• 제목/요약/키워드: JEONG HEE KIM

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항암화학요법 유발 말초신경병증의 한의학적 치료에 대한 국내 연구동향 고찰 (A Review of Domestic Research on Traditional Korean Medicine for Chemotherapy-Induced Peripheral Neuropathy)

  • 최수현;윤채림;정나현;정다희;심유현;정해인;하나연;김진성
    • 대한한방내과학회지
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    • 제45권3호
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    • pp.358-380
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    • 2024
  • Objectives: This study was performed to research Korean medical treatment methods for chemotherapy-induced peripheral neuropathy by summarizing domestic studies. Methods: All domestic research papers on the Korean medical treatment of chemotherapy-induced peripheral neuropathy were selected from the literature published until April 2024 in four domestic databases. In total, 26 domestic papers were selected. Results: Eighteen clinical studies and eight experimental studies were published by April 2024. Most of the studied patients were in their fifties, and 93.4% of the subjects were women. Uchashinki-hwan (牛車腎氣丸) was the most frequently prescribed herbal formula, and Rehmanniae Radix Preparata was the most commonly used herb. All studies showed significant effects of Korean medical treatment, and any adverse events were not reported. Conclusion: This study included all domestic research papers on chemotherapy-induced peripheral neuropathy to identify research trends in the Korean medicine community. Based on this, it is meaningful to confirm areas that need to be supplemented in future research plans. However, large-scale studies are needed.

Enhancement of nerve growth factor production and release by buthanol fraction of Liriope platyphylla in C6 cells and rat cultured astrocyte

  • Hur, Jin-Young;Lee, Pyeong-Jae;Kim, Jeong-Min;Kim, Ho-Cheol;Kim, Sun-Yeou
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.135.3-136
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    • 2003
  • Liriope platyphylla (LP) Wang et Tang has been used for tonic, anti-tussive and expectorant in Korea. In the current study, we found that buthanol fraction of Liriope platyphylla-conditioned media of C6 and primary astrocyte induced the neurite outgrowth of PC 12 cells, which effect was reversed by addition of NGF-antibody. We demonstrated that buthanol fraction of Liriope platyphylla increased the expression and secretion of NGF through RT-PCR and ELISA. (omitted)

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Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats

  • Kim, Eun Jin;Oh, Hyun-A;Choi, Hyuck Jai;Park, Jeong Hill;Kim, Dong-Hyun;Kim, Nam Jae
    • Journal of Ginseng Research
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    • 제37권1호
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    • pp.87-93
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    • 2013
  • To evaluate the effect of the saponin of heat-processed ginseng (Sun ginseng, SG), we investigated the protective effect of SG total saponin fraction against adenine-induced chronic renal failure in rats. SG saponin significantly decreased the levels of urea nitrogen and creatinine in the serum, but increased the urinary excretion of urea nitrogen and creatinine, indicating an improvement of renal function. SG saponin also inhibited adenine-induced kidney hypertrophy and edema. SG saponin reduced serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and lactate dehydrogenase activities increased by adenine. Based on these findings, the ameliorating effect of SG on chronic renal failure may result from its saponin.

Iridoid Glycosides Isolated from Oldenlandia diffusa Inhibit LDL-Oxidation

  • Kim Dong-Hyun;Lee Hyo-Jung;Oh Young-Jun;Kim Min-Jung;Kim Sung-Hoon;Jeong Tae-Sook;Baek Nam-In
    • Archives of Pharmacal Research
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    • 제28권10호
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    • pp.1156-1160
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    • 2005
  • An iridoid glycoside, oldenlandoside III (5) was isolated from the n-butanol fraction of methanol extracts of the aerial parts of Oldenlandia diffusa Roxb. along with six others previously characterized iridoid glycosides; geniposidic acid (1), scandoside (2), feretoside (3), 10-O-ben-zoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7). Compounds 1, 2, and 7 inhibited LDL-oxidation, and showed $63.3{\pm}2.0,\;62.2{\pm}1.6,\;and\;63.8{\pm}1.5\%$ inhibition, respectively, at a concentration of 20 ${\mu}g/mL$.