[KSCI] Korea Science Citation Index Service

Anti-proliferation Effects of Isorhamnetin Isolated from Persicaria thunbergii on Cancer Cell Lines

Lee, Su-Kyung (Korea Research Institute of Bioscience and Biotechnology, KIST)
Kwon, Byoung-Mog (Korea Research Institute of Bioscience and Biotechnology, KIST)
Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University)
Kim, Sung-Hoon (Lab. of Angiogenesis and Chemoprevention, Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University)
Lee, Jae-Hyeok (Department of Oriental Pharmaceutical development, Nambu University)
Park, Hee-Wook (College of Pharmacy, Woosuk University)
Kim, Ju-Sin (College of Pharmacy, Woosuk University)
Moon, Mi-Kyeong (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)

Publication Information

Natural Product Sciences / v.12, no.4, 2006 , pp. 214-216 More about this Journal

Abstract

Isorhamnetin from the aerial parts of Persicaria thunbergii has been reported to have anti-tumor activity mediated by the inhibition of farnesyl protein transferase. In this study, we investigated the anti-proliferation effects of isorhamnetin on NIH3T3, K-RAS, H-RAS and SW620 cells, and it showed anti-proliferative effects in a dose-dependent manner with $IC_{50}$ value 4.1, 7.9, 20.2, and $22.4{\mu}g/ml$ , repectively.

Keywords

Isorhamnetin; Persicaria thunbergii; anti-proliferative activity;

Citations & Related Records

Times Cited By KSCI : 2 (Citation Analysis)
Times Cited By SCOPUS : 1

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