A Case of Thyroid Papillary Cancer with Spinal Metastasis

유두상 갑상선 암의 척추전이 1예

  • Yang, Suk Min (Department of Otolaryngology, School of Medicine, Ajou University) ;
  • Chang, Jae Won (Department of Otolaryngology, School of Medicine, Ajou University) ;
  • Shin, Yoo Seob (Department of Otolaryngology, School of Medicine, Ajou University) ;
  • Kim, Chul-Ho (Department of Otolaryngology, School of Medicine, Ajou University)
  • 양석민 (아주대학교 의과대학 이비인후-두경부외과학교실) ;
  • 장재원 (아주대학교 의과대학 이비인후-두경부외과학교실) ;
  • 신유섭 (아주대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김철호 (아주대학교 의과대학 이비인후-두경부외과학교실)
  • Received : 2013.08.26
  • Accepted : 2013.09.27
  • Published : 2013.11.30

Abstract

Thyroid cancer is known as its relatively high cure rate after surgical treatment and spinal metastasis of thyroid cancer is extremely rare as the prevalence is only 2-13%. Spinal metastasis is usually asymptomatic and discovered incidentally in most cases. A 66-year-old man was diagnosed as thyroid papillary cancer with spinal metastasis. We treated the patient by surgery, adjuvant radiotheraphy and radioactive iodine therapy. C6 corpectomy was followed for the residual spinal metastasis by the department of neurosurgery. The patient had no functional complication by the surgical process. At 24 months after surgery, there was no sign of recurrence and the patient led social life without any discomfort. We present this case with a review of the related literatures.

Keywords

References

  1. Ramadan S, Ugas MA, Berwick RJ, Notay M, Cho H, Jerjes W, et al. Spinal metastasis in thyroid cancer. Head Neck Oncol. 2012;4:39. https://doi.org/10.1186/1758-3284-4-39
  2. Eustatia-Rutten CF, Romijn JA, Guijt MJ, Vielvoye GJ, van den Berg R, Corssmit EP, et al. Outcome of palliative embolization of bone metastases in differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2003;88(7):3184-3189. https://doi.org/10.1210/jc.2003-030231
  3. Quan GM, Pointillart V, Palussiere J, Bonichon F. Multidisciplinary treatment and survival of patients with vertebral metastases from thyroid carcinoma. Thyroid. 2012;22(2):125-130. https://doi.org/10.1089/thy.2010.0248
  4. Harel R, Angelov L. Spine metastases: Current treatments and future directions. Eur J Cancer. 2010;46(15):2696-2707. https://doi.org/10.1016/j.ejca.2010.04.025
  5. Sciubba DM, Petteys RJ, Dekutoski MB, Fisher CG, Fehlings MG, Ondra SL, et al. Diagnosis and management of metastatic spine disease. A review. J Neurosurg Spine. 2010;13(1):94-108. https://doi.org/10.3171/2010.3.SPINE09202
  6. Zettinig G, Fueger BJ, Passler C, Kaserer K, Pirich C, Dudczak R, et al. Long-term follow-up of patients with bone metastases from differentiated thyroid carcinoma--surgery or conventional therapy? Clin Endocrinol(Oxf). 2002;56(3):377-382. https://doi.org/10.1046/j.1365-2265.2002.01482.x
  7. Muresan MM, Olivier P, Leclere J, Sirveaux F, Brunaud L, Klein M, et al. Bone metastases from differentiated thyroid carcinoma. Endocr Relat Cancer. 2008;15(1):37-49. https://doi.org/10.1677/ERC-07-0229
  8. Tokuhashi Y, Ajiro Y, Oshima M. Algorithms and planning in metastatic spine tumors. Orthop Clin North Am. 2009;40(1):37-46, v-vi. https://doi.org/10.1016/j.ocl.2008.09.002
  9. Jeon MJ, Kim TY, Han JM, Yim JH, Rhim SC, Kim WB, et al. Intramedullary spinal cord metastasis from papillary thyroid carcinoma. Thyroid. 2011;21(11):1269-1271. https://doi.org/10.1089/thy.2011.0148
  10. Basu S, Abhyankar A. Adding surgery as a complementary approach to radioiodine therapy in patients of differentiated thyroid carcinoma with large solitary flat bone metastases: The unresolved issues. J Surg Oncol. 2012;105(6):622. https://doi.org/10.1002/jso.22116