• 대한의용생체공학회:의공학회지
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• 제24권3호
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• pp.175-181
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• 2003

근피로 연구는 주로 등척성(isometric)운동에서 수행되었고 등장성(isotonic)운동에서 얻은 근전도 신호는 통제하기 힘든 잡음이 많아 등척성운동에서 사용된 주파수분석기법을 동일하게 적용하였을 때 신뢰할만한 중앙주파수 자료와 근피로 판정용 변수를 구하는데 어려움이 있었다 이에 본 연구에서는 등장성운동에서 측정한 근전도신호의 중앙주파수 검출방법에 따른 근피로 판정 변수들의 차이를 비교해 보고자 하였다 이를 위해 동일한 근전도신호를 가지고 FFT 수행간격과 연속적인 FFT구간의 중첩비율을 다르게 하여 중앙주파수를 검출하고 이들의 선형회귀직선을 구하여 회귀직선상의 변수인 초기중앙주파수, 기울기. 근피로지수를 비교한 결과, 초기중앙주파수의 경우 FFT 수행간격이 넓을수록 조금씩 상승하는 것으로 나타났고, 기울기의 경우 FFT 수행간격이 넓을수록 중첩구간이 적을수록 기울기의 감소경향이 뚜렷하게 나타났다. 근피로지수의 경우는 특정 FFT 수행간격에서 가장 높은 수치를 나타냈다

• 약학회지
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• 제57권4호
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• pp.282-288
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• 2013

Zinc oxide nanoparticles (ZnONPs) are widely used in a variety of products and cosmetic products including paper, paints, plastics and sunscreen. However, information on the safety of ZnONPs are not enough and many publications suggest possible toxic effects on environmental and human health. Furthermore, physico-chemical characteristics of nanoparticles makes it hard to test toxicity using the test guidelines of chemicals adopted by regulatory bodies. In this study, stability of ZnONPs was investigated using different types of isotonic solution, which is important in the toxicity study of intravenous route. Precipitation, aggregation, size, zeta potential and morphology of ZnONPs were evaluated with different times and concentrations. Precipitation of ZnONPs were observed in ionic isotonic solution including phosphate-buffered saline, Kreb's-Ringer solution, physiological salt solution and cell culture media of DMEM (Dulbecco's Modified Eagle's Medium) with 10% fetal bovine serum. On the other hand, they were stable without precipitation in non-ionic isotonic solution such as 5% glucose and 2% glycerol, respectively, which are biocompatible for intravenous injection. The average size of ZnONPs in 5% glucose and 2% glycerol was stably maintained, which is less than 30 nm and very similar as that in water dispersion of ZnONPs, provided by the manufacturer. The stability was maintained during the experimental period of 5 days and diluted state up to 15,000 ppm. These data suggest that 5% glucose and 2% glycerol solution can be used for the vehicles of ZnONPs in the toxicity study of intravenous injection route.

• 한국융합학회논문지
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• 제12권12호
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• pp.411-418
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• 2021

본 연구의 목적은 근감소증이 있는 유방암 환자를 대상으로 서로 다른 근 수축형태의 저항성 운동을 실시하여 상지 근기능 및 타액 내 사이토카인에 미치는 효과를 규명함으로써 유방암 생존자의 재발 방지를 위한 효과적인 운동프로그램의 기초자료를 제공하는데 있다. 근감소증이 있는 유방암 환자(등척성 운동집단 10명, 등장성 운동집단 10명)를 대상으로 8주간 60~70%RM의 강도로 60분 동안 주 3회 실시하였으며, 비교집단(n=10)은 일상생활을 유지하도록 하였다. 8주 운동 전후의 차이를 분석한 결과 어깨관절의 굴곡(p=.001), 외전(p=.001), 외회전(p=.045) 및 사이토카인인 IL-6(p=.000) IL-10(p=.001)의 경우 등장성 운동을 실시하였을 때 더 긍정적인 효과가 있었다.

• 대한의용생체공학회:의공학회지
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• 제44권4호
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• pp.284-292
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• 2023

This study attempted to observe muscle activity and muscle fatigue among isotonic exercise of Biceps Brachii and Deltoidus Medius, which correspond to upper limb muscles, using metronome. For the experiment, 13 adult men participated to evaluate biosignals (ECG, EMG). For quantitative evaluation, 1RM and MVIC test were carried out and a constant pace isotonic excise session was conducted. Five sets of exercise were performed, and each set proceeded to the failure point while the speed condition (30bpm) was assigned. As a result of the experiment, muscle activity in both muscles was significantly reduced in fifth set compared to first set. Muscle fatigue has been confirmed to occur at a significant level within the set, but there was only a significant difference in both muscles in the first and second sets between sets. This is similar to the results of previous studies that gives the same rest time(2min), but further research is needed to see if the conditions for the number of repetitions are affected. Based on the recent increase of interest in muscle strength exercise, this study was conducted to observe the results by varying the conditions of common exercise.

• Journal of Biosystems Engineering
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• 제36권4호
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• pp.285-289
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• 2011

Muscle fatigue is characterized as a progressive increase in discomfort arising from the active muscle at moderate load levels are maintained. The median frequency is the most commonly used as a parameter to describe muscle fatigue. However, the estimate of the median frequency is difficult to indicate muscle fatigue because of its high standard deviation and instability. This paper investigates the power changes of the appropriate low frequency band as a fatigue parameter in EMG during isotonic exercise. To select the appropriate band, linear regression lines are employed to calculate the slopes and the coefficient of determination. Three females and seven males volunteered to participate in surface EMG recordings placed on the biceps brachii and each recording experiment continued until their exhaustion. The results of experiment shows that the power changes of the selected low frequency band (15~45 Hz) have linear slopes and high determinant coefficients. Therefore, this fatiguing parameter using the power changes of the low frequency band is valid to measure the state of muscular fatigue.

• PNF and Movement
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• 제5권2호
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• pp.55-62
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• 2007

Purpose : The purpose of this study was to examine the effects of Rhythmic Stabilization(RS) and Combination of Isotonic(CI) of Proprioceptive Neuromuscular Facilitation on balance in patients with hemiplegia. Methods : Ten patients with hemiplegia were trained with RS and CI for six weeks. Two Standard Scale(TSS), Functional Reach Test(FRT), Time Up and Go test(TUG) and Berg Balance Scale(BBS) were used to prove their improvement of balance. Results : Body weight bearing decreased on less affected side and increased on more affected side. Distance of forward reaching for FRT increased. Time for TUG decreased. BBS score increased. They all showed significant difference. Conclusion : This study suggests that balance training with RS and CI of Proprioceptive Neuromuscular Facilitation improved balance in patients with hemiplegia.

• PNF and Movement
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• 제2권1호
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• pp.25-33
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• 2004

Purpose : The purpose of this article is to summarize the characteristics of isotonic combination. Method : Some studies of the motor unit activation patterns during isometric, concentric, and eccentric actions, neural strategies in the control of muscle force, and concentric versus combined concentric-eccentric training were reviewed. Results & Conclusions : Eccentric torque may be relatively higher than concentric torque for two potential reasons: 1) stretch responses in the antagonist are not elicited to restrain the motion as can occur concentrically and 2) stretch responses in the agonist may augment eccentric torque production. Concentric-eccentric training has a greater influence on functional capacity than that of concentric training. Both maximal force and average force throughout the motion were significantly higher when the dynamic action was started with preactivation as compared to the mode without preactivation. The peak torques observed during the concentric phase of the eccentric-concentric muscle actions were higher than those noted in the pure concentric contraction.

• Journal of the Korean Statistical Society
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• 제21권2호
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• pp.201-207
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• 1992

The algorithm for obtaining the isotonic regression in simple tree order, the most basic and simplest model next to the simple order, is considered. We propose to call it "Pool-the-Maximum-Violators" algorithm (PMVA) in conjunction with the "Pool-Adjacent-Violators" algorithm (PAVA) in the simple order. The dual problem of obtaining the isotonic regression in simple tree order is our main concern. An intuitively appealing relation between the primal and the dual problems is demonstrated. The interesting difference is that in simple order the required number of pooling is at least the number of initial violating pairs and any path leads to the solution, whereas in the simple tree order it is at most the number of initial violators and there is only one advisable path although there may be some others leading to the same solution.o the same solution.

• 응용통계연구
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• 제9권1호
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• pp.153-164
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• 1996

분포함수의 모수가 순서제약조건을 갖는 경우에 깁스샘플러(Gibbs sampler)를 이용한 모수 추정에 관해 논의하였다. 순서화 모수를 갖는 지수분포족 및 이항분포모형을 고려하고 완전조건부 분포를 유도하였으며 순서제약 조건을 만족하는 표본추출을 위해 일 대 일 대응 추출 알고리즘을 적용하였다. 동위회귀 최우추정량 및 동위베이지안 추정량과 그 결과를 비교하였다.

• 한국전문물리치료학회지
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• 제10권1호
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• pp.109-128
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• 2003

This study tested whether repeated measurement of median frequency (MDF)-related variables could express the muscle power changes during a 12-week DeLome strengthening program, by using consecutive overlapping FFT (Fast Fourier transformation) and integrated EMG (IEMG) from surface EMG data for isometric and isotonic exercise. To evaluate the effect of training, the following were recorded every 3 weeks for the elbow flexors and knee extensors of 5 healthy male volunteers: MVC, lRM, limb circumference, and surface EMG during isometric MVC or isotonic contraction at 10RM load. From the EMG data, IEMG and variables from a regression analysis between MDF and time were obtained. MVC, lRM, IEMG, and initial MDF increased linearly over the training period. The fatigue index and slope of the regression line increased temporarily until the 6th week and decreased thereafter. From these results, there appeared to be enhanced neural recruitment of fast twitch fibers in the first 6 weeks and continued enhancement in the recruitment and hypertrophy of fast twitch fibers, which led to increased fatigue resistance, over the last 6 weeks. Accordingly, the MDF and IEMG analysis technique could demonstrate the effect of the program detected significant changes in both isometric and isotonic contractions. EMG analysis methods can be used to estimate the electrophysiological and histological changes in skeletal muscles during a strengthening program.