• Journal of Pharmaceutical Investigation
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• 제20권3호
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• pp.115-119
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• 1990

The reaction rates, duration times and neutralizing capacities of the antacids which are frequently used in Korean market and three different commercial combination products were evaluated in vitro by Fuchs method and Johnson-duncan method, respectively. In vivo tests of combination products were determined in the fasted state of rat by Aspiration method. Comparing the result of in vitro test with that of in vivo test, the maximal pH was lowered by 2-3 value and the durational time increased by two folds in vivo test. Each antacid composition and combination products from three phamaceutical companies (A, B, and C) were studied, respectively. The duration times measured by Fuchs method were double compared to those by Johnson-Duncan method. A and C preparation maintained the pH range from 3 to 7 for 60 min by Fuchs method. In vovo test, maximum pH of A, B and C preparation was 6.50, 3.65, 2.65 and duration time of those was 200, 500, 0 min, respectively.

• 동력기계공학회지
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• 제3권2호
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• pp.89-97
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• 1999

In this paper the forming simulations of ellipse bulge have been researched by using $PAM-STAMP_{TM}$ to estimate the sheet metal forming and the plastic deformation characteristic of ellipse bulge. Thin elliptical diaphragms of brass, copper, aluminum, and mild steel are bulged in elliptical dies having aspect ratios of 1.33 and 2. In order to compare the simulation results with the experiment and ellipse bulge's theory derived by using Johnson and Duncan's theory, the relations of hydraulic pressure and polar height, polar thickness strain and polar height, were compared. According to this study, the results of simulation and ellipse bulge's theory derived by using Johnson and Duncan's theory, and the bursting pressure and the bursting polar height are good agreement to the experiment. So, the results of simulation by using $PAM-STAMP_{TM}$ and the ellipse bulge's theory will give engineers good information to make assessment the formability and plastic deformation characteristic of hydraulic ellipse bulge test.

• 대한기계학회논문집
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• 제8권4호
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• pp.394-399
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• 1984

본 연구에서는 Duncan과 Johnson의 사각 벌지에 관한 이론식을 재료의 성질 및 파괴 특성을 결정하는데 유용한 방법인 타원벌지에 응용하여 고찰 검토하였다. 또 실험에는 각 점에서 변형도를 광격자법(photo grid method)에 의해서 측정했다. 그리고 극점의 곡률반경을 모아레 측정법으로 타원벌지에 처음 적용하여 구해서 이를 이론치와 서로 비교 함으로서 실험적인 측정법의 유용성을 밝혔다.

• Journal of Pharmaceutical Investigation
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• 제23권4호
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• pp.217-223
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• 1993

The combined products of antacid and anti-ulcer agent were prepared with antacid composed of aluminium hydroxide dried gel, magnesium hydroxide and simethicone with a ratio of 1:1:0.1 (M) and anti-ulcer agent, aceglutamide aluminium (AGA). The efficacy of antacid was evaluated in vitro with Fuchs, Johnson-Duncan and Rosset-Rice methods and in vivo using an aspiration method in rat. The addition of anti-ulcer agent did not affect the neutralizing capacity of M significantly. The combined products with the M/AGA ratios of 2.3:1 and 3.4:1 produced the maximum pH of $4.0{\sim}5.8$ and the duration time of $64{\sim}137$ min in vitro test. The in vivo neutralizing test in rats showed the rapid increase of gastric pH up to 3.5 within 30 min and the gastric pH of $4{\sim}6$ was kept for 5 hr.