• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2009.05a
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• pp.27-28
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• 2009

경동맥 내중막두께(intima media thickness: IMT)는 2000년 미국심장학회에서 관상동맥 질환이나 허혈성 뇌질환 위험도의 독립적인 인자임을 인정하여 일차 진단지표로 권장함에 따라 세계적으로 그 관심이 확산되고 있다. 최근 국내에서도 서구화되어 가는 식생활 패턴으로 인해 고혈압, 동맥경화, 뇌졸중, 관상동맥 질환 등의 심뇌혈관계 질환 발병률이 높아지고 있다. 서구의 연구결과에 의하면 경동맥 내중막 두께는 인종, 성별, 연령에 따라 많은 차이를 보이기 때문에 임상적 진단에 기초가 되는 한국형 경동맥 내숭막두께 정상치 확립이 요구된다. 경동맥의 내중막두께는 경동맥 팽대부에서 근위부 10 mm 부위의 far wall 총경동맥 부위에서 심혈관계 위험 인자와 가장 상관성이 많은 것으로 보고되고 있다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2009.05a
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• pp.207-208
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• 2009

B-모드 초음파를 이용한 경동맥 내중막 두께(IMT intima-media thickness) 측정은 관상동맥 질환이나 허혈성 뇌질환 위험도의 독립적인 인자로 매우 중요하다. 본 연구에서는 NTSC(national television system committee) 방식으로 경동씩 초음파 동영상신호를 획득하여 프레임으로 나누어 각각의 IMT를 측정하였다. 각각의 측정값을 시간축으로 재구성하여 시간도메인에서 IMT 의 시변동성을 분석하였다. IMT 시변동성 분석을 통하여 상대적으로 부정맥피험자가 정상피험자에 비해 IMT 평균값이 작아 위험도가 낮다고 평가 될 수 있지만 시변동성 분석으로 IMT 평균값이 작아도 혈관의 기능적 특징이 부족하여 위험도가 높다는 것을 알 수 있었다. 경동맥의 형태적 특징과 기능적 특징을 반영하는 이 분석방법은 경동맥 내중막 두께측정의 신뢰성을 향상시키며 관련질환의 위험도와 중증도를 세분화 할 수 있는 새로운 방법이 될 수 있을 것이다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.2
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• pp.160-167
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• 2015

The purpose of this study was to investigate the correlation of Intima-Media Thickness of common carotid artery(CCA-IMT) and The Second Derivative of Photoplethysmogram Waveforms(SDPTG). 38 subjects with acute ischemic stroke were recruited from the patients admitted to Dong-Eui Medical Center from the June 2013 to January 2014. We assessed 38 patient's SDPTG data and CCA-IMT data by B Mode ultrasonography. then 38 subjects were divided into two groups by the CCA-IMT difference; CCA-IMT 〈 0.8 mm group(n=11), CCA-IMT $$\geq_-$$ 0.8 mm group(n=27). We analyzed their characteristics, risk factor, blood test result, life style by CCA-IMT difference. As a result, Age, Hypertension were significantly higher in the CCA-IMT $$\geq_-$$ 0.8 mm group then in the CCA-IMT < 0.8 mm group. Regular exercise were significantly higher in the CCA-IMT < 0.8 mm group then in the CCA-IMT $$\geq_-$$ 0.8 mm group. The result of Multiple regression analysis on the factors affecting the CCA-IMT was hypertension, total cholesterol, age. and The result of Pearson's Correlation analysis on CCA-IMT and SDPTG is that e/a ratio, SDPTG AI were respectively and significantly correlated with CCA-IMT. According to the analysis, the Relationship between CCA-IMT and SDPTG in Ischemic Stroke Patients were founded. We suggest that further investigation with larger and better controlled trials of the Relationship between CCA-IMT and SDPTG could contribute to better understand the effects of risk factors on atherosclerosis.

• Korean Journal of Clinical Laboratory Science
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• v.47 no.4
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• pp.188-193
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• 2015

Carotid Intima-Media Thickness (CIMT) testing is a test that precisely assesses cerebrovascular and coronary heart diseases. According to many previous studies, CIMT predicts atherosclerosis and is highly correlated to cardiovascular disease risk factors. It has also been reported that CIMT is an independent predictor of risk factors for myocardial infarction and stroke. Therefore, the purpose of this study is to investigate CIMT and other independent factors through a correlation study with the clinical laboratory test results of a blood test. As a result, this study could not prove the correlation between CIMT and risk factors of cardiovascular disease (TC, TG, LDL cholesterol, and HDL cholesterol) due to an insufficient number of subjects. Nevertheless, a positive correlation was demonstrated between CIMT and ALT (p<0.05), GGT (p<0.05), Uric acid (p<0.05), and CEA (p<0.05) at a statistically significant level, suggesting a continuation of the study.

• Clinical and Experimental Pediatrics
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• v.54 no.7
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• pp.292-297
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• 2011

Purpose: Our study aimed to evaluated sex differences in clinical features of obese high school students. Methods: One hundred three obese high school students (body mass index [BMI]${\geq}$85th percentile) and 51 control students (BMI<85th percentile) were enrolled in this study. Anthropometric measurements were performed. Fasting serum glucose, insulin, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and high-sensitive C-reactive protein were measured. Abdominal fat thickness, degree of fatty liver, and carotid intima-media thickness were measured by ultrasound. Results: In control and obese groups, waist circumference was significantly longer in boys but body fat mass was Significantly higher in girls. In the control group, total cholesterol and LDL-C were higher in girls. In the obese group, however, aspartate aminotransferase, alanine aminotransferase and triglyceride were higher and HDL-C was lower in boys. Preperitoneal fat thickness was significantly higher in obese girls. In obese group, the degree of fatty liver was significantly higher in boys. Carotid intima-media thickness was not significantly different between boys and girls. Conclusion: Obese adolescents had distinguishable sex differences in body measurements, metabolic abnormalities, abdominal fat thickness and fatty liver. We can infer that these characteristics may extend into adult obesity.

• The Journal of Advanced Prosthodontics
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• v.2 no.4
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• pp.122-127
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• 2010

PURPOSE. The aim of this study was to examine the relationship between tooth loss and sub-clinical atherosclerosis in Korean adults. MATERIALS AND METHODS. The subjects were part of a cohort study conducted in Ansan city by the Korea University medical school as part of the Korean Genome project. 749 subjects over than 40 years old were evaluated. After taking panoramic radiography, the amount of tooth loss was calculated. The intima-media thickness (IMT) was assessed by using ultrasonography at the common carotid artery. Traditional cardiovascular risk factors for atherosclerosis were also evaluated. The relationship between tooth loss and the IMT was evaluated using ANOVA with Scheffe's multiple comparison method in univariate analysis. Multiple regression analysis was also performed to determine the significance between the IMT and tooth loss. RESULTS. With age, tooth loss increased, but there was no significant increase in other traditional cardiovascular risk factors. Univariate analysis revealed the IMT to be positively related with the amount of tooth loss. Regression analysis of the IMT in the anterior and posterior tooth loss revealed that only the posterior tooth loss was significantly related with the IMT at all sites of the common carotid artery (right far wall, P = .015; left far wall, P = .008; right near wall, P < .001; left near wall, P = .001). CONCLUSION. This study verified the positive relationship between the increased tooth loss at the posterior area and the accumulation of atheroma in arteries.

• Journal of Sasang Constitutional Medicine
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• v.21 no.2
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• pp.123-136
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• 2009

1. Objectives : This study is a pilot study to construct of metabolic syndrome model with constitutional type. We focused on the correlation of Metabolic syndrome(MetS) and ordinary symptoms with Taeumin at 40. 2. Methods : 32 subjects who had taken health examinations and diagnosis of Sasang constitution from Oct 1, 2008 to Dec 31, 2008 at Kyung-Hee medical center were included and underwent B-mode ultrasonography for measurement of intima-media thickness of common carotid arteries. MetS was defined by the criteria of the criteria of the National Cholesterol Education Program Adult Treatment Panel III. 3. Results and Conclusions : Mean intima-media thickness of common carotid artery was higher in subjects with MetS compared with control subjects(0.56$\pm$0.12 vs 0.54$\pm$0.08mm) however. The ordinary symptoms shown to differentiate the MetS group and the control group were related to "dark urine color," "dryness of eyes," and "night sweat". Therefore, these ordinary symptoms can be said to be indicators of the Taeumin with Mets syndrome.

• Journal of radiological science and technology
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• v.36 no.1
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• pp.25-30
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• 2013

Increased intima-media thickness(IMT) of the common carotid artery is an early marker of atherosclerosis and a powerful predictor of coronary and cerebrovascular diseases. The purpose of this study was to evaluate the correlation between carotid artery IMT and cardiovascular risk factors. Total 134 adult were performed with Ultrasonography to measure IMT at common carotid artery, the physical measurements and blood tests, the following results were obtained. As a result, IMT showed higher value in male IMT than female IMT. And, the IMT increased according to the age increased. Also, TC and AI have positive significant correlation with IMT. In Conclusion, cardiovascular risk factors with adult are associated with increased IMT of common carotid artery.

• Journal of Preventive Medicine and Public Health
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• v.42 no.1
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• pp.29-34
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• 2009

Objectives : This study was performed to evaluate the relationship between C-reactive protein(CRP) and carotid intima-media thickness(carotid IMT) in a population of middle-aged Koreans. Methods : A total of 1,054 men and 1,595 women(aged 40-70 years) from Kanghwa County, Korea, were chosen for the present study between 2006 and 2007. We measured high-sensitivity CRP and other major cardiovascular risk factors including anthropometrics, blood pressure, blood chemistry, and carotid ultrasonography. Health related questionnaires were also completed by each study participant. Carotid IMT value was determined by the maximal IMT at each common carotid artery. The relationship between CRP level and carotid IMT was assessed using multiple linear and logistic regression models after adjustment for age, body mass index, menopause(women), systolic blood pressure, total/HDL cholesterol ratio, triglyceride level, fasting glucose, smoking, and alcohol consumption. Results : Mean carotid IMT values from the lowest to highest quartile of CRP were 0.828, 0.873, 0.898, and 0.926 mm for women(p for trend<0.001), and 0.929, 0.938, 0.949, and 0.979 mm for men(p for trend=0.032), respectively. After adjustment for major cardiovascular risk factors, the relationship between CRP and carotid IMT was significant in women(p for trend=0.017), but not in men(p for trend=0.798). Similarly, adjusted odds ratio of increased IMT, defined as the sex-specific top quartile, for the highest versus lowest CRP quartiles was 1.55(95% CI=1.06-2.26) in women, but only 1.05(95% CI=0.69-1.62) in men. Conclusions : CRP and carotid IMT levels appear to be directly related in women, but not in men.

• Journal of Biomedical Engineering Research
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• v.42 no.3
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• pp.100-106
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• 2021

Measuring Intima-media thickness (IMT) with ultrasound images can help early detection of coronary artery disease. As a result, numerous machine learning studies have been conducted to measure IMT. However, most of these studies require several steps of pre-treatment to extract the boundary, and some require manual intervention, so they are not suitable for on-site treatment in urgent situations. in this paper, we propose to use deep learning networks U-Net, Attention U-Net, and Pretrained U-Net to automatically segment the intima-media complex. This study also applied the HE, HS, and CLAHE preprocessing technique to wireless portable ultrasound diagnostic device images. As a result, The average dice coefficient of HE applied Models is 71% and CLAHE applied Models is 70%, while the HS applied Models have improved as 72% dice coefficient. Among them, Pretrained U-Net showed the highest performance with an average of 74%. When comparing this with the mean value of IMT measured by Conventional wired ultrasound equipment, the highest correlation coefficient value was shown in the HS applied pretrained U-Net.