• 대한두경부종양학회지
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• 제12권1호
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• pp.32-42
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• 1996

This study was desinged to evaluate the effect of radioactive iodine-131 therapy in differentiated thyroid carcinoma treated at the Presbyterian Medical Center, Chonju during the 20-year period from 1975 to 1994. The authors reviewed 246 patients who received radioactive iodine-131. An analysis of the therapeutic response and survival rates of the 246 patients has been carried out. The male to female ratio was 1 : 3.6. The peak incidence was in the 4th and 6th decades. The histologic findings in the 246 patients were papillary adenocarcinoma in 200 cases, follicular adenocarcinoma in 29 cases, mixed type in 14 cases, and others in 3 cases. Combined treatment modalities of 246 patients consisted of sugery and radioiodine in 222 cases, surgery with radioiodine and external irradiation in 11 cases, and surgery with radioiodine, external irradiation and chemotherapy in 5 cases. 42 of the 246 cases showed recurrence and the commonest type of combined treatment for recurrent case was surgery followed by radioiodine-131. The highest accumulated total dosage of radioiodine-131 was 480mCi in that case femoral metastasis was noticed. The most common locoregional metastatic site was ipsilateral cervical node, and neighbouring muscle, vessel, trachea, recurrent layngeal nerve, in order of frequency. The determinate 10-year survival rate was 91.8% in the group receiving surgery followed by radioiodine-13l and 71.4% in patients receiving surgery, radioiodine-13l with XRT. The determinate 10-year survival rate was better for patients under 40 years of age who received radioiodine as compared to patients over 40 year of age(85.7% vs. 33.3%). The most usual primary therapeutic dosage in the group of cervical lesion was 90$\sim$120mCi after surgery.

• Nuclear Engineering and Technology
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• 제51권2호
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• pp.641-645
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• 2019

Experimental equipment for studying the sorption properties of iodine sorbents using radioactive methyliodide has been developed. The sorption capacity index ${\alpha}$ is proposed as a criterion parameter for assessing the quality of impregnated activated charcoals. It was found that this parameter does not depend on the dynamic conditions during the sorbent test. It was shown that values of the sorption capacity index allow to recommend iodine sorbents for industrial gas cleaning processes.

• 한국방사선학회논문지
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• 제6권1호
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• pp.79-82
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• 2012

요오드는 원자력 시설에서 사고가 발생할 경우 방사선 피폭을 검토할 때 고려해야 할 중요한 핵종 중 하나이다. 그러므로 체르노빌 사고 시 대기 중에는 유기물 형태의 요오드가 비유기물 형태의 요오드보다 많이 관찰되었다. 본 연구에서는 시료의 양 및 측정시간에 변화를 주었으며, 또한 $^{131}I$ 액체선원을 사용하여 증류수에 희석한 시료 및 다시마를 함께 섞은 시료를 이용하여 검출하한치를 측정 분석하였다. 방사능농도 하한치에 들어 인체에는 무해함을 확인 할 수 있었다. $^{131}I$선원의 시간이 흐를수록 카운트가 줄어듦을 알 수 있었다. 반감기를 계산해본 결과 7~9사이의 결과를 얻었고, $^{131}I$를 혼합한 시료의 경우 최고 7일이 지난 후에는 초기 조건에서 반으로 감소한다는 것을 알 수 있었다.

• 대한핵의학회지
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• 제9권1호
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• pp.59-71
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• 1975

53 patients with hyperthyroidism have been analyzed with special reference to therapeutic response to radioactive iodine ($^{131}I$) treatment. Mean effective half-life, 24 hour uptake rate and radiation dose of $^{131}I$ in hyperthyroid patients included in this study were respectively. 1. Mean effective half-life of $^{131}I\;was\;4.7{\pm}1.5$ days in the tracer dose and $5.0{\pm}1.5$ days in the therapeutic dose. 2. Mean 24 hour uptake rate of $^{131}I\;was\;72.7{\pm}11.1%$ in the tracer dose and $73.4{\pm}12.3%$ in the theapeutic dose. 3. Mean radiation dose of $^{131}I\;was\;5,319{\pm}2,648$ RAD as predicted and $5,692{\pm}2,843$ RAD as actual. A single dose of radioactive iodine treatment was satisfactory in 34 patients (radioiodine sensitive) and multiple doses of radioactive iodine treatments were required in 19 patients (radioiodine resistant). A radioiodine resistant group of patients with hyperthyroidism was distinctively characteristic in the following aspects. 1. Mean thyroid weight calculated in the resistant group ($63.9{\pm}14.0gm$) was significantly (p<0.01) greater than that of the sensitive group ($46.6{\pm}13.3gm$). 2. Mean 24 hour uptake rate of the tracer dose in the resistant group ($67.3{\pm}10.7%$) was significantly (p<0.01) lower than that of the sensitive group ($75.7{\pm}10.5%$). 3. Mean 24 hour uptake rate of the therapeutic dose in the resistant group ($68.5{\pm}13.7%$) was significantly (p<0.05) lower than that of the sensitive group ($76.1{\pm}10.9%$). 4. Mean predicted radiation dose, of $^{131}I$ in the resistant group ($3,684{\pm}1,745$ RAD) was significantly (p<0.01) lower than that of the sensitive group ($6,232{\pm}2,683$ RAD). 5. Mean actual radiation dose of $^{131}I$ in the resistant group ($4,100{\pm}1,691$ RAD) was significantly (p<0.01) lower than that of the sensitive group ($6,582{\pm}3,024$ RAD). 6. No significant difference was detected in terms of effective half-life of $^{131}I$ among the groups (p>0.05). 7. The average mean % difference of effective half-life, uptake rate and radiation dose measured following the tracer and therapeutic dose of $^{131}I$ were not statistically significant (p>0.05). Therefore effective half-life, uptake rate and radiation dose of the therapeutic dose of $^{131}I$ were readily predictable following the tracer dose of $^{131}I$. 8. It is concluded that the possibility of resistance to radioactive iodine treatment may be anticipated in patients with thyroid gland large in size and compromised $^{131}I$ uptake rate.

• Clinical and Experimental Pediatrics
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• 제51권2호
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• pp.214-218
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• 2008

신경모세포종은 소아에서 발생하는 흔한 두개외 고형 종양 중 하나로서 진행된 경우 고용량 항암요법 및 자가 말초혈조혈모세포이식 후에도 재발이 잘 되어 예후가 매우 나쁘다. Iodine-131 metaiodobenzylguanidine ($^{131}I-MIBG$)는 치료에 잘 반응하지 않는 신경모세포종 4기 환자를 위한 대증적 치료 요법으로 제한적으로 이용되어 왔다. 저자들은 자가 말초혈조혈모세포이식 후 재발된 신경모세포종 3례에서 $^{131}I-MIBG$를 이용하여 통증을 경감시키고 생존 기간을 늘이는 고식적인 치료 효과를 얻어 이들에 대한 증례 보고를 하는 바이다.

• Nuclear Engineering and Technology
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• 제9권1호
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• pp.1-6
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• 1977

간장 질환 진단용 방사성 의약품인 $^{131}$ I 표지 1 요오드화 브로모프탈레인(MIBSP-$^{131}$ I)을 PH 5.3의 인삼염 완충용액에서 MIBSP와 $^{131}$ I$_2$의 동위원소 교환반응으로 제조할수 있음을 제시하였다. 비방사성 MIBSP는 브로모썰포프탈레인(BSP)을 IC1로 요오드화하고 나서 쎄파덱스 LH-20 크로마토그래피로 분리하여 얻었다. MIBSP와 $^{131}$ I의 동위원소 교환반응은 매우 빨리 일어나 10$0^{\circ}C$에서 5분안에 대략 95%의 표지수율을 보였다. 순수한 최종생성물 MIBSP-$^{131}$ I는 미량의 $H_2O$$_2$ 존재하에 약 5분간 더 반응시킨 후 PH를 조절하고 무균여과함으로써 간단히 얻어졌다.

• 대한핵의학회지
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• 제24권1호
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• pp.80-86
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• 1990

Fifty seven patients with differentiated thyroid carcinoma were performed radioactive iodine-131 whole body scans after administration of diagnostic dose $(2\sim10\;mCi)$ and therapeutic dose $(30\sim150\;mCi)$ within three months. We evaluated the state of radioactive iodine-131 uptakes in whole body scan to detect correct metastasis of thyroid carcinoma. The results are as follows: 1) In 20 of the 57 patients (35%), the therapeutic scan showed the additional uptakes that were not seen in the diagnostic scan. 2) In 9 (64.2%) of the 14 patients who had been received the thyroid ablation theraphy with I-131 previously, new additional lesions were found in the therapeutic scan but only 11 (25%) of the 32 patients who had not been received the thyroid ablation theraphy disclosed new uptake lesions (p < 0.01). 3) The additional uptake lesions of therapeutic scan were significantly more common in the bony metastatic foci (55.7%) than other areas (p < 0.01). In 11 (55%) of 20 patients, additional uptake regions were anterior neck areas (thyroid bed or regional lymph node). We conclude that diagnostic scan with $2\sim5$ mCi I-131 is inadequate in evaluating residual iodine avid tissues of patients with thyroid carcinoma. Also post-theraphy I-131 whole body scan would be important to evaluate the correct staging and prognosis of thyroid carcinoma, and to follow-up patients.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2003년도 춘계학술발표대회 요약집
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• pp.341.2-341.2
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• 2003

• Nuclear Engineering and Technology
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• 제50권8호
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• pp.1355-1363
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• 2018

Many radionuclides exist in normal environment and artificial radionuclides also can be detected. The radionuclides ($^{131}I$) are widely used for labeling compounds and radiation therapy. In Korea, the radionuclide ($^{131}I$) is produced at the Radioisotope Production Facility (RIPF) at the Korea Atomic Energy Research Institute in Daejeon. The residents around the RIPF assume that $^{131}I$ detected in environmental samples is produced from RIPF. To ensure the safety of the residents, the radioactive concentration of $^{131}I$ near the RIPF was investigated by monitoring environmental samples along the Gap River. The selected geographical places are near the nuclear installation, another possible location for $^{131}I$ detection, and downstream of the Gap River. The first selected places are the "front gate of KAERI", and the "Donghwa bridge". The second selected place is the sewage treatment plant. Therefore, the Wonchon bridge is selected for the upstream of the plant and the sewage treatment plant is selected for the downstream of the plant. The last selected places are the downstream where the two paths converged, which is Yongshin bridge (in front of the cogeneration plant). In these places, environmental samples, including sediment, fish, surface water, and aquatic plants, were collected. In this study, the radioactive iodine ($^{131}I$) detection along the Gap River will be investigated.

• Nuclear Engineering and Technology
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• 제3권3호
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• pp.141-147
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• 1971

Tetrachloro-p-tetraiodo-R-Fluorescein 및 sodium orthoiodohippurate등 요오드화 합물과 요오드화합물이 아닌 human serum Albumin을 요오드 표지함에 있어서 표지속도와 수율등을 비교 검토하였다. 위의 각각의 화합물들을 여러가지 다른 조건하에 있는 $Na^{131}$ I, 즉, 환원제를 함유한것, 환원제를 함유하지 않으며 거의 순수하게 131 I$^{-}$형으로 있는것, 및 환원제를 함유하지 않으며 상당량이 131 IO$_3$$^{-}$형으로 있는것 등을 써서 표지 반응시켰다. 환원제인 $Na_2$S$_2$O$_3$를 함유한 $Na^{131}$ I를 쓰는 경우는 위의 세가지 화합물들의 표지수율이 10% 내외로 매우 저조하였으며 환원제는 없지만 상당량이 $Na^{131}$ I$^{-}$로 존재하는 $Na^{131}$ I를 쓰는 경우도 50~60%의 낮은 수율이었다. 환원제가 없으며 대부분 $Na^{131}$ I$^{-}$로 존재하는 $Na^{131}$ I를 쓰는 경우에만 70~90%의 높은 표지수율을 보였다. 이들 반응에 관여하는 중간체에 대해서도 토의하였다.