• Tuberculosis and Respiratory Diseases
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• 제46권5호
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• pp.723-728
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• 1999

Pulmonary embolism from metallic mercury is rare. It may occur after a deliberate intravenous injection of mercury as a suicide gesture, in the presence of drug abuse or severe psychiatric disturbance, with the hope of increasing athletic and sexual performance, and accidentally during right heart catheterization while sampling blood with mercury containing syringes. We have experienced the first case of pulmonary embolism associated with intravenous mercury injection in Korea. The blood mercury level remain elevated within the toxic range to date. This may be due to the continued absorption of embolized mercury. Multifocal areas of patchy perfusion defects are in both upper lung fields on perfusion scan of lung. Few of the abnormalities of respiratory or renal function reported previously were demonstrated. We report the case of a young male patient presenting with a clinical picture of pulmonary embolism, in whom widespread deposit of metallic mercury were demonstrated throughout both lungs and elsewhere in the body.

• 동의생리병리학회지
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• 제23권4호
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• pp.919-924
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• 2009

The liver is one of the principal organs involved in glucose metabolism. Diabetes mellitus(DM) commonly develops in patients with liver cirrhosis as a result of hepatocyte dysfunction. Hepatic encephalopathy(HE) is a major neuropsychiatric complication of liver cirrhosis. HE develops frequently in advanced stage of liver cirrhosis due to portal hypertension. We experienced a case of liver cirrhosis with DM and HE in 67 years old male patient. The patient's symptoms were lethargy, general malaise, asterixis, dizziness, and heavy headedness. Hwangryunjihwang-tang, Saengkankunbi-tang, Injinchija-tang and Injinho-tang were prescribed to the patient. Finally, the symptoms had been improved, however significant change was not observed from serum ammonia, fasting blood sugar and postparandial blood sugar. So we hope that this case report will be helpful in treating patient of liver cirrhosis.

• 동의생리병리학회지
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• 제19권6호
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• pp.1694-1700
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• 2005

Paraquat is a nonselective contact herbicide that may induced damage to many organs poisoned with it. But there is no effective treatment modality. This report is about one case of treatment for paraquat poisoning. The patient was hospitalized of Wonkwang university Gwangju Oriental Medical Hospital at the department of Internal Medicine. For 26 days of hospitalization period, the authors supplied gamdutanggami(甘豆湯加味), which consists of Radix glycyrrhizae(甘草), Semen Glycine(黑豆), burned powder of Rhizoma rhei(大黃沙炭末), Succus phyllostachyos(竹瀝) and chinese ink(墨汁), decoction of Galla chinensis(五倍子) and Radix glycyrrhizae(甘草), and fluid. And then he showed improvement of condition and returned to a daily life. This report has a limitation for proof of oriental medicine remedial value. Because this is the only one case of a small quantity of paraquat poisoning patient less than 20cc. Actually there are a few paper regarding the Oriental medicine remedial value in paraquat poisoning patient, so we hope luther study and report ensue.

• 대한한방내과학회지
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• 제38권1호
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• pp.81-91
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• 2017

Objectives: This study aimed to explore and describe how two patients diagnosed with type II diabetes mellitus were successfully cured solely through the use of herbal medicine. Methods: The patients were administered the herbal medicine to reduce symptoms of stress-induced fever with dryness. The prescribed herbal medicines included Yangkyuksanwha-tang, Hyungbangsabaek-san, Hyungbangjihwang-tang, and Hyungbangdojeock-san. Results: The therapeutic outcomes showed that all numerical levels of symptoms such as thirst, polyuria, weight loss, blood sugar, and glycated hemoglobin (HbA1c) recovered to within normal levels. Conclusions: The results of this study suggest that our medical treatment of type II diabetes mellitus diagnosed as Sogal was a valid treatment. We hope that our team's new evidence and findings will shed positive light on the treatment of type II diabetes mellitus using herbal medicine.

• 대한한방종양학회지
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• 제5권1호
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• pp.119-136
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• 1999

Anti-cancer medi-alcohols in oriental herb prescriptions were divided by chef effects. Each medi-alcohols were analyzed and studied abut frequency, character, target, effect. Also, they were divided into the method of making medi-alcohols. The results were summerized as follows. 1. The department of using medi-alcohol in anticancer herbal scriptions were limited in gynecology, dermatology and digestive internal medicine. There were a lot in gynecology. 2. In analysis about medi-alcohols of dermato scriptions by chef effect, the herbs of relieving exterior syndrome were a lot first and the herbs of invigorating-qi were second. 3. In analysis about meld-alcohols of dermato scripions by chef effect, the herbs of promoting blood circulation to remove blood stasis were a lot first and the herbs of invigorating-qi were second. 4. The method of making medi-alcohol was divided into four types ; boiling, making up pills, extration, filtration. I hope that the medi-alcohol will be used as practional references.

• Genomics & Informatics
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• 제10권4호
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• pp.239-243
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• 2012

Gestational diabetes mellitus (GDM) is a complex metabolic disorder of pregnancy that is suspected to have a strong genetic predisposition. It is associated with poor perinatal outcome, and both GDM women and their offspring are at increased risk of future development of type 2 diabetes mellitus (T2DM). During the past several years, there has been progress in finding the genetic risk factors of GDM in relation to T2DM. Some of the genetic variants that were proven to be significantly associated with T2DM are also genetic risk factors of GDM. Recently, a genome-wide association study of GDM was performed and reported that genetic variants in CDKAL1 and MTNR1B were associated with GDM at a genome-wide significance level. Current investigations using next-generation sequencing will improve our insight into the pathophysiology of GDM. It would be important to know whether genetic information revealed from these studies could improve our prediction of GDM and the future development of T2DM. We hope further research on the genetics of GDM would ultimately lead us to personalized genomic medicine and improved patient care.

• 대한한방내과학회지
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• 제43권1호
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• pp.41-52
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• 2022

Objectives: The purpose of this study is to investigate recent trends in randomized controlled trials (RCTs) on the treatment of Coronavirus disease 2019 (COVID-19) patients with traditional Chinese medicine (TCM) and analyze the results for the activation of COVID-19 Korean medicine research. Methods: We searched for RCTs published from December 2019 to October 2021 in the Chinese National Knowledge Infrastructure Database (CNKI). The investigation focused on the type of study, the purpose of the study, and the treatment methods. Results: A total of 8 RCTs were selected and analyzed from the 447 searched studies. All studies attempted to observe the effects of herbal medicine. Herbal medicine included granules, decoctions, and intravenous injections. The most frequently used herb type was drugs for clearing away heat and detoxification and releasing the exterior syndrome. In most studies, the effectiveness of TCM treatment of COVID-19 was significantly high. Conclusions: Although more quality studies are needed to support these results, TCM treatment for COVID-19 has been effective. Therefore, we hope that Korean medicine studies on infectious diseases will be actively conducted like TCM and contribute to national health.

• 대한한방종양학회지
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• 제9권1호
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• pp.99-108
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• 2003

Recently, the proportion of the population older has increased rapidly. As the aged population is increasing, the prevalence of malignancy rises with age, too. We believe that the potential benefits of approach to cancer care in the elderly are self-evident. In order to investigate the characteristics of cancer in the elderly, we reviewed literature related with the biology of the aged with cancer. The elderly undergo age-related changes in their physiology which may result in altered tolerance to disease and to the requirements of the management of illness. The possible reasons for the increased prevalence of cancer in the elderly are a longer potential duration of exposure to carcinogens, a reduced ability of repair DNA and reduced host defences against malignancy. In general, cancer patients in the elderly have a shorter survival. Because it is impossible to offer the active treatment of cancer in the elderly. Also, they have the problems that the psychosocial change and reduce of physiological function such as absorption, metabolism and excretion. We hope that other groups will further research cancer in the elderly in future.

• 대한한방내과학회지
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• 제28권2호
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• pp.294-303
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• 2007

Objectives : We are aimed to identify anti-tumor effects of realgar on some kinds of cancer cells through molecular biologic methods. Materials & Methods : We used 5 kinds of cancer cell lines: lung cancer cells(A549). stomach cancer cells(KATO) and neuroglioma cells(SUN-1118. U-87MG, U-373MG). We injected the boiled extracts of realgar $50{\mu}g$. $100{\mu}g$ to cultural media( ml )for 24 hours. We measured the killing effects on 5 kinds of cancer cells through inverted and fluorescence microscope, the suppressive effects on viability of those cells via XTT assay and the effects on the revelation of Bax and Bcl-2 proteins related to apoptosis by western blotting. Results : In the changes of morphology, the extracts of realgar showed more significant killing effects on all cancer cells. especially KATO, SNU-1118, U-87MG, U-373MG, than the control group with dose dependence, which was statistically significant. In XTT assay, the extracts of realgar showed more suppressive effects on viability of all cancer cells, especially KATO and U-373MG, than the control group with dose dependence, which was statistically significant. In the revelation of proteins related to apoptosis, the extracts of realgar increased the level of Bax and decreased that of Bcl-2 in all cancer cells with dose dependence. Conclusions : We identified that realgar had more anti-tumor effects on stomach cancer and neuroglioma than on lung cancer in the experiments above. However, these basic experiments were performed in vitro. We hope the anti-tumor effects of realgar will be practically identified through more progressive research.

• 동의생리병리학회지
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• 제24권6호
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• pp.1094-1098
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• 2010

With the high prevalence of functional dyspepsia in the world, it was difficult to get objective diagnosis, treatment and assessment for the reason that there were many different symptoms and signs. The purpose of this study is to develop a standard instrument of pattern identification for functional dyspepsia which will be applied to clinical research. The items and structure of the instrument were based on review of published literature. The advisor committee on this study was organized by 11 oriental division of gastroenterology professors of oriental medical colleges nationwide. The experts discussed developing the instrument, and we also took professional advices by e-mail. We divided the symptoms and signs of functional dyspepsia into 6 pattern identification, such as disharmony of liver and stomach, retention of undigested food, damp-heat in the spleen and stomach, simultaneous occurrence of cold and heat syndromes, deficiency and cold of the spleen and the stomach, and insufficiency of stomach eum. We got the mean weights to each symptom of six pattern identification which had been scored on a 5-point scale ranging from 1 to 5 by the 11 experts. We made out the Korean instrument of the pattern identification composed of 45 questions for functional dyspepsia. Although there are some limitations in our study, the instrument is meaningful and certain worth of its own. We hope to improve the instrument through the further clinical studies and discussions.