• Journal of Korean Society of Steel Construction
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• v.8 no.4 s.29
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• pp.85-94
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• 1996

This paper investigated structural behaviors of joint of concrete filled steel tube column and P.C reinforced concrete beam through a series of hysteretic behavior experiment. The results are summarised as follows: (1) The joint stiffness of concrete filled square steel tube column and P.C reinforecd beam was higher than that of concrete filled circular steel tube column and P.C reinforecd beam, and it was decreased as the increase of the number of hysteretic cycle. (2) The aspects of the hysteretic behavior in the joint was stable as the increase of the number of hysteretic cycle, and rotation resisting capacity of joint of concrete filled square steel tube column and P.C reinforced concrete beam was higher than those of the concrete filled circular steel tube column and P.C reinforced concrete beam. (3) Some restriction must be put upon the ratio of axial force in this joint model because the load carrying capacity was decreased by flexural and flexural-torsional buckling in case of the ratio of axial force 0.6. (4) The emprical formula to predict the ultimate capacity of joint model to superimpose shearing strength of steel web(H section) and bending strength of reinforced concrete beam was expected.

• Journal of National Security and Military Science
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• s.2
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• pp.121-163
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• 2004

Science technique development expanded into, not only land, sea, and air operations but also those of airspace, and cyber battle spaces. It is generally accepted at this time that space centric operations currently cannot be effectively divided from air operations. However, science and technology advancements make it possible to integrate Army, Navy, Airforce, and Marine forces into effective operations as never before. The Republic of Korea Armed Forces needs to establish a more effective joint concept. The US military, considered by many experts as the most effective in the world, understands the necessity of joint operations and accordingly has highly developed its own concept of joint operations. The US joint operational concepts demonstrated their effectiveness during the Iraqi War by dominating the battlefield through effective use of all combat and non-combat power. Following the US Iraqi War experience, the US Department of Defense continued to enhance Joint Capability through the acceleration of US Military Transformation involving all components. The future national security of the Republic of Korea, faced with the peculiarity of communist threat in the form of North Korea, and the conflicting interest of four strong powers; the United States, China, Japan, and Russia, depends on small but strong armed forces employing all available combat power through effective National and Military Strategy, and considering domestic and international constraints. In order to succeed in future wars, military operations following joint operational concepts must effectively employ all available combat power in a timely manner. The Republic of Korea Armed Forces must establish a joint forces concept in order to integrate all available combat power during employment. Therefore we must establish military operations that develop the military structure and organization, doctrine, weapon systems, training and education of our armed forces based on the key concept of joint operations.

• BMB Reports
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• v.42 no.10
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• pp.636-641
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• 2009

The penetrating of monoclonal antibodies (mAbs) into solid tumor may be hampered by their large size. The antibody mimetics, composed of two complementarity-determining regions (CDRs) through a cognate framework region (FR), have been demonstrated to have the capacity to penetrate tumors superior to its parental intact IgG. In this study, we used CDR and FR sequences from the humanized anti-HER2 monoclonal antibody trastuzumab to design four antibody mimetics. Then these antibody mimetics were fused to human IgG Fc to generate mimetics-Fc small antibodies. One of the four mimetics-Fc antibodies binds well to HER2-overexpressing SK-BR3 cells and effectively inhibits the binding of trastuzumab. This mimetics-Fc, denoted as HMTI-Fc, was shown to be effective in mediating antibody-dependent cellular cytotoxicity and exhibit an antiproliferative effect in SK-BR3 cells. To our knowledge, the HMTI-Fc antibody shown here is the smallest fully functional antibody and may have a potential for treatment of cancer.

• Journal of Surface Science and Engineering
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• v.42 no.6
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• pp.294-300
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• 2009

The Friction Stir Welding (FSW) has mainly been used for making butt joints in Al alloys. The development of Friction Stir Lap Welding (FSLW) would expand the number of applications. In this study, for effective application on thin aluminum alloy lap joint, non-heat treatment A5052 alloys were joined by FSLW with the length of probe 2.3 mm and 3.0 mm. Investigating the characteristics of joint area showed the results were as below ; When the length of probe was 2.3 mm, good joint area was formed at all welding condition except for 600 rpm-700 mm/min. In the case of 3.0 mm probe length, there was formed good joint area without defects at 1500 rpm-100 mm/min. The width of joint area, position and size of defects were very important factors for FSLW, due to heat input and stirring intensity.

• Journal of Biomedical Engineering Research
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• v.22 no.3
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• pp.293-301
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• 2001

A patient-specific musculoskeletal model, whose parameters can be identified noninvasively, was developed for the automatic generation of patient-specific stimulation pattern in FES. The musculotendon system was modeled as a torque-generator and all the passive systems of the musculotendon working at the same joint were included in the skeletal model. Through this, it became possible that the whole model to be identified by using the experimental joint torque or the joint angle trajectories. The model parameters were grouped as recruitment of muscle fibers, passive skeletal system, static and dynamic musculotendon systems, which were identified later in sequence. The parameters in each group were successfully estimated and the maximum normalized RMS errors in all the estimation process was 8%. The model predictions with estimated parameter values were in a good agreement with the experimental results for the sinusoidal, triangular and sawlike stimulation, where the normalized RMS error was less than 17%, Above results show that the suggested musculoskeletal model and its parameter estimation method is reliable.