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http://dx.doi.org/10.4047/jap.2010.2.4.122

Relationship between tooth loss and carotid intima-media thickness in Korean adults  

Chin, Ui-Jung (Department of Prosthodontics, Graduate School of Clinical Dentistry, Korea University)
Ji, Suk (Department of Periodontology, Anam Hospital, Korea University)
Lee, Su-Young (Department of Prosthodontics and Dental Research Institute, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Ryu, Jae-Jun (Medical College Dept. of Dentistry, Korea University)
Lee, Jung-Bok (Institute of Human Genetics, College of Medicine, Korea University)
Shin, Chol (Department of Internal Medicine, College of Medicine, Korea University)
Shin, Sang-Wan (Department of Prosthodontics, Graduate School of Clinical Dentistry, Korea University)
Publication Information
The Journal of Advanced Prosthodontics / v.2, no.4, 2010 , pp. 122-127 More about this Journal
Abstract
PURPOSE. The aim of this study was to examine the relationship between tooth loss and sub-clinical atherosclerosis in Korean adults. MATERIALS AND METHODS. The subjects were part of a cohort study conducted in Ansan city by the Korea University medical school as part of the Korean Genome project. 749 subjects over than 40 years old were evaluated. After taking panoramic radiography, the amount of tooth loss was calculated. The intima-media thickness (IMT) was assessed by using ultrasonography at the common carotid artery. Traditional cardiovascular risk factors for atherosclerosis were also evaluated. The relationship between tooth loss and the IMT was evaluated using ANOVA with Scheffe's multiple comparison method in univariate analysis. Multiple regression analysis was also performed to determine the significance between the IMT and tooth loss. RESULTS. With age, tooth loss increased, but there was no significant increase in other traditional cardiovascular risk factors. Univariate analysis revealed the IMT to be positively related with the amount of tooth loss. Regression analysis of the IMT in the anterior and posterior tooth loss revealed that only the posterior tooth loss was significantly related with the IMT at all sites of the common carotid artery (right far wall, P = .015; left far wall, P = .008; right near wall, P < .001; left near wall, P = .001). CONCLUSION. This study verified the positive relationship between the increased tooth loss at the posterior area and the accumulation of atheroma in arteries.
Keywords
Korean; Tooth loss; Intima-media thickness (IMT); Atherosclerosis;
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1 Beck JD, Elter JR, Heiss G, Couper D, Mauriello SM, Offenbacher S. Relationship of periodontal disease to carotid artery intimamedia wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol 2001;21:1816-22.   DOI   ScienceOn
2 Soder B, Yakob M, Nowak J, Jogestrand T. Risk for the development of atherosclerosis in women with a high amount [corrected] of dental plaque and severe gingival inflammation. Int J Dent Hyg 2007;5:133-8.   DOI   ScienceOn
3 Burke GL, Evans GW, Riley WA, Sharrett AR, Howard G, Barnes RW, Rosamond W, Crow RS, Rautaharju PM, Heiss G. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke 1995;26:386-91.   DOI   ScienceOn
4 Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000 2001;25:8-20.   DOI   ScienceOn
5 Brodala N, Merricks EP, Bellinger DA, Damrongsri D, Offenbacher S, Beck J, Madianos P, Sotres D, Chang YL, Koch G, Nichols TC. Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs. Arterioscler Thromb Vasc Biol 2005;25:1446-51.   DOI   ScienceOn
6 Choe H, Kim YH, Park JW, Kim SY, Lee SY, Jee SH. Tooth loss, hypertension and risk for stroke in a Korean population. Atherosclerosis 2009;203:550-6.   DOI   ScienceOn
7 Persson GR, Persson RE. Cardiovascular disease and periodontitis: an update on the associations and risk. J Clin Periodontol 2008;35:362-79.   DOI   ScienceOn
8 Pihlstrom BL. Periodontal risk assessment, diagnosis and treatment planning. Periodontol 2000 2001;25:37-58.   DOI   ScienceOn
9 Piconi S, Trabattoni D, Luraghi C, Perilli E, Borelli M, Pacei M, Rizzardini G, Lattuada A, Bray DH, Catalano M, Sparaco A, Clerici M. Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness. FASEB J 2009;23:1196-204.   DOI   ScienceOn
10 Okoro CA, Balluz LS, Eke PI, Ajani UA, Strine TW, Town M, Mensah GA, Mokdad AH. Tooth loss and heart disease: findings from the behavioral risk factor surveillance system. Am J Prev Med 2005;29:50-6.   DOI   ScienceOn
11 Castillo R, Fields A, Qureshi G, Salciccioli L, Kassotis J, Lazar JM. Relationship between aortic atherosclerosis and dental loss in an inner-city population. Angiology 2009;60:346-50.   DOI   ScienceOn
12 Bond MG, Wilmoth SK, Enevold GL, Strickland HL. Detection and monitoring of asymptomatic atherosclerosis in clinical trials. Am J Med 1989;86:33-6.   DOI   ScienceOn
13 Leivadaros E, van der Velden U, Bizzarro S, ten Heggeler JM, Gerdes VE, Hoek FJ, Nagy TO, Scholma J, Bakker SJ, Gans RO, ten Cate H, Loos BG. A pilot study into measurements of markers of atherosclerosis in periodontitis. J Periodontol 2005;76:121-8.   DOI   ScienceOn
14 Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135-43.   DOI   ScienceOn
15 Paquette DW, Brodala N, Nichols TC. Cardiovascular disease, inflammation, and periodontal infection. Periodontol 2000 2007;44:113-26.   DOI   ScienceOn
16 Lalla E, Lamster IB, Hofmann MA, Bucciarelli L, Jerud AP, Tucker S, Lu Y, Papapanou PN, Schmidt AM. Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol 2003;23:1405-11.   DOI   ScienceOn
17 Blaizot A, Vergnes JN, Nuwwareh S, Amar J, Sixou M. Periodontal diseases and cardiovascular events: meta-analysis of observational studies. Int Dent J 2009;59:197-209.
18 Desvarieux M, Demmer RT, Rundek T, Boden-Albala B, Jacobs DR Jr, Sacco RL, Papapanou PN. Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation 2005;111:576-82.   DOI   ScienceOn
19 Engebretson SP, Lamster IB, Elkind MS, Rundek T, Serman NJ, Demmer RT, Sacco RL, Papapanou PN, Desvarieux M. Radiographic measures of chronic periodontitis and carotid artery plaque. Stroke 2005;36:561-6.   DOI   ScienceOn
20 Papapanou PN. Epidemiology of periodontal diseases: an update. J Int Acad Periodontol 1999;1:110-6.
21 Reich E, Hiller KA. Reasons for tooth extraction in the western states of Germany. Community Dent Oral Epidemiol 1993;21:379-83.   DOI   ScienceOn
22 Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997;96:1432-7.   DOI   ScienceOn
23 Lusis AJ. Atherosclerosis. Nature 2000;407:233-41.   DOI   ScienceOn
24 Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr 2006;83:456-60.
25 Ridker PM, Silvertown JD. Inflammation, C-reactive protein, and atherothrombosis. J Periodontol 2008;79:1544-51.   DOI   ScienceOn
26 Ministry of Helath & Welfare, Korea Centers for Disease Control and Prevention, 2007 Statistics of National Health, p. 66. 2008.
27 Southerland JH, Taylor GW, Moss K, Beck JD, Offenbacher S. Commonality in chronic inflammatory diseases: periodontitis, diabetes, and coronary artery disease. Periodontol 2000 2006;40:130-43.   DOI   ScienceOn
28 Kinane D, Bouchard P; Group E of European Workshop on Periodontology. Periodontal diseases and health: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol 2008;35:333-7.
29 Salonen JT, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb 1991;11:1245-9.   DOI