• Title/Summary/Keyword: Iodine treatment

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The Variation of Serum Thyroglobulin Measured after Thyrogen Administration (Thyrogen 투여 후 측정된 Thyroglobulin 농도변화)

  • Kim, Ji-Na;An, Jae-seok;Won, Woo-Jae
    • The Korean Journal of Nuclear Medicine Technology
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    • v.22 no.1
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    • pp.80-83
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    • 2018
  • Purpose Assessment of Serum Thyroglobulin (sTg) value in total thyroidectomy patients having an ablation dose of radioactive iodine indicates remaining cancer or metastasis. Especially, sTg in patients on withdrawal thyroxine or thyrogen administration for radioiodine ablation is an important indicator to determine the direction of further treatment and prognosis. Current guidelines suggest measurement of sTg is performed at 72 hours after the last injection of thyrogen. and assumes that sTg reaches maximum serum levels at that time. The purpose of this study is to evaluate the variation of sTg measured after thyrogen administration. Materials and Methods We compared with sTg performed at 24hours(D0) and 72hours(D2) after the last injection of thyrogen. We reviewed D0 and D2 from 276 patients were divided them into three groups according to ablation dose of radioactive iodine, 5mCi(A group), 30~80mCi(B group) and 100~200mCi(C group). We used T-test for comparison between D0 and D2. sTg was measured in serum using immunoradiometric assay (Tg-plus RIA; BRAHMS, Berlin, Germany). Results There is no critical variation between D0 and D2 in A group(n=100)(P=0.32), The case of increase(D2>D0) is 45, no change(D2=D0) is 23, decrease(D2D0 is 91, D2=D0 is 28, D2D0 is 19, D2=D0 is 2. The biggest increase is 143.6 ng/mL from 98.4 to 242. Conclusion There was a significant difference in the group over 30mCi. and the case of D2>D0 is 45%, 58.7%, 90.5% for each group. therefore, D2 increased as the dose of radioactive iodine increased. Furthermore, the most sTg values of D0 and D2 are variation under 2.0 ng/mL, so reproducibility as well as sensitivity of sTg will be important at values below 2ng/mL.

The Experiences of Thyroid Cancer Patients Receiving Radioactive Iodine Therapy (갑상선암환자의 방사성요오드 치료 경험 분석)

  • Kim, Ju-Sung;Son, Hyun-Mi
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.12
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    • pp.4935-4944
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    • 2010
  • The purpose of this study was to investigate the perceived difficulties during both pre-treatment period and admission period for radioactive iodine therapy (RAIT), the level of information about RAIT provided by medical staffs and the satisfaction of RAIT process in thyroid cancer patients receiving RAIT. Participants were 165 thyroid cancer patients, who had total thyroidectomy and had been offered RAIT. The data were collected using structured questionnaire and open-ended questions and analyzed by descriptive statistics and content analysis. The most frequent perceived difficulties of RAIT was associated with thyroid specific symptoms during both pre-RAIT period and RAIT admission period(38.2% vs 43.0%). The rating of RAIT information provided by medical staffs was evaluated as over moderate level(mean $3.63{\pm}0.80$). The RAIT process satisfaction was investigated as moderate level(mean $6.43{\pm}2.21$). the satisfaction of RAIT was the highest in medical attention and coping procedure (mean $7.64{\pm}2.37$) however it was the lowest in adequacy of RAIT information(mean $5.67{\pm}2.78$). Thus the nursing intervention program for thyroid cancer patient undergoing RAIT should be developed to support needs of thyroid cancer patients related to thyroid specific symptoms and to improve patients' understanding about RAIT procedure so that patients have competence to participate in therapeutic activities efficiently.

The Preparation of Low Cost Activated Carbon Fibers for Removal of Volatile Organic Chemicals and Odor (저가 탄소섬유를 이용한 악취제거 기술 개발)

  • Lim, Yun-Soo;Yoo, Ki-Sang;Kim, Hee-Seok;Chung, Yun-Joong
    • Journal of the Korean Ceramic Society
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    • v.38 no.10
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    • pp.928-935
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    • 2001
  • In this study, two kinds of activated carbon fibers were prepared from PAN-based stabilized fibers by physical activation with steam. The variations in specific surface area, amount of iodine adsorption and pore size distribution of the activated carbon fibers after the activation process were discussed. The activated carbon fibers were prepared by two different methods, namely a 1- and 2-step method. For the 2-step method, carbonization of fibers in $N_2$ atmosphere was carried out to make carbon fibers and then activated by steam. In normal two step steam activation, BET surface area of about $1019m^2/g$ was obtained in the study. In the 1-step steam activation process, the carbonization and activation were simultaneously carried out. In the one step steam activation, BET surface area of $1635m^2/g$ was obtained after heat-treatment at $990^{\circ}C$. However, nitrogen adsorption isotherms for oxidized PAN based activated carbon fibers that were prepared by both methods were type I in the Brunauer-Deming-Deming-Teller (BDDT) classification even though they have different BET surface areas, amounts of iodine adsorption and pore size distributions.

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The Study of Radiation Exposed dose According to 131I Radiation Isotope Therapy (131I 방사성 동위원소 치료에 따른 피폭 선량 연구)

  • Chang, Boseok;Yu, Seung-Man
    • Journal of the Korean Society of Radiology
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    • v.13 no.4
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    • pp.653-659
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    • 2019
  • The purpose of this study is to measure the (air dose rate of radiation dose) the discharged patient who was administrated high dose $^{131}I$ treatment, and to predict exposure radiation dose in public person. The dosimetric evaluation was performed according to the distance and angle using three copper rings in 30 patients who were treated with over 200mCi high dose Iodine therapy. The two observer were measured using a GM surverymeter with 8 point azimuth angle and three difference distance 50, 100, 150cm for precise radion dose measurement. We set up three predictive simulations to calculate the exposure dose based on this data. The most highest radiation dose rate was showed measuring angle $0^{\circ}$ at the height of 1m. The each distance average dose rate was used the azimuth angle average value of radiation dose rate. The maximum values of the external radiation dose rate depending on the distance were $214{\pm}16.5$, $59{\pm}9.1$ and $38{\pm}5.8{\mu}Sv/h$ at 50, 100, 150cm, respectively. If high dose Iodine treatment patient moves 5 hours using public transportation, an unspecified person in a side seat at 50cm is exposed 1.14 mSv radiation dose. A person who cares for 4days at a distance of 1 meter from a patient wearing a urine bag receives a maximum radiation dose of 6.5mSv. The maximum dose of radiation that a guardian can receive is 1.08mSv at a distance of 1.5m for 7days. The annual radiation dose limit is exceeded in a short time when applied the our developed radiation dose predictive modeling on the general public person who was around the patients with Iodine therapy. This study can be helpful in suggesting a reasonable guideline of the general public person protection system after discharge of high dose Iodine administered patients.

Preparation and Characterization of Carbonized Material from Al-Fe-Mg-Si Nanocomposites Impregnated Biomass

  • Kim, Jin Woo;Lee, Chul Jae
    • International Journal of Advanced Culture Technology
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    • v.6 no.2
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    • pp.129-136
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    • 2018
  • Our present study, we impregnated Al-Fe-Mg-Si (NFM) nanocomposites having various concentrations 0, 1000, 3000, and 5000 mg/L in biomass in order to make carbonized biomass. We characterized the properties of the impregnated samples through thermogravimetric/differential thermal analysis (TG-DTA), pore distribution, scanning electron microscopy (SEM). The best results were observed for a NFM nanocomposites concentration of 5000 mg/L. After the first heat treatment, carbonization, and activation processes, the fixed carbon ratio and iodine adsorptivity were increased by 21.89% and 368 mg/g, 23.98% and 475 mg/g, 26.40% and 238 mg/g, respectively. The remove rate of malodorous and VOCs were that the sample shows good removal capabilities. From above results, our sample could be used for the removal of noxious and malodorous gases and for the purification of wastewater.

Characterization of extracellular fructosyl transferase from aureobasidium pullulans C-23 (Aureobasidium pullulans C-23이 생산하는 세포외 fructosyl transferase의 특성)

  • 이광준;최정도;임재윤
    • Korean Journal of Microbiology
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    • v.29 no.5
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    • pp.301-306
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    • 1991
  • Extracellular fructosyl transferase from Aureobasidium pullulans C-23 was characterized. The molecular weight of the isolated enzyme was determined to be approximately 170,000 by SDS polyacrylamide gel electrophoresis. The enzyme has the pI value of about 3.7. The enzyme was almost completely inhibited by 5mM $Hg^{2+}$ , but was not significantly affected by other cations tested. The enzyme was inactivated by treatment of tryptophan-specific reagent N-bromo- succinimide and tyrosine-specific reagent iodine. The substrate sucrose showed protective effect on the inactivation of the enzyme by the both reagents. These results suggest that tryptophan and tyrosine residues are probably located at or near active site of the enzyme.

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Management of Infected Median Sternotomy Wound by Muscle Flap -5 cases- (근육편에 의한 정중 흉골절개 감염의 치료 -5례 치험-)

  • Kim, Hyeong-Gon;Jo, Seon-Hwan;Choe, Jong-Beom
    • Journal of Chest Surgery
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    • v.27 no.7
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    • pp.634-638
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    • 1994
  • Infection of a median sternotomy incision may result in a large, unsightly,unstable,and potentially fatal wound. During the past 8 years, 5 consecutive patients [ 4 male and 1 female ] had repair of infected sternotomy wound. We describe our current preferred techniques and the results we have achieved with them. As soon as the sternal infection was shown, operative wound was opened and irrigated more than 4 times a day with 0.5% Betadine iodine solution until the exudate became clean with no growth of bacteria. Operation was performed in one-stage, which consisted of aggressive debridement of the infected bone and muscle transposition. Reconstruction was with one-side or both pectoralis flaps in all patients and rectus abdominis in 2 patients. There was no mortality or morbidity within 30 days postoperatively. We conclude that early aggressive debridement and muscle transposition remain the treatment of choice for most patients with infected median sternotomy wounds.

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A Case of Thyroid Papillary Cancer with Spinal Metastasis (유두상 갑상선 암의 척추전이 1예)

  • Yang, Suk Min;Chang, Jae Won;Shin, Yoo Seob;Kim, Chul-Ho
    • Korean Journal of Head & Neck Oncology
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    • v.29 no.2
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    • pp.79-82
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    • 2013
  • Thyroid cancer is known as its relatively high cure rate after surgical treatment and spinal metastasis of thyroid cancer is extremely rare as the prevalence is only 2-13%. Spinal metastasis is usually asymptomatic and discovered incidentally in most cases. A 66-year-old man was diagnosed as thyroid papillary cancer with spinal metastasis. We treated the patient by surgery, adjuvant radiotheraphy and radioactive iodine therapy. C6 corpectomy was followed for the residual spinal metastasis by the department of neurosurgery. The patient had no functional complication by the surgical process. At 24 months after surgery, there was no sign of recurrence and the patient led social life without any discomfort. We present this case with a review of the related literatures.

A Case of Ectopic Thyroid Cyst Accompanied by Acute Airway Obstruction (급성 상기도 폐색을 동반한 이소성 갑상선 기원의 낭종 1예)

  • Kang, Dae-Woon;Lee, Yoon Se;Lim, Yune Sung;Lee, Jin-Choon
    • Korean Journal of Bronchoesophagology
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    • v.17 no.1
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    • pp.50-52
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    • 2011
  • Ectopic thyroid gland is a defined as thyroid tissue located in a site other than its usual pre-tracheal location. Ultrasound examination, CT scan, thyroid scan, and thyroid iodine uptake test are all valuable modalities for a differential diagnosis. Although most of cases are asymptomatic, treatment is indicated when there are symptoms related to progressive growth of mass. This article reports a ectopic thyroid cyst in the anterior neck that was similar to deep neck infection accompanied by acute airway obstruction.

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