• 생명과학회지
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• 제17권12호
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• pp.1627-1633
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• 2007

c-Jun N-terminal kinase (JNK)-interacting protein 1(JIP1)은 비계단백질(scaffold protein)로서 신경 세포와 ??장${\beta}$세포에서 많이 발현된다. 본 연구에서는 배양한 흰쥐 해마신경세포에서 JIP1, JIP-2 및 JIP-3을 모두 인식하는 항체를 이용하여 이들의 세포내 표현을 조사하였다. 전반적으로 JIP은 세포체와 가지돌기에 반점 모양으로 표현되었다. 이 JIP 반점들을 통계적으로 분석한 결과 흥분성 연접후표지인 PSD95 및 ${\alpha}CaMKII$ 반점 과 각각 $54.8{\pm}4.0%$ 및 $94.1{\pm}4.5%$가 겹쳐졌다. 반면에 억제성 연접후표지인 그리신수용체 및 gephyrin 반점과는 각각 단지 $8.6{\pm}0.5%$ 및 $7.3{\pm}0.5%$만 겹쳐졌다. 한편 lipid raft의 표지인 flotillin 반점의 상당부분$(29.3{\pm}1.0%)$이 JIP 반점과 겹쳐졌다. 또한, JIP은 일부 가지돌기의 끝부분에 매우 강하게 발편되었으며 축삭에는 표현이 미미하였다. 이 결과들은 JIP 단백질이 흥분성 연접후구역, 일부 lipid raft, 그리고 일부 가지돌기 끝부분에 주로 위치함을 의미한다.

• Biomolecules & Therapeutics
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• 제26권5호
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• pp.458-463
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• 2018

The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell. Structural computation showed that the binding affinity of Acebutolol on the JNK-JIP1 interaction site was comparable to the known inhibitor, BI-78D3. Our results suggest that Acebutolol, an FDA-approved beta blocker for hypertension therapy, could have a new repurposed effect on type 2 diabetes elevating glucose uptake process by inhibiting JNK-JIP1 interaction.

• 한국주거학회논문집
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• 제15권1호
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• pp.215-222
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• 2004

• 복식
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• 제54권1호
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• pp.159-168
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• 2004

During the Chosun(조선) and Ming(명) Dynasty, embroidered patches called hyoong bae(흉배), were worn on the front and back of official robes worn by courtiers based on class distinction. It was discovered in Jip Sah(Genghis Khan's history books) that the miniatures, patterns used in the Won(원) Period, were passed down to the Ming Dynasty in the $14^{th}$ century. Shape patterns included circles, triangles, squares, and ovals. Other patterns included dragons, deer, leaves, and branches. However it was found that there was no class distinction in wearing these patches. Out of 14 different miniatur, 41 men had worn these patches.

• 대한한의학회지
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• 제29권4호
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• pp.213-217
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• 2008

Since at least the late 12th century, medical herbs grown naturally or cultivated in Korea have been referred to as 'HyangYak'(鄕藥, $Xi\bar{a}ngY\grave{a}o$). Herbs from other countries are referred to as 'DangYak'(唐藥, $D\bar{a}ngY\grave{a}o$). Some senior historians claim medicines made solely from HyangYak are purely Korean, since they originated and were developed fully within Korea. However, these localized medicines became abundant as the result of exchanges between Korea and other countries. Originally published in 1433, 'HyangYakJipSungBang' is the authoritative result of earlier writings of medical books using HyangYak. Comprised of a total of 85 volumes, it was large in scale and divided into three main sections: 1) a detailed description of the 703 kinds of HyangYak, 2) explanations of the 10,706 different herbal formulae and 959 types of symptoms or diseases, and 3) descriptions of the 1,416 various acupuncture and moxibustion formulae. It's noted that 'HyangYakJipSungBang' was not written all at once. In the process of its writing, the number of formulae increased through medical exchanges between Korea and China during the 15th century.

• 한국해양공학회지
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• 제38권1호
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• pp.30-42
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• 2024

This study examined the jack-up spudcan penetration for a new type of offshore wind substructure newly proposed using the jack-up concept to reduce construction costs. The jack-up spudcan for offshore wind turbines should be designed to penetrate a stable soil layer capable of supporting operational loads. This study evaluated multi-layered soil conditions using centrifuge tests: loose sand over clay and loose sand-clay-dense sand. The penetration resistance profiles of spudcan recorded at the centrifuge tests were compared with the ISO and InSafeJIP methods. In the tests, a spudcan punch-through effect slightly emerged under the sand-over-clay condition, and a spudcan squeezing effect occurred in the clay-over-sand layer. On the other hand, these two effects were not critically predicted using the ISO method, and the InSafeJIP result predicted only punch-through failure. Nevertheless, ISO and InSafeJIP methods were well-matched under the conditions of the clay layer beneath the sand and the penetration resistance profiles at the clay layer of centrifuge tests. Therefore, the ISO and InSafeJIP methods well predict the punch-through effect at the clay layer but have limitations for penetration resistance predictions at shallow depths and strong stratum soil below a weak layer.

• 대한가정학회지
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• 제44권1호
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• pp.151-157
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• 2006

Ten types of male headgear-Kwonwoonkwan, crown-like headgear, hats with a square flap, hats with feathers, crowns with plumes, Ballip, hats with flat crowns, Somo, turban, and fur hats-were described in Jip-Sah, which was published in the 14th century. Mongolian people used summer headgear, winter hats, and crown ornaments, which had been used until the Ch'ing dynasty of China. From the late 12th century to 1304, the headgear styles remained the same, suggesting that the Mongolian people kept their tradition. Kwonwoonkwan, crown-like headgear, and Somo, presented in Jip-Sah, were also described in U. Yadamsuren's album, a pictorial depiction of the 20th century Mongolian headgear.

• 주물기술
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• 제3권1호
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• pp.62-71
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• 1979

• 월간 양돈
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• 제29권1호통권329호
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• pp.220-221
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• 2007

• 물과 미래
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• 제18권1호
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• pp.40-50
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• 1985