• 약학회지
• /
• 제41권4호
• /
• pp.433-438
• /
• 1997

MT 51005 as a potent inhibitor of phospholipase C(PLC) was purified from the culture broth of a fungal strain No. 51005 isolated from soil. It was identified as a benzaldehyde d erivative, anguillosporal. by the physico-chemical properties and spectroscopic data. Anguillosporal showed the inhibitory activity against purified PLC with an $IC_{50}\;of\;13{\mu}g/ml$. And it also inhibited the formation of inositol phosphates($IP_t$) in platelet-derived growth factor(PDGF)-stimulated $NIH3T3{\gamma}1$ cells with an $IC_{50}\;of\;0.8{\mu}g/ml$.

• 한국지반공학회논문집
• /
• 제16권1호
• /
• pp.211-220
• /
• 2000

과압밀 점토층에 설치된 4개의 직경 305 mm 현장타설 말뚝(1개의 일반 현장타설 말뚝과 불포화 점토층에서 발생하는 주면 마찰력을 경감시키기 위해 분리형 튜브를 사용한 3개의 분리형 현장타설 말뚝)의 거동을 분석 비교하기 위한 실험적 연구를 수행하였다. 흡수력 측정을 하기 위해 말뚝 주변에 지반흡수력 측정 장치를 설치하였고 지표면 표고 변화도 측정하였다. 지표면 표고는 최고 40 mm까지 팽창하였고, 일반 말뚝은 5 mm, 분리형 말뚝은 1.5 mm 미만의 말뚝 두부 수직인발변위가 관측되었다. 분리형 말뚝에서 관측된 주면마찰력은 일반형 말뚝에 비해 미소하여 분리형 튜브를 사용한 분리형 현장타설 말뚝이 주위 지반의 팽창 수축에 의해 말뚝에 발생하는 주면 마찰력을 경감시키는데 매우 효과적이었다.

• 기본간호학회지
• /
• 제25권1호
• /
• pp.46-57
• /
• 2018

Purpose: The purposes of the study were to examine the knowledge and practice about Middle East Respiratory Syndrome (MERS) isolation precaution, and to explore influencing factors of the isolation practice among hospital nurses. Methods: A total of 182 nurses were recruited from four general hospitals where MERS patients had been treated. The knowledge and practice of MERS isolation precaution were measured by the scales developed based on the CDC guidelines. The collected data were analyzed by SPSS/WIN 22 with descriptive statistics, T-test, One-way ANOVA, Pearson correlation coefficients, and hierachical multiple regression analysis. Results: The nurses were 30 years old in average, and half of them had less than 5 years of clinical experience. and knowledge on droplet precautions (${\beta}=.171$, p=.019) were the significant predictors, explaining 19.6% of variance in the MERS isolation guideline practice. Clinical experience (${\beta}=.225$, p=.002), working at infection unit (${\beta}=-.203$, p=.011). Conclusion: The knowledge on droplet precaution and general knowledge on MERS were the important modifiable factor to improve the MERS isolation guideline practice among hospital nurses, even after adjusting clinical experience and demographic variables. It is necessary to develop an efficient education program on specific guidelines for prevention and management of infection by improving the knowledge on infectious disease such as MERS as well as droplet precaution which are modifiable factors.

• Nuclear Engineering and Technology
• /
• 제53권3호
• /
• pp.967-973
• /
• 2021

In 2011, an earthquake and subsequent tsunami hit the Fukushima Daiichi Nuclear Power Plant, causing simultaneous accidents in several reactors. This accident shows us that if there are several reactors on site, the seismic risk to multiple units is important to consider, in addition to that to single units in isolation. When a seismic event occurs, a seismic-failure correlation exists between the nuclear power plant's structures, systems, and components (SSCs) due to their seismic-response and seismic-capacity correlations. Therefore, it is necessary to evaluate the multi-unit seismic risk by considering the SSCs' seismic-failure-correlation effect. In this study, a methodology is proposed to obtain the seismic-response-correlation coefficient between SSCs to calculate the risk to multi-unit facilities. This coefficient is calculated from a probabilistic multi-unit seismic-response analysis. The seismic-response and seismic-failure-correlation coefficients of the emergency diesel generators installed within the units are successfully derived via the proposed method. In addition, the distribution of the seismic-response-correlation coefficient was observed as a function of the distance between SSCs of various dynamic characteristics. It is demonstrated that the proposed methodology can reasonably derive the seismic-response-correlation coefficient between SSCs, which is the input data for multi-unit seismic probabilistic safety assessment.

• 기본간호학회지
• /
• 제13권3호
• /
• pp.428-436
• /
• 2006

Purpose: To investigate the levels of uncertainty and anxiety at admission and discharge to the isolation unit for patients undergoing hematopoietic stem cell transplantation (HSCT). Method: The data were collected from 60 patients who were admitted to the department of HSCT. Uncertainty and anxiety were assessed using the Mishel Uncertainty in Illness Scale (MUIS) and Anxiety Inventory (STAI). Collected data were analyzed using the SAS program. Results: The mean score for anxiety at admission was 2.20, and at discharge 2.10. The mean score for uncertainty at admission was 2.19, and at discharge 2.07. The anxiety at admission the group with physical discomfort was higher than that of group without physical discomfort. A positive relationship was found between anxiety and uncertainty at admission and at discharge. The major variables were expectation for cure and physical discomfort, explaining 25.87% of the anxiety at admission. The major variable was expectation for cure, explaining 20.94% of the uncertainty at admission. Conclusion: Front the above results, it can be concluded that support and consideration are required to reduce anxiety of the inpatient in single room.

• 한국지진공학회논문집
• /
• 제11권3호
• /
• pp.63-72
• /
• 2007

비상디젤발전기는 원전의 안전성에 큰 영향을 미치는 매우 중요한 기기이다. 본 연구에서는 세 종류의 비상디젤발전기를 대상으로 가동중 진동을 계측하여 기초시스템에 따른 가동중 진동의 저감효과를 비교하였다. 대상 원전은 영광 5호기, 울진 2호기 및 울진 3호기 원전의 비상디젤발전기로 하였다. 영광 5호기와 울진 3호기의 비상디젤발전기는 동일한 종류의 비상디젤발전기로서 기초형식만 앵커볼트 고정과 스프링-댐퍼시스템을 이용한 면진으로 구분된다. 울진 2호기 비상디젤발전기는 기초부분에 seismic block을 설치하고 코일스프링을 이용하여 진동저감효과를 고려하였으므로 좋은 비교가 될 것이다. 이러한 진동계측의 목적은 기초형태에 따른 진동저감 효과를 비교해 보기 위함이다. 결과적으로 스프링-댐퍼 시스템이 진동저감과 시스템의 안정적 거동측면에서 좋은 효과를 보이고 있음을 알 수 있었다.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
• /
• 제10권5호
• /
• pp.123-136
• /
• 2021

RPC(Remote Procedure Call) 기반 GPU(Graphics Processing Unit) 가상화 기술은 다수의 사용자 가상머신에게 GPU를 공유하기 위한 기술 중 하나이다. 하지만 클라우드 환경에서 일반적인 GPU는 CPU나 메모리와는 다르게 가상머신의 자원 사용량을 제한할 수 있는 자원 격리(Isolation) 기술을 제공하지 않는다. 특히 RPC 기반 가상화 환경에서는 각 가상머신에서 실행되는 GPU 작업은 멀티 프로세스 형태로 수행되기 때문에 자원격리 기술의 부재는 자원 경쟁으로 인한 성능 저하 문제를 발생시킨다. 그리고 GPU 메모리 경쟁은 가상머신들의 자원 요구량이 많을수록 성능저하를 가속화하고 가상머신 사이의 균등한 성능을 보장하지 못하기 때문에 공평성이 저하되는 문제를 발생시킨다. 본 논문에서는 RPC 기반 GPU 가상화 환경에서 사용자 가상머신들의 GPU 메모리 요구량이 가용 GPU 메모리 용량을 초과했을 때 발생하는 자원 경쟁으로 인한 성능 저하 문제 분석하고 이를 해결하기 위한 GPU 메모리 관리 기법을 제안한다. 또한, 실험을 통해 본 논문에서 제안한 GPU 메모리 관리 기법이 GPGPU 작업의 성능을 향상시킬 수 있다는 것을 보여준다.

• Journal of Animal Science and Technology
• /
• 제51권5호
• /
• pp.427-432
• /
• 2009

본 연구에서는 xylanase, mannanase를 생산하는 미생물균주를 분리하기 위해 1차로 토양 및 낙엽 등에서 곰팡이 균주를 약 50여주 분리하였으며, 1차 선발된 균주로부터 xylanase, mannanase를 생산하는 미생물 분리를 위해 xylanase 생성균주 선별배지, mannanase 생성균주 선별배지에 single colony를 접종한 후 clear zone이 생기는 15종의 균주를 2차 선발하였다. 2차 선발된 균주를 개별적으로 배양하여, DNS 방법을 활용하여 xylanase, mannanase 효소활성을 측정하여 6종의 균주를 선발하였다. 선별된 균주는 액상배양에서 생산한 xylanase, mannanase 효소활성이 각각 0.9~1.6 unit/mL, 0.2~0.4 unit/mL 범위로 나타났다. 이 중 결과가 좋은 3종을 선정하여 고상배양으로 배양한 균주의 xylanase, mannanase 효소활성은 각각 103.7~220.0 unit/g, 20.1~40.3 unit/g으로 분석되었다. 선별된 3종의 균주중 xylanase, mannanase 효소활성이 각각 197.3 unit/g, 39.9 unit/g으로 가장 높은 E-3 균주를 최종적으로 선발하였다. 최종으로 분리한 E-3 균주는 형태학적 특징과 DNA 염기서열을 비교한 결과 Aspergillus niger와 99% 일치하였다.

• Journal of Preventive Medicine and Public Health
• /
• 제43권2호
• /
• pp.99-104
• /
• 2010

The World Health Organization (WHO) announced the emergence of a novel influenza on April 24, 2009, and they declared pandemic on June 11. In Korea, the proportion of influenza-like illness and the consumption of antiviral agents peaked in early November. The government established the Central Headquarters for Influenza Control and operated the emergency response system. In the quarantine stations, we checked the body temperature and collected quarantine questionnaires from all the arrivals from infected countries. We also isolated the confirmed cases in the national isolation hospitals. However, as the community outbreaks were reported, we changed strategy from containment to mitigation. We changed the antiviral agent prescription guideline so that doctors could prescribe antiviral agents to all patients with acute febrile respiratory illness, without a laboratory diagnosis. Also the 470 designated hospitals were activated to enhance the efficacy of treatment. We vaccinated about 12 million people and manage the adverse event following the immunization management system. In 2010, we will establish additional national isolation wards and support hospitals to establish fever clinics and isolation intensive care unit (ICU) beds. We will also make a computer program for managing the national isolation hospitals and designated hospitals. We will establish isolation rooms and expand the laboratory in quarantine stations and we will construct a bio-safety level 3 laboratory in each province. In addition, we plan to construct a bio-safety level 4 laboratory at a new Korea Centers for Disease Control and Prevention (KCDC) facilities in Ossong.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
• /
• 제29권4호
• /
• pp.69-77
• /
• 2023

Purpose: During the COVID-19 pandemic, there have been many cases of converting regular hospital wards into temporary negative pressure isolation wards. The purpose of this study is to evaluate the minimum airflow differences that satisfies the pressure difference criteria(-2.5 Pa) according to airtightness of switching type wards, in preparation for utilization of aging regular wards as negative pressure isolation wards. Methods: Visual inspection and field measurements were conducted using blower door to evaluate airtightness of 5 hospital wards. CONTAM simulation was used to assess the airflow differences when pressure difference between the corridor and wards met the criteria at various levels of airtightness. Results: The ACH₅₀ of evaluated wards ranged from 19.3 to 50.1 h^-1 with an average of 37.0 h^-1, indicating more than four times leakier than other building types. The minimum airflow differences increased as the airtightness of the wards decreased and the size of the wards increased. Implications: When operating rapidly converted negative pressure isolation wards, understanding airtightness is crucial for determining the minimum airflow differences to maintain the pressure differences. The analysis of this study suggests that improving the airtightness of aging rooms is essential and the minimum airflow differences should be suggested considering both the airtightness and size of rooms.