• 제목/요약/키워드: JST

검색결과 60건 처리시간 0.031초

조위승청탕(調胃升淸湯) 전탕액(煎湯液)이 XO/HX에 의해 손상(損傷)된 배양(培養) 해마신경세포(海馬神經細胞)에 미치는 효과(效果) (Effects of Jowiseungcheongtang water extract on Cultured Primary Hippocampal Cell Culture Damaged by XO/HX)

  • 김형순;김경요;고기덕;김일환;송승연
    • 사상체질의학회지
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    • 제14권1호
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    • pp.67-78
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    • 2002
  • Jowiseungcheongtang(JST) has been in Sasang constitution medicine for many years as a therapeutic agent for cerebral disease. But the effect of Jowiseungcheongtang(JST) on neurotoxicity is not known. The purpose of this study was to determine the effects of Jowiseungcheongtang(JST) on the hippocampal cell injured by Xanthine Oxidase/Hypoxanthine. The results were as follows: 1. XO/HX decreased the survival rate of the cultured hippocampal cells on NR assay and MTT assay. 2. JST water extract have efficacy of decreasing a amount of lipid peroxidation increased by XO/HX in cultured hippocampal cells. 3. JST water extract have efficacy of increasing DNA synthesis decreased by XO/HX in cultured hippocampal cells. From the above results, It is concluded that JST has marked efficacy in preventing cultured hippocampal cells from the damages by XO/HX.

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The Effect of Jeongshin-tang on Interleukin-1 $\beta$ and $\beta$-Amyloid-Induced Cytokine Production in Human Brain Astrocytes

  • Kim Bo Kyung;Shin Soon Shik;Kang Seon Tae
    • 동의생리병리학회지
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    • 제18권1호
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    • pp.254-259
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    • 2004
  • Jeongshin-tang (JST) is a Korean herbal prescription, which has been successfully applied for the various neuronal diseases. However, it's effect remains unknown in experimental models. To investigate the biological effect of JST in Alzheimer's disease (AD) in vitro model, we analized the production of interleukin (IL)-6 and IL-8, and expression of cyclooxygenase (COX)-2 in IL-1β plus β-amyloid [25-35] fragment (A)-stimulated human astrocytoma cell line U373MG. JST alone had no effect on the cell viability. The production of IL-6 and IL-8 was significantly inhibited by pretreatment with JST (1mg/㎖) on IL-1β plus A-stimulated U373MG cells. Maximal inhibition rate of IL-6 and IL-8 production by JST was about 41.22% (P<0.01) and 34.45% (P<0.05), respectively. The expression level of COX-2 protein was up-regulated by IL-1β plus A but the increased level of COX-2 was inhibited by pretreatment with JST (1 mg/㎖). These data indicate that JST has a regulatory effect on cytokine production and COX-2 expression, which might explain it's beneficial effect in the treatment of AD.

조위승청탕(調胃升淸湯)의 위점막(胃粘膜) 손상(損傷) 방어효과(防禦效果)에 관한 연구(硏究) (Study for defensive effect of Jowesungcheong-tang on gastric mucosal damage in mice)

  • 박성식;한진수
    • 사상체질의학회지
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    • 제14권1호
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    • pp.100-111
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    • 2002
  • 1. The Purpose of study An experimental study has done to examine the effect of defense on gastric mucosal damage of Jowesungcheong-tang. 2. The Material and Method of study Mice had intragastric injected with JST extract before indome thacin treatment which induces hemorrh age erosion artificially. General morphology, infiltrative cell in mucosa, the distribution of UEA-I, COX-1, MAC-1. ICAM, and Apoptotic cell were objected (Ahhreviation) JST :Jowesungcheong-tang, UEA-I : ulex europaeus agglutinin-I, COX-1: cyclooxyhenase-1, ICAM : intercellular adhesion molecule-1, GPE : Gastropathy elicitated mice 3. The results and Conclusions of study 1) The degree of hemorrhage erosion in GPE-group had increased conspicuously in gastric gland proper. JST -group were the same as normal 2) The noticeable increase of granular lecocytes and lymphocytes in GEP-group were seen, but in JST group, the configuration is decreased 3) The decrease of UEA-I positive reacted cells, COX-1, surface epithelial cells and the increase of MAC-l positive cells, ICAM-l positive cells had shown in GPE-group, but in JST-group UEA-I positive cells, COX-1 surface epithelial cells were in creased and MAC-1 positive cells, ICAM-l positive cells were decreased than GPE-group. 4) A number of apoptotic cells were distributed in hemorrhage erosion. The remarkable decrease of apoptotic cells were shown in JST-group.

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한국의 제주에서 발견된 바다거북 잡종(Caretta caretta ${\times}$ Chelonia mydas)에 대한 첫 보고 (First Report of a Hybridization between Caretta caretta and Chelonia mydas from Jeju Island, South Korea)

  • 구교성;한상현;오홍식
    • 환경생물
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    • 제32권4호
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    • pp.377-381
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    • 2014
  • 이 논문은 국내에서 발견된 잡종 바다거북 (Caretta caretta ${\times}$ Chelonia mydas)에 대한 첫 번째 보고이다. 2012년 5월 7일 바다거북류 한 개체(JST01)가 제주도 동쪽해안에서 사체로 발견되었다. 국내에서 빈번하게 관찰되는 바다거북류 두 종(C. caretta and C. mydas)과 JST01의 외부형태를 비교한 결과, 채색, 등갑의 형태, 부리(upper beak)의 모양, 연갑판에 거치 그리고 앞발 발톱 개수 등의 외부형태는 C. caretta와 일치하였다. 반면, 연갑판, 서계갑판 그리고 늑갑판의 수, 용골이 없는 매끈한 등갑, 늑갑판과 정갑판이 접촉하지 않는 점 등은 C. mydas의 특징과 일치하였다. 결론적으로 C. caretta와 C. mydas의 외부형질들을 복합적으로 가지고 있는 JST01은 서로 다른 두 종간에 생겨난 교잡종이라 판단된다. 이상의 결과는 바다거북류에서 나타나는 잡종형성에 대한 연구에 중요한 기초자료가 될 것이다.

Current Situation of the International Recognition of Toxicologists -Update of the Japanese Society of Toxicology-

  • Horii, Ikuo
    • Toxicological Research
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    • 제17권
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    • pp.193-196
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    • 2001
  • Issuance of certification and licensing for toxicologists authorized by the Japanese Society of Thxicology (JST) became effective on July 24, 1997. The certification system consists of examination, eligibility requirements for the applicants, authorization/license by the board of trustees of JST, and the re-certification of previously authorized qualification. In the last 2-3 years, about 30-40% of candidates for the examination have succeeded. The Committee has estimated that the level of the examination would be sufficient to determine qualified toxicologists. This updated status and a detailed explanation are to be presented at the workshop. In global terms, the JST special committee agrees that "harmonization of certification/registration procedure for qualified toxicologists means to ensure/set the minimum requirement for the global authorization of qualified toxicologists". The following items in global authorization are ad-dressed for further discussion: (1) What's the benefit\ulcorner (2) Toxicological safety assessment standards, and (3) the JST position for authorization.orization.

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Numerical Study of Inflation of a Dipolar Magnetic Field by Injecting Plasma with Different Beta

  • Kajimura, Yoshihiro;Funaki, Ikkoh;Shinohara, Iku;Usui, Hideyuki;Nakashima, Hideki
    • 한국추진공학회:학술대회논문집
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    • 한국추진공학회 2008년 영문 학술대회
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    • pp.553-556
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    • 2008
  • A Magneto Plasma Sail(MPS) produces propulsive force by the interaction between the solar wind and an artificial magnetic field inflated by injecting plasma. Using a 2D hybrid PIC code, we evaluate the inflation of magnetic field when Argon(Ar) plasma with different ${\beta}_{in}$ including the value less than one is injected into the dipolar magnetic field generated by a superconducting coil. It is found that the magnetic field can be inflated by injecting plasma within an angle of $30^{\circ}$ in the polar direction and the magnetic field decays in the polar direction according to $B{\propto}r^{-2.4}$ after the plasma(${\beta}_{in}$=0.1) is injected.

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DB뱅크 - 일본의 과학 기술 정보가 '보인다'

  • 김휘출
    • 디지털콘텐츠
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    • 4호통권47호
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    • pp.62-65
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    • 1997
  • JOIS(JICST On-Line Information System)은 일본의 과학기술 발전을 위해 설립된 일본과학기술정보센터(JST : Japan Science and Technology Coporation : http;//www.jst-c.go.jp)에서 일본의 과학기술, 의학 등에 관한 정보를 제공하기 위하여 1976년에 세워진 데이터뱅크이다.

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진간식풍탕 전탕액이 GO에 의해 손상된 배양 척수감각신경세포의 LDH 활성도에 미치는 영향 (Effects of Jingansikpung-tang Water Extract on LDH Activity of Cultured Spinal Sensory Neurons Damaged by GO)

  • 박광수;권강범;성은경;송용선;류도곤
    • 동의생리병리학회지
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    • 제16권3호
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    • pp.563-566
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    • 2002
  • To evaluate the effect of Jingansikpung-tang(JST) water extract on cultured mouse spinal sensory neuron which was inhibited by glucose oxidase(GO)-induced cytotoxicity, MTT and LDH activity assay were carried out after the cultured mouse spinal sensory neuron were pre-incubated with various concentrations of JST extract for 3 hours prior to exposure of GO. The results obtained were as follows: GO, a oxygen radical, decreased the survival rate of the cultured mouse spinal sensory neuron cells on MTT assay. JST water extract have efficacy of decreasing LDH activity increasing by GO in cultured mouse spinal sensory neuron. From above the results, it is concluded that JST water extract has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process.