• Journal for History of Mathematics
• /
• v.22 no.4
• /
• pp.15-28
• /
• 2009

In this paper, we study the 17th Century Chosun's mathematics book ${\ll}$Muk Sa Jib San Beob${\gg}$ written by Chosun's mathematician Kyeong Seon Jing. Our study of thebook shows the ${\ll}$Muk Sa Jip San Beop${\gg}$ as an important 17th Century mathematics book and also as a historical data showing the mathematical environment of 17th Century Chosun.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.8
• /
• pp.3705-3708
• /
• 2012

Effects of Cantharidinate on apoptosis of human colorectal cancer UTC-116 cells were investigated by means of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, H and E staining, flow cytometry, and Raman Spectra analysis. The results showed Cantharidinate to exert inhibitory action on proliferation of human colorectal cancer UTC-116 cells, inducing apoptosis, arresting cells in G1 phase, with decline of S and G2 phases. In addition, the results of Raman spectrum showed significant changes in the UTC-116 cells chemical structure with stretching after the application of Cantharidinate. Taken together, these results suggest that the treatment of human colorectal cancer with Cantharidinate may be associated with multiple molecular mechanisms for apoptosis. Furthermore, similar to fluorouracil, Cantharidinate should be considered as novel assistant drug for controlling the growth of human colorectal cancer UTC-116 cells.

• Current Optics and Photonics
• /
• v.1 no.6
• /
• pp.587-597
• /
• 2017

The extraction of the valid measurement region from the interference fringe pattern is a significant step when measuring gear tooth flank form deviation with grazing incidence interferometry, which will affect the measurement accuracy. In order to overcome the drawback of the conventionally used method in which the object image pattern must be captured, an improved segmentation approach is proposed in this paper. The interference fringe patterns feature, which is smoothed by the nonlinear diffusion, would be extracted by the structure tensor first. And then they are incorporated into the vector-valued Chan-Vese model to extract the valid measurement region. This method is verified in a variety of interference fringe patterns, and the segmentation results show its feasibility and accuracy.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.7
• /
• pp.3427-3430
• /
• 2012

Aim: The significance of the mucinous adenocarcinoma in TNM staging and prognosis for colorectal tumor patients is still controversial. The aim was to provide a meta-analysis for TNM staging and prognostic features of colorectal tumors. Methods: 30 individual case-control studies were finally included into this meta-analysis, involving a total of 444,489 cancer cases and 45,050 mucinous adenocarcinomas, of relations with TNM staging and prognostic features. Results: Compared to non-mucinous adenocarcinoma patients, the TNM IV stage accounted for a larger percentage of mucinous adenocarcinomas (OR=1.48, 95%CI 1.28-1.71, POR<0.001) and the prognosis was significantly poor (HR=1.06, 95%CI 1.04-1.08, P<0.001). After heterogeneity testing, the results was similar to the holistic approach outcome (HR=1.48, 95%CI 1.35-1.62, P<0.001). Conclusion: Compared to patients with non-mucinous adenocarcinomas, mucinous adenocarcinoma patients with later TNM staging make up a big percentage, and mucinous adenocarcinoma is an independent risk factor for poor prognosis.

• Steel and Composite Structures
• /
• v.26 no.6
• /
• pp.693-703
• /
• 2018

To better understand the influence of hollow ratio on the hollow concrete-filled circular steel tubular (H-CFT) stub columns under axial compression and to propose the design formula of ultimate bearing capacity for H-CFT stub columns, 3D finite element analysis and laboratory experiments were completed to obtain the load-deformation curves and the failure modes of H-CFT stub columns. The changes of the confinement effect between core concrete and steel tube with different hollow ratios were discussed based on the finite element results. The result shows that the axial stress of concrete and hoop stress of steel tube in H-CFT stub columns are decreased with the increase of hollow ratio. AfteGr the yield of steel, the reduction rate of longitudinal stress and the increase rate of circumferential stress for the steel tube slowed down. The confinement effect from steel tube on concrete also weakened slowly with the increase of hollow ratio. Based on the limit equilibrium method, a simplified formula of ultimate bearing capacity for the axially loaded H-CFT stub columns was proposed. The predicted results showed satisfactory agreement with the experimental and numerical results.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.4
• /
• pp.1575-1579
• /
• 2015

Some microRNAs (miRNAs) have been shown to act as oncogenes or tumor suppressor genes in human melanomas. miR-328 is upregulated in blood cells of melanoma patients compared to in healthy controls. This suggests a role for miR-328 in melanoma that warrants investigation. In this study, we demonstrated miR-328 levels to be dramatically decreased in human melanoma cell lines. Moreover, forced expression of miR-328 inhibited proliferation and induced G1-phase arrest of the SK-MEL-1 melanoma cell line. We identified TGFB2 as a direct target gene for miR-328 using a fluorescent reporter assay and western blotting. Levels of TGFB2 were dramatically increased in human melanoma cell lines and were inversely correlated with the miR-328 expression level. Our findings provide new insights into the mechanisms of human melanoma development, indicating that miR-328 has therapeutic potential for this disease.

• Bulletin of the Korean Chemical Society
• /
• v.35 no.1
• /
• pp.117-122
• /
• 2014

As a Chinese herbal medicine used in East Asia for thousands years, Cortex Magnoliae Officinalis (CMO) was observed to possess a protective effect against OH-induced DNA damage in the study. To explore the mechanism, the antioxidant effects and chemical contents of five CMO extracts were determined by various methods. On the basis of mechanistic analysis, and correlation analysis between antioxidant effects & chemical contents, it can be concluded that CMO exhibits a protective effect against OH-induced DNA damage, and the effect can be attributed to the existence of phenolic compounds, especially magnolol and honokiol. They exert the protective effect via antioxidant mechanism which may be mediated via hydrogen atom transfer (HAT) and/or sequential electron proton transfer (SEPT). In the process, the phenolic-OH moiety in phenylpropanoids is oxidized to the stable quinine-like form and the stability of quinine-like can be ultimately responsible for the antioxidant.

• Journal of Korean Medical classics
• /
• v.28 no.2
• /
• pp.87-102
• /
• 2015

Objectives : I intended to find out the origin and development of symptom discrimination based on theory of triple energizers before Tang Dynasty(唐代). Methods : I extracted the topic-related contents from books in this era. After arraying them in a chronological order, I analyzed the materials. Results : The author in Zhong Zang Jing(中藏經) first mentioned that symptom of Huo Luan(霍亂) was deeply related with triple energizers. Ge Hong(葛洪) did not only come out with some symptoms and mechanisms for Shang Han(傷寒) and Za Bing(雜病), but also applied them to their usages for herb medicine. Chao Yuan Fang(巢元方) suggested its symptoms were more closely related with Shang Han and Za Bing than before. For the first time, Chao subdivided its symptoms to both cold-heat and weakness-strength sides. Sun Sai Miao(孫思邈) supplemented its discrimination invented by Chao(巢元方), adding more symptoms and prescriptions for triple energizers. Wang Tao(王燾) showed more prescriptions for triple energizers than before, and initially designed the discrimination for Huo Luan, diabetes(消渴), and epidemic Wen Bing(溫病). Conclusions : Before Tang dynasty, the symptom discrimination based on theory of triple energizers had been originated and developed for the purpose of repairing Za Bing, not just treating Wen Bing.

• Bulletin of the Korean Chemical Society
• /
• v.35 no.2
• /
• pp.617-621
• /
• 2014

An efficient and selective method for the synthesis of ethyl 2-amino/aryloxy-3-aryl-4-oxo-5-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylate derivatives has been developed. The main process involved the reaction of diethyl 1-phenyl-3-((triphenylphosphoranylidene)amino)-1H-pyrrole-2,4-dicarboxylate and aromatic isocyanates, followed by addition of amines/phenols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate.

• Journal of Smart Tourism
• /
• v.1 no.1
• /
• pp.41-52
• /
• 2021

This paper explored the digital application of intangible cultural heritage from the perspective of cultural ecology. Through field investigations, combined with cultural ecology theory, an ontology-based semantic web technology was proposed, and Nanjing "Yunjin" brocade weaving technique was selected as the research object. The specific steps were as follows: First, based on the field surveys and cultural ecology theory, the intangible cultural ecological environment was divided into natural and social environments. Next, constructing the intangible cultural heritage ontology was constructed, including the collection and collation of Nanjing Yunjin weaving technique knowledge corpus, based on user needs analysis and corpus analysis, CIDOC CRM was used to create rules to build the ontology. Finally, based on the MediaWiki platform and Semantic MediaWiki, the semantic web model of the intangible cultural heritage was designed, and its semantic retrieval function was realized, thereby achieving the practical application of intangible cultural heritage digitization. Based on the perspective of cultural ecology, a set of intangible digital application models was proposed, which expanded the digital application of the cultural ecology theory, verified the application of this model in the sustainable development of cultural tourism, and provided reference for the sustainable development of cultural tourism.