• Yonsei Medical Journal
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• v.59 no.9
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• pp.1015-1025
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• 2018

Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged as a potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors and cytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This review focuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissue repair, based on the available data in the literature.

• Nuclear Engineering and Technology
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• v.53 no.5
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• pp.1534-1539
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• 2021

This study reports on the dissolution behavior of SrO in LiCl at varying SrO concentrations from low concentrations to excess. The amount of SrO dissolved in the molten salt and the species present upon cooling were determined. The thermal behavior of LiCl containing various concentrations of SrO was investigated. The experimental results were compared with results from the simulated results using the HSC Chemistry software package. Although the reaction of SrO with LiCl in the standard state at 650 ℃ has a slightly positive Gibbs free energy, SrO was found to be highly soluble in LiCl. Experimentally determined SrO concentrations were found to be considerably higher than those present in used nuclear fuel (<2 g/kg). As Sr-90 is one of the most important heat-generating nuclides in used nuclear fuel, this finding will be impactful in the development of fast, simple, and proliferation-resistant heat reduction processes for used nuclear fuel without the need for separating nuclear materials. Heat reduction is important as it decreases both the volume necessary for final disposal and the worker handling risk.

• Childhood Kidney Diseases
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• v.23 no.2
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• pp.67-76
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• 2019

Kidney disease is a major global health issue. Hemodialysis and kidney transplantation have been used in the clinic to treat renal failure. However, the dialysis is not an effective long-term option, as it is unable to replace complete renal functions. Kidney transplantation is the only permanent treatment for end-stage renal disease (ESRD), but a shortage of implantable kidney tissues limits the therapeutic availability. As such, there is a dire need to come up with a solution that provides renal functions as an alternative to the current standards. Recent advances in cell-based therapy have offered new therapeutic options for the treatment of damaged kidney tissues. Particularly, cell secretome therapy utilizing bioactive compounds released from therapeutic cells holds significant beneficial effects on the kidneys. This review will describe the reno-therapeutic effects of secretome components derived from various types of cells and discuss the development of efficient delivery methods to improve the therapeutic outcomes.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.35 no.1
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• pp.107-115
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• 2019

This research explores a historical trajectory of the Milwaukee Art Museum from its establishment to the third expansion over the last six decades. After established in 1957 by the architect, Eero Saarinen, this museum underwent three expansions led by three different architects including, David Kahler, Santiago Calatrava, and James Shields. Reasons for expanding the museum were varied. A lack of exhibition space, an absence of visual identity, and path interruption problem within urban contexts were the main factors of a series of expansion. Furthermore, this research points out that there are three issues in the process of the expansion. The first is connection issues between the downtown and the lakefront in which the museum has blocked the public flow. The second, there were controversies on the allocation of the expanded space among the main body of the decision including architects, curators, and stakeholders. The last one is relationships among architects. This is related to each architect's attitude toward the museum. Drawing on historical documents and interviews with the regional architects, I argue that the identity and values of the museum have changed over time through the expansions rather than having the invariable.

• Asian Journal of Business Environment
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• v.11 no.1
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• pp.39-50
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• 2021

Purpose: This study seeks to establish the environmental damage theory applicable to Kenya. The analysis is based on annual data drawn from World Bank on carbon dioxide emissions (CO2e) and gross domestic product per capita (GDPPC) for Kenya spanning 1963 to 2017. Research Methodology: The study adopts explanatory research design and autoregressive distributed lag model for analysis. Results: The results revealed a coefficient of -0.017 for GDPPC and 0.004 for GDPPC squared indicating that economic growth has negative effect on CO2e in the initial stages of growth but positive effect in the high growth regime with the marginal effect being higher in the initial growth regime. The findings suggest a U-shaped relationship consistent with Brundtland Curve Hypothesis (BCH). Conclusions: The findings emphasize the need for sustainable development path that enables present generations to meet own needs without compromising the capacity of future generations to meet their own. Sustainable development may include, investment in renewable energies like wind, solar and adoption of energy efficient technologies in production and manufacturing. The study concludes that BCH is applicable to Kenya and that developing affordable and effective mechanisms to boost sustainable development implementation is necessary to decrease the anthropogenic impact in the environment without any attendant reduction in the economic growth.

• Bulletin of the Korean Chemical Society
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• v.7 no.4
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• pp.262-266
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• 1986

A multi-reference many-body perturbation theory (MRMBPT) method is critically tested in second order by comparing with the corresponding configuration interaction (CI) calculations. Excitation energies of the four-valence-electron states of transition metal atoms and ions are used for the comparison. The agreement between the second order MRMBPT and CI calculations is very reasonable, confirming the reliability of the second order MRMBPT method. The reliability of calculations with the present second order MRMBPT method was only been inferred empirically in the past since most results have been gauged by the agreement with experiment and/or with other MRMBPT calculations based upon different sets of orbitals and configuration spaces. The present MRMBPT method appears to be an efficient ab initio multi-reference method for the calculation of electron correlation effects in atoms and molecules, and it is shown how MRMBPT can be used to estimate core-core and core-valence correlation effects which are often omitted in CI calculations because too many configurations and correlating electrons are involved.

• Journal of the Korean Society of Propulsion Engineers
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• v.24 no.3
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• pp.31-40
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• 2020

The structure and dynamics of multiple shock waves are studied numerically using a finite volume solver for a model with nozzle exit Mach number of 1.75. At first, the shock variation based on images were analyzed using a Matlab program then later to the wall static pressure variation. The amplitude and frequency variation for multiple shock waves are analyzed. The cross-correlation between the shock location suggests that the first and the second shocks are well correlated while the other shocks show a phase lag in the oscillation characteristics. The rms values of pressure fluctuations are maximum at the shock locations while the other parts in the flow exhibit a lower value os standard deviation.

• Journal of Public Diplomacy
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• v.1 no.1
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• pp.80-110
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• 2021

Public diplomacy (PD) scholars tend to consider two main principals: the country or agent that conducts PD (Actor A), and target groups in the host country in which PD is conducted (Actor B). The field currently lacks theories of how communications between Actors A and B can be disrupted by a third party, such as a group of motivated trolls, an organised advocacy group, or a hostile country and its agents. The purpose of this article is to outline some theoretical considerations for how the PD research field might move away from a two-actor model of PD to one in which disruption is part of the discussion. The case study explores the activities of an interest group called Media Watchdogs of Sweden (MEWAS). MEWAS was a group of around 200 members who met in a hidden Facebook group to coordinate off-platform activities aimed at influencing perceptions of how the Swedish government handled the COVID-19 pandemic in the eyes of foreign governments, researchers, decision-makers, and media. Much critical news coverage in the international press has been linked to this group. Unpacking some of MEWAS' activities, which can be considered a quite typical mixture of legitimate and illegitimate communication techniques used by activist groups, can help to shed light on some difficult questions regarding disruption in PD.

• Advances in concrete construction
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• v.11 no.2
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• pp.89-98
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• 2021

Investigations on the dynamic behavior of concrete members, incorporating steel fibers with different aspect ratios, are limited so far and do not covered comprehensively in prior studies. Present endeavor is devoted to examine the dynamic response of the steel fibrous concrete beams and slabs under the influence of impact loading. These members were reinforced with steel fibers in different length of 25 mm and 50 mm. Four concrete mixes were designed and used based on the proportion of long and short fibers. Twenty-four slabs and beams were fabricated with respect to the concrete mix and these specimens were tested in impact load experiment. Testing observations revealed that the maximum dynamic deflection or ductility of the member can be achieved with increasing the fiber length. Structural behavior of the tested structures was predicted using nonlinear finite element analysis with specific material constitutive relationships. Eight nodes plate elements have been considered in the present dynamic analysis. Dynamic fracture energy of the members was calculated and agreement ratio, of more than 70%, was noticed between the experimental and analysis outcomes.

• Advances in concrete construction
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• v.11 no.3
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• pp.239-253
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• 2021

The behavior of concrete containing waste glass as a replacement of cement or aggregate was studied previously in the most of researches, but the present investigation focuses on the recycling of waste glass powder as a substitute for silica fume in high strength concrete (HSC). This endeavor deals with the efficiency of using waste glass powder, as an alternative for silica fume, in the flexural capacity of HSC beam. Thirteen members with dimensions of 0.3 m width, 0.15 m depth and 0.9 m span length were utilized in this work. A comparison study was performed considering HSC members and hybrid beams fabricated by HSC and conventional normal concrete (CC). In addition to the experiments on the influence of glass powder on flexural behavior, numerical analysis was implemented using nonlinear finite element approach to simulate the structural performance of the beams. Same constitutive relationships were selected to model the behavior of HSC with waste glass powder or silica fume to show the matching between the modeling outputs for beams made with these powders. The results showed that the loading capacity and ductility index of the HSC beams with waste glass powder demonstrated enhancing ultimate load and ductility compared with those of HSC specimens with silica fume. The study deduced that the recycled waste glass powder is a good alternative to the pozzolanic powder of silica fume.