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http://dx.doi.org/10.7314/APJCP.2012.13.7.3427

TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis  

Chen, Jing-Xiang (Department of Emergency, Jiangjin Central Hospital)
Tang, Xu-Dong (Department of Gastroenterology, Daping Hospitail, Third Military Medical University)
Xiang, De-Bing (Department of Oncology, Jiangjin Central Hospital)
Dong, Xiao-Ling (Department of Hepatobiliary Surgery, Jiangjin Central Hospital)
Peng, Fang-Yi (Department of Clinical Laboratory, Jiangjin Central Hospital)
Sun, Gui-Yin (Department of Oncology, Jiangjin Central Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.7, 2012 , pp. 3427-3430 More about this Journal
Abstract
Aim: The significance of the mucinous adenocarcinoma in TNM staging and prognosis for colorectal tumor patients is still controversial. The aim was to provide a meta-analysis for TNM staging and prognostic features of colorectal tumors. Methods: 30 individual case-control studies were finally included into this meta-analysis, involving a total of 444,489 cancer cases and 45,050 mucinous adenocarcinomas, of relations with TNM staging and prognostic features. Results: Compared to non-mucinous adenocarcinoma patients, the TNM IV stage accounted for a larger percentage of mucinous adenocarcinomas (OR=1.48, 95%CI 1.28-1.71, POR<0.001) and the prognosis was significantly poor (HR=1.06, 95%CI 1.04-1.08, P<0.001). After heterogeneity testing, the results was similar to the holistic approach outcome (HR=1.48, 95%CI 1.35-1.62, P<0.001). Conclusion: Compared to patients with non-mucinous adenocarcinomas, mucinous adenocarcinoma patients with later TNM staging make up a big percentage, and mucinous adenocarcinoma is an independent risk factor for poor prognosis.
Keywords
Mucinous colorectal adenocarcinoma; TNM; prognosis; meta-analysis;
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1 Catalano V, Loupakis F, Graziano F, et al (2009). Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first- line oxaliplatin- and /or irinotecan-based chemotherapy. Br J Cancer, 100, 881-7.   DOI
2 Catalano V, Loupakis F, Graziano F, et al (2011). Prognosis of mucinous histology for patients with radically resected stage II and III colon cancer. Ann Oncol, 23, 135-41.
3 Cerottini JP, Caplin S, Pampallona S, Givel JC (1999). Prognostic factor s in colorectal cancer. Oncol Rep, 6, 409-14.
4 Chen JS, Hsieh PS, Hung SY, et al (2004). Clinical signifi cance of signet ring cell rectal carcinoma. Int J Colorectal Dis, 19, 102-7.   DOI
5 Chiang JM, Yeh CY, Changchien CR, et al (2010). Mucinous adenocarcinoma showing different clinicopathological and molecular characteristics in relation to different colorectal cancer subgroups. Int J Colorectal Dis, 25, 941-7.   DOI
6 Consorti F, Lorenzotti A, Midiri G, et al (2000). Prognostic significance of mucinous carcinoma of colon and rectum: a prospective case control study. J Surg Oncol, 73, 70-4.   DOI   ScienceOn
7 Cusack JC, Giacco GG, Cleary K, et al (1996). Survival factors in 186 patients younger than 40 years old with colorectal ad nocarcinoma. J Am Coll Surg, 183, 105-12.
8 Du W, Mah JTL, Lee J, et al (2004). Incidence and survival of mucinous adenocarcinoma of the colorectum: a population-based study from an Asian country. Dis Colon Rectum, 47, 78-85.   DOI
9 Enriquez JM, Diez M, Tobaruela E, et al (1998). Clinical, histopatho logical, cytogenetic and prognostic differences between mucinous andnonmucinous colorectal adenocarcinomas. Rev Esp Enferl Dig, 90, 568-72.
10 Farhat MH, Barada KA, Tawil AN, et al (2008). Effect of mucin productio non survival in colorectal cancer: a case control study. World J Gastroenterol, 14, 6981-5.   DOI
11 Ghabeljoo M, Jafarabadi MA, Mohammadi SM, et al (2011). Patterns of survival for anatomical sites of colorectal cancer with shift to advanced lesions in Iran. Asian Pac J Cancer Prev, 12, 1225-31.
12 Greenson JK, Huang SC, Herron C, et al (2009). Pathologic predictors of microsatellite instability in colorecta l cancer. Am J S urg Pathol, 33, 126-33.   DOI
13 Hyngstrom JR, Hu C- Y, Xing Y, et al (2012). Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma: analysis from the national cancer data base. Ann Surg Oncol, 2012 Apr 4. [Epub ahead of print]
14 Grillo-Ruggieri F, Mantello G, Berardi R, et al (2007). Mucinousrectal adenocarcinoma can be associated to tumor downstaging after preoperative chemoradiotherapy. Dis Colon Rectum, 50, 1594-603.   DOI
15 Hill DA, Furman WL, Billups CA, et al (2007). Colorectal carcinoma in child hood and adolescence: a clinicopathologic review. J Clin Oncol, 25, 5808-14.   DOI   ScienceOn
16 Huang GL, Guo HQ, Yang F, et al (2012). Activating transcription factor 1 is a prognostic marker of colorectal cancer. Asian Pac J Cancer Prev, 13, 1053-7.   과학기술학회마을   DOI
17 Jass JR, Sobin LH. Histologic Typing of Intestinal Tumours (1989). 2nd edn. Berlin: Springer-Verlag, 1989.
18 Jivapaisarnpong P, Boonthongtho K (2011). Clinicopathological characteristics of mucinous and non- mucinous adenocarcinoma in the colon andrectum in Rajavithi Hospital, Thailand. J Med Assoc Thai, 94, S41-5.
19 Kanemitsu Y, Kato T, Hirai T, et al (2003). Survival after curative resection for mucinous adenocarcinoma of the colorectum. Dis Colon Rectum, 4, 160-7.
20 Kang H, O'Connell JB, Maggard MA, Sack J, Ko CY (2005). A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum, 48, 1161-8.   DOI   ScienceOn
21 Langner C, Harbaum L, Pollheimer MJ, et al (2012). Mucinous differentiation in colorectal cancer-indicator of poor prognosis? Histopathology, 60, 1060-72.   DOI
22 Nozoe T, Anai H, Nasu S, et al (2000). Clinicopathological characteristics of mucinous carcinoma of the colon and rectum. J Surg Oncol, 75, 103-7.   DOI   ScienceOn
23 Lee WS, Chun HK, Lee WY, et al (2007). Treatment outcomes in patients with signet ring cell carcinoma of the colorectum. Am J Surg, 194, 294-8.   DOI
24 Min BS, Kim NK, Ko YT, et al (2009). Clinicopathological features of signetring cell carcinoma of the colon and rectum: a case - matched study. Hepatogastroenterology, 56, 984-8.
25 Negri FV, Wotherspoon A, Cunningham D, et al (2005). Mucinous histology predicts for reduced fluorouracil responsiveness and survival in advanced colorectal cancer. Ann Oncol, 16, 1305-10.   DOI   ScienceOn
26 Pande R, Sunga A, Levea C, et al (2008). Significance of signetring cells in patients with colorectal cancer. Dis Colon Rectum, 51, 50-5.   DOI
27 Papadopoulos VN, Michalopoulos A, Netta S, et al (2004). Prognostic significance of mucinous component in colorectal carcinoma. Tech Coloproctol, 8, S123-5.   DOI
28 Safaee A, Moghimi-Dehkordi B, Fatemi SR et al (2010). Characteristics of colorectal mucinous adenocarcinoma in Iran. Asian Pac J Cancer Prev, 11, 1373-5.
29 Sengul N, Wexner SD, Woodhouse S, et al (2006). Effects of radiotherapy on different histopathological types of rectal carcinoma. Colorectal Dis, 8, 283-8.   DOI
30 Song W, Wu SJ, He YL, et al (2009). Clinicopathologic features and survival of patients with colorectal mucinous, signetring cell or non-mucinous adenocarcinoma: experience at an institution in southern China. Chin Med J (Engl), 122, 1486-91.
31 Wu CS, Tung SY, Chen PC, et al (1996). Clinicopathological study of colorectal muc ino uscarcinoma in Taiwan: a multivariate analysis. J Gastroenterol Hepatol, 11, 77-81.   DOI   ScienceOn
32 Sultan I, Rodriguez - Galindo C, El- Taani H, et al (2010). Distinct features of colorectal cancer in children and adolescents a population- based study of 159 cases. Cancer, 116, 758-65.   DOI
33 Sun XF, Carstensen JM, Stal O, et al (1996). Interrelations of clinicopathologic variables and their prognostic value in colorectal adenocarcinoma. APMIS, 104, 35-8.
34 Verhulst J, Ferdinande L, Demetter P, et al (2012). Mucinous subtype as prognostic factor in colorectal cancer:a systematic review and meta-analysis. J Clin Pathol, 65, 381-8.   DOI
35 Xie L, Villeneuve PJ, Shaw A (2009). Survival of patients diagnosed with either colorectal mucinous or non - mucinous adenocarcinoma: a population- based study in Canada. Int J Oncol, 34, 1109-15.
36 Yamaguchi T, Taniguchi H, Fujita S, et al (2012). Clinicopathological characteristics and prognostic factors of advanced colorectal mucinous adenocarcinoma. Histopathology Mar 27. doi: 10.1111/j.1365-2559.2012.04235.x.   DOI
37 Ye S, Liu X, Wang Q (2002). Colon mucinous adenocarcinoma:107 cases report. J Fujian Med, 24, 12-3.
38 You JF, Hsieh LL, Changchien CR, et al (2006). Inverse effects of mucin on survival of matched hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer patients. Clin Cancer Res, 12, 4244-50.   DOI
39 Zhen M, Li J, Zhou L (2005). Pathological features and prognosis of colon mucinous adenocarcinoma. J China Oncol, 15, 383-6.