• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10825-10830
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• 2015

The present study was conducted to investigate effects and mechanisms of action of phenolic alkaloids of Menispermum dauricum (PAMD) on gastric cancer in vivo. In vitro, cell apoptosis of human gastric cancer cell line SGC-7901 was observed using fluorescence staining. In vivo, a mice model was constructed to observe tumor growth with different doses. Cell apoptosis was examined using flow cytometry and K-RAS protein expression using Western blotting. The mRNA expression of P53, BCL-2, BAX, CASPASE-3, K-RAS was examined by real-time PCR. PAMD significantly suppressed tumor growth in the xenograft model of gastric cancer in a dose-dependent manner (p<0.01). Functionally, PAMD promoted cell apoptosis of the SGC-7901 cells and significantly increased the rate of cell apoptosis of gastric tumor cells (p<0.05). Mechanically, PAMD inhibited the expression of oncogenic K-RAS both at the mRNA and protein levels. In addition, PAMD affected the mRNA expression of the cell apoptosis-related genes (P53, BCL-2, BAX, CASPASE-3). PAMD could suppress gastric tumor growth in vivo, possibly through inhibiting oncogenic K-RAS, and induce cell apoptosis possibly by targeting the cell apoptosis-related genes of P53, BCL-2, BAX, CASPASE-3.

• The Journal of Korean Medicine
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• v.33 no.2
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• pp.73-77
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• 2012

Objectives: This report reports a clinical case of a patient with recurrent aphthous stomatitis (RAS) for 10 years who was completely cured using Korean medicine. Methods: A male patient with terribly severe RAS was hospitalized, and then treated with Jibaekpalmi-hwon, indirect moxibustion (KI 1 and CV 4) and acupuncture. The clinical outcome was observed by self-reported VAS measurement and macroscopy. Results: The severity of stomatitis became improved gradually and completely recovered during 17 hospital days, and RAS has not recurred for three months as an outpatient. The blood test including complement activity was in the normal range. Conclusions: This case report provides information about a therapeutic effect of Jibaekpalmi-hwon and Korean medicine on RAS.

• Journal of Powder Materials
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• v.27 no.6
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• pp.464-467
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• 2020

Nickel nanopowders are obtained by the spark discharge method, which is based on the evaporation of the electrode surface under the action of the discharge current, followed by vapor condensation and the formation of nanoparticles. Nickel electrodes with a purity of 99.99% are used to synthesize the nickel nanoparticles in the setup. Nitrogen is used as the carrier gas with a purity of 99.998%. XRD, TEM, and EDX analyses of the nanopowders are performed. Moreover, HRTEM images with measured interplanar spacings are obtained. In the nickel nanopowder samples, a phase of approximately 90 wt% with an expanded crystal lattice of 6.5% on average is found. The results indicate an unusual process of nickel nanoparticle formation when the spark discharge method is employed.

• 대한예방의학회:학술대회논문집
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• 1999.10a
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• pp.138-139
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• 1999

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.05a
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• pp.100-101
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• 2003

• Bulletin of the Korean Chemical Society
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• v.26 no.2
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• pp.327-330
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• 2005

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.4
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• pp.299-307
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• 2015

Severe acute pancreatitis (SAP) is normally related to multiorgan dysfunction and local complications. Studies have found that local pancreatic renin-angiotensin system (RAS) was significantly upregulated in drug-induced SAP. The present study aimed to investigate the effects of angiotensin II receptors inhibitor valsartan on dual role of RAS in SAP in a rat model and to elucidate the underlying mechanisms. 3.8% sodium taurocholate (1 ml/kg) was injected to the pancreatic capsule in order for pancreatitis induction. Rats in the sham group were injected with normal saline in identical locations. We also investigated the regulation of experimentally induced SAP on local RAS expression in the pancreas through determination of the activities of serum amylase, lipase and myeloperoxidase, histological and biochemical analysis, radioimmunoassay, fluorescence quantitative PCR and Western blot analysis. The results indicated that valsartan could effectively suppress the local RAS to protect against experimental acute pancreatitis through inhibition of microcirculation disturbances and inflammation. The results suggest that pancreatic RAS plays a critical role in the regulation of pancreatic functions and demonstrates application potential as AT1 receptor antagonists. Moreover, other RAS inhibitors could be a new therapeutic target in acute pancreatitis.

• Journal of Korea Water Resources Association
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• v.45 no.9
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• pp.959-968
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• 2012

HEC-RAS has been applied to simulate water level variation in the Ara waterway during the flood season. To support decision making necessary for operation of the hydraulic structures especially during the flood season, it is important to consider various factors such as water level of the Han River, Gulpo River, and tidal level of the west sea in conjunction with operation of the hydraulic structures such as the Gyulhyun Weir, the West sea gate, and pumping stations. Especially for operation of the west sea gate, the Rule-script option was employed to determine the opening height considering the variation of the water level in the waterway and the west sea simultaneously. For model verification, comparison of water level computed at the upstream and downstream of the regulation weir shows a good agreement with observed data measured during the flood event in September 2010. The HEC-RAS model developed in this study will contribute to support operation of the waterway during the flood season.

• Journal of The Korean Astronomical Society
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• v.35 no.4
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• pp.209-220
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• 2002

In order to increase the completeness of the investigations of stellar abundances, we can use spectrum synthesis method, new atomic data and observation of stellar spectra with resolution comparable to solar spectral atlases. We made a brief review of main problems of these three ways. We present new results of abundance determinations in the atmospheres of four stars. The first is the implementation of new atomic data to well known Przybylski's star. We show that the number of spectral lines, which can be identificated in the spectrum of this star, can be significantly higher. The second example is the investigation of $\zeta$ Cyg. We found the abundances of 51 elements in the atmosphere of this mild barium star. The third example is halo star HD221170. Our preliminary abundance pattern consists of 42 elements. The heaviest elements in this pattern are U and Th. The last star is the spectroscopic binary HD153720. The number of elements investigated in the spectra of components of this star is not large, but the results show that the components are Am-stars.

• Journal of Life Science
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• v.22 no.4
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• pp.538-544
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• 2012

Ethanol is known as being carcinogenic to humans. In addition, the anti-proliferative effects of ethanol have been described for a variety of tissues and cells. In this study, we investigated the anti-proliferative effects of ethanol on various cancer cells, particularly on oncogenic $ras$-transformed or-injected cells. Ethanol treatment inhibited the cell proliferation of normal control cells, but did not suppress the proliferation of various cancer cells and oncogenic $ras$-transformed cells. Furthermore, ethanol treatment did not interfere with DNA synthesis, which was induced by microinjecting the oncogenic $H-Ras^{V12}$ protein. The anti-proliferative effect of ethanol was rescued by antioxidants, such as $N$-acetylcysteine and 4-methlpyrazole. These results suggest that ethanol cytotoxicity is exerted through free radical formation, and that the anti-proliferative action site of ethanol cytotoxicity either lies upstream, or is independent of Ras.