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Impact of Insulin Resistance on Acetylcholine-Induced Coronary Artery Spasm in Non-Diabetic Patients

  • Kang, Kwan Woo;Choi, Byoung Geol;Rha, Seung-Woon
    • Yonsei Medical Journal
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    • v.59 no.9
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    • pp.1057-1063
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    • 2018
  • Purpose: Coronary artery spasm (CAS) and diabetes mellitus (DM) are implicated in endothelial dysfunction, and insulin resistance (IR) is a major etiological cause of type 2 DM. However, the association between CAS and IR in non-diabetic individuals has not been elucidated. The aim of the present study was to evaluate the impact of IR on CAS in patients without DM. Materials and Methods: A total of 330 eligible patients without DM and coronary artery disease who underwent acetylcholine (Ach) provocation test were enrolled in this study. Inclusion criteria included both hemoglobin A1c <6.0% and fasting glucose level <110 mg/dL without type 2 DM. Patients were divided into quartile groups according the level of homeostasis model assessment of insulin resistance (HOMA-IR): 1Q (n=82; HOMA-IR<1.35), 2Q (n=82; $1.35{\leq}HOMA-IR<1.93$), 3Q (n=83; $1.93{\leq}HOMA-IR<2.73$), and 4Q (n=83; $HOMA-IR{\geq}2.73$). Results: In the present study, the higher HOMA-IR group (3Q and 4Q) was older and had higher body mass index, fasting blood glucose, serum insulin, hemoglobin A1c, total cholesterol, and triglyceride levels than the lower HOMA-IR group (1Q). Also, poor IR (3Q and 4Q) was considerably associated with frequent CAS. Compared with Q1, the hazard ratios for Q3 and Q4 were 3.55 (95% CI: 1.79-7.03, p<0.001) and 2.12 (95% CI: 1.07-4.21, p=0.031), respectively, after adjustment of baseline risk confounders. Also, diffuse spasm and accompanying chest pain during Ach test were more strongly associated with IR patients with CAS. Conclusion: HOMA-IR was significantly negatively correlated with reference diameter measured after nitroglycerin and significantly positively correlated with diffuse spasm and chest pain.

Angular Dependence of Ferromagnetic Resonance Linewidth in Exchange Coupled CoFe/MnIr Bilayers (교환 결합력을 갖는 CoFe/MnIr 박막에서 강자성 공명 선폭의 각도 의존성 연구)

  • Yoon, Seok Soo;Kim, Dong Young
    • Journal of the Korean Magnetics Society
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    • v.26 no.2
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    • pp.50-54
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    • 2016
  • We analyzed the angular dependence of ferromagnetic resonance linewidth in exchange coupled CoFe/MnIr bilayers. The maximum and minimum linewidth was observed in the easy and hard direction of unidirectional anisotropy by exchange coupling, respectively, and it was well agreed with the angular dependence of exchange bias field. The maximum linewidth was due to the twist of CoFe magnetization near CoFe/MnIr interface from direction of pinned MnIr spin to direction of applied magnetic field. While, minimum linewidth more higher than that of CoFe was related to rotatable anisotropy field, and explained by easy axis distribution of MnIr grains.

Studies on the Nitrogen Effect in Red Discoloration of Rice IR 667 (수도 IR 667의 적고현상에 미치는 질소의 영향에 관한 연구)

  • 곽병화
    • Journal of Plant Biology
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    • v.14 no.4
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    • pp.5-13
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    • 1971
  • Pot and paddy field tests were conducted to study red discoloration of rice var. IR 667 leaves with reference to the leading Korean native variety Jinhung and Paldal, with the following results: 1. Minor elements such as Mn, Fe, B, Al, Ca and Si had no influence on the discoloration, but a supply of various soluble nitrogen compounds completely restricted it. The more prosperous the growth of IR 667 with nitrogen, the more severe the discoloration appears when nitrogen absorptin becomes limited. 2. Chlorotic pigments extracted from both IR 667 and Jinhung were compared spectrophotometrically, and found to have different spectral peaks. IR 667 had peak closer to red than Jinhung, indicating the characteristic of the variety. IR 667 was observed to be more sensitive to nitrogen deficiency than Jinhung or the other japonica variety. 3. It was concluded that all the factors limiting nitrogen supply for IR 667 growth, such as low nitrogen application, restriction of root respiration (low temperature, poor drainage, toxic gases or substances in the root zone, etc.) and pest injuries, would result in the appearance of the so-called red discoloration, because of the reduction in nitrogen uptake. Since, the discoloration of IR 667 is varietal characteristic when grown in Korea, control of it may be beneficial cultural practice in increasing grain yield, although the increased succeptibility to pests and a drop in the rate of maturity due to relatively high nitrogen level in the leaves may result in an unexpected drop in yield. It is anticipated that further exploration conducted from practical point of view will establish the relatioknships between the extent of red discoloration, nitrogen availability and grain yield in IR 667.

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$^{192}$Ir 선원의$\gamma$선 자기흡수효과 측정

  • 조운갑;한현수;박춘득;박울재;이철영
    • Proceedings of the Korean Nuclear Society Conference
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    • 1998.05b
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    • pp.752-756
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    • 1998
  • 산업용 및 의료용으로 사용되는 $^{192}$ Ir 방사선원에 대한 $\psi$선 자기흡수효과인자를 실험을 통하여 구하였다. 이를 위하여 3 mm $\psi$ x 3 mm t, 2.5 mm $\psi$ x 2.5 mm t, 2 mm $\psi$ x 2 mm Ir의 원주형 Ir 표적과 3 mm $\psi$ x 0.25 mm t, 3 mm $\psi$ x 0.1 mm t의 원판형 Ir 표적을 하나로의 PTS(Pneumatic Transport System)조사공에서 중성자 조사하였다. 이온전리함을 사용하여 각 Ir 표적의 방사능을 측정하고 계산에 의해서 구한 생성방사능 값과의 비를 구하는 방법으로 $^{192}$ Ir의 ${\gamma}$선 자기흡수효과인자를 구하였다. 이 값들은 원주형 표적에 대하여 각각 0.614, 0.687, 0.704 였고 원판형 표적에 대하여 각각 0.827, 0.875 였다. 원주형 Ir 표적내부의 중성자 자기흡수효과의 정도를 알아보기 위하여 2.5 mm $\psi$ x 0.25 mm t Ir 표적 10장을 포개어 중성자 방사화시킨 후 각 표적의 방사능을 측정한 결과 가장 바깥쪽 표적의 방사능이 중심부에 위치한 표적보다 약 2배정도 방사화가 많이 일어남을 알 수 있었다. 이번에 구한 ${\gamma}$선 자기흡수효과인자는 향후 산업용 및 의료용으로 사용되는 $^{192}$ Ir 방사선원의 사용자에게 제공되는 최종방사능을 평가하는데 유용하게 사용될 수 있다.

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Fabrication of Ti/Ir-Ru electrode by spin coating method for electrochemical removal of copper

  • Kim, Joohyun;Bae, Sungjun
    • Environmental Engineering Research
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    • v.24 no.4
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    • pp.646-653
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    • 2019
  • Recovery of valuable metals in the industrial wastewater and sludge has attracted an attention owing to limited metallic resources in the earth. In this study, we firstly fabricated Ti/Ir-Ru electrodes by spin coating technique for effective recovery of Cu in electrowinning process. Two different Ti/Ir-Ru electrodes were fabricated using 100 and 500 mM of precursors (i.e., Ir-Ru). SEM-EDX and AFM revealed that Ir and Ru were homogenously distributed on the surface of Ti plate by the spin coating, in particular the electrode prepared by 500 mM showed distinct boundary line between Ir-Ru layer and Ti substrate. XRD, XPS, and cyclic voltammetry also revealed that characteristics of IrO2, RuO2, and TiO2 and its electrocatalytic property increased as the concentration of coating precursor increased. Finally, we carried out Cu recovery experiments using two Ti/Ir-Ru as anodes in electrowinning process, showing that both anodes showed a complete removal of Cu (1 and 10 g/L) within 6 h reaction, but much higher kinetic rate constant was obtained by the anode prepared by 500 mM. The findings in this study can provide a fundamental knowledge for surface characteristics of Ti/Ir-Ru electrode prepared by spin coating method and its potential feasibility for effective electrowinning process.

A First-principles Study on Magnetism of $Fe_2 /Ir_4$(001) Superlattice

  • Kim, Jae Il;Lee, In Gee
    • Journal of Magnetics
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    • v.6 no.3
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    • pp.80-82
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    • 2001
  • We have investigated magnetism of $Fe_2 /Ir_4$(001) superlattice in terms of a first-principles calculation by using an all-electron full-potential linearized augmented plane-wave (FLAPW) method within the generalized gradient approximation (GGA). We considered two magnetic states, the ferromagnetic (FM) and antiferromagnetic (AFM) coupled states between the Fe layers. It was found that the FM state was energetically more stable than the AFM one by 0.166 eV. Calculated magnetic moments of the Fe layers were, in absolute values, 2.45$\mu_B$ and 2.30 $\mu_B$for the FM and AFM states, respectively. We also found that the Ir layers had very small magnetic moments less than 0.1 $\mu_B$ for both magnetic states. In all the magnetic states, the subinterface Ir layers were coupled antiferromagnetically to the interface Ir layers, while the interface Ir layers were always coupled frerromagnetically to the interface Fe layers. These results contradicted to recent experimental reports of magnetically "dead"Fe layers in Fe/Ir superlattices for which the Fe layer thickness was less than two atomic layers. We attributed that the experimentally observed "dead"Fe layers were due to possible interdiffusion between Ir and Fe layers.en Ir and Fe layers.

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GFAP IMMUNOREACTIVITY IN SATELLITE CEllS OF TRIGEMINAL GANGLION FOllOWING AXOTOMY OF INFERIOR ALVEOLAR NERVE IN RAT (흰쥐에서 하치조신경 절단에 따른 삼차신경절 위성페포에서 GFAP-IR의 변화)

  • Lee, Chang-Seop;Lee, Sang-Ho;Kim, Heung-Jung
    • Journal of the korean academy of Pediatric Dentistry
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    • v.25 no.1
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    • pp.249-256
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    • 1998
  • Glial fibrillary acidic proteins (GFAP) are a group of intermediate filaments that are distributed in the cytoplasm of glial cells. GFAP immunoreactivity (GFAP-IR) increase after central and peripheral nerve injuries. The purpose of this study was to determine change of GFAP-IR in rat trigeminal ganglion satellite cells following the axotomy of inferior alveolar nerve(IAN). The immunohistochemistry was carried out using the avidin-biotin-peroxidase complex(ABC) method. 1. Control group : Astrocytes in central root of trigeminal ganglion had strong GFAP-IR, but satellite cells of trigeminal ganglion occasionally had GFAP-IR. The patterns of reactivity in satellite cells of trigeminal ganglion were not concenturated in any specific region of trigeminal ganglion. 2. Three day group after IAN axotomy : There were highly GFAP-IR in satellite cells of trigeminal ganglion in mandibular region. GFAP-IR in maxillary and ophthalmic regions were less intense compared to mandibular region. 3. Seven day group after IAN axotomy : GFAP-IR that were increased compared to control group were seen in the mandibular region. But GFAP-IR were less intense compared to three day group. These results suggest that GFAP-IR increase in specific region of trigeminal ganglion following peripheral axotomy. therefore we suppose that GFAP study offer research tool in trigeminal neuralgia.

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Surface Properties of Re-Ir Coating Thin Film on Tungsten Carbide Surface (Tungsten Carbide 표면에 코팅된 Re-Ir 박막의 표면 특성)

  • Lee, Ho-Shik;Cheon, Min-Woo;Park, Yong-Pil
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.24 no.3
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    • pp.219-223
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    • 2011
  • Rhenium-Iridium(Re-Ir) thin films were deposited onto the tungsten carbide(WC) molding core by sputtering system. The Re-Ir films were prepared by multi-target sputtering with iridium, rhenium and chromium as the sources. Argon and nitrogen were inlet into the chamber to be the plasma and reactive gases. The Re-Ir thin films were prepared with targets having atomic percent of 3:7 and the Re-Ir thin films were formed with 240 nm thickness. The Re-Ir thin films on tungsten carbide molding core were analyzed by scanning electron microscope(SEM) and surface roughness. Also, adhesion strength and coefficient friction of Re-Ir thin film were examined. The Re-Ir coating technique has been intensive efforts in the field of coating process because the coating technique and process have been their feature, like hardness, high elasticity, abrasion resistance and mechanical stability and also have been applied widely the industrial and biomedical areas. In this report, tungsten carbide(WC) molding core was manufactures using high performance precision machining and the efforts of Re-Ir coating on the surface roughness.

MODEL DUST ENVELOPES FOR ASYMPTOTIC GIANT BRANCH STARS. I. OH/IR STARS

  • Suh, Kyung-Won
    • Journal of Astronomy and Space Sciences
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    • v.12 no.2
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    • pp.157-167
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    • 1995
  • OH/IR stars are the most massive and youngest subclass in asymptotic giant branch stars which pass through sporadic superwind phases. We have modeled the dust envelopes around OH/IR stars with close attention to the evolution of the structure of the dust shells. We use various dust density distributions to take account the effect of the superwind due to the helium shell flash by adding a density increased region. Depending on the position and quality of the density increased region, the model results are different from the results with conventional density distribution. The new results fit the observations of some OH/IR stars better. Especially, the OH/IR stars with excessive 30-100$\mu$m emission can be better explained by the new results. The IR two-color diagrams comparing the results of the superwind models and IRAS observation of 95 OH/IR stars have been made. The new results can explain much wider regions on the IR two-color diagrams.

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Growing High-Quality Ir-Sb Nanostructures by Controlled Electrochemical Deposition

  • Nisanci, Fatma Bayrakceken
    • Journal of Electrochemical Science and Technology
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    • v.11 no.2
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    • pp.165-171
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    • 2020
  • The electrochemical preparation and spectroscopic characterisation of iridium-antimony (Ir-Sb) species is important owing to their potential applications as nanostructure materials. Nanostructures, i.e. nanoflower and nanodisk, of Ir-Sb were electrodeposited on conductive substrates using a practical electrochemical method based on the simultaneous underpotential deposition (UPD) of Ir and Sb from the IrCl3 and Sb2O3 at a constant potential. Electrochemical UPD mechanism of Ir-Sb was studied using cyclic voltammetry and potential-controlled electrochemical deposition techniques. Herein, X-ray diffraction, scanning electron microscopy, energy dispersive spectroscopy, X-ray photoelectron and Raman spectroscopy were used to determine the morphological and structural properties of the electrochemically-synthesised Ir-Sb nanostructures.