• Biomolecules & Therapeutics
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• v.8 no.1
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• pp.53-63
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• 2000

This study was performed to elucited the mechanisms of the antidiuretic action by SKP-450, a $K^+$ channel opener, given into the vein, and of the diuretic action observed only in the ipsilateral kidney, when given into a renal artery, in dog. The antidiuretic action of SKP-450 was not affected by renal denervation or pretreatment with glibenclamide, a ATP-dependent $K^+$ channel blocker. The diuretic action of SKP-450 was inhibited by renal denervation or pretreatment with glibenclamide. SKP-450 given into carotid artery had little effect on renal function. These results suggest that the antidiuretic action of SKP-450 given into the vein is caused by some endogenous substances probably not related to $K^+$ channel, whereas the diuretic action of SKP-450 observed only in ipsilateral kidney, when given into a renal artery, is provoked through $K^+$ channel related to renal nerves.

• Proceedings of the Korean Information Science Society Conference
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• 2012.06d
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• pp.187-189
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• 2012

The medium access control (MAC) protocol is designed only for single channel in the IEEE 802.11 standard. That means the throughput of the network is limited by the bandwidth of the single channel. The multiple channels can be exploited to get more concurrent transmission. In this paper, we propose a novel Multi-channel MAC that utilizes the channel more efficiently than other Multi-channel MAC protocols.

• Proceedings of the IEEK Conference
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• 2001.09a
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• pp.579-582
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• 2001

The performance of a coherent rake receiver of DS-CDMA systems is significantly affected by the accuracy of channel estimation. The performance of the channel estimator can be improved by employing a channel estimation filter (CEF) whose impulse response is adjusted according to the channel condition. In this paper, we consider the design of an adaptive channel estimator for DS-CDMA systems with a pilot channel. The proposed channel estimator estimates the channel condition, which can be performed without haying exact a priori information on the operating condition. The estimated channel condition adjusts the impulse response of the CEF. Numerical results show that the use of the proposed channel estimator can provide BER performance quite robust to a wide range of channel condition.

• Journal of information and communication convergence engineering
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• v.8 no.1
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• pp.40-44
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• 2010

opportunistic spectrum access (OSA) allows unlicensed users to share licensed spectrum in space and time with no or little interference to primary users, with bring new research challenges in MAC design. We propose a cognitive MAC protocol using statistical channel information and selecting appropriate idle channel for transmission. The protocol based on the CSMA/CA, exploits statistics of spectrum usage for decision making on channel access. Idle channel availability, spectrum hole sufficiency and available channel condition will be included in algorithm statistical information. The model include the control channel and data channel, the transmitter negotiates with receiver on transmission parameters through control channel, statistical decision results (successful rate of transmission) from exchanged transmission parameters of control channel should pass the threshold and decide the data transmission with spectrum hole on data channel. A dynamical sensing range as a important parameter introduced to maintain the our protocol performance. The proposed protocol's simulation will show that proposed protocol does improve the throughput performance via traditional opportunistic spectrum access MAC protocol.

• The Korean Journal of Physiology and Pharmacology
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• v.7 no.1
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• pp.15-23
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• 2003

Cellular redox state is known to be perturbed during ischemia and that $Ca^{2+}$ and $K^2$ channels have been shown to have functional thiol groups. In this study, the properties of thiol redox modulation of the ATP-sensitive $K^2$ ($K_{ATP}$) channel were examined in rabbit ventricular myocytes. Rabbit ventricular myocytes were isolated using a Langendorff column for coronary perfusion and collagenase. Single-channel currents were measured in excised membrane patch configuration of patch-clamp technique. The thiol oxidizing agent 5,5'-dithio-bis-(2-nitro-benzoic acid) (DTNB) inhibited the channel activity, and the inhibitory effect of DTNB was reversed by dithiothreitol (disulfide reducing agent; DTT). DTT itself did not have any effect on the channel activity. However, in the patches excised from the metabolically compromised cells, DTT increased the channel activity. DTT had no effect on the inhibitory action by ATP, showing that thiol oxidation was not involved in the blocking mechanism of ATP. There were no statistical difference in the single channel conductance for the oxidized and reduced states of the channel. Analysis of the open and closed time distributions showed that DTNB had no effect on open and closed time distributions shorter than 4 ms. On the other hand, DTNB decreased the life time of bursts and increased the interburst interval. N-ethylmaleimide (NEM), a substance that reacts with thiol groups of cystein residues in proteins, induced irreversible closure of the channel. The thiol oxidizing agents (DTNB, NEM) inhibited of the $K_{ATP}$ channel only, when added to the cytoplasmic side. The results suggested that metabolism-induced changes in the thiol redox can also modulate $K_{ATP}$ channel activity and that a modulatory site of thiol redox may be located on the cytoplasmic side of the $K_{ATP}$ channel in rabbit ventricular myocytes.

• JSTS:Journal of Semiconductor Technology and Science
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• v.15 no.6
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• pp.608-614
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• 2015

A multi-channel audio CODEC with inter-channel interference suppression is proposed, in which channel switching noise-referred sampling error is significantly reduced. It also supports a coarse/fine mode operation for fast frequency tracking with good harmonic performance. The proposed multi-channel audio CODEC was designed in a 65 nm CMOS process. Measured results indicated that SNR and SNDR of ADC were 93 dB and 84dB, respectively, with SNDR improved by 43 dB. Those of DAC were 96 dB and 87 dB, respectively, with SNDR improved by 45 dB when all the channels are running independently.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.160-160
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• 1993

목적: Guinea pig heart의 ATP sensitive $K^{＋}$ channel xenopus oocyte에 발현시켜 연구하고져 본 실험을 행하였다. 실험방법: 기니픽 심장으로부터 ,RNA를 분리하여 50ng/$\mu$l의 농도로 50nl를 xenopusdp 주입하였다. Xenpus oocyte에서 conventional electrode를 이용 막전휘를 측정하였고, pH selective 미세전극으로 세포내 pH를 측정하였다. 막전위에 미치는 potassium channel opener, blocker, KCN의 작용을 관찰하였다. 결과: 기니픽 심장 mRNA를 주입하거나 주입하지 않은 xenopus oocyte에서 $K^{＋}$channel opener인 cromakalin, RP49356등은 과분극을 일으키지 못하였다. 그러나 세포내 ATP 감소제인 KCN은 농도 의존적으로 과분극을 일으켰으나 ,glibenclamide에 의해 차단되는 않았다. mRNA를 주입한 oocyte에서 Na-H 자극제인 NH$_4$Cl은 pH 변동을 일으켜 NA-H exchange를 expression 시켰다. 결론: Xenopus oocyte는 cromakalin등에 의해 open되는 $K^{＋}$channel 은 없었고, 기니픽 심근의 ATP sensitive $K^{＋}$channel로 expression 되지 않았으나 Na-H exchange 는 expression 됨을 알 수 있었다. KCN으로 open 되는 $K^{＋}$channel이 있었으나 glibenclamide에는 차단되지 않는 channel이였다.

• IE interfaces
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• v.16 no.3
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• pp.311-321
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• 2003

We propose the improved channel assignment and management methods for an efficient use of traffic channel resource for supporting 12.2 Kbps, 64 Kbps, and 384 Kbps traffic with the different quality of service(QoS) in the radio network controller(RNC) in asynchronous IMT-2000 system. We consider two types of traffic channel block assignments for utilizing the traffic channel efficiently; the Completely Shared(CS) channel assignment and the Partially Dedicated and Partially Shared(PDPS) channel assignment. The former is that all traffic channel blocks are completely shared with all traffic types. The latter is that some traffic channel block is independently assigned to each traffic type and the other blocks are completely shared with some traffic type. We also propose the traffic channel management method which consists of the block and task management step, for efficiently assigning, releasing, and managing the channel resource. Finally, we evaluate the performance through various numerical examples when applying our proposed channel block assignment and resource management methods.

• Journal of information and communication convergence engineering
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• v.8 no.3
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• pp.273-276
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• 2010

Opportunistic spectrum access (OSA) allows unlicensed users to share licensed spectrum in space and time with no or little interference to primary users, with bring new research challenges in MAC design. We propose a cognitive MAC protocol using statistical channel information and selecting appropriate idle channel for transmission. The protocol based on the CSMA/CA, exploits statistics of spectrum usage for decision making on channel access. Idle channel availability, spectrum hole sufficiency and available channel condition will be included in algorithm statistical information. The model include the control channel and data channel, the transmitter negotiates with receiver on transmission parameters through control channel, statistical decision results (successful rate of transmission) from exchanged transmission parameters of control channel should pass the threshold and decide the data transmission with spectrum hole on data channel. The proposed protocol's simulation will show that proposed protocol does improve the throughput performance via traditional opportunistic spectrum access MAC protocol.

• Proceedings of the SAREK Conference
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• 2008.11a
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• pp.215-220
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• 2008

A microchannel PCHE is manufactured by the two technologies of micro photo-etching and diffusion bonding. In this paper, heat transfer and pressure drop characteristics by applying various configuration for the flow channel in the microchannel PCHE is experimentally investigated. The flow channel configurations are designed three types such as straight, wavy and offset strip channels. The performance experiment of each configuration is performed for Reynolds numbers in ranges of $100{\sim}700$ under various flow conditions for the hot side and the Reynolds number of cold side is fixed at 350. The inlet temperatures of the hot side and cold side are conducted as $40^{\circ}C$ and $20^{\circ}C$, respectively. The heat transfer performance of wavy channel, which was similar to that of offset strip channel, was much higher than that of straight channel. The effectiveness of wavy channel and offset strip channel was evaluated as about $0.5{\sim}0.9$. The pressure drop of wavy channel was highest among configurations and that of offset strip channel was lower than that of straight channel because the round curved surface of each strip edge was reduced the pressure loss.