• Macromolecular Research
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• v.16 no.2
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• pp.139-148
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• 2008

Biodegradable and elastic poly(L-lactide-co-$\varepsilon$-caprolactone) (PLCL) was electrospun to prepare nanofibers, and N-isopropylacrylamide (NIPAAm) was then grafted onto their surfaces under aqueous conditions using $^{60}Co-{\gamma}$ irradiation. The graft yield increased with increasing irradiation dose from 5 to 10 kGy and the nanofibers showed a greater graft yield compared with the firms. SEM confirmed that the PLCL nanofibers maintained an interconnected pore structure after grafting with NIPAAm. However, overdoses of irradiation led to the excessive formation of homopolymer gels on the surface of thc PLCL nanofibers. The equilibrium swelling and deswelling ratio of the PNIPAAm-g-PLCL nanofibers (prepared with 10 kGy) was the highest among the samples, which was consistent with the graft yield results. The phase-separation characteristics of PNIPAAm in aqueous conditions conferred a unique temperature-responsive swelling behavior of PNIPAAm-g-PLCL nanofibers, showing the ability to absorb a large amount of water at < $32^{\circ}C$, and abrupt collapse when the temperature was increased to $40^{\circ}C$. In accordance with the temperature-dependent changes in swelling behavior, the release rate of indomethacin and FITC-BSA loaded in PNIPAAm-g-PLCL nanofibers by a diffusion-mediated process was regulated by the change in temperature. Both model drugs demonstrated greater release rate at $40^{\circ}C$ relative to that at $25^{\circ}C$. This approach of the temperature-controlled release of drugs from PNIPAAm-g-PLCL nanofibers using gamma-ray irradiation may be used to design drugs and protein delivery carriers in various biomedical applications.

• YAKHAK HOEJI
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• v.37 no.5
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• pp.511-519
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• 1993

The short and variabke transit of drug throught GI tracj and the inter-and intra-subject variations of the transit restrict the sustained drug absorption after oral adminstration. These restrictions may be solved by retaining the dosage forms in the stomach. Then the dosage form will act as a platform which releases the drug slowly and makes the GI absorption occur for a long time. In this study, as the platforms, PVP hydrogels were synthesized by chemical and y-irradiation method in the cylindrical test tube. The chemical method means the synthesis of the hydrogel by heating the mixed solution of N-vinyl-2-pyrrolidone [monomer], acrylated albumin [crosslinking agent], 2, 2'-agobis(2-methylpropionitrile) [initiator] and proxyphylline [drug] at $65^{\circ}C$ for 5 hr. The $\gamma$-irradiation method means the synthesis of the hydrogel by irradiation with $^{60}$ Co $\gamma$-ray of the mixed solution of the monomer, acrylated albumin, and flurbiprofen [drug] at room temperature with total 0.2 Mrad for 3 hr. Our intention is to design the hydrogel tablet (diameter : 1.20 cm, thickness : 0.60 cm) which swells in the gastric fluid after oral administration to such a size that passing through the pylorus could be inhibited during the period of drug release. After releasing drug, the hydrogel should be degraded by the enzymeatic digestion in the stomach, or by hydrolysis and eventually solubilized. Thus, in votro tests were performed to examine the factors that affect swelling and drug release from the PVP hydrogels. Experimental results show that the hydrogels swell to a size larger than the diameter of the pylorus(l.3$\pm$0.7 cm) and the hydrogel prepared by the chemical method is digested by pepsin. But the hydrogel prepared by the $\gamma$-irradiation method was not digested by the pepsin and just collapsed with time. Thus, the swelling of the hydrogel synthesized by $\gamma$-irradiation was independent albumin acrylation time and pepsin concentration. But drug content and radiation dose affected the swelling and drug release kinetics of the hydrogel. Drug release from the hydrigels was prolonged up to about 24 hr. Therefore, it was concluded that by adjusting these factors, the albumin-crosslinked PVP hydrogel synthesized by $\gamma$-irradiation method is expected to be retained in the stomach for up to 60hr and be a potential platform of drugs for long-term GI absorption.

• Nuclear Engineering and Technology
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• v.52 no.7
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• pp.1503-1510
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• 2020

Ultra-low noise charge sensitive amplifiers (CSAs) based on various types of circuit board substrates, such as FR4, Teflon, and ceramics (Al₂O₃) with two different designs, PA1 and PA2, have been developed. They were tested to see the noise effect from the dielectric loss of the substrate capacitance before and after irradiation. If the electronic noise from the CSAs is to be minimized and the energy resolution enhanced, the shaping time has to be optimized for the detector, and a small feedback capacitance of the CSA is favorable for a better SNR. Teflon- and ceramic-based PA1 design CSAs showed better noise performance than the FR4-based one, but the Teflon-based PA1 design showed better sensitivity than ceramic based one at a low detector capacitance (<10 pF). In the PA2 design, the equivalent noise and the sensitivity were 0.52 keV FWHM for a silicon detector and 7.2 mV/fC, respectively, with 2 ㎲ peaking time and 0.1 pF detector capacitance. After 10, 100, 10³, 10⁴, and 10⁵ Gy irradiation the ENC and sensitivity characteristics of the developed CSAs based on three different substrate materials are also discussed.

• Applied Chemistry for Engineering
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• v.29 no.5
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• pp.503-509
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• 2018

In this study, we used the ultrasonic extraction process as a method to extract antioxidant substances from kudzu, and measured the content of iso-flavonoids puerarin, daidzein, daidzin contained in kudzu. The response surface methodology which is a statistical analysis method for optimizing the extraction amount of iso-flavonoids from the kudzu and the process condition for maximizing the yield was applied. It is the final objective of this study to effectively derive the condition of the process that matches the target response with a minimum number of experiments and analyze the effect of each process condition on the response. In the response surface methodology, the central composite design was applied and the optimum condition was analyzed, and the three independent variables were set to ultrasonic irradiation time, volume ratio of ethanol/ultrapure water, ultrasonic irradiation power. Using the response surface methodology, the optimum conditions with the maximum extraction yield and the content of iso-flavonoids were evaluated as ultrasonic irradiation time (24.75 min), ethanol / ultrapure water volume ratio (39.75 vol%), ultrasonic irradiation power (592.36 W). The overall satisfaction level appears as high as 0.8938, which is recognized at a significance level within 5%. As a result of analyzing the optimization process, it was confirmed that the ultrasonic irradiation time is the factor that most affects the responses.

• Journal of Soil and Groundwater Environment
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• v.25 no.3
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• pp.23-31
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• 2020

The performance of a downward-irradiation sonoreactor was investigated using calorimetry, KI dosimetry, luminol (Sonochemiluminescence, SCL) method, and aluminium foil erosion method as one of the basic steps for the optimal design of downward-irradiation sonoreactors. The applied frequency was 28 kHz and the input electrical power was 280 - 300 W. The liquid height, from the reactor bottom to the transducer module surface, ranged from 1λ (53.6 mm) to 2λ (107.1 mm). For various liquid heights, the magnitude of calorimetric power and the mass of cavitation-generated I₃^- ion varied significantly. It was found that the additional application of mechanical mixing resulted in higher sonochemical activity, especially in the cavitational active zone, which was induced by violent liquid flow in the reactor. In aluminium foil erosion tests, it was found that less ultrasound energy reached the bottom of the reactor due to the violent liquid flow and no significant sonophysical effect was observed for higher mixing rate conditions (100 and 200 rpm).

• Environmental Engineering Research
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• v.16 no.4
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• pp.243-252
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• 2011

Several mathematical relationships have been developed to describe bacterial responses to UV irradiation. Pseudomonas aeruginosa was taken as a bacterial model. The results obtained showed that the kinetics of disinfection is far to be as uniform. In fact, application of the model of Chick-Watson in its original form or modification, taking into account the speed change during the disinfection process, has not significantly improved results. The application of both models of Collins-Selleck and Hom constitute a major opportunity to simulate goodly the kinetics of UV disinfection. The results obtained showed that despite the major advantage held by applying the Hom model in this process of disinfection and for all strains studied, the model of Collins-Selleck gave the best results for the description of the UV inactivation process. The design of reactors, operating in continuous disinfection system, requires taking into account the hydrodynamic behaviour of water in the reactor. Knowing that a reduction of 4-log is necessary in the case of wastewater reuse for irrigation, a model integrating the expression of disinfection kinetics and the hydrodynamics through the UV irradiation room was proposed. The results highlight the interest to develop reactors in series working as four perfectly mixed reactors.

• The KSFM Journal of Fluid Machinery
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• v.12 no.5
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• pp.7-12
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• 2009

A nuclear fuel test loop(after below, FTL) is installed in the IRI of an irradiation hole in HANARO for testing the neutron irradiation characteristics and thermo hydraulic characteristics of a fuel loaded in a light water power reactor or a heavy water power reactor. There is an in-pile section(IPS) and an out-pile section(OPS) in this test loop. When HANARO is operated normally, the fuel loaded into the IPS has a nuclear reaction heat generated by a neutron irradiation. To remove the generated heat and to maintain the operation conditions of the test fuel, a main cooling water system(MCWS) is installed in the OPS of the FTL. The MCWS is composed of a main cooler, a pressurizer, two circulation pumps, a main heater, an interconnection pipe line and instruments. The interconnection pipeline is a closed loop which is connected to an inlet and an outlet of the IPS respectively. The MCWS is under a cold function test during a start-up period. This paper describes the system flow network analysis results of the flow control of a main cooling water system in the HANARO fuel test loop. It was confirmed through the results that the flow was met the system design requirements.

• Proceedings of the Korean Nuclear Society Conference
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• 2002.05a
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• pp.242-242
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• 2002

Two MIMAS MaX fuel rods base-irradiated in a commercial PWR have been reinstrumented and irradiated at a test reactor. The fabrication data for two MOX roda are characterized together with base irradiation information. Both Rods were reinstrumented to be fitted with thermocouple to measure centerline temperature of fuel. One rod was equipped with pressure transducer for rod internal pressure whereas the other with cladding elongation detector. The post irradiation examinations for various items were performed to determine fuel and cladding in-pile behavior after base irradiation. By using well characterized fabrication and re-instrumentation data and power history, the fuel performance code, COSMOS, is verified with measured in-pile and PIE information. The COMaS code shows good agreement for the cladding oxidation and creep, and fission gas release when compared with PIE dad a after base irradiaton. Based on the re-instrumention information and power history measured in-pile, the COSMOS predicts re-instrumented in-pile thermal behaviour during power up-ramp and steady operation with acceptable accuracy. The rod internal pressure is also well simulated by COSMOS code. Therfore, with all the other verification by COSMOS code up to now, it can be concluded that COSMOS fuel performance code is applicable for the design and license for MaX fuel rods up to high burnup.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.444-449
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• 2004

The design modification of bottom guide structures of the instrumented capsule, which is used for the irradiation test in the HANARO reactor, was required because of the trouble of the bottom guide arm's pin during irradiation. The previous structure with 3-pin arms was changed into the cone shape of one body. The specimens of the bottom end cap ring with three different sizes (${\Phi}68/70/72mm$) were designed and manufactured. The out-pile tests for the capsule with previous and new three bottom guide structures were performed in the one-channel flow test facilities. In order to evaluate the compatibility with HANARO and the structural integrity of the capsule, a loading/unloading, a pressure drop, a thermal performance, a vibration, and an endurance test were conducted. From out-pile test results, the capsule with the cone shape bottom guide structures was found to be more stable than the previous structure and the optimized size of the bottom guide structure selected was 70mm in diameter. It is expected that the new bottom guide structures will be applicable to all material and special capsules which will be designed and manufactured for the irradiation tests in the future.

• Nuclear Engineering and Technology
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• v.55 no.6
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• pp.2195-2205
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• 2023

One of the salient nuclear fuel performance parameters for new fuel types under development is changes in fuel thickness. To test the new commercially fabricated U-10Mo monolithic plate-type fuel, an irradiation experiment was designed that consisted of multiple mini-plate capsules distributed within the Advanced Test Reactor (ATR) core, the mini-plate 1 (MP-1) experiment. Each capsule contains eight mini-plates that were either fueled or "dummy" plates. Fuel thickness changes within a fuel assembly can be characterized by measuring the gaps between the plates ultrasonically. The channel gap probe (CGP) system is designed to measure the gaps between the plates and will provide information that supports qualification of U-10Mo monolithic fuel. This study will discuss the design and the results from the use of a custom-designed CGP system for characterizing the gaps between mini-plates within the MP-1 capsules. To ensure accurate and repeatable data, acceptance and calibration procedures have been developed. Unfortunately, there is no "gold" standard measurement to compare to CGP measurements. An effort was made to use plate thickness obtained from post-irradiation measurements to derive channel gap estimates for comparison with the CGP characterization.