• Journal of Ginseng Research
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• v.44 no.4
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• pp.611-618
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• 2020

Background: It is well recognized that gut microbiota is involved in the biotransformation of ginsenosides by converting the polar ginsenosides to nonpolar bioactive ginsenosides. However, the roles of the gut microbiota on the pharmacokinetics of ginsenosides in humans have not yet been fully elucidated. Methods: Red ginseng (RG) or fermented red ginseng was orally administered to 34 healthy Korean volunteers, and the serum concentrations of the ginsenosides were determined using liquid chromatography-tandem mass spectrometry. In addition, the fecal ginsenoside Rd- and compound K (CK)eforming activities were measured. Then, the correlations between the pharmacokinetic profiles of the ginsenosides and the fecal ginsenoside-metabolizing activities were investigated. Results: For the RG group, the area under the serum concentratione-time curve values of ginsenosides Rd, F2, Rg3, and CK were 8.20 ± 11.95 ng·h/mL, 4.54 ± 3.70 ng·h/mL, 36.40 ± 19.68 ng·h/mL, and 40.30 ± 29.83 ng·h/mL, respectively. For the fermented red ginseng group, the the area under curve from zero to infinity (AUC_∞) values of ginsenosides Rd, F2, Rg3, and CK were 187.90 ± 95.87 ng·h/mL, 30.24 ± 41.87 ng·h/mL, 28.68 ± 14.27 ng·h/mL, and 137.01 ± 96.16 ng·h/mL, respectively. The fecal CK-forming activities of the healthy volunteers were generally proportional to their ginsenoside Rd-eforming activities. The area under the serum concentration-time curve value of CK exhibited an obvious positive correlation (r = 0.566, p < 0.01) with the fecal CK-forming activity. Conclusion: The gut microbiota may play an important role in the bioavailability of the nonpolar RG ginsenosides by affecting the biotransformation of the ginsenosides.

• Progress in Superconductivity and Cryogenics
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• v.5 no.3
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• pp.6-10
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• 2003

Silver nano-powder was added to Ma $B_2$ to make (Ag)$_{(x)wt.%}$(Mg $B_2$)$_{(l00-x)wt.%}$ (A $g_{x}$-Mg $B_2$) (10 $\leq$ x $\leq$ 50) composite superconductors to investigate the effect of the Ag nano-powder on the vortex pinning. Pellets made out of the mixed powder were put inside stainless steel tubes, which were sintered at 85$0^{\circ}C$ in Ar atmosphere. No impurity phase was identified for as-rolled samples. However, both the Mg $B_2$ and the A $g_{x}$-Mg $B_2$ composite pellets, when sintered, contain small amount of Mg $B_4$ and MgAg impurity phases. From the magnetization study, it was found that the flux pinning was improved in the high magnetic field region (> 3 T) only when 10w/o Ag was added to Mg $B_2$. The "two step" structures in ZFC M(T) curve gradually increased as the amount of Ag added increased. Pinning centers can be created by adding a suitable amount of Ag nano-powder which is not too large to increase the decoupling between the Mg $B_2$ grains.crease the decoupling between the Mg $B_2$ grains.

• Journal of computational fluids engineering
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• v.20 no.3
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• pp.35-40
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• 2015

Centrifugal pumps consume considerable amounts of energy in various industrial applications. Therefore, improving the efficiency of pumps machine is a crucial challenge in industrial world. This paper presents numerical investigation of flow characteristics in volutes of centrifugal pumps in order to compare the energy consumption. A wide range of volumetric flow rate has been investigated for each case. The standard k-${\varepsilon}$ is adopted as the turbulence model. The impeller rotation is simulated employing the Multi Reference Frames(MRF) method. First, two different conventional design methods, i.e., the constant angular momentum(CAM) and the constant mean velocity (CMV) are studied and compared to a baseline volute model. The CAM volute profile is a logarithmic spiral. The CMV volute profile shape is an Archimedes spiral curve. The modified volute models show lower head value than baseline volute model, but in case of efficiency graph, CAM curve has higher values than others. Finally for this part, CAM curve is selected to be used in the simulation of different cross-section shape. Two different types of cross-section are generated. One is a simple rectangular shape, and the other one is fan shape. In terms of different cross-section shape, simple rectangular geometry generated higher head and efficiency. Overall, simulation results showed that the volute designed using constant angular momentum(CAM) method has higher characteristic performances than one by CMV volute.

• Food Science and Biotechnology
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• v.17 no.1
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• pp.90-94
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• 2008

Dynamic rheological properties of honey samples with 3 different moisture contents (17.2, 19.0, and 21.0%) were evaluated at various low temperatures (-15, -10, -5, and $0^{\circ}C$) using a controlled stress rheometer. The honey samples displayed a liquid-like behavior, with loss modulus (G") predominating over storage modulus (G') (G">>G'), showing the high dependence on frequency ($\omega$). The magnitudes of G' and G" decreased with an increase in temperature and water content while a predominant increase of G' was noticed at $-15^{\circ}C$. The time-temperature superposition (TTS) principle was applied to bring G" values for honeys at various temperatures together into a master curve. The G" over the temperature range of -15 to $0^{\circ}C$ obeyed the Arrhenius relationship with a high determination coefficient ($R^2=0.98-0.99$). Activation energy value (Ea=112.4 kJ/mol) of honey with a moisture content of 17.2% was higher than those (Ea=98.8-101.1 kJ/mol) of other honey samples with higher moisture contents.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.9
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• pp.1364-1372
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• 1997

In this paper, the forging of helical gears has been investigated. Punch is tooth-shaped as is the die insert. The punch compresses a cylindrical billet placed in a die insert. As a consequence the material of billet flows into the tooth region. The forging has been analysed by using the upper-bound method. A kinematically admissible velocity field has been developed, wherein, an involute curve has been introduced to represent tooth profile of the gear. Numerical calculations have been carried out to investigate the effects of various parameters, such as module, number of teeth, helix angle and friction factor on the forging of helical gears. Some forging experimentswere carried out with aluminum alloy to show the validity of the analysis. Good agreement was found between the predicted values of the forging load and obtained from the experimental results.

• Transactions of the Korean Society of Mechanical Engineers
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• v.9 no.2
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• pp.135-139
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• 1985

A J$_{IC}$ test procedure by ultrasonic method performed to observe the crack opening behavior of fatigue precrack and detect the initiation of crack propagation of compact tension specimen in this paper. Pulse-echo method with 5 MHz transducer was used on the Cr-Mo steel quenched and tempered at 593.deg. C. We obtained the following results in the elastic-plastic fracture toughness test by ultrasonic method. Echo height is a little increased linearly and rapidly at the early stage of loading . Then it is decreased considerably, finally at the unstable crack growth stage, it is rapidly increased at an unpredictable rae. The initiation of crack propagation is supposed to be at the stage deviated from linearly decreased region and then blunted. J$_{IC}$ value(10.15-12.15 Kgf/mm) by ultrasonic method is lower than that(12.2 Kgf/mm) by R-curve method. But, it is required that the research for the more exact evaluation about correlation between echo height and the crack opening behavior of precrack tip will be continued. continued.ued.

• Transactions of Materials Processing
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• v.20 no.4
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• pp.296-302
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• 2011

The objective of this paper is to determine the effect of process parameters on the behavior of a 18Cr-10Mn-$0.44N_2$ nitrogen steel sample deformed by hot rolling. Compression tests were carried out at high temperatures to determine the flow stresses needed for a finite element(FE) analysis. The strain rate, ranging from 0.1 to $1.0s^{-1}$, significantly affected the flow stress at temperatures higher than $1,000^{\circ}C$. Non-isothermal rolling simulations and laboratory rolling tests were performed with plate specimens 14.5mm thick, 135mm wide and 226mm long. A rolling reduction of 15% per pass leading to a cumulative rolling reduction of 60% was determined as optimal. The extension ratio of 176.5% in the length direction was about 30.4 times greater than the extension ratio of 5.8% in the width direction. Isotropic properties for tensile strength, microstructure and grain size were measured after mock-up hot rolling tests. The results from the mockup tests were found to be in good agreement with those of the simulations.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2007.10a
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• pp.190-194
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• 2007

The forging process design and microstructure evolution for gas turbine disk of a Waspaloy is investigated in this study. Parameters related to deformation are die and preform geometry, and forging temperature of die and workpiece. Die and preform design are considered to reduce the forging load, and to avoid the forging defects. Blocker and finisher dies for multistage forging are designed and the initial billet geometry is determined. The control of hot forging parameters such as strain, strain rate and temperature also is important because the microstructure change in hot working affects the mechanical properties. The dynamic recrystallization evolution has been studied in the temperature range 900-$1200^{\circ}C$ and strain rate range 0.01-1.0s-1 using hot compression tests. Modeling equations are required represent the flow curve, recrystallized grain size, recrystallized volume fraction by various tests. In this study, we used to thermo-viscoplastic finite element modeling equation of DEFORM-2D to predict the microstructure change evolution during thermo-mechanical processing. The microstructure is updated during the entire thermal and deformation processes in forging.

• Journal of Biomedical Engineering Research
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• v.30 no.3
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• pp.226-232
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• 2009

In this study, treadmill walking and overground walking were compared at the same condition based on kinematics and energy expenditures(EE). In addition, we compared the actual energy expenditure and calculated EE by treadmill. The kinematics of treadmill and overground walking were very similar. The values at each joint were significantly different(P<0.05), but magnitude of the difference was generally less than 4$^{\circ}$. In the EE using cardiopulmonary exercise, EE of treadmill walking was significantly greater when measured on the overground. It seemed to be the increased stress during the gait by the continuous movement of the belt. As the velocity increased, there was significant difference between actual EE and calculated EE by treadmill due to EE curve increasing exponentially. Therefore the further study would be required to find the correlation of the two methods and calibrate the values from them.

• Proceedings of the KIEE Conference
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• 1998.11a
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• pp.13-15
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• 1998

EM(Electro Magnetic) pump is used for the purpose of transporting liquid sodium coolant with electrical conductivity in the LMR(Liquid Metal Reactor). In the present study. pilot EM pump has been designed by using of equivalent circuit method which is commonly employed to analyze linear induction machines for the test of removal of residual heat. The length and diameter of the pump have fixed values of 840 mm and 101.6 mm each by taking account of geometrical size of circulation loop for the installation of EM pump. Flowrate versus developing pressure is related from Laithwaite's standard design formula and the characteristic analyses of developing force and efficiency are carried out according to change of input frequency. From the characteristic curve, input frequency of 13 Hz is determined as the design frequency. On the other hand, The annular air gap size of 6.05 mm is selected not to bring about too much hydraulic loss. Resultantly design analysis makes pump have the electrical input of 604 VA and the hydrodynamical capacity of 1.3 bars and 40 l/min.