• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.57-65
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• 2023

There are differing opinions among scholars as to whether "chuseo" (ugly writing) should be considered as one of the schools in modern calligraphy. Those who do not recognize "chuseo" argue that it lacks traditional rules for stroke formation and therefore loses its distinctiveness. However, the existence and development of "chuseo" are closely related to the constant exploration and reform of modern calligraphy, as well as the increasing aesthetic awareness and changing aesthetic standards of calligraphers with changing times. As a result, there are now more people who recognize "chuseo" as a legitimate form of calligraphy. Calligraphers who lead the times learn and accumulate experiences by adhering to traditional calligraphic principles. However, there are calligraphers who discard the traditional Confucian concept of "chungyong" (中庸) and display "ugliness" in their works. Ok Heung-hwa and Jeung Sang are two such calligraphers who created their own style by incorporating ancient oracle bone inscriptions as their main focus and folk calligraphy as their bloodline. This paper aims to explore and study the definition and formation process of "chuseo" by analyzing the works of Ok Heung-hwa and Jeung Sang. At the same time, it aims to summarize the characteristics and aesthetic beauty of "chuseo".

• Journal of the Korea Society of Computer and Information
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• v.28 no.4
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• pp.133-142
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• 2023

National parks are one of the important types of protected area management systems established by IUCN and a management model for implementing effective conservation and sustainable use of natural and cultural heritage in countries around the world, and they assume important roles in conservation, scientific research, education, recreation and driving community development. In the context of big data, this study takes China's Liaohe National Park, a typical representative of global coastal wetlands, as a case study, and using Python technology to collect tourists' travelogues and reviews from major OTA websites in China as a source. The text spans from 2015 to 2022 and contains 2998 reviews with 166,588 words in total. The results show that wildlife resources, natural landscape, wetland ecology and the fishing and hunting culture of northern China are fully reflected in the perceptions of visitors to Liaohe National Park; visitors have strong positive feelings toward Liaohe National Park, but there is still much room for improvement in supporting services and facilities, public education and visitor experience and participation.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.121-121
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• 2022

한국과 미국은 2018년 8월에 발표한 메콩우호국(Friends of the Lower Mekong, FLM) "메콩지역 수자원 데이터 관리 및 정보공유 강화에 관한 공동성명"을 계기로 메콩유역의 실시간 수자원 변동 모니터링 및 분석과 수자원 데이터 공동활용 역량을 강화하여 효율적이고 과학적인 수자원관리 지원과 함께 한국의 신남방정책과 미국의 인도-태평양 전략 시너지효과를 극대화하고자 메콩 주변국 재해경감 및 수자원 데이터 활용 역량강화를 위한 글로벌 위성기반 수문자료의 생산·활용 및 홍수·가뭄 등의 수재해 분석기술을 개발하고 있다. 여기에는 한국 K-water의 물관리 기술과 미국 NASA, USACE의 위성활용 및 수자원분석 기술을 접목하여 메콩지역의 체계적인 물관리 및 재해로부터 안전성 확보 기여에 목표를 두고 연구를 진행 중에 있다. 본 연구에서는 전 세계적으로 광범위하게 활용되고 있는 미공병단(USACE, U.S. Army Corps of Engineers)의 HEC software 프로그램을 메콩 시범지역(pilot area)에 적용하여 수리/수문모델 구축을 진행하고 있다. 구축되는 모형은 유역 상류 댐의 연계 모의운영 및 하류 홍수분석이 동시 가능한 HEC-RTS(Real-Time Simulation)로 이는 HEC-HMS, -ResSim, -RAS와 -FIA 모형이 순차적으로 결합된 수리/수문 모델링 시스템이다. 모형의 시범적용 지역은 현지 메콩위원회(MRC, Mekong River Comission)의 의견 등을 반영, 메콩강 하류지역(Lower Mekong) 본류 유역에 위성자료 활용 및 준실시간(near real-time)으로 댐 모의운영 등을 고려할 수 있는 JingHong댐(중국 란창강 최하류)에서 라오스 Xayaburi댐(메콩강 최상류)까지의 구간을 선정하였으며, 전년도에는HEC-RTS 중 HMS(Hydrologic Modeling System) 모형 적용을 중심으로 가용한 위성자료(GPM IMERG)를 활용하여 과거 홍수사상에 대한 모의를 고려한 강우-유출모형의 구축을 완료하였다. 이에 연속하여 금년도에는 동일유역 내 하천 단면 등이 확보된 Chiang Saen 지점에서 Xayaburi 댐까지의 구간에 대해 RAS(River Analysis System)을 구축할 예정으로 구축된 RAS 모형은 HEC-RTS에 포함되어 메콩 시범지역의 종합적 수리/수문분석에 적용될 예정이다.

• Journal of the Daesoon Academy of Sciences
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• v.17
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• pp.35-48
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• 2004

The third teachings of Confucianism, Buddhism, and Taoism have been coexisted and had effect on the oriental spirits for long times. The doctrines of the Confucianism, the Buddhism, and the Taoism are represented as 'moral culture', 'practice', and "training" respectively. The practices of three teachings had individual ways. But in the late Han-dynasty, they had coexisted and effects on one another, then finally had been united since the Song-dynasty. The Confucianism, which advocated "xiū-jǐ-zhì-rén(修己治人: Practising oneself and controlling others)" and "nèi-shèng-wài-wáng(內聖外王: Establishing natural law in oneself and presenting it to others)", put an emphasis on the practice for personality by "Kŏgzĭ(孔子)" and "Mèngzĭ(孟子)". For example, the practices of "Yăng qi(養氣)", "Jìn Xīn(盡心)", and "Cún Xīn(存心)" reflect this doctrines. In the Song-dynasty, "Zhū-xī(朱熹)" established the 'New Confucianism', the study of "Jū-Jìng-qióng-lĭ'", which put an equality with "human nature" and natural law. It is so-called as "Seong-li-hark" in Korea. Therefore, it came to life again by emphasizing 'jīng-shì: Ruling the world' and "moral culture". The Taoism, which pursued "yán-mìng-cháng-shòu(延命長壽: Maintenance of a Scanty existence long life)" and "dào-tōng-shén-xian"(道通神仙: Spiritual awakening Shén-Xian), originally put an emphasis on the practice of body and mind. For example, "Lăozi(老子)" and "Zhuāngzĭ(莊子)" suggested "bāoyī(包一)", "Shŏuyī(守一)", and "Zuòwàng(坐忘)". After the religious body of the Taoism had been established, "Gè-hóng(葛洪)" accomplished the "Nèidān(內丹)" and "Wàidān(外丹)" as practice methods. As times went over, the "Nèidān(內丹)" of "Yăng-Shēng-Wŭ-Dà-Yāo(養生五大要)" including "bì-gŭ(辟穀)", "fú-qì(服氣)", "dăo-yĭn(導引)", "fáng-zhōng(房中)", and "fú-ěr(服餌)", has been the mainstreams for practice. Since the Song dynasty, "sān-jiào-hé-yī-sī-xiǎng(三敎合一思想: Three Teachings are the each other same thoughts)" had been put on emphasis and the three teachings were effected one another, and all of them attached importance to practical training. Therefore, the practice ways in civil societies have been mixed, the origins of them are difficult to divide definitely. The Korean society also has the vague origins of them and reflects the theses historic traditions.

• Journal of Microbiology and Biotechnology
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• v.33 no.9
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• pp.1213-1227
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• 2023

Fetal growth restriction (FGR) is a prevalent obstetric condition. This study aimed to investigate the role of Toll-like receptor 9 (TLR9) in regulating the inflammatory response and gut microbiota structure in FGR. An FGR animal model was established in rats, and ODN1668 and hydroxychloroquine (HCQ) were administered. Changes in gut microbiota structure were assessed using 16S rRNA sequencing, and fecal microbiota transplantation (FMT) was conducted. HTR-8/Svneo cells were treated with ODN1668 and HCQ to evaluate cell growth. Histopathological analysis was performed, and relative factor levels were measured. The results showed that FGR rats exhibited elevated levels of TLR9 and myeloid differentiating primary response gene 88 (MyD88). In vitro experiments demonstrated that TLR9 inhibited trophoblast cell proliferation and invasion. TLR9 upregulated lipopolysaccharide (LPS), LPS-binding protein (LBP), interleukin (IL)-1β and tumor necrosis factor (TNF)-α while downregulating IL-10. TLR9 activated the TARF3-TBK1-IRF3 signaling pathway. In vivo experiments showed HCQ reduced inflammation in FGR rats, and the relative cytokine expression followed a similar trend to that observed in vitro. TLR9 stimulated neutrophil activation. HCQ in FGR rats resulted in changes in the abundance of Eubacterium_coprostanoligenes_group at the family level and the abundance of Eubacterium_coprostanoligenes_group and Bacteroides at the genus level. TLR9 and associated inflammatory factors were correlated with Bacteroides, Prevotella, Streptococcus, and Prevotellaceae_Ga6A1_group. FMT from FGR rats interfered with the therapeutic effects of HCQ. In conclusion, our findings suggest that TLR9 regulates the inflammatory response and gut microbiota structure in FGR, providing new insights into the pathogenesis of FGR and suggesting potential therapeutic interventions.

• Journal of Venture Innovation
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• v.6 no.3
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• pp.73-93
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• 2023

This study provides a prospect for the fast growing the smartwatch market by investigating the relationship between the satisfaction and the continuous use intention of Apple watch users, as well as the factors influencing their satisfaction. Based on the TAM, this study uses system quality, information quality, and self-efficacy as independent variables, perceived usefulness, perceived ease of use, and satisfaction as mediators, and continuous use intention as the dependent variable. We analyze the data of 256 individuals who completed an online survey with SPSS 26.0 and AMOS 26.0 software. This study conducts several tests and analyses to empirically evaluate the data including reliability analysis, factor analysis, feasibility analysis, path analysis, hypothesis verification, and mediation analysis. Our results investigate which factors may influence consumers' intention to continuously using Apple Watch devices in the future. In summary, satisfaction has a positive effect on the intention to continuously use smartwatchs. Perceived usefulness and perceived ease of use have a positive effect on satisfaction. Among the three factors (system quality, information quality, and self-efficacy), only self-efficacy has no significant impact on perceived usefulness but had a positive effect on perceived ease of use. In addition, system quality and information quality positively affect perceived usefulness, perceived ease of use, satisfaction, and continuous intention to use an Apple Watch. Taking the Apple Watch as the subject of our research topic, this study provides theoretical value by exploring the impact of user's satisfaction with their smartwatch on their continuous usage intention. This study further explains the influence of system quality, information quality, and self-efficacy on user satisfaction. Additionally, this research offers valuable insight to practitioners by confirming that information quality, system quality, and self-efficacy are important features for enhancing satisfactory user experiences which in turn may increase users' intention to continued using smartwatches.

• Journal of Ginseng Research
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• v.47 no.6
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• pp.714-725
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• 2023

Background: Our previous investigation indicated that the preparation of Panax ginseng Meyer (P. ginseng) inhibited melanogenesis. It comprised salicylic acid (SA), protocatechuic acid (PA), p-coumaric acid (p-CA), vanillic acid (VA), and caffeic acid (CA). In this investigation, the regulatory effects of P. ginseng phenolic acid monomers on melanin production were assessed. Methods: In vitro and in vivo impact of phenolic acid monomers were assessed. Results: SA, PA, p-CA and VA inhibited tyrosinase (TYR) to reduce melanin production, whereas CA had the opposite effects. SA, PA, p-CA and VA significantly downregulated the melanocortin 1 receptor (MC1R), cycle AMP (cAMP), protein kinase A (PKA), cycle AMP-response element-binding protein (CREB), microphthalmia-associated transcription factor (MITF) pathway, reducing mRNA and protein levels of TYR, tyrosinase-related protein 1 (TYRP1), and TYRP2. Moreover, CA treatment enhanced the cAMP, PKA, and CREB pathways to promote MITF mRNA level and phosphorylation. It also alleviated MITF protein level in α-MSH-stimulated B16F10 cells, comparable to untreated B16F10, increasing the expression of phosphorylation glycogen synthase kinase 3β (p-GSK3β), β-catenin, p-ERK/ERK, and p-p38/p38. Furthermore, the GSK3β inhibitor promoted p-GSK3β and p-MITF expression, as observed in CA-treated cells. Moreover, p38 and ERK inhibitors inhibited CA-stimulated p-p38/p38, p-ERK/ERK, and p-MITF increase, which had negative binding energies with MC1R, as depicted by molecular docking. Conclusion: P. ginseng roots' phenolic acid monomers can safely inhibit melanin production by bidirectionally regulating melanin synthase transcription. Furthermore, they reduced MITF expression via MC1R/cAMP/PKA signaling pathway and enhanced MITF post-translational modification via Wnt/mitogen-activated protein kinase signaling pathway.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.389-399
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• 2023

Recently, there has been a growing focus on the Entrepreneurial Intention of Chinese College Students as a key driver of motivational behavior. However, previous research has provided limited analysis on the actual impact of Social Support on the Entrepreneurial Intention of Chinese College Students. The purpose of this study is to enhance the Entrepreneurial Intention of Chinese College Students and to ascertain the mediating effect of Career Adaptability in the relationship between Social Support and Entrepreneurial Intention. Zhejiang Province, the top-ranked province in private economy in China, possesses a strong economic development momentum and an innovative entrepreneurial atmosphere. Therefore, this study selected 194 third and fourth-year undergraduate students from universities in Zhejiang Province as participants and collected data through a survey utilizing measures of Social Support, Career Adaptability, and Entrepreneurial Intention. The collected data was analyzed for correlations between the measured variables using SPSS 26 and Stata 17 SEM Builder for quantification and validation. The results of the study revealed that, firstly, while Social Support did not have a direct impact on Entrepreneurial Intention, it was found to have an indirect influence on Entrepreneurial Intention through Career Adaptability and its various sub-variables. Secondly, Social Support among College Students was found to have a positive impact on Career Adaptability. Thirdly, Career Adaptability among College Students was found to have a positive impact on Entrepreneurial Intention. Based on these analytical findings, this study provides theoretical and practical implications as well as fundamental information for entrepreneurship education and Career Adaptability at the university level.

• Animal Bioscience
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• v.37 no.3
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• pp.471-480
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• 2024

Objective: The objective of this study was to investigate the regulation relationship of Ten-eleven translocation 1 (Tet1) in DNA demethylation and the proliferation of primordial germ cells (PGCs) in chickens. Methods: siRNA targeting Tet1 was used to transiently knockdown the expression of Tet1 in chicken PGCs, and the genomic DNA methylation status was measured. The proliferation of chicken PGCs was detected by flow cytometry analysis and cell counting kit-8 assay when activation or inhibition of Wnt4/β-catenin signaling pathway. And the level of DNA methylation and hisotne methylation was also tested. Results: Results revealed that knockdown of Tet1 inhibited the proliferation of chicken PGCs and downregulated the mRNA expression of Cyclin D1 and cyclin-dependent kinase 6 (CDK6), as well as pluripotency-associated genes (Nanog, PouV, and Sox2). Flow cytometry analysis confirmed that the population of PGCs in Tet1 knockdown group displayed a significant decrease in the proportion of S and G2 phase cells, which meant that there were less PGCs entered the mitosis process than that of control. Furthermore, Tet1 knockdown delayed the entrance to G1/S phase and this inhibition was rescued by treated with BIO. Consistent with these findings, Wnt/β-catenin signaling was inactivated in Tet1 knockdown PGCs, leading to aberrant proliferation. Further analysis showed that the methylation of the whole genome increased significantly after Tet1 downregulation, while hydroxyl-methylation obviously declined. Meanwhile, the level of H3K27me3 was upregulated and H3K9me2 was downregulated in Tet1 knockdown PGCs, which was achieved by regulating Wnt/β-catenin signaling pathway. Conclusion: These results suggested that the self-renewal of chicken PGCs and the maintenance of their characteristics were regulated by Tet1 mediating DNA demethylation through the activation of Wnt4/β-catenin signaling pathway.

• Korean Journal of Radiology
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• v.22 no.7
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• pp.1213-1224
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• 2021

Objective: To develop a machine learning (ML) pipeline based on radiomics to predict Coronavirus Disease 2019 (COVID-19) severity and the future deterioration to critical illness using CT and clinical variables. Materials and Methods: Clinical data were collected from 981 patients from a multi-institutional international cohort with real-time polymerase chain reaction-confirmed COVID-19. Radiomics features were extracted from chest CT of the patients. The data of the cohort were randomly divided into training, validation, and test sets using a 7:1:2 ratio. A ML pipeline consisting of a model to predict severity and time-to-event model to predict progression to critical illness were trained on radiomics features and clinical variables. The receiver operating characteristic area under the curve (ROC-AUC), concordance index (C-index), and time-dependent ROC-AUC were calculated to determine model performance, which was compared with consensus CT severity scores obtained by visual interpretation by radiologists. Results: Among 981 patients with confirmed COVID-19, 274 patients developed critical illness. Radiomics features and clinical variables resulted in the best performance for the prediction of disease severity with a highest test ROC-AUC of 0.76 compared with 0.70 (0.76 vs. 0.70, p = 0.023) for visual CT severity score and clinical variables. The progression prediction model achieved a test C-index of 0.868 when it was based on the combination of CT radiomics and clinical variables compared with 0.767 when based on CT radiomics features alone (p < 0.001), 0.847 when based on clinical variables alone (p = 0.110), and 0.860 when based on the combination of visual CT severity scores and clinical variables (p = 0.549). Furthermore, the model based on the combination of CT radiomics and clinical variables achieved time-dependent ROC-AUCs of 0.897, 0.933, and 0.927 for the prediction of progression risks at 3, 5 and 7 days, respectively. Conclusion: CT radiomics features combined with clinical variables were predictive of COVID-19 severity and progression to critical illness with fairly high accuracy.