• 제목/요약/키워드: Iron Nanoparticles

검색결과 197건 처리시간 0.027초

The Effects of Nanoparticles for Irradiation (방사선조사에서 나노 입자 혼합물의 영향)

  • Yea, Ji-Woon;Shin, Hyun-Jin
    • Journal of Yeungnam Medical Science
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    • 제28권2호
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    • pp.145-152
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    • 2011
  • Background: To evaluate the changes in the radiation dose and temperature distribution on irradiated egg albumin and nanoparticle ($Fe_3O_4$) powder mixed egg albumin. Methods: A new type of phantom was designed by fabricating a $30{\times}30{\times}30cm$ acryl square inside a $3{\times}3{\times}3cm$ small square and dividing it into two parts. In the control group, only egg albumin was irradiated, and in the test group, 25 nm 20 mg/cc, 25 nm 40 mg/cc, and 1 um 40mg/cc nanoparticles with egg albumin were irradiated. The radiation isodose distributions and temperature changes were then observed. Results: No significant changes were observed in the radiation dose and temperature distribution. Conclusion: The nanoparticles were considered not to have had any effect on the radiation dose and temperature distribution under the experimental conditions. Further studies can be conducted based on the changes in the mixture material.

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High Throughput Magnetic Separation for Human DNA by Aminosilanized Iron Oxide Nanoparticles (아미노실란화 철산화물 나노입자를 이용한 Human DNA의 초고속 자성분리)

  • Kang, Ki-Ho;Chang, Jeong-Ho
    • Journal of the Korean Ceramic Society
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    • 제45권10호
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    • pp.605-609
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    • 2008
  • This work describes the preparation of functionalized magnetic nanoparticles(MNPs) and their bioapplication to human DNA separation. Silica coated MNPs were prepared by changing the volume ratio of tetraethyl orthosilicate(TEOS) for controlled coating thickness on the original nanoparticle of MNPs. The sol-gel process in silica coating on MNPs surface was adapted for relatively mild reaction condition, low-cost, and surfactant-free. And then amino functionalized magnetic nanoparticles were synthesized using amine groups as surface modifiers. The result of adsorption efficiency for human DNA with amino-functionalized silica coated MNPs was calculated as a function of the number of amine groups.

Fluorescently Labeled Nanoparticles Enable the Detection of Stem Cell-Derived Hepatocytes

  • Ha, Young-Eun;Shin, Jin-Sup;Lee, Dong-Yun;Rhim, Tai-Youn
    • Bulletin of the Korean Chemical Society
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    • 제33권6호
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    • pp.1983-1988
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    • 2012
  • Stem cell transplantation is emerging as a possible new treatment for liver cirrhosis, and recent animal studies have documented the benefits of stem cell therapy in a hepatic fibrosis model. However, the underlying mechanism of stem cell therapy is still unclear. Among the proposed mechanisms, the cell replacement mechanism is the oldest and most important, in which permanently damaged tissue can be replaced by normal tissue to restore function. In the present study, Cy5.5-labeled superparamagnetic iron oxide (SPIO) was used to label human mesenchymal stem cells. The uptake of fluorescently labeled nanoparticles enabled the detection and monitoring of the transplanted stem cells; therefore, we confirmed the direct incorporation and differentiation of SPIO into the hepatocyte-like transplanted stem cells by detecting human tyrosine aminotransferase (TAT), well-known enzymatic marker for hepatocyte-specific differentiation.