• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권1호
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• pp.35-40
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• 2021

Objectives: Among the many intervention programs for children with autism spectrum disorder (ASD), the Early Start Denver Model (ESDM) is one of the few approaches that has succeeded in demonstrating clinical efficacy in randomized control trials. Here, we investigate the clinical efficacy of ESDM intervention in young children with ASD in a community setting within Japan. Methods: All subjects were children with ASD who received ESDM intervention during the study period. Each ESDM session lasted 75 min and occurred once per week for at least 12 weeks. The outcome measures consisted of the Kyoto Scale of Psychological Development (K-test), Aberrant Behavior Checklist-Japanese version (ABC-J), and the Clinical Global Impression-Severity scale (CGI-S). Results: Twenty-seven subjects (29.4±6.4 months old) received ESDM intervention that lasted for 8.0±2.6 months on average. The score on Language and Social developmental quotient on the K-test increased significantly after the intervention. The total scores on the ABC-J and CGI-S significantly decreased after completion of the ESDM intervention. Conclusion: Our results suggest that ESDM intervention could reduce the severity of distinct clinical features of ASD, such as impairments in social interaction and communication assessed by the K-test, and maladaptive behavior rated by the ABC-J and CGI-S. We believe that the ESDM adapted to each institution might become one of the standard options for children with ASD in Japan.

• 한국심리학회지 : 문화 및 사회문제
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• 제22권2호
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• pp.165-182
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• 2016

행복에 대한 연구는 서구 중심의 학자들과 학문적 토대 아래 이루어져 왔다. 서양에서는 행복을 개인적인 성취와 대인관계에서의 긍정적인 정서적 경험으로 개념화하고 있다. 하지만 일본이나 중국 같은 동양권 문화에서 수행되었던 연구에 따르면 행복의 개념이 서양의 개념과 다르다는 것을 제안해준다. 본 연구는 83명의 대학생들을 대상으로 양적 분석 방법과 질적 분석 방법을 사용해 한국인들이 행복을 어떻게 개념화 하고 있는지 알아보았다. Yukiko와 Kitayama (2009)에서 일본인들과 미국인들의 행복개념을 비교 연구할 때 사용한 방법을 이용하여 한국인의 행복개념을 이전의 일본과 미국 데이터와 비교하는 작업을 실시했다. 분석결과, 한국인들은 행복으로 인해 생기는 긍정적인 결과와 부정적인 결과를 모두 고려하는 변증법적인 행복 개념을 가지고 있어 일본인들과 비슷한 행복개념을 보이는 것으로 나타났으며, 행복을 지배적으로 긍정적인 경험으로 지각하는 미국인들과는 차이를 보였다. 또한 한국인들은 정서 상태로서의 행복과 삶의 다른 영역 (대인관계, 일)에 영향을 미치는 기능으로서의 행복으로 분류하는 것으로 나타났다. 본 연구는 한국인들의 행복개념을 체계적으로 분석하는 시도를 통해 한국인이 가지는 행복개념의 특수성을 기존의 서구 중심의 행복 연구와 이론에서 정의하는 행복개념과 함께 고려하는 통합적인 시각이 필요하다는 점을 시사해준다.

• Environmental Analysis Health and Toxicology
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• 제15권4호
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• pp.131-137
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• 2000

최근 독성 유해물질의 환경으로의 방출로 인해 인간 및 생태계에 대한 위해성 문제가 심각하게 제기되고 있다. 독성화학물질을 포함한 여러 환경 오염물질의 위해성평가는 화학물질의 유해성과 노출량 측정을 동시에 측정함으로써 가능한데 이 경우 생물지표(biomarker)가 최근 각광을 받고 있다. 본 연구에서는 동물의 행동에 관련된 신경전달물질의 생성에 결정적 역할을 하는 tyrosine hydroxylase(TH)및 그 유전자가 생물지표로서 이용 가능성이 있는지를 검토하였다. Ovary cDNA library의 PCR 스크리닝을 통한 송사리 TH유전자를 부분적으로 를론하였으며(327 bp), DNA염기서열 분석 결과 쥐 (rat)의 TH유전자와 동일한 염기서열을 보였다. 그리고 다이아지논 처리구 및 무처리구에서 송사리의 머리부분(head)및 몸통 부분(body)에서 추출된 총RNA에 TH mRNA가 존재함을 RT-PCR를 통하여 확인하였다. 그러나 다이아지논의 처리효과가 송사리의 행동에 미치는 영향을 보기 위해서는 TH의 발현을 보다 정량적으로 검토할 필요가 있을 것으로 판단된다. 생물지표로서 TH의 활성 및 mRNA의 기관별 또는 조직별 검출은 독성물질에 영향을 받는 어류 신경행동 변화를 모니터링 할 수 있는 유용한 수단이 될 것이다. 나아가 환경관리에 있어서 신경화학물질과 분자생물학적 상관관계를 통한 이상반응행동의 분석은 환경 위해성평가에 상당히 기여할 것이다.

• 기록학연구
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• 제12호
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• pp.179-235
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• 2005

In this article, the task of evaluating the official documents that were created and issued by the Joseon Governor General office during the Japanese occupation period, with new perspectives based upon the Macro-Appraisal approaches developed by the Canadian scholars and personnel, will be attempted. Recently, the Canadian people and the authorities have been showing a tendency of evaluating the meaning and importance of a particular document with perspectives considering the historical situation and background conditions that gave birth to that document to be a more important factor, even than considering the quality and condition of that very document. Such approach requires the archivists to determine whether they should preserve a certain document or not based upon the meaning, functions and status of the entity that produced the document or the meaning of the documentation practice itself, rather than the actual document. With regard to the task of evaluating the official documents created and issued by the Joseon Governor General office and involved the city plans devised by the office back then, this author established total of 4 primary tasks that would prove crucial in the process of determining whether or not a particular theme, or event, or an ideology should be selected and documents involving those themes, events and ideologies should be preserved as important sources of information regarding the Korean history of the Japanese occupation period. Those four tasks are as follow: First, the archivists should study the current and past trends of historical researches. The archivists, who are usually not in the position of having comprehensive access to historical details, must consult the historians' studies and also the trends mirrored in such studies, in their efforts of selecting important historical events and themes. Second, the archivists should determine the level of importance of the officials who worked inside the Joseon Governor General office as they were the entities that produced the very documents. It is only natural to assume that the level of importance of a particular document must have been determined by the level of importance(in terms of official functions) of the official who authorized the document and ordered it to be released. Third, the archivists should be made well aware of the inner structure and official functions of the Joseon Governor General office, so that they can have more appropriate analyses. Fourth, in order to collect historically important documents that involved the Koreans(the Joseon people), the archivists should analyze not only the functions of the Joseon Governor General office in general but also certain areas of the Office's business in which the Japanese officials and the Koreans would have interacted with each other. The act of analyzing the documents only based upon their respective levels of apparent importance might lead the archivists to miss certain documents that reflected the Koreans' situation or were related to the general interest of the Korean people. This kind of evaluation should provide data that are required in appraising how well the Joseon Governor General office's function of devising city plans were documented back then, and how well they are preserved today, utilizing a comparative study involving the Joseon Governor General office's own evaluations of its documentations and the current status of documents that are in custody of the National Archive. The task would also end up proposing a specialized strategy of collecting data and documents that is direly needed in establishing a well-designed comprehensive archives. We should establish a plan regarding certain documents that were documented by the Joseon Governor General office but do not remain today, and devise a task model for the job of primary collecting that would take place in the future.

• 한국통신학회논문지
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• 제6권1호
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• pp.9-20
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• 1981

통신부에서 직접 경영하는 공중전기통신사업은 1982년 1월 1일을 기하여 한국전기통신공사가 전단하게 됨에 따라 통신부의 행정조직은 혁신적으로 개정되리라 한다. 체제에, 통신과학을 전정하는 입장에서 우리나라 통신행정의 핵심이 될 전기통신정책과 전파감리의 발전을 위하여 가장 중요한 조직창조와 인사개혁의 양측면을 적극 공론함으로써 그의 방향을 제시하였다. 이 비교연구로서는 공중전기통신사업을 일본전신전화공사에 의한 영업과 우정성에 의한 감리로서 모범적으로 운행하고 있는 일본국의 사례를 택하였으며, 국내외의 관계문헌과 최신의 자료에 의하여 고찰하였다.

• 대한기계학회논문집A
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• 제36권3호
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• pp.245-252
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• 2012

본 연구는 간단한 수치해석적 방법을 통해 연성재료의 파괴를 예측하는 방법을 소개하였다. 응력에 의해 계산된 파괴 변형률을 통해 손상을 계산하는 과정을 다중 관통균열이 있는 평판 인장시험편의 유한요소 해석을 통해 구현하였다. 이 기법은 ABAQUS 에서 제공하는 user-defined subroutine 을 이용하여 구현되었다. 제시된 기법을 적용하여 다중균열 해석을 수행하였고 이 결과를 일본 연구자에 의해 수행된 실험 결과와 비교하였다. 해석결과와 실험결과가 비교적 잘 일치함을 확인하였고 이를 통해 제시된 기법의 타당성을 검증할 수 있었다.

• Genomics & Informatics
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• 제12권1호
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• pp.35-41
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• 2014

Single-nucleotide polymorphisms (SNPs) have been emerging out of the efforts to research human diseases and ethnic disparities. A semantic network is needed for in-depth understanding of the impacts of SNPs, because phenotypes are modulated by complex networks, including biochemical and physiological pathways. We identified ethnicity-specific SNPs by eliminating overlapped SNPs from HapMap samples, and the ethnicity-specific SNPs were mapped to the UCSC RefGene lists. Ethnicity-specific genes were identified as follows: 22 genes in the USA (CEU) individuals, 25 genes in the Japanese (JPT) individuals, and 332 genes in the African (YRI) individuals. To analyze the biologically functional implications for ethnicity-specific SNPs, we focused on constructing a semantic network model. Entities for the network represented by "Gene," "Pathway," "Disease," "Chemical," "Drug," "ClinicalTrials," "SNP," and relationships between entity-entity were obtained through curation. Our semantic modeling for ethnicity-specific SNPs showed interesting results in the three categories, including three diseases ("AIDS-associated nephropathy," "Hypertension," and "Pelvic infection"), one drug ("Methylphenidate"), and five pathways ("Hemostasis," "Systemic lupus erythematosus," "Prostate cancer," "Hepatitis C virus," and "Rheumatoid arthritis"). We found ethnicity-specific genes using the semantic modeling, and the majority of our findings was consistent with the previous studies - that an understanding of genetic variability explained ethnicity-specific disparities.

• Interdisciplinary Bio Central
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• 제3권1호
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• pp.4.1-4.7
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• 2011

Forty-seven wild accessions of Lotus japonicus Regal (Japanese trefoil) indigenous to Japan were investigated for nine morphological characters. Average temperature and annual precipitation were negatively correlated with stem color and seed weight. On the other hand, latitude was positively correlated with these traits. Consequently, accessions from sites at higher latitudes with low temperatures and precipitation tend to have dark red stems and heavy seeds. Cluster analysis based on nine morphological characters classified 47 wild accessions into six major groups. Cluster I included four accessions of tall and erect plants. These plants are phenotypically similar to commercial variety 'Empire'. Cluster II consisted of three accessions of creep plants with pale red stems. Cluster III contained 24 accessions that had average values for all morphological characters evaluated. Cluster IV included two accessions of erect plants with rounded leaflets and dark red stems. Cluster V included four accessions of small, creep plants with pale red stems. Cluster VI included seven accessions of small and erect plants, a phenotype that also applies to ?Gifu B-129?, which is used as experimental strain worldwide. These data were deposited into LegumeBase, an online database (http://www.legumebase.brc.miyazaki-u.ac.jp/) supported by the National BioResource Project (NBRP) in Japan.

• Interdisciplinary Bio Central
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• 제3권1호
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• pp.2.1-2.4
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• 2011

Arabidopsis is well-known to the world's plant research community as a model plant. Many significant resources and innovative research tools, as well as large bodies of genomic information, have been created and shared by the research community, partly explaining why so many researchers use this small plant for their research. The genome sequence of Arabidopsis was fully characterized by the end of the $20^{th}$ century. Soon afterwards, the Arabidopsis research community began a 10-year international project on the functional genomics of the species. In 2001, at the beginning of the project, the RIKEN BioResource Center (BRC) started its Arabidopsis resource project. The following year, the National BioResource Project was launched, funded by the Japanese government, and the RIKEN BRC was chosen as a core facility for Arabidopsis resource. Seeds of RIKEN Arabidopsis transposon-tagged mutant lines, activation-tagged lines, full-length cDNA over-expresser lines, and natural accessions, as well as RIKEN Arabidopsis full-length cDNA clones and T87 cells, are preserved at RIKEN BRC and distributed around the world. The major resources provided to the research community have been full-length cDNA clones and insertion mutants that are suitable for use in reverse-genetics studies. This paper provides an overview of the Arabidopsis resources made available by RIKEN BRC and examples of research that has been done by users and developers of these resources.

• Journal of the Korean Wood Science and Technology
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• 제44권6호
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• pp.809-820
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• 2016

The goal of this study was to predict lamina yield from logs of different diameter for production of cross laminated timber. Log characteristics of red pine (Pinus densiflora) and Japanese cedar (Cryptomeria japonica), including diameter, length, volume, and defects were used for statistical and geometrical analyses, along with the lamina characteristics, including width, thickness, and defects. Based on the data obtained, the strong factors influencing the yield and grade of lamina from the two species were statistically evaluated. A geometrical approach was used for analysis of the yield from logs of given diameters. Statistical analysis showed that lamina yield was dependent on target lamina size but the grade of lamina was not related to any of the log characteristics. The suggested yield equations from the geometrical approach indicated an accuracy of less than 20% difference.