• Mycobiology
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• v.51 no.3
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• pp.157-163
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• 2023

Cordyceps fumosorosea is an important species in the genus of Cordyceps, containing a variety of bioactive compounds, including fumosorinone (FU). This study was a ground-breaking assessment of FU levels in liquid and solid cultures. The present study focused on the impacts of solid-state fermentation (SSF) using solid substrates (wheat, oat, and rice), as well as the effects of fermentation parameters (pH, temperature, and incubation period), on the generation of FU. All the fermentation parameters had significant effects on the synthesis of FU. In a study of 25 ℃, 5.5 pH, and 21 days of incubation period combinations calculated -to give maximal FU production, it was found that the optimal values were 25 ℃, 5.5 pH, and 21 days, respectively. In a solid substrate medium culture, FU could be produced from SSF. At 30 days, a medium composed of rice yielded the most FU (798.50 mg/L), followed by a medium composed of wheat and oats (640.50 and 450.50 mg/L), respectively. An efficient method for increasing FU production on a large scale could be found in this approach. The results of this study might have multiple applications in different industrial fermentation processes.

• Journal of Environmental Health Sciences
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• v.34 no.1
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• pp.108-115
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• 2008

This study was performed to investigate the current status, in Korea, of the production of asbestos containing products (ACPs) such as asbestos cement products, asbestos friction materials, asbestos joint sheets, asbestos textile products, and other asbestos-containing products from May 2 to July 30, 2007. The information on ACPs was obtained through written questionnaires from 16 of the 27 companies that produce ACPs in Korea. The production amounts of asbestos containing gaskets were 70 tons in 2004, 90 tons in 2005, and 55 tons in 2006 in 4 companies and that of asbestos friction materials were 435.5 tons in 2004, 540.4 tons in 2005, and 454.3s ton in 2006 in 10 companies. The type and number of ACPs were:- 19 asbestos cement products, produced by 2 companies; 47 asbestos friction materials produced by 18 companies; 12 asbestos joint sheets productes by 4 companies; 18 asbestos textile products from 3 companies, and 6 other asbestos products from 5 companies. The database of ACPs was constructed to include the products name, identification number, name of company, production year, composition, asbestos content (%), usage, specification, and a picture. The database will be used to efficiently identify ACPs and to avoid asbestos exposure in workers and the general population.

• Biomolecules & Therapeutics
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• v.20 no.1
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• pp.50-56
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• 2012

WIN-34B showed analgesic and anti-inflammatory effects in various animal models of pain and osteoarthritis. However, the molecular mechanism by which WIN-34B inhibits pain and inflammation in vivo remains to be elucidated. We investigated the molecular mechanisms of the actions of WIN-34B using various in vitro models using fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA FLSs), RAW264.7 cells and peritoneal macrophages. WIN-34B inhibited the level of IL-6, $PGE_2$, and MMP-13 in IL-$1{\beta}$-stimulated RA FLSs in a dose-dependent manner. The mRNA levels were also inhibited by WIN-34B. The level of $PGE_2$, NO, IL-$1{\beta}$, and TNF-${\alpha}$ were inhibited by WIN-34B at different concentrations in LPS-stimulated RAW264.7 cells. The production of NO and $PGE_2$ was inhibited by WIN-34B in a dose-dependent manner in LPS-stimulated peritoneal macrophages. All of these effects were comparable to the positive control, celecoxib or indomethacin. I${\kappa}B$B signaling pathways were inhibited by WIN-34B, and the migration of NF-${\kappa}B$ into the nucleus was inhibited, which is consistent with the degradation of $I{\kappa}B-{\alpha}$. Taken together, the results suggest that WIN-34B has potential as a therapeutic drug to reduce pain and inflammation by inhibiting the production of pro-inflammatory mediators.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2006.05a
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• pp.399-402
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• 2006

The outer race of CV(constant velocity) joint is an important load-supporting automotive part, which transmits torque between the transmission gear box and driving wheel. The outer race is difficult to forge because its shape is very complicated and the required dimensional tolerances are very small. Traditional warm and cold forging methods have their own limitations to produce such a complex shaped part; warm forging requires complex system with relatively higher manufacturing cost, while cold forging is not applicable to materials with limited formability. Therefore, multistage forging may be advantageous to produce complex shaped parts. In order to build a multistage forging system, it is necessary to characterize mechanical properties in response to system design parameters such as temperature, forging speed and reduction. For the analysis of formability of multistage forging process, finite element method(FEM) has been used for the process analysis. As a model case, a constant velocity (CV) joint forging process is analyzed by FEM, since CV joint has a complex shape and also its required dimensional tolerances are very tight. The data acquired by FEM is compared with operational forging data obtained from an industrial production line. Based on this comparative analysis, multistage forging process for CV joints is proposed.

• Bulletin of the Society of Naval Architects of Korea
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• v.20 no.2
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• pp.51-59
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• 1983

The versatile practical use of electron beam welding which is very high energy density is still in early stage, but in the special welding field, the welding process is used in manufactured goods. The investigation for electron beam welding up to the present was almost achieved not for the mechanical properties of welded joint but for the process itself. On this investigation, the fatigue strength, crack propergation phenomena and hardness of weld metal and heat affected zone of partially penetrated welded joint of HT80 steel by electron beam welding was accomplished. The tensile fatigue strength in weld line direction of the joint was about $25kg/mm^2$. There still appeared spikes on the tips of penetration, and the crack initiated at the tips of spikes not from the roots. The hardness of the weld metal was higher than it of base metal because of production of martensite by rapid cooling.

• KDI Journal of Economic Policy
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• v.14 no.3
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• pp.3-21
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• 1992

By localizing the production of core parts and intermediate goods previously imported from Japan, Korean firms have been striving to increase their market share and profit in the final goods market in which Japanese firms are dominating. Korean producers' efforts, however, have often been thwarted by Japanese suppliers' "strategic" behavior. This competitive strategy involves Japanese exporters supplying parts and intermediate goods at very high prices until Korean firms must locally develop them, and then setting the prices far below the previous level so that the profitability of localization is dramatically reduced, or even means a loss for the Korean manufacturer. This paper intends to explain the strategic behavior of Japanese firms through the concepts of strategic interactions and joint economies. Strategic interactions can be aggressive or accommodating depending on whether competitors are dealing with strategic substitutes or complements. Joint economies exist in multi-stage competition when competition in the previous state favorably influences "profits" of the ensuing stage. Competiton between Korean and Japanese firms (a two-stage game involving production and technology rivalries) can be characterized by joint economies and strategic substitutes: joint economies since technological improvement results in more profits in the production stage; and strategic substitutes since an increase in marginal profits of one firm brings about a decrease in marginal profits of the other in a duopolitic production stage. This implies that the flood of "low price" Japense substitutes is an almost "natural" phenomenon in the context of the duopolistic market described in this paper. In the technology competition stage, on the other hand, technology development and technology transfer can be either strategic complements or substitutes. This implies that, in typical comparative static analyses, the effect of changes in exogenous variables cannot be expected a priori. Thus it becomes very difficult to determine the desirability of applying various policy measures such as countervailing duties, R&D subsidies, and creating demand for localized products. For these reasons, it is indeed likely that the measures suggested as means of circumventing the strategic behavior of Japanese firms (and enhancing technological development of Korean firms) may not work.

• Korean Journal of Agricultural Science
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• v.32 no.2
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• pp.107-126
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• 2005

The most limited production resource in Korea is land. During the period from 1995 to 2002, annual farm land area of 17,600ha have been converted to urban and industrial land. The self-sufficiency rate of rice, Korean staple food, is expected to be decreased from 97.5% in 2003 to 60-70% in 2020. Under such conditions, this study is aimed at first identifying multi-functional benefits of the reclamation projects such as agricultural production, industrial water supply, urban land supply, transportation effects, sightseeing effects and environmental values with and without the projects. To carry out the objectives, three existing tideland reclamation projects such as Daeho, Kumgang and Yongsangang irrigation project stage II were evaluated and Saemangeum tideland reclamation project which was jointly revaluated by environmental NGO and Govn't appointed specialists in 2000 was reviewed. According to this study results, tide land reclamation projects were showed financially and economically feasible and environmentally sustainable. The joint cost like estuary dam should be allocated based on the multi-functional benefits of the projects. To allocate the joint cost, legal and institutional improvement should adapt the joint cost allocation method as the specific cost-remaining benefit method. Korea has more than 402,000 ha of tidal flat of which 76,396ha have been reclaimed in 2003. To meet food security and to cope with shortage of land, phil-environmental reclamation projects should be continuously implemented and necessary tidal flats for protecting environmental ecosystem should be remained according to the detail survey results of reclaimable resources.

• Journal of the Korean Society of Food Culture
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• v.37 no.5
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• pp.438-445
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• 2022

Laminaria japonica is a type of brown algae widely consumed in Asian countries and contains many essential nutrients and exhibits anti-obesity, antioxidant, and anti-inflammatory effects. In this study, the antioxidant and immunomodulatory effects of a Laminaria japonica water extract (LJE) were investigated using an in vitro model. Mean total polyphenol content of LJE was 2.16±0.11 ㎍ GAE/mg, and LJE dose-dependently inhibited ABTS radical activity but did not scavenge DPPH radicals. In addition, LJE enhanced nitric oxide (NO) production and upregulated the mRNA expressions of proinflammatory cytokines (i.e., tumor necrosis factor-α and interleukin-6) in RAW 264.7 cells. On the other hand, LJE inhibited NO production and downregulated proinflammatory cytokine mRNA levels in endotoxin-stimulated RAW 264.7 cells. Thus, our data show that LJE has moderate antioxidant activity and biphasic immunomodulatory effects on RAW 264.7 cells. In summary, the study indicates that LJE has potential therapeutic use as a novel biphasic immuno-modulator.

• The Journal of the Korea Contents Association
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• v.17 no.11
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• pp.319-330
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• 2017

Since the placement of the THAAD missiles has recently cooled the relationship between Korea and China, many Korea-China joint films and entertainment businesses have collapsed. To make matters worse, there is also many opinions for "Korea-China joint film useless" in China through the results of many Korea-China joint films. In my opinion, the causes of failures of the Korea-China joint films are the lack of understanding and experience of Korean filmmakers in the Chinese film industry. So, By examining the history of Chinese cinema in this paper, I want to establish the character formation of the Chinese film industry. And cause a criminal-thriller genre has to undergo more stringer censorship than any other genre, I will introduce the production process of remake of the Korean film . By introducing the censorship method of the Chinese film industry and the actual cases applied, I want to help understand the present status of Chinse film industry. Also, I intend to give some proposals to Korean filmmakers preparing a Korea-China joint film, and express my brief opinion for the development of the Korea-China joint film industry.