• Korean Journal of Clinical Laboratory Science
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• v.44 no.3
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• pp.103-111
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• 2012

Low-Density Lipoprotein cholesterol (LDLC) is the most important marker for the treatment of hyperlipidemia in NCEP-ATP III(National Cholesterol Education Program-Adult Treatment Panel III) guideline. Therefore, LDL cholesterol is pathologically meaningful, accurate measurement should be a top priority. Currently, LDLC is directly measured in most cases, but, the estimate is still used in mass health examination or screening test. This study is about the comparison of LDL-Cholesterol direct measurement with the estimate using various formula (Friedewald: [LDL-F=TC-HDL-TG/5], Nakajima: [LDL-N=TC-HDL-TG/4], Hattori: [LDL-H =0.94TC-0.94HDL-0.19TG], Puavilai: [LDL-P=TC-HDL-TG/6], Carvalho: [LDL-C=3(TC-HDL)/4]) for calculating more accurate value. We analyzed total cholesterol (TC), try-glyceride (TG), high-density lipoprotein cholesterol (HDLC), and LDLC levels of 210 subjects between June and November in 2011. Until now, the Friedewald formula is the most commonly used estimate for the LDLC. When Friedewald formula was applied, the correlation coefficient (r) was 0.940, showing high correlation. But, the result of the direct method was significantly different, compared with those of the Friedewald formula in triglyceride levels ${\geq}400mg/dL$(p<0.05). There was the highest correlation when we used LDL-P formula(r=0.947) in triglyceride levels <400 mg/dl. Also there was the lowest mean difference regardless of triglyceride level. Therefore, the study showed that TG/6 is more precise means of calculation than TG/5. On the other hand, the calculation of LDL-Cholesterol was underestimated, compared with direct measurement. It is necessary to have more data and modified Friedewald formula should be used for the accurate calculation.

• The Mathematical Education
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• v.57 no.3
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• pp.231-246
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• 2018

In this paper, we applied Sfard's reification theory to analyze the secondary students' level of conceptualization with regard to the formula of quadratic equation. Through the generation and development of mathematical concepts from a historical perspective, Sfard classified the formulation process into three stages of interiorization, condensation, and reification, and proposed levels of formulation. Based on this theory, we constructed a test tool reflecting the reversibility of the nature of manipulation of Piaget's theory as a criterion of content judgement in order to grasp students' conceptualization level of the formula of quadratic equation. By applying this tool, we analyzed the conceptualization level of the formula of quadratic equation of the $9^{th}$ and $10^{th}$ graders. The main results are as follows. First, approximately 45% of $9^{th}$ graders can not memorize the formula of quadratic equation, or even if they memorize, they do not have the ability of accurate calculation to apply for it. Second, high school curriculum requires for students to use the formula of the quadratic equation, but about 60% of $10^{th}$ graders have not reached at the level of reification that they can use the formula of quadratic equation. Third, as a result of imaginarily correcting the error of the previous concept, there was a change in the levels of $9^{th}$ graders, and there was no change in $10^{th}$ graders.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.4
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• pp.397-404
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• 2005

The propose of this study was to investigate taurine intake in formula-fed and breast-fed infants and to estimate the level of taurine of blood and urine in order to determine the requirement of taurine intake in infants. These results will be useful to suggest the guideline of requirement of taurine intake and may contribute toward the proper use of breast milk substitutes. Experimental groups were breast-fed infants (n=10) and formula-fed infants (n=10) of 20 normal delivery infants in general hospital. This study was longitudinal study from birth up to 16weeks (0 week, 4 weeks, 8 weeks, 12 weeks, 16 weeks). The items of test were anthropometry(weight, height, head circumference, chest circumference), intake of taurine, taurine level of blood and urine in breast-fed and formula-fed infants. There were no significant differences between breast-fed and formula-fed infants in weight, height, head and chest circumference. There is a need for future studies of exclusive infants with larger samples to determine which growth pattern should be considered as the norm. Taurine concentration of plasma and urine did not differ between breast-fed and formula-fed infants. Taurine intake recommendations for infants is about 30mg/day from this study. This data will be useful for production of human-like formula milk and suggestion of an index of selection of a consumer in taurine.

• Honam Mathematical Journal
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• v.37 no.1
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• pp.7-27
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• 2015

Kuneth formula is to compute (co)-homology of $A{\otimes}B$ for known (co)-homology of the complexes A and B. In the ordinary case, this is done by using elementary homological methods in an abelian category. However, when we consider the bounded cochain complex with values in $\mathbb{R}$ and its structure as a real Banach space, the techniques of homological algebra for constructing K$\ddot{u}$nneth type formulas on it are not effective. The most notable facts are the image of a morphism of Banach spaces is not necessarily closed, and also the closed summand of a Banach space need not be a topological direct summand. The main goal of this paper is to construct the theory of K$\ddot{u}$nneth type formula on bounded cohomology with real coefficients in the suitable category of Banach spaces with some restricted conditions.

• Journal of the Korean Data and Information Science Society
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• v.27 no.6
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• pp.1585-1592
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• 2016

Estimation of winning percentage in baseball has always been particularly interesting to many baseball fans. We have fitted models including linear regression and Pythagorean formula to the Korean baseball data of seasons from 1982 to 2015. Using RMSE criterion for both the linear formula and the Pythagorean formula, we compared two models in predicting the actual winning percentage. Pythagorean expectation is superior to linear formula when there is either high or low winning percentage. Two methods yield very similar efficiencies when the actual winning percentage is about 50%. To understand and use for estimating winning percentage, it is easier linear formula as estimated equations.

• Journal of Korean Elementary Science Education
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• v.33 no.2
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• pp.242-257
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• 2014

Researchers have employed a diversity of definitions and measurement methods for creativity. As a result, creativity research is underrepresented in the literature and the findings of different studies often prove difficult to draw into a coherent body of understanding. With regard to assessment, there are some important problems both in creativity research and practice, such as originality bias and Big-C creativity bias in teachers' perceptions about creativity and creative thinking, and additive rather than multiplicative scoring systems of creativity assessment. Drawing upon most widely accepted conceptions of the creativity construct, I defined 'student's scientific creativity' as the ability to make a product both original and useful to the student in terms of little-c creativity, and 'scientist's scientific creativity' as the ability to come up with a product both original and useful to the science community in terms of Big-C creativity. In this study, an 'Assessment Formula for Scientific Creativity' was developed, which is consisted of the multiplication of originality and usefulness scores rather than the sum of the two scores, and then, with scores calculated from the assessment formula, the scientific explanations generated by children were categorized into four types: routine, useful, original, and creative types. The assessment formula was revealed to be both valid and reliable. The implications of the assessment formula for scientific creativity are examined. The new assessment formula may contribute to the comprehensive understanding of scientific creativity to guide future research and the appropriate interpretation of previous studies.

• Journal of Korean Medical classics
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• v.33 no.4
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• pp.67-81
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• 2020

Objectives : This research aims to suggest a automatic data extract method for herbal formula combinations from medical classics' texts. Methods : This research was carried out by using Access of Microsoft Office 365 in Windows 10 of Microsoft. The subject text for extraction was 『Euijongsonik』. Using data sets of herb and dosage terminology, herbal medicinals and their dosages were extracted. Afterwards, using the position value of the character string, the formula combinations were automatically extracted. Results :The PC environment of this research was Intel Core i7-1065G7 CPU 1.30GHz, with 8GB of RAM and a Windows 10 64bit operation system. Out of 6,115 verses, 19,277 herb-dosage combinations were extracted. Conclusions : In this research, it was demonstrated that in the case of classical texts that are available as data, knowledge on herbal medicine could be extracted without human or material resources. This suggests an applicability of classical text knowledge to clinical practice.

• Communications for Statistical Applications and Methods
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• v.25 no.3
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• pp.321-328
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• 2018

In clinical trials with repeated measurements, the time-averaged difference (TAD) may provide a more powerful evaluation of treatment efficacy than the rate of changes over time when the treatment effect has rapid onset and repeated measurements continue across an extended period after a maximum effect is achieved (Overall and Doyle, Controlled Clinical Trials, 15, 100-123, 1994). The sample size formula has been investigated by many researchers for the evaluation of TAD in two treatment groups. For the evaluation of TAD in multi-arm trials, Zhang and Ahn (Computational Statistics & Data Analysis, 58, 283-291, 2013) and Lou et al. (Communications in Statistics-Theory and Methods, 46, 11204-11213, 2017b) developed the sample size formulas for continuous outcomes and count outcomes, respectively. In this paper, we derive a sample size formula to evaluate the TAD of the repeated binary outcomes in multi-arm trials using the generalized estimating equation approach. This proposed sample size formula accounts for various correlation structures and missing patterns (including a mixture of independent missing and monotone missing patterns) that are frequently encountered by practitioners in clinical trials. We conduct simulation studies to assess the performance of the proposed sample size formula under a wide range of design parameters. The results show that the empirical powers and the empirical Type I errors are close to nominal levels. We illustrate our proposed method using a clinical trial example.

• Journal of Korean Society on Water Environment
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• v.30 no.1
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• pp.87-94
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• 2014

According to the technical guideline of water pollutant load management, the rainfall captured ratio which can be estimated by the empirical formula is an important element to estimate reduction loads of non-point pollutants water quality control basin. In this study, the rainfall captured ratio is altered to stormwater captured ratio considering its meaning in the technical guideline of water pollutant load management, and the new empircal formula of stormwater captured ratio is suggested. In order to do this, we calculate stormwater captured ratio by using the hourly rainfall data of seven urban weather stations (Busan, Daegu, Daejeon, Gangreung, Seoul, Gwangju, and Jeju) for 43 years. The regression coefficients of the existed empirical formula cannot reflect the catchment properties at all, because they are fixed values regardless of regions. However the empirical formula of stormwater captured ratio has flexible regression coefficients by runoff coefficient(C), so it is allowed to consider the characteristics of runoff in catchment. It is expected that reduction loads of storage based water quality control basin can be more reasonably estimated than before.

• Nuclear Engineering and Technology
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• v.46 no.4
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• pp.481-488
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• 2014

An analysis of the uncertainty quantification related to LBLOCA using the Monte-Carlo calculation has been performed and compared with the tolerance level determined by the Wilks' formula. The uncertainty range and distribution of each input parameter associated with the LOCA phenomena were determined based on previous PIRT results and documentation during the BEMUSE project. Calulations were conducted on 3,500 cases within a 2-week CPU time on a 14-PC cluster system. The Monte-Carlo exercise shows that the 95% upper limit PCT value can be obtained well, with a 95% confidence level using the Wilks' formula, although we have to endure a 5% risk of PCT under-prediction. The results also show that the statistical fluctuation of the limit value using Wilks' first-order is as large as the uncertainty value itself. It is therefore desirable to increase the order of the Wilks' formula to be higher than the second-order to estimate the reliable safety margin of the design features. It is also shown that, with its ever increasing computational capability, the Monte-Carlo method is accessible for a nuclear power plant safety analysis within a realistic time frame.