• 제목/요약/키워드: Interpolymer complexes

검색결과 4건 처리시간 0.022초

Mucoadhesive Drug Carrier Using Poly(acrylic acid)/poly(vinyl alcohol) Interpolymer Complexes by Template Polymerization

  • Oh, Jung-Min;Cho, Chong-Su;Chun, Myung-Kwan;Choi, Hoo-Kyun
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.408.1-408.1
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    • 2002
  • A interpolymer complexes composed of poly(acrylic acid)(PAA) and po!y(vinyl alcohol)(PVA) were prepared by template polymerization of acrylic acid in the presence of PVA for mucoadhesive drug delivery. FT -IR results showed that the PAA/PVA interpolymer complex was formed by hydrogen bonding between the carboxyl groups of PAA and the hydroxyl group of PVA. The dissolution rate or the swelling ratio of the PAA/PVA interpolymer complexes was dependent on the pH and molecular weight of PVA that was used as a template. (omitted)

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Immobilization of Alchidine on Polyvinyl Alcohol Gels

  • Soh, Dea-wha
    • Transactions on Electrical and Electronic Materials
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    • 제4권1호
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    • pp.11-14
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    • 2003
  • The regularities of immobilization of natural medicinal substances - alchidine on gels of poly(vinyl alcohol) - are investigated. It is shown that the polymer components of alchidine interact with nonionic polymer with formation of interpolymer complexes. The influence of the different factors on the properties of complexes is considered and the constants of alchidine distribution in the system gel - water are calculated.

고분자 전해질 콤플렉스 : 감마 히드록시부틸산과 키토산의 상호작용 (Polyelectrolyte Complexes : Interaction between ${\gamma}$-hydroxybutyric acid (GHB) and chitosan)

  • Lee, Kwang-Soon;Son, Tae-Won;Kim, Young-Hun;Jeong, Min-Gi;Park, Yong-Hyeok
    • 한국섬유공학회:학술대회논문집
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    • 한국섬유공학회 2003년도 가을 학술발표회 논문집
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    • pp.217-218
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    • 2003
  • Oppositely charged polyelectrolytes are generally known to form sbalbe interpolymer complexs. Such polyelectrolyte complexes are high practical relevance in industrial applications as flocculants, coatings, and binders, as well as in biological systems and in biomedical applications. Most insoluble polyelectrolyte complexes seem to exhibit 1:1 charge stoichiometry, independent of the charge density on the macromolecules and the structure of their backbones, provided that all charged groups are accessible for electrostatic interactions. (omitted)

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Molecular Conformation-Dependent Complexation between Acidic- and Basic-Polypeptides via Hydrogen Bonding in Solution

  • 장천학;김현돈;조병기;이장우
    • Bulletin of the Korean Chemical Society
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    • 제16권1호
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    • pp.42-47
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    • 1995
  • Interpolymer complex formation between basic polypeptide poly(L-proline) Form Ⅱ (PLP(Ⅱ)) and acidic polypeptides poly(L-glutamic acid) (PLGA) and poly(L-aspartic acid)(PLAA) has been studied in water-methanol (1:2 v/v) mixed-solvent by viscometry, potentiometry, light scattering and circular dichroism (CD) measurements. It has been found that polymer complexes between PLP(Ⅱ) and PLGA (or PLAA) are formed via hydrogen bonding with a stoichiometric ratio of PLP(Ⅱ)/PLGA (or PLAA)=1:2 (in unit mole ratio) and that PLP(Ⅱ) forms polymer complex more favorably with PLGA than with PLAA. In addition, the minimum (for pH 5.0) and the maximum (for pH 3.2) in reduced viscosity of dilute PLP(Ⅱ)-PLGA mixed solutions are observed at 0.67 unit mole fraction of PLGA (i.e., [PLP(Ⅱ)]/[PLGA]=1/2). These findings could be explained in terms of molecular structure (or conformation) of the complementary polymers associated with the complex formation.