequently, not only were the criteria of coastal urban flood prediction and warning system decided on the watershed of On-Cheon stream, but also the deployment flow charts of flood prediction and warning system and operation system was evaluated. This study indicates the criteria of flood prediction and warning system on the coastal areas and modeling methods with application of ArcView GIS, HEC-RAS and SWMM on the basin. For the future, flood prediction and warning system should be considered and developed to various basin cases to reduce natural flood disasters in coastal urban area.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2022.05a
• /
• pp.121-121
• /
• 2022

한국과 미국은 2018년 8월에 발표한 메콩우호국(Friends of the Lower Mekong, FLM) "메콩지역 수자원 데이터 관리 및 정보공유 강화에 관한 공동성명"을 계기로 메콩유역의 실시간 수자원 변동 모니터링 및 분석과 수자원 데이터 공동활용 역량을 강화하여 효율적이고 과학적인 수자원관리 지원과 함께 한국의 신남방정책과 미국의 인도-태평양 전략 시너지효과를 극대화하고자 메콩 주변국 재해경감 및 수자원 데이터 활용 역량강화를 위한 글로벌 위성기반 수문자료의 생산·활용 및 홍수·가뭄 등의 수재해 분석기술을 개발하고 있다. 여기에는 한국 K-water의 물관리 기술과 미국 NASA, USACE의 위성활용 및 수자원분석 기술을 접목하여 메콩지역의 체계적인 물관리 및 재해로부터 안전성 확보 기여에 목표를 두고 연구를 진행 중에 있다. 본 연구에서는 전 세계적으로 광범위하게 활용되고 있는 미공병단(USACE, U.S. Army Corps of Engineers)의 HEC software 프로그램을 메콩 시범지역(pilot area)에 적용하여 수리/수문모델 구축을 진행하고 있다. 구축되는 모형은 유역 상류 댐의 연계 모의운영 및 하류 홍수분석이 동시 가능한 HEC-RTS(Real-Time Simulation)로 이는 HEC-HMS, -ResSim, -RAS와 -FIA 모형이 순차적으로 결합된 수리/수문 모델링 시스템이다. 모형의 시범적용 지역은 현지 메콩위원회(MRC, Mekong River Comission)의 의견 등을 반영, 메콩강 하류지역(Lower Mekong) 본류 유역에 위성자료 활용 및 준실시간(near real-time)으로 댐 모의운영 등을 고려할 수 있는 JingHong댐(중국 란창강 최하류)에서 라오스 Xayaburi댐(메콩강 최상류)까지의 구간을 선정하였으며, 전년도에는HEC-RTS 중 HMS(Hydrologic Modeling System) 모형 적용을 중심으로 가용한 위성자료(GPM IMERG)를 활용하여 과거 홍수사상에 대한 모의를 고려한 강우-유출모형의 구축을 완료하였다. 이에 연속하여 금년도에는 동일유역 내 하천 단면 등이 확보된 Chiang Saen 지점에서 Xayaburi 댐까지의 구간에 대해 RAS(River Analysis System)을 구축할 예정으로 구축된 RAS 모형은 HEC-RTS에 포함되어 메콩 시범지역의 종합적 수리/수문분석에 적용될 예정이다.