Effect of Renal Denervation and Glibenclamlde, ATP-dependent $K^+$ Channel Blocker, on Renal Action of SKP-450, $K^+$ Channel Opener, in Dog

$K^+$ Channel 개방제인 SKP-450의 신장작용에 대한 신장 신경제거와 ATP-의존성 $K^+$ Channel 차단제인 Glibenclamide의 영향

This study was performed to elucited the mechanisms of the antidiuretic action by SKP-450, a $K^+$ channel opener, given into the vein, and of the diuretic action observed only in the ipsilateral kidney, when given into a renal artery, in dog. The antidiuretic action of SKP-450 was not affected by renal denervation or pretreatment with glibenclamide, a ATP-dependent $K^+$ channel blocker. The diuretic action of SKP-450 was inhibited by renal denervation or pretreatment with glibenclamide. SKP-450 given into carotid artery had little effect on renal function. These results suggest that the antidiuretic action of SKP-450 given into the vein is caused by some endogenous substances probably not related to $K^+$ channel, whereas the diuretic action of SKP-450 observed only in ipsilateral kidney, when given into a renal artery, is provoked through $K^+$ channel related to renal nerves.