• Journal of Life Science
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• v.17 no.12
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• pp.1627-1633
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• 2007

c-Jun N-terminal kinase (JNK)-interacting protein 1 (JIP1), also known as Islet-brain 1 (IB1), is a scaffold protein that is highly expressed in neurons and pancreatic ${\beta}-cells$. In this study subcellular localization of JIP was investigated in cultured rat hippocampal neurons using an antibody that recognize all variants of JIP1, JIP-2 and JIP-3. The overall expression profile of JIP is punctate throughout soma and dendrites. Statistic analysis showed that $54.8{\pm}4.0%\;and\;94.1{\pm}4.5%$ of total JIP immunopuncta overlapped with those of excitatory postsynaptic markers SD-95 and ${\alpha}Camik$, respectively. In contrast, only $8.6{\pm}0.5%\;and\;7.3{\pm}0.5%$ of JIP clusters overlapped with those of inhibitory postsynaptic markers glycine receptor (GlyR) and gephyrin, respectively. JIP clusters overlapped or juxtaposed with SV2 but not GAD, markers for general and inhibitory nerve terminals, respectively. A substantial fraction $(29.3{\pm}1.0%)$ of flotillin immunopuncta, a marker for lipid rafts, clusters overlapped with those of JIP. In addition, JIP was highly expressed in some select ends of dendrites but minimal in axons. These data suggest important roles of JIP in excitatory postsynaptic sites, lipid rafts and dendritic ends.

• Biomolecules & Therapeutics
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• v.26 no.5
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• pp.458-463
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• 2018

The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell. Structural computation showed that the binding affinity of Acebutolol on the JNK-JIP1 interaction site was comparable to the known inhibitor, BI-78D3. Our results suggest that Acebutolol, an FDA-approved beta blocker for hypertension therapy, could have a new repurposed effect on type 2 diabetes elevating glucose uptake process by inhibiting JNK-JIP1 interaction.

• Journal of the Korean housing association
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• v.15 no.1
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• pp.215-222
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• 2004

• Journal of the Korean Society of Costume
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• v.54 no.1
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• pp.159-168
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• 2004

During the Chosun(조선) and Ming(명) Dynasty, embroidered patches called hyoong bae(흉배), were worn on the front and back of official robes worn by courtiers based on class distinction. It was discovered in Jip Sah(Genghis Khan's history books) that the miniatures, patterns used in the Won(원) Period, were passed down to the Ming Dynasty in the $14^{th}$ century. Shape patterns included circles, triangles, squares, and ovals. Other patterns included dragons, deer, leaves, and branches. However it was found that there was no class distinction in wearing these patches. Out of 14 different miniatur, 41 men had worn these patches.

• The Journal of Korean Medicine
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• v.29 no.4
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• pp.213-217
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• 2008

Since at least the late 12th century, medical herbs grown naturally or cultivated in Korea have been referred to as 'HyangYak'(鄕藥, $Xi\bar{a}ngY\grave{a}o$). Herbs from other countries are referred to as 'DangYak'(唐藥, $D\bar{a}ngY\grave{a}o$). Some senior historians claim medicines made solely from HyangYak are purely Korean, since they originated and were developed fully within Korea. However, these localized medicines became abundant as the result of exchanges between Korea and other countries. Originally published in 1433, 'HyangYakJipSungBang' is the authoritative result of earlier writings of medical books using HyangYak. Comprised of a total of 85 volumes, it was large in scale and divided into three main sections: 1) a detailed description of the 703 kinds of HyangYak, 2) explanations of the 10,706 different herbal formulae and 959 types of symptoms or diseases, and 3) descriptions of the 1,416 various acupuncture and moxibustion formulae. It's noted that 'HyangYakJipSungBang' was not written all at once. In the process of its writing, the number of formulae increased through medical exchanges between Korea and China during the 15th century.

• Journal of Ocean Engineering and Technology
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• v.38 no.1
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• pp.30-42
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• 2024

This study examined the jack-up spudcan penetration for a new type of offshore wind substructure newly proposed using the jack-up concept to reduce construction costs. The jack-up spudcan for offshore wind turbines should be designed to penetrate a stable soil layer capable of supporting operational loads. This study evaluated multi-layered soil conditions using centrifuge tests: loose sand over clay and loose sand-clay-dense sand. The penetration resistance profiles of spudcan recorded at the centrifuge tests were compared with the ISO and InSafeJIP methods. In the tests, a spudcan punch-through effect slightly emerged under the sand-over-clay condition, and a spudcan squeezing effect occurred in the clay-over-sand layer. On the other hand, these two effects were not critically predicted using the ISO method, and the InSafeJIP result predicted only punch-through failure. Nevertheless, ISO and InSafeJIP methods were well-matched under the conditions of the clay layer beneath the sand and the penetration resistance profiles at the clay layer of centrifuge tests. Therefore, the ISO and InSafeJIP methods well predict the punch-through effect at the clay layer but have limitations for penetration resistance predictions at shallow depths and strong stratum soil below a weak layer.

• Journal of the Korean Home Economics Association
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• v.44 no.1 s.215
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• pp.151-157
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• 2006

Ten types of male headgear-Kwonwoonkwan, crown-like headgear, hats with a square flap, hats with feathers, crowns with plumes, Ballip, hats with flat crowns, Somo, turban, and fur hats-were described in Jip-Sah, which was published in the 14th century. Mongolian people used summer headgear, winter hats, and crown ornaments, which had been used until the Ch'ing dynasty of China. From the late 12th century to 1304, the headgear styles remained the same, suggesting that the Mongolian people kept their tradition. Kwonwoonkwan, crown-like headgear, and Somo, presented in Jip-Sah, were also described in U. Yadamsuren's album, a pictorial depiction of the 20th century Mongolian headgear.

• JUMULGISUL / FOUNDRY TECHNOLOGY
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• v.3 no.1
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• pp.62-71
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• 1979

• The Korea Swine Journal
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• v.29 no.1 s.329
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• pp.220-221
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• 2007

• Water for future
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• v.18 no.1
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• pp.40-50
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• 1985