• Microbiology and Biotechnology Letters
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• v.15 no.5
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• pp.352-355
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• 1987

The isolation and characterization of type II restriction endonuclease from Clostridium thermocellum ATCC 27405 were described. This enzyme (Cth I endonuclease) is an isoschizomer of Bcl I endonuclease recognizing 5'-TGATCA-3'. Cth I endonuclease requires MG$^{2+}$ ion for its activity and is maximally active at PH 1.5 to 10.5 in the Presence of 0 to 10mM NaCl. Cth I endonuclease is heat stable and has an optimum temperature of 6$0^{\circ}C$. The activity of Cth I enzyme is sensitive to dam methylation.

• The Korean Journal of Pharmacology
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• v.27 no.2
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• pp.135-144
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• 1991

Using T-lymphocytes obtained from rat peripheral blood, we found that the 44kD/pI6.8 protein was the major phosphoprotein of T-lymphocytes under basal condition, and that the 44kD/pI6.3 protein was a new phosphoprotein appeared in T-lymphocytes stimulated with ${\beta}-agonist$. The phosphorylation of the 44kD/pI6.3 protein was also induced by forskolin but inhibited by H-8 pretreatment. To clarify the character of the 44kD/pI6.3 protein, we used Con-A and kinase inhibitors, H-7 and W-7. Con-A stimulation induced phosphorylation of 44kD/pI 6.3 protein but that was inhibited by W-7 pretreatment. The phosphorytation of 44kD/pI6.3 protein was not induced by the PKC activator, PMA. Instead, the phosphorylation of 44kD/pI6.8 protein was reduced by H-7, a PKC inhibitor. From the above results,it can be concluded that the 44kD/pI6.3 protein can be a common substrate for A-kinase and CaM kinase. The two dimensional tryptic peptide mapping revealed that the 44kD/pI6.8 and 44kD/pI6.3 proteins are different.

• Communications of the Korean Mathematical Society
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• v.10 no.1
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• pp.23-26
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• 1995

Throughout this paper R will always denote an integral domain with the quotient field K. Let A denote the polynomial ring R[x], I be an ideal of $A, I_K = I \otimes_R K$ and $J = I_K \cap A$.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.29 no.2
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• pp.150-156
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• 1996

Insulin-like growth factor-1 (IGF-I) is a mitogenic peptide with molecular mass of 7kDa. It is produced mainly in the liver and has important functions in the regulation of development and somatic growth. Recently, several investigations were undertaken to examine the biological actions and structures of IGF-I in fish. In this study, the serum levels of IGF-I were estimated from flounder, Parlichthys oilvaceus, before, during and after fasting, and the levels were accounted for 47 ng/ml, 40 ng/ml and 45 ng/ml, respectively. These results suggest that food deprivation primarily reduces IGF-I level in the blood.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.291.1-291.1
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• 2013

We examined the temperature-dependent structural and magnetic properties of HgI2 in the temperature range of 300~400 K. HgI2 is a diamagnetic material and can be used for X-ray or γ-ray detectors. DCmagnetization measurements on HgI2 showed that there is a small but distinguishable change in its diamagnetic properties near 375 K. The magnetic property change is not expected because Hg and I are known as nonmagnetic elements. X-ray diffraction (XRD) measurements revealed a structural transition in the temperature of 350~400 K. Temperature-dependent x-ray absorption fine structure (XAFS) demonstrated that the chemical valence states of both Hg and I did not changed in the temperature range of 300~400 K. However, XAFS revealed that the bond-length disorder was slightly increased in the temperature range, particularly, near Hg atoms. The structural changes of HgI2 are likely related to its diamagnetic property change. We will discuss the relation between the diamagnetic properties and local structural properties of HgI2 in detail.

• Molecules and Cells
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• v.28 no.5
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• pp.495-499
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• 2009

Although insulin-like growth factor-I (IGF-I) and androgen receptor (AR) are well known effectors of skeletal muscle, the molecular mechanism by which signaling pathways integrating AR and IGF-I in skeletal muscle cells has not been previously examined. In this study, the role of PI3K/Akt on IGF-I-induced gene expression and activation of AR in skeletal muscle cells was investigated. C2C12 cells were treated with IGF-I in the absence or presence of inhibitors of PI3K/Akt pathway (LY294002 and Wortmannin). Inhibition of the PI3K/Akt pathway with LY294002 or Wortmannin led to a significant decrease in IGF-I-induced AR phosphorylation and total AR protein expression. Furthermore, IGF-I-induced AR mRNA and skeletal ${\alpha}-actin$ mRNA were blocked by LY294002 or Wortmannin. Confocal images showed that IGF-I-induced AR translocation from cytosol to nucleus was inhibited significantly in response to treatment with LY294002 or Wortmannin. The present results suggest that modulating effect of IGF-I on AR gene expression and activation in C2C12 mouse skeletal muscle cells is mediated at least in part by the PI3K/Akt pathway.

• Bulletin of the Korean Mathematical Society
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• v.58 no.5
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• pp.1069-1078
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• 2021

Let R be a commutative ring with identity. A proper ideal I of R is called 1-absorbing primary ([4]) if for all nonunit a, b, c ∈ R such that abc ∈ I, then either ab ∈ I or c ∈ ${\sqrt{1}}$. The concept of 1-absorbing primary ideals in a polynomial ring, in a PID and in idealization of a module is studied. Moreover, we introduce weakly 1-absorbing primary ideals which are generalization of weakly prime ideals and 1-absorbing primary ideals. A proper ideal I of R is called weakly 1-absorbing primary if for all nonunit a, b, c ∈ R such that 0 ≠ abc ∈ I, then either ab ∈ I or c ∈ ${\sqrt{1}}$. Some properties of weakly 1-absorbing primary ideals are investigated. For instance, weakly 1-absorbing primary ideals in decomposable rings are characterized. Among other things, it is proved that if I is a weakly 1-absorbing primary ideal of a ring R and 0 ≠ I₁I₂I₃ ⊆ I for some ideals I₁, I₂, I₃ of R such that I is free triple-zero with respect to I₁I₂I₃, then I₁I₂ ⊆ I or I₃ ⊆ I.

• Annual Conference of KIPS
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• 2000.10a
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• pp.657-660
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• 2000

병렬 파일 시스템은 늦은 디스크 I/O로 인한 성능 저하를 개선하기 위해 병렬 I/O를 제공한다. 이때 계산과 디스크 I/O를 중첩시키는 선반입 기법으로 디스크 I/O로 인한 성능 저하를 더욱 개선할 수 있다. 하지만 I/O 위주의 프로그램에서는 선반입으로 인하여 시스템에서 제공하는 I/O 대역폭을 넘어 최악의 경우 기존의 선반입 기법은 성능개선을 위한 최선이 될 수 없을 뿐 아니라 선반입 기법 자체가 과부하가 될 수 있다. 본 논문에서는 이런 상황을 고려하여 I/O 대역폭 개선을 위한 이단 선반입 기법을 제시하여 성능개선을 제공한다.

• Journal of Oriental Neuropsychiatry
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• v.16 no.2
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• pp.233-242
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• 2005

'Ul-zeong' comes from obsturction of qi by stress. The mind affect the body. The patient has depressed mood, irritable sign, chest discomfort, costral pain, angry state or some strange feeling on the throat. $'Y{\acute{i}}q{\acute{i}}ngbi{\grave{a}}nq{\grave{i}}'$ is a psychological therapy that a doctor changes the patient ' s psychological condition by using various method. 'yi' means moving, 'qing' means changing. Art therapy means a therapy by using artistic activities and included in $'y{\acute{i}}q{\acute{i}}ngbi{\grave{a}}nq{\grave{i}}'$ In this case, a female patient, 35 years old, who suffered from 'ul-zeong' with depressed mood, anxiety, general body weakness, anorexia, constipation. We used $'y{\acute{i}}q{\acute{i}}ngbi{\grave{a}}nq{\grave{i}}'$ besides herbal medication, acupuncture to her and her condition got improved. Therefore we reported it for the treatment.

• YAKHAK HOEJI
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• v.41 no.6
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• pp.756-764
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• 1997

Ile-224 in I269S mutant horse liver alcohol dehydrogenase isoenzyme S (HLADH-S) was mutated to serine by site-directed mutagenesis in order to study the role of the residue in c oenzyme binding to the enzyme. The specific activity of the I269S and I224S mutant enzyme to ethanol was increased 6-fold and all Michaelis constants($K_a,\;K_b,\;K_p,\;and\;K_q$,/TEX>) were larger than those for the wild-type and I269S enzyme. The substitution decreased the afffinity to coenzymes and increased the specific activity of the enzyme. The mutant enzyme showed the highest catalytic efficiency for octanol among the primary alcohols. But it didn`t have activities on retinoids and 5${\beta}$-cholanic acid-3-one. From these results, it was confirmed that the hydrophobic interaction of Ile-224 residue with coenzyme was related to coenzyme affinity in ADH reaction. The substitution also affected the substrate affinities to the enzyme.