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Bisphosphonates-related osteonecrosis of the jaw in Korea: a preliminary report

  • Lee, Jeong Keun;Kim, Kyung-Wook;Choi, Jin-Young;Moon, Seong-Yong;Kim, Su-Gwan;Kim, Chul-Hwan;Kim, Hyeon-Min;Kwon, Yong-Dae;Kim, Yong-Deok;Lee, Dong-Keun;Min, Seung-Ki;Park, In-Sook;Park, Young-Wook;Kook, Min-Suk;Park, Hong-Ju;Baek, Jin-A;Park, Jun-Woo;Kwon, Tae-Geon
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.39 no.1
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    • pp.9-13
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    • 2013

  • Objectives: Bisphosphonates (BP) are widely used in medicine for inhibiting bone resorption; however bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a major side effect of BP. To date, there have been no specific reports on the incidence of BRONJ among Koreans. This study investigated the preliminary results from a nationwide survey of BRONJ in the Departments of Oral and Maxillofacial Surgery (OMFS) at individual training hospitals. Materials and Methods: A total of 15 OMFS departments (10 from dental schools, 4 from medical schools, and 1 from a dental hospital) participated in a multi-centric survey. This study assessed every BRONJ case diagnosed between January 2010 and December 2010. The patient age and BP type were evaluated. Results: A total of 254 BRONJ cases were collected. The majority of BRONJ cases were associated with oral BP therapy, while 21.8% of the cases were associated with intravenous administration. Alendronate was the drug most frequently related to BRONJ (59.2% of cases), followed by risedronate (14.3%) and zolendronate (17.0%). The average age of BRONJ patients was $70.0{\pm}10.1$ years, with a range of 38-88 years of age. With the number of BP patients in Korea reported to be around 600,000 in 2008, the estimated incidence of BRONJ is at least 0.04% or 1 per 2,300 BP patients. Conclusion: The results suggest that the estimated incidence of BRONJ in Korea is higher than the incidence of other countries. Future prospective studies should be carried out to investigate the exact epidemiological characteristics of BRONJ in Korea.

  • https://doi.org/10.5125/jkaoms.2013.39.1.9 인용 PDF KSCI

Numerical analysis for hydrodynamic interaction effects between vessel and semi-circle bank wall

  • Lee, Chun-Ki;Moon, Serng-Bae;Oh, Jin-Seok;Lee, Sang-Min
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.7 no.4
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    • pp.691-698
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    • 2015

  • The hydrodynamic interaction forces and moments induced by the vicinity of bank on a passing vessel are known as wall effects. In this paper, the characteristics of interaction acting on a passing vessel in the proximity of a semi-circle bank wall are described and illustrated, and the effects of ship velocity, water depth and the lateral distance between vessel and semi-circle bank wall are discussed. For spacing between ship and semi-circle bank wall (SP) less than about 0.2 L and depth to ship's draft ratio (h/d) less than around 2.0, the ship-bank interaction effects increase steeply as h/d decreases. However, for spacing between ship and semi-circle bank wall (SP) more than about 0.3 L, the ship-bank interaction effects increase slowly as h/d decreases, regardless of the water depth. Also, for spacing between ship and semi-circle bank wall (SP) less than about 0.2 L, the hydrodynamic interaction effects acting on large vessel increase largely as ship velocity increases. In the meantime, for spacing between ship and semi-circle bank wall ($S_P$) more than 0.3 L, the interaction effects increase slowly as ship velocity increases.

  • https://doi.org/10.1515/ijnaoe-2015-0048 인용 PDF KSCI

Overexpression of PgSQS1 Increases Ginsenoside Production and Negatively Affects Ginseng Growth Rate in Panax ginseng

  • Shim, Ju-Sun;Lee, Ok-Ran;Kim, Yu-Jin;Lee, Jung-Hye;Kim, Ju-Han;Jung, Dae-Young;In, Jun-Gyo;Lee, Beom-Soo;Yang, Deok-Chun
    • Journal of Ginseng Research
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    • v.34 no.2
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    • pp.98-103
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    • 2010

  • The medicinal plant Panax ginseng (P. ginseng) contains various phytosterols and bioactive triterpene saponins (ginsenosides). Squalene synthase catalyzes the first committed step in ginsenoside biosynthesis. Transgenic plants of P. ginseng were generated by introducing the squalene synthase gene derived from P. ginseng. Adventitious roots of the transgenic ginseng grew best in B5 medium, and 2 g of inoculum secured an optimal growth rate. Two phytohormones, indolebutyric acid and 1-naphtalene acetic acid, increased root growth and decreased ginsenoside production. Treatment with two selected elicitors, chitosan and jasmonic acid, and a precursor of the isoprenoid pathway, mevalonic acid, enhanced ginsenoside production and retarded ginseng growth rate.

  • https://doi.org/10.5142/jgr.2010.34.2.098 인용 PDF KSCI