• Korean journal of applied entomology
• /
• v.47 no.4
• /
• pp.365-368
• /
• 2008

Adult longevity and fecundity of the foxglove aphid, Aulacorthum solani Kaltenbach, were studied at $12.5{\sim}25^{\circ}C$ with $60{\sim}70%$ RH under 16L:8D and the results were put together to build a life table. The longevity of foxglove gradually increased with decreasing temperature below $25^{\circ}C$. Also total fecundity increased with decreasing temperature and highest fecundity was 74.1 nymphs per female at $15^{\circ}C$. However, daily fecundity increased with increasing temperatures up to $20^{\circ}C$ showing 2.9 nymphs per day and thereafter decreased. Net reproduction rate ($R_0$) was highest of 58.7 at $15^{\circ}C$. The intrinsic rate of increase per day ($r_m$) and the finite rate of increase per day (${\lambda}$) were highest of 0.27 and 1.32, respectively and the doubling time (Dt) was shortest of 2.52. the mean generation time (T) was 10.99 at $22.5^{\circ}C$.

• Archives of Pharmacal Research
• /
• v.2 no.1
• /
• pp.35-47
• /
• 1979

In order to increase the dissolution rate of furosemide(4-choro-N-furfury1-5-sulfamoy1 anthranilic acid_, various ratio coprecipitates with water-soluble polymers, such as polyvinylpyrrolidone and polythylene glycol, of different molecular weight, were prepared and quantitatively studied by comparing their dissolution characteristics of furosemide at powder state and at nondisintegrating disk state containing constant surface area at various temperatures and rotating velocities. The dissolution characteristics of furosemide from pure furosemide disks and 1:2(w/w) furosemide-PVP coprecipitate disks were in accordance with Noyes-Nernst equation and the rate constant of dissolution was proportional to the square root of rotating velocity of the disks. The intrinsic rate of dissoluton at 150 rpm, 37.deg.C was $2.21{\times}10^{-7}$ for the PVP 10, 000 COPRECIPITATE, $1.64{\times}10^{-7}$ for the PVP 40, 000 coprecipitate, and$ 1.44 {\times} 10^{-7}$for the PVP 360, 000 corprecipitate, while the rate was $1.27{\times}10^{-8}M/cm^{2} min$ for pure furosemide, repectively. The activation energy of dissolution was about 17, 000 for furosemide and about 7, 300 cal/mole for the 1:2 furosemide PVP 40, 000 coprecipitate, respectively.

• Management & Information Systems Review
• /
• v.37 no.4
• /
• pp.41-62
• /
• 2018

As the volume of unstructured data increases through various social media, Internet news articles, and blogs, the importance of text analysis and the studies are increasing. Since text analysis is mostly performed on a specific domain or topic, the importance of constructing and applying a domain-specific dictionary has been increased. The quality of dictionary has a direct impact on the results of the unstructured data analysis and it is much more important since it present a perspective of analysis. In the literature, most studies on text analysis has emphasized the importance of dictionaries to acquire clean and high quality results. However, unfortunately, a rigorous verification of the effects of dictionaries has not been studied, even if it is already known as the most essential factor of text analysis. In this paper, we generate three dictionaries in various ways from 39,800 news articles and analyze and verify the effect each dictionary on the accuracy of document classification by defining the concept of Intrinsic Rate. 1) A batch construction method which is building a dictionary based on the frequency of terms in the entire documents 2) A method of extracting the terms by category and integrating the terms 3) A method of extracting the features according to each category and integrating them. We compared accuracy of three artificial neural network-based document classifiers to evaluate the quality of dictionaries. As a result of the experiment, the accuracy tend to increase when the "Intrinsic Rate" is high and we found the possibility to improve accuracy of document classification by increasing the intrinsic rate of the dictionary.

• Journal of Pharmaceutical Investigation
• /
• v.10 no.4
• /
• pp.23-29
• /
• 1980

Ampicillin-polyvinylpyrrolidone coprcipitates, 1 : 5 ratio w/w, were prepared by the solvent method to increase the solubility and dissolution rate of ampicillin anhydrous. It was found that the solubility and dissolution rate of the coprecipitate were higher than that of ampicillin anhydrous, mechanical mixture of ampicillin and polyvinylpyrrolidone in powder state. The intrinsic, dissolution rate, G, are $1.15{\times}10^{-4}\;mole\;cm^{-2}\;min^{-1}$ for the coprecipitate, $1.09{\times}10^{-5}\;mole\;cm^{-2}\;min^{-1}$ for ampicillin anhydrous, and the activation energy of the coprecipitate and ampicillin anhydrous are $9.091{\times}10^3cal/mole$ and $1.854{\times}10^3cal/mole$, respectively.

• Management Science and Financial Engineering
• /
• v.16 no.3
• /
• pp.49-70
• /
• 2010

Customer population management models can be classified into three categories: the first category includes the models that analyze the customer population at cohort level; the second one deals with the customer population at aggregate level; the third one has interest in the interactions among the customer populations in the competitive market. Our study proposes a model that can analyze the dynamics of customer population in consumer-durables market at aggregate level. The dynamics of customer population includes the retention curves from the purchase or at a specific duration time, the duration time expectancy at a specific duration time, and customer population growth or decline including net replacement rate, intrinsic rate of increase, and the generation time of customer population. For this study, we adopt mathematical ecology models, redefine them, and restructure interdisciplinary models to analyze the dynamics of customer population at aggregate level. We use the data of previous research on dynamic customer population management at cohort level to compare its results with those of ours and to demonstrate the useful analytical effects which the precious research cannot provide for marketers.

• Archives of Pharmacal Research
• /
• v.24 no.6
• /
• pp.584-589
• /
• 2001

Isopropryl 2-(1-3-dithiethane-2-ylidene)-2 [N-(4-methyl-thiazole-2-yl) carbamoyl] acetate (YH439) is currently under phase ll clinical trials by the Yuhan Research Center for use as a hepatoprotective agent. Unfortunately, the oral bioavailbility of YH439, which is sparingly soluble in water (i.e., $0.3{\;}\mu\textrm{g}/ml{\;}or{\;}0.91{$\mu}M$ at room temperature), reportedly, is negligibleregardless of the dose administered to rats in the 10-300 mg/kg range. The bioavailability of the compound increased up to 24%, when administered in the form of a micellar solution ($700{\;}\mu\textrm{g}/ml$or 2.1 mM for YH439) at a dose of 10 mg/kg, suggesting that its limited solubility is associated with its negligible bioavailability. In order to obtain additional informmation concerning the bioavailability of YH439, the mechanism(s) involved in gastrointestinal (Gl) absorption were investigated in the present study. For this purpose, the transport of YH430 across a Caco-2 cell monolayer was measured in a $Transwell^{\circledR}$. A permeability of $4.07{\times}10^{-5}{\;}cm/s$ was obtained for the absorptive (i.e., apical to basolateral direction) transport of $0.42{\mu}M$ YH439, implicating that the in vivo Cl absorption is nearly complete. The absorptive transport exhibited a slight concentration-dependency with an intrinsic clearance ($CL_{i}$) of $0.38{\mu}L/{\textrm{cm}^2}/sec$, which accounted for 28.1% of the total intrinsic clearance (i.e., $CL_i$ plus the intrinsic clearance for the linear component) of the transport. Thus, saturation of the absorption process appears to be a minor factor in limiting the bioavailability of the compound. The apparent permeability of YH439 from the basolateral to the apical direction (i.e., efflux, $6.67{\times}10^{-5}{\;}cm/s$) was comparable to that for absorptive transport, but, interestingly, a more distinct concentration-dependency was observed for this transport. However, the efflux does not appear to influence the bioavailability of the compound, as evidenced by the sufficiently high permeability in the absorption direction. Rather, a reportedly extensive first-pass hepatic metabolism appears to be a principal factor in limiting the bioavailability. In this respect, reducing the first-pass metabolism by some means would lead to a higher bioavailability of the compound. Thus, elevation of the absorption rate of YH439 becomes a necessity. From a practical point of view, increasing the concentration of YH439 in the Cl fluid appears to be a feasible way to increase the absorption rate, because the compound is primarily absorbed via a linear mechanism. In summary, the solubilization of YH439, as previously demonstrated for a micellar solution of the compound, appears to be a practical way to increase the oral bioavailability of YH439.

• The Journal of Fisheries Business Administration
• /
• v.46 no.2
• /
• pp.59-74
• /
• 2015

This study aims to estimate optimal harvesting production, fishing efforts, and stock levels of yellow croaker caught by the offshore Stow Net and the offshore Gill Net fisheries using the current value Hamiltonian method and the surplus production model. As analyzing processes, firstly, this study uses the Gavaris general linear model to estimate standardized fishing efforts of yellow croaker caught by the above multiple fisheries. Secondly, this study applies the Clarke Yoshimoto Pooley(CY&P) model among the various exponential growth models to estimate intrinsic growth rate(r), environmental carrying capacity(K), and catchability coefficient(q) of yellow croaker which inhabits in offshore area of Korea. Thirdly, the study determines optimal harvesting production, fishing efforts, and stock levels of yellow croaker using the current value Hamiltonian method which is including average landing price of yellow croaker, average unit cost of fishing efforts, and social discount rate based on standard of the Korean Development Institute. Finally, this study tries sensitivity analysis to understand changes in optimal harvesting production, fishing efforts, and stock levels of yellow croaker caused by changes in economic and biological parameters. As results drawn by the current value Hamiltonian model, the optimal harvesting production, fishing efforts, and stock levels of yellow croaker caught by the multiple fisheries were estimated as 19,173 ton, 101,644 horse power, and 146,144 ton respectively. In addition, as results of sensitivity analysis, firstly, if the social discount rate and the average landing price of yellow croaker continuously increase, the optimal harvesting production of yellow croaker increases at decreasing rate and then finally slightly decreases due to decreases in stock levels of yellow croaker. Secondly, if the average unit cost of fishing efforts continuously increases, the optimal fishing efforts of the multiple fisheries decreases, but the optimal stock level of yellow croaker increases. The optimal harvest starts climbing and then continuously decreases due to increases in the average unit cost. Thirdly, when the intrinsic growth rate of yellow croaker increases, the optimal harvest, fishing efforts, and stock level all continuously increase. In conclusion, this study suggests that the optimal harvesting production and fishing efforts were much less than actual harvesting production(35,279 ton) and estimated standardized fishing efforts(175,512 horse power) in 2013. This result implies that yellow croaker has been overfished due to excessive fishing efforts. Efficient management and conservative policy on stock of yellow croaker need to be urgently implemented.

• Korean journal of applied entomology
• /
• v.42 no.1
• /
• pp.53-56
• /
• 2003

Development and reproduction of the rice armyworm, Pseudaletia separata Walker, were investigated under different temperatures (13, 15, 18, 20, 25, 30, and 33$^{\circ}C$ ). It took 80.6 days to grow from egg to pre-adult at 15$^{\circ}C$, and 27.3 days at 30$^{\circ}C$ (3.0 times shorter growth period compared with that at 30$^{\circ}C$ ). The range of developmental temperature of rice armywom was 15-30$^{\circ}C$. Survival rate from hatched larva to pre-adult was the highest as 70.6% at 25$^{\circ}C$. Pre-oviposition period and the adult longevity were 4.2 and 12.3 days at 15$^{\circ}C$, and 2.9 and 8.0 days at 30$^{\circ}C$, respectively. The highest average fecundity per female was 816.6 at 25$^{\circ}C$. The net reproductive rate (R$\_$o/) and intrinsic rate of natural increase (r$\_$m/) were the highest at 25$^{\circ}C$ as 913.0 and 0.175, respectively. As a result, it was considered that optimum of temperature for P. separata growth was = 25.0$^{\circ}C$.

• Nutrition Research and Practice
• /
• v.8 no.2
• /
• pp.132-137
• /
• 2014

BACKGROUND/OBJECTIVES: In this study, the apoptogenic activity and mechanisms of cell death induced by hexane extract of aged black garlic (HEABG) were investigated in human leukemic U937 cells. MATERIALS/METHODS: Cytotoxicity was evaluated by MTT (3-(4, 5-dimethyl-thiazol-2-yl)-2, 5-diphenyl tetrazoliumbromide) assay. Apoptosis was detected using 4,6-diamidino-2-phenyllindile (DAPI) staining, agarose gel electrophoresis and flow cytometry. The protein levels were determined by Western blot analysis. Caspase activity was measured using a colorimetric assay. RESULTS: Exposure to HEABG was found to result in a concentration- and time-dependent growth inhibition by induction of apoptosis, which was associated with an up-regulation of death receptor 4 and Fas legend, and an increase in the ratio of Bax/Bcl-2 protein expression. Apoptosis-inducing concentrations of HEABG induced the activation of caspase-9, an initiator caspase of the mitochodrial mediated intrinsic pathway, and caspase-3, accompanied by proteolytic degradation of poly(ADP-ribose)-polymerase. HEABG also induced apoptosis via a death receptor mediated extrinsic pathway by caspase-8 activation, resulting in the truncation of Bid, and suggesting the existence of cross-talk between the extrinsic and intrinsic pathways. However, pre-treatment of U937 cells with the caspase-3 inhibitor, z-DEVD-fmk, significantly blocked the HEABG-induced apoptosis of these cells, and increased the survival rate of HEABG-treated cells, confirming that HEABG-induced apoptosis is mediated through activation of caspase cascade. CONCLUSIONS: Based on the overall results, we suggest that HEABG reduces leukemic cell growth by inducing caspase-dependent apoptosis through both intrinsic and extrinsic pathways, implying its potential therapeutic value in the treatment of leukemia.

• Journal of Applied Biological Chemistry
• /
• v.51 no.3
• /
• pp.102-110
• /
• 2008

Complementation assay of the urea uptake-defective yeast mutants led to the identification of the Arabidopsis AtTIP4;1 gene encoding the aquaporin. However, its physiological functions still remain elusive. In the present study, histochemical and genetic analyses were performed to understand the physiological roles of AtTIP4;1 in urea uptake. The AtTIP4;1 product was detectible in the roots, but not in the leaves, the stem, and the flower. Its promoter allowed the expression of the $\beta$-glucuronidase reporter gene in the roots and the apical meristem in Arabidopsis. The AtTIP4;1 products were induced under nitrogen-deficient conditions. To investigate the role of the tonoplast intrinsic protein in urea transport and developments, Arabidopsis with the loss- and the gain-of-function mutations by T-DNA insertion in AtTIP4;1 and 35S promoter-mediated overexpression of AtTIP4;1 were identified, respectively. The transfer DNA insertion and the AtTIP4;1-overexpressed plants showed normal growth and development under normal or abiotic stress growth conditions. The urea-uptake studies using $^{14}C$-labeled urea revealed higher accumulation of urea in the AtTIP4;1-overexpressed plants. These results provide evidence that overexpression of AtTIP4;1 leads to the increase in the urea-uptake rate in plants without detectable defects to the growth and development.