• 한국식품영양과학회지
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• 제33권1호
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• pp.22-27
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• 2004

인진쑥의 방사선에 의한 산화적 손상에 대한 DNA 방어효과를 확인하기 위하여 마우스 림프구에서 단세포전기영동법과 CHO 세포에서 미소핵 형성 시험 그리고 마우스의 간과 흉선 조직의 DNA에서 8-OHdG의 형성정도를 관찰하였다. 그 결과 단세포전기영동법 및 미소핵 형성 시험에서는 50 $\mu\textrm{g}$/mL의 농도에서 가장 높은 DNA 손상 억제 효과를 나타내었으며, 8-OHdG 형성 정도는 간과 흉선 모두 30 mg/kg 농도 투여군에서 높은 방어효과를 나타내었다. 이상의 결과에서 인진쑥 추출물은 DNA 상해를 효과적으로 방어하였고 특히, 기존에 알려진 방사선 방호물질에 비하여 독성이 적은 천연물이라는 관점에서 방사선 방어제로 적용이 가능할 것으로 사료된다.

• 대한소아치과학회지
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• 제33권4호
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• pp.624-632
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• 2006

기존에 사용하고 있는 할로겐 광중합기는 여러 가지 장점에도 불구하고 중합시간이 오래 걸린다는 문제 때문에 시술시간이 길어지는 단점이 있는데, 최근에 개발된 플라즈마 광중합기는 매우 짧은 시간에 중합시킬 수 있다고 제조회사는 주장하고 있다. 본 연구에서는 임상에서 흔히 상용하고 있는 복합 레진을 광중합 할 때, 할로겐 광중합으로 얻을 수 있는 플라즈마 광중합기의 적절한 중합시간을 알아보고자 한다. 2mm 두께의 레진 샘플을 만들어 광중합 하고 24 시간 후 상, 하면의 미세경도를 측정하였다. point $4^{(R)}$에서는 플라즈마 광중합기로 6초간 중합했을 때 할로겐과 유사한 경도를 얻었지만, $Z250^{(R)}$에서는 $Flipo^{(R)}$만 9초간 중합시 할로겐과 유사한 광중합을 나타냈다. 이번 연구에서 사용한 플라즈마 광중합기는 적어도 6초 혹은 9초정도 광중합 했을 때 할로겐과 유사한 중합을 얻을 수 있다는 것을 알 수 있었다.

• 대한간호학회지
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• 제30권2호
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• pp.514-526
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• 2000

The active treatment phase in preparation for bone marrow transplantation(BMT) of che- motherapy regimen and total body irradiation (TBI) containing regimen requires considerable teaching. There have been researches that are related to treatment onto BMT patients and to psychological change during BMT process. However, it was hard to find researches focused on learning needs of patients undergoing BMT. The purpose of this study was to provide the basic data for effective educational program about BMT by investigating the learning needs in patients undergoing BMT. The subjects consisted of 90 BMT patients have been admitted to the department of BMT at three university hospitals. Data were obtained from October 1998 to March 1999 and analyzed by SAS program for unpaired t-test, ANOVA, Duncan test. The results were as follows : 1. Learning needs related to demographic characteristics was identified as below. That of male was higher than that of female. That of under age 29, unmarried, religious and university graduated group was higher than that of opposite group but it didn't show significant difference. Learning needs of group of patients who were employed was significantly higher then that of unemployed patients. 2. According to types of diagnosis, learning needs of myelodysplastic syndrome(MDS) patients was the higher than that of others, but admission frequency was the least. Learning needs of unrelated matched BMT(UBMT) patients was higher than that of autologous BMT patients. However, it didn't show significant difference. With regard to learning needs according to process of BMT, learning needs of Pre- BMT period or Post-BMT period was significantly higher than that of BMT day. 3. Learning needs related to BMT was relatively high (total mean: 3.11 of 4.0). The order of the mean score of leaning needs was shown as follows : Restricted activities after discharge, Relapse symptom, Complications of BMT, Kinds of available drugs at home. Therefore the learning needs that is related to life after discharge and to relapse and complications after BMT was high. 4. Learning needs related to radiation therapy was high (total mean: 3.35 of 4.0). The learning needs in radiation therapy items was the Skin care of radiation therapy and Purpose of radiation therapy. 5. Learning needs related to graft versus host disease(GVHD) therapy was high (total mean: 3.55 of 4.0). The highest learning needs in GVHD therapy items was the Preventive method GVHD. less admission frequency and UBMT patients. It is necessary that education for BMT patients should be focused on life after discharge and on relapse and complications after BMT. Especially education for allogeneic BMT patients should be emphasized on GVHD. For all of these, it is necessary to develop systematic and concrete educational program.

• 한국작물학회지
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• 제41권3호
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• pp.348-353
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• 1996

1. 돌연변이처리후 실내에서 처리된 종자의 발아율, 제 1 엽 및 뿌리의 생장율을 보면 gamma ray나 화학제 처리된 Dema M$_1$, 유묘의 경우 생존율이 l~49%정도 감소하였고 Grosso의 경우는 그 감소의 폭이 Dema보다 적어 두 품종간의 돌연변이제에 대한반응의 차가 컸으며 같은 처리농도의 화학돌연변이제를 처리할 경우 두번에 나누어 중간의 휴지기를 두고 처리하는 것이 한 번에 처리하는 것보다 식물체의 생장 저해정도가 덜하였다. 2. 포장 M$_1$식물체의 간장의 감소율을 보면 화학약제의 경우 8.5~38.5%의 범위로 간장이 줄어들었으며 특히 1.5 mM의 MNH 처리시는 두 품종 모두 파종된 식물체가 고사하였고 0.75~l.0mM의 MNH처리시 15~38%심하였다. 그러나 이중처리할 때는 1.0~l.5mM이상의 고농도로 처리하여도 간장의 생장 감소율은 단일처리보다 상대적으로 덜 하였으며 이는 두 품종 모두 비슷한 경향이었다. 3. Dema에서는 gamma ray 180Gy처리시 간장의 감소가 28% 정도로 가장 심하였고 Grosso에서는 150Gy에서 13%로 가장 심한 경향이었다. 4. M$_2$식물체의 엽록소 돌연변이 발생율을 보면 화학약제나 방사선 처리 모두 처리강도가 높을수록 albino, xantha등의 엽록소 돌연변이체가 많이 나타났으며 약제의 이중 처리시 엽록소 돌연변이의 출현률이 다른 처리보다 높았다.

• Journal of Electrical Engineering and Technology
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• 제13권2호
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• pp.936-942
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• 2018

The diagnostic multi-leaf collimator preventing unnecessary dose from entering into patients during the diagnostic examination was made in this study. The movement of the entire 50 leaves was embodied with the group of 25 ones thereof configured in a pair facing each other on the left and right of the median line. Dimensions of the length, width, and height of each shielding leaf were $5{\times}0.5{\times}0.5cm^3$ resulting in the maximum boost field of $10{\times}10cm^2$. The material of multi-leaf collimator had the excellence on the machinability with the use of the SKD-11 alloy tool steel having the high wear resistance against frequent movement, and it was devised to control both-side's shielding leaves by moving 2 motors unlike existing remedial multi-leaf collimator that use as many motors as the number of 50 shielding leaves. Thereafter, the transmission dose of leaves, cross-leaf leakage dose, and inter-leaf leakage dose were measured by the developed multi-leaf collimator attached to X-ray equipment. An ionization chamber was used to detect doses there from, and the comparative analysis was carried out by means of the radiographic film that was easy to detect the dose leakage in between each leaf. Results obtained from the test conducted in comparative analysis yielded approximately 98%, 96%, and 94% of shielding efficiency realized at each level of energy of 80kV, 100kV, and 120kV it was confirmed there was no dose leakage resulted from the varied level of irradiation energy. Thus the multi-leaf collimator to be developed based on this study is thought that it could fully reduce the unnecessary dose to patients in the diagnostic test and the shielding efficiency thereof is expected to be increasing if it is made in a miniaturized form with a way of increasing the thickness of each leaf later for an extended application to general diagnostic purposes.

• PNF and Movement
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• 제7권3호
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• pp.17-27
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• 2009

The purpose of this study was to investigate the effect of close kinetic chain(CKC) and open kinetic chain(OKC) posion on proprioceptive neuromuscular facilitation applied to the unilateral upper extremity on the muscle activation of lower extremity. All subjects were randomly assigned to two groups: open kinetic chain group(n=5),closed kinetic chain group(n=5). All participants were PNF patterns applied on the unilateral upper extremity in all subjects were the kinetic chain(CKC) and open kinetic chain(OKC) posion on flexion/abduction/external rotation. The hold and approximation techniques for the irradiation were applied to end range. All measurements for each subject took the following tests: pre-test, post - test in 4weeks, post-testin 8weeks. EMG data was collected from the vastus medialis, tibialis anterior, biceps femoris, and gastrocnemius muscle of both lower extreamity using surface EMG system, Each EMG value in individual muscle was normalized for maximal voluntary contraction. The data were analyzed using Two-way analysis of variance(ANOVA) with repeated measures to determine the statistical significances. The results of this study are summarized as follows. First, during for close kinetic chain(CKC) and open kinetic chain(OKC) posion on PNF pattern application, all of the %MVIC values of close kinetic chain and open kinetic chain posion increased sign ificantly compared(p<0.05). Second, The close kinetic chain(CKC) and open kinetic chain(OKC) posion on PNF pattern application was significantly increased with in the intervention period(p<.05). Third, there was a no significant open kinetic chain posion on PNF pattern application of sing muscle group with in the intervention period.(p<0.05) there was a significant close kinetic chain posion on PNF pattern application of sing muscle group with with in the intervention period(p<0.05). Forth, interaction of the exercise position and muscle was also significant. Post-hoc tests revealed that the activation levels of vastus medialis muscle and tibialis anterior muscle was higher in the closed kinetic chain position(p<.05). that the activation levels of vastus medialis and gastrocnemius muscle was higher in the open kinetic chain position(p<.05). In conclusion, it was found that the application of PNF patterns to the unilateral upper extremity effect on the muscle activation of lower extremity and both open kinetic chain exercise and closed kinetic chain exercise was significantly increased muscle activity. Further studies are needed to analyzed long term effects and subjects resulting from these changed.

• Radiation Oncology Journal
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• 제4권2호
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• pp.99-105
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• 1986

암의 방사선 치료는 단독, 혹은 수술이나 화학요법과의 병합치료를 통하여 좋은 생존율을 보여주고 있으나 정상 조직의 손상으로 인한 후유증은 아직도 해결되지 못하고 있는 문제중의 하나이다. 그러므로 정상조직의 손상에 대한 연구는 암 조직의 방사선에 대한 연구와 함께 필수적이며, 근래에 계속되고는 있으나 실제 임상에서 사용되고 있는 방법과 같은 분할조사에 대한 계통적인 연구는 매우 드물다. 이에 저자는 60마리의 백색 마우스를 사용하여 $2\times3cm$의 조사야로 고식적인 방법으로 분할 조사한 후 전 조사량에 따른 병리조직학적인 변화를 분석하고 잠혈반응 검사와의 상관관계를 규명하여, 직장에 심한 후유증이 오지 많을 수 있는 가능한 최대 내 선량을 추정하여 임상치료에 이용할 수 있는 기본 자료로 삼고자 하였으며 그 결과는 다음과 같다. 점막 및 점막하 부종은 1,000 rad군에서부터 관찰되었다. 소혈관 울혈은 2,000 rad군에서 현저하였고 염증세포의 침윤은 3,000 rad군에서 현저하였다. 점막의 탈락은 3,000 rad군에서부터 관찰되기 시작하였다. 잠혈반응은 점막탈락, 혹은 괴양의 정확한 척도로 삼기에는 부적당하였으나 총 조사량의 증가와 함께 잠혈반응의 양성도도 증가하는 추세를 보여 간접적인 지표로 삼을 수는 있으리라고 생각되었다. 소낭선세포의 분열상이 5,000 rad군에서도 관찰되는 것으로 미루어 5,000 rad의 조사에서도 재생능력이 남이 있음을 시사하였다.

• 대한핵의학회지
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• 제5권2호
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• pp.19-40
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• 1971

Since the iron balance is maintained by regulated intestinal absorption rather than regulated excretion, there have been many reports concerning the factors which may influence the intestinal iron absorption. As the liver is the largest iron storage organ of the body, any hepatocellular damage may result in disturbances in iron metabolism, e,g., frequent co-existence of hemochromatosis and liver cirrhosis, or elevated serum iron level and increased iron absorption rate in patients with infectious hepatitis or cirrhosis. In one effort to demonstrate the influence of hepatocellular damage on intestinal iron absortion, the iron absorption rate was measured in the rabbits whose livers were injured by a single subcutaneous injection of carbon tetrachloride (doses ranging from 0.15 to 0.5cc per kg of body weight) or by a single irradiation of 2,000 to 16,000 rads with $^{60}Co$ on the liver locally. A single oral dose of $1{\mu}Ci\;of\;^{59}Fe$-citrate with 0.5mg of ferrous citrate was fed in the fasting state, 24 hours after hepatic damage had been induced, without any reducing or chelating agents, and stool was collected for one week thereafter. Serum iron levels, together with conventional liver function tests, were measured at 24, 48, 72, 120 and 168 hours after liver damage had been induced. All animals were sacrificed upon the completing of the one week's test period and tissue specimens were prepared for H-E and Gomori's iron stain. Following are the results. 1. Normal iron absorption rate of the rabbit was $41.72{\pm}3.61%$ when 0.5mg of iron was given in the fasting state, as measured by subtracting the amount recovered in stool collected for 7 days from the amount given. The test period of 7 days is adequate, for only 1% of the iron given was excreted thereafter. 2. The intestinal iron absorption rate and serum iron level were significantly increased when the animal was poisoned by a single subcutaneous injection of 0.15cc. per kg. of body weight of carbon tetrachloride or more, or the liver was irradiated with a single dose of 12,000 rads or more. The results of liver function tests which were done simultaneously remained within normal limit except SGOT and SGPT which were somewhat increased. 3. In each case, there has been good correlation between the extent of liver cell damage and degree of increased iron absorption rate or serum iron level. 4. The method of liver damage appeared to make no obvious difference in the pattern of iron deposit in liver. This may be partly due to the fact that tissue specimens were obtained too late, for by this time the elevated serum iron level had returned within normal range and the pathological changes were almost healed. 5. The possible factors and relationship between intestinal iron absorption and hepatic parenchymal cell damage has been discussed.

• 방사선산업학회지
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• 제5권3호
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• pp.211-220
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• 2011

This study was carried out to develop salt tolerant varities of rapeseed (Brassica napus L.) which can be grown in the high salty reclaimed land. The seeds of three varieties 'Naehan', 'Tammi', and 'Halla' were treated by proton ion beams and gamma rays with 0 to 2,000 Gy. For the selection of salt tolerant lines, emergence and survival rate, and growth characteristics of $M_2$ to $M_4$ generations were investigated in the Saemangeum reclaimed fields with the different salt concentrations. The lines with potential salt tolerance were selected in the $M_4$ generation and tested indoor for their growth characteristics. There was no significant changes in the soil pH for $M_4$ generation during growth period. However, soil EC was higher in early spring than sowing period (mid October). In $M_4$ generation test, the seeds of original and selected line showed high rates of emergence and survival, as determined one month after sowing. After wintering, however, the original varieties showed the significant reduction in the survival rate, while the selected lines showed a higher survival rate and good growth, leading to the completion of their life cycle. Consequently we selected 9 lines from $M_4$ generation with better performance in growth and yield. Soil EC was $2.8{\sim}4.3dS{\cdot}m^{-1}$ during $M_4$ generation growth period. The laboratory test of the lines selected from $M_4$ generation was made for their salt tolerance potential. The selected lines showed higher chlorophyll and proline contents than the original varieties. There was also no significant difference in the emergence rate of seed between the original and selected varieties. In 200 mM natural sea salt, the $N{\gamma}600-21-1-641$ line derived from 'Naehan' was the highest in growth rate, leaf chlorophyll and proline contents. $T{\gamma}800-20-2-461$ line derived from 'Tammi' didn't show significant difference in growth rate compared to original variety in 200 mM and withered in 250 mM like other lines as time passed. $H{\gamma}200-7-1-740$ line showed similar growth and chlorophyll content compared to its original variety.

• 폴리머
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• 제38권1호
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• pp.69-73
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• 2014

본 연구에서는 방사선 기술을 이용하여 항염증 특성을 가지는 천연 추출물을 함유하는 고분자 하이드로젤을 제조하여 항염증 패치로서의 유용성을 확인하였다. 천연 추출물로는 오래 전부터 전통 민간요법으로 항염제나 궤양 및 종양 치료 등에 사용되고 있는 느릅나무를 사용하였고, 생체 적합성 고분자인 poly(vinyl alcohol)(PVA)와 보습률 향상을 위해 글리세린을 첨가하여 감마선 가교에 의해 다당류 함유 고분자 하이드로젤을 제조하였다. 제조된 하이드로젤은 항염증 패치로 사용하기에 우수한 기계적 물성을 나타내었고, 사이토카인 분비를 효과적으로 억제함은 물론 세포독성도 나타나지 않는 것을 확인하였다. 결론적으로 느릅나무 추출 다당류가 함유된 하이드로젤은 항염증 패치로써 유용하게 사용될 수 있음을 확인하였다.