Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.408.1-408.1
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- 2002
Mucoadhesive Drug Carrier Using Poly(acrylic acid)/poly(vinyl alcohol) Interpolymer Complexes by Template Polymerization
- Oh, Jung-Min (College of Pharmacy, Chosun University) ;
- Cho, Chong-Su (School of Agricultural Biotechnology, Seoul National University) ;
- Chun, Myung-Kwan (School of Agricultural Biotechnology, Seoul National University) ;
- Choi, Hoo-Kyun (School of Agricultural Biotechnology, Seoul National University)
- Published : 2002.10.01
Abstract
A interpolymer complexes composed of poly(acrylic acid)(PAA) and po!y(vinyl alcohol)(PVA) were prepared by template polymerization of acrylic acid in the presence of PVA for mucoadhesive drug delivery. FT -IR results showed that the PAA/PVA interpolymer complex was formed by hydrogen bonding between the carboxyl groups of PAA and the hydroxyl group of PVA. The dissolution rate or the swelling ratio of the PAA/PVA interpolymer complexes was dependent on the pH and molecular weight of PVA that was used as a template. (omitted)
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