• 제목/요약/키워드: Internal Acting

검색결과 181건 처리시간 0.023초

LPG 엔진용 고압 핀틀노즐 내부유동 수치해석 (Prediction of the internal flow in a pintle nozzle for LPG engine)

  • 정홍철;김병철
    • 대한기계학회논문집B
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    • 제21권8호
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    • pp.1077-1085
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    • 1997
  • The use of "clean fuels" such as butane, propane, and mixtures of these (LPG) is an attractive way to reduce exhaust emissions. In this study internal flow of the pintle type injector for LPG engine is studied. The breakup of liquid jet is the result of competing, unstable hydrodynamic forces acting on the liquid jet as it exits the nozzle. The nozzle geometry and up-stream injection conditions affect the characteristics of flow inside the nozzle, such as turbulence and cavitation bubbles. A set of calculations of the internal flow in a pintle type nozzle were performed using a two dimensional flow simulation under different nozzle geometry and upstream flow conditions. The calculation showed that the turbulent intensity and discharge coefficient are related to needle leading angle(.alpha.) and needle lift.edle lift.

뒷굽이 있는 케이슨 안벽에 작용하는 토압에 대한 연구 (Study on Earth Pressure Acting Against Caisson Structure with the Heel)

  • 유건선
    • 한국해안·해양공학회논문집
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    • 제29권2호
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    • pp.67-76
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    • 2017
  • 본 연구에서는 케이슨 안벽의 뒷굽이 주동토압에 미치는 영향을 조사하였다. 한계해석법을 사용하여 뒷굽의 길이에 따라 벽면마찰력이 뒷굽 상부에서 발생하는 활동면의 경사각에 미치는 영향을 분석하였다. 분석결과 뒷굽의 길이가 짧을수록 내측 활동면의 경사각은 증가하나, 외측 활동면의 경사각은 일정하였다. 실제 케이슨 안벽에서 발생하는 파괴면에 작용하는 토압과 동일한 토압을 갖는 뒷굽 끝에서의 가상의 연직배면에 작용하는 토압에 대하여 뒷굽의 상대 길이-뒤채움 토사의 내부마찰각-벽면마찰각-가상의 연직배면에 작용하는 배면마찰각 등의 상관관계를 구하였다. 뒷굽이 짧을수록 케이슨 안벽에 작용하는 토압이 Rankine 토압보다는 작아지나 뒷굽의 길이를 고려하지 않은 Coulomb 토압보다는 항상 크게 나타났다.

흡입 스테로이드와 지속성 베타2 항진제의 병용요법으로 완전히 조절되지 않는 천식 환자에서 추가 montelukast의 효과 (The Efficacy of Added Montelukast in Persistent Asthmatics Who Were Not Completely Controlled on Inhaled Corticosteroids and Inhaled Long-acting β2-agonists)

  • 최정희;박해심;이관호;심재정;어수택;이상표;이용철;최원일;이재호;김주인;이명구;정기석
    • Tuberculosis and Respiratory Diseases
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    • 제63권4호
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    • pp.337-345
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    • 2007
  • 연구배경: 천식 치료의 근간을 이루고 있는 흡입용 스테로이드제에 대한 반응은 천식 환자마다 다양하다. 또한, 코르티코스테로이드가 천식의 기도염증에서 중요한 매개체인 류코트리엔을 효과적으로 억제하지 못하는 것으로 보고되었다. 이에 저자들은 흡입용 스테로이드와 지속성 베타2 항진제의 병용요법으로도 증상이 완전히 조절되지 않는 지속성 천식 환자에서 montelukast를 추가하였을 때의 유효성을 평가하고자 하였다. 방법: 4주간의 준비기간을 거쳐서 흡입용 스테로이드와 지속성 베타2 항진제의 병용요법으로도 증상이 완전히 조절되지 않는 지속성 천식 환자 198명을 선정하여 8주 동안 montelukast 10mg 정을 1일 1회 취침 전 복용토록 하였다. ACQ 증상 점수와 $FEV_1%$ 치를 montelukast 치료 전후로 각각 측정하였으며, 치료 후에 환자와 연구자 각각 천식과 비염에 대하여 '호전되었음, 변화없음, 악화되었음' 중의 하나로 평가하도록 하였다. 결과: 8주간 montelukast를 추가한 후 ACQ 증상 점수의 평균 변화량은 -4.8점[95% CI (-5.7,-3.9)]으로, 유의하게 천식 증상이 호전됨을 보였다 (p<0.001). $FEV_1%$치는 증가하는 경향을 보였으나 통계적으로 유의하지는 않았다(p>0.05). 방문 2시점에서 시행한 천식에 대한 환자와 연구자의 종합 평가에서 각각 약 60%의 환자와 연구자가 '개선되었음'으로 평가하였으며(${\kappa}=0.85$), 비염의 종합 평가에서 각각 55%의 환자와 51%의 연구자가 '개선되었음'으로 평가하였다(${\kappa}=0.93$). 결론: 흡입용 스테로이드 및 지속성 베타2 항진제의 병용제제로도 천식증상이 완전히 조절되지 않는 중등증 이상의 지속성 천식 환자에서 류코트리엔 조절제의 추가는 천식의 조절을 향상시킬 수 있다.

인트라 베인식 油壓 베인펌프의 베인 先端部 潤滑모드 (The Lubrication Mode Between the Vane Tip and Camring in an Oil Hydraulic Vane Pump with Intravanes.)

  • Jung, Jae-Youn;Kyogoku, Keiji;N
    • Tribology and Lubricants
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    • 제6권1호
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    • pp.52-56
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    • 1990
  • The Lubrication Mode of line contacts between the vane and camring in an oil hydraulic vane pump with intravanes has been investigated. Variations of the radial acting force of a vane were calculated from previously measured results of dynamic internal pressure in four chambers surrounding a vane, and variations of the lubrication mode were estimated in both the rotational speed range from 500 to 1500 rpm and in the delivery pressure range from 1 to14 Mpa. The results indicate the variations of the radial acting force. It is found that the regimes of lubrication in the vane tip contacts cover rigid-isoviscous to rigid-variable viscosities.

쌍곡선포물선 대공간 구조물의 측벽개구율에 따른 지붕의 풍압특성 (Characteristic of Wind Pressure Distribution on the Roof of Hyperbolic Paraboloid Spatial Structures)

  • 유장열;유기표
    • 한국공간구조학회논문집
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    • 제13권1호
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    • pp.51-57
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    • 2013
  • There can be diverse causes in the destruction of a large space structure by strong wind such as characteristics of construction materials and changes in internal and external wind pressure of the structure. To evaluate the wind pressure of roof against the large space structure, wind pressure experiment is performed. However, in this wind pressure experiment, peak internal pressure coefficient is set according to the opening of the roof in Korea wind code. In this article, it was tried to identify the change of internal pressure coefficient and the characteristics of wind pressure coefficient acting on the roof by two kinds of opening on the side of the structure with Hyperbolic Paraboloid Spatial Structures roof. When analyzing internal pressure coefficient according to roof shape, it was found that minimum (52%) and maximum (30%~80%) overestimation was made comparing to partial opening type proposed in the current wind load. It is judged that evaluation according to the opening rate of the structure should be made to evaluate the internal pressure coefficient according to load.

갑상선 기능항진증에 대한 국내 한의약 실험연구 고찰 - 2000년 이후 (Review of Domestic Experimental Studies of Herbal Medicines for Hyperthyroidism since 2000)

  • 이민혜;전찬용;강미숙;최유경
    • 대한한방내과학회지
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    • 제37권6호
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    • pp.949-960
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    • 2016
  • Objectives: This study reviewed experimental studies on the effects of herbal medicines in treating hyperthyroidism. Methods: We analyzed the experimental studies of herbal medicines done in Korea to treat hyperthyroidism that have been reported since 2000 by searching 4 Korean databases with the keyword "hyperthyroidism". Results: Two single herbal medicines and 15 complex herbal medicines were used in 15 experimental studies. There was 1 clinical study and 14 nonclinical studies, among them, 2 in vitro experiments and 12 in vivo experiments. It was confirmed that the herbal medicines used have improving effects on hyperthyroidism by inhibiting the oversupplied thyroid hormones and hypermetabolic symptoms. Conclusions: There should be further studies on the antioxidative effects and acting mechanisms of herbal medicines and more clinical studies on hyperthyroidism.

연료노즐 내부유동 현상의 수치해석 (Calculation of the internal flow in a fuel nozzle)

  • 구자예;박장혁;오두석;정홍철
    • 대한기계학회논문집B
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    • 제20권6호
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    • pp.1971-1982
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    • 1996
  • The breakup of liquid jet is the result of competing, unstable hydrodynamic forces acting on the liquid jet as it exit the nozzle. The nozzle geometry and up-stream injection conditions affect the characteristics of flow inside the nozzle, such as turbulence and cavitation bubbles. A set of calculation of the internal flow in a single hole type nozzle were performed using a two dimensional flow simulation under different nozzle geometry and up-stream flow conditions. The calculation showed that the turbulent intensity and discharge coefficient are related to needle position. The diesel nozzle with sharp inlet under actual engine condition has possibility of cavitation, but round inlet nozzle has no possibility of cavitation.

Direct Switch from Tiotropium to Indacaterol/Glycopyrronium in Chronic Obstructive Pulmonary Disease Patients in Korea

  • Lee, Sang Haak;Rhee, Chin Kook;Yoo, Kwangha;Park, Jeong Woong;Yong, Suk Joong;Kim, Jusang;Lee, Taehoon;Lim, Seong Yong;Lee, Ji-Hyun;Park, Hye Yun;Moon, Minyoung;Jung, Ki-Suck
    • Tuberculosis and Respiratory Diseases
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    • 제84권2호
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    • pp.96-104
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    • 2021
  • Background: Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 ㎍ to indacaterol/glycopyrronium (IND/GLY) 110/50 ㎍ once daily in COPD patients in Korea. Methods: This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 ㎍ once daily for ≥12 weeks prior to study initiation. Patients aged ≥40 years, with predicted post-bronchodilator forced expiratory volume in 1 second (FEV1) ≥50%, post-bronchodilator FEV1/forced vital capacity <0.7 and smoking history of ≥10 pack-years were included. Eligible patients were randomized in a 1:1 ratio to either IND/GLY or TIO. The primary objective was to demonstrate superiority of IND/GLY over TIO in pre-dose trough FEV1 at week 12. Secondary endpoints included transition dyspnea index (TDI) focal score, COPD assessment test (CAT) total score, and rescue medication use following the 12-week treatment, and safety assessment. Results: Of the 442 patients screened, 379 were randomized and 347 completed the study. IND/GLY demonstrated superiority in pre-dose trough FEV1 versus TIO at week 12 (least squares mean treatment difference [Δ], 50 mL; p=0.013). Also, numerical improvements were observed with IND/GLY in the TDI focal score (Δ, 0.31), CAT total score (Δ, -0.81), and rescue medication use (Δ, -0.09 puffs/day). Both treatments were well tolerated by patients. Conclusion: A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation.

기미론에 대한 문헌적 연구 (A study on the literal research kimi - theory)

  • 김인락
    • 한국한의학연구원논문집
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    • 제3권1호
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    • pp.169-181
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    • 1997
  • Kimi(氣味) means five tastes(五味), sour, bitterness, sweetness, hot taste and astringency, and four conditions(四氣), cold, hot, warm and cool, in the oriental medicine. This is defined based on yn-yang 5 evolutive phasis(陰陽五行), and 5 evolutive phasis on the change of season. Four seasons, spring, summer, autumm, winter are clearly different but, the rainy season(長夏) is not. In the thee of Ki (氣), not worm not hot(平) is included in addition to the four conditions that is because the rainy season is not differentiated clearly. KImi have realations to the four seasons, that is, warm and hot taste is considered as spring, hot and astringency as summer, not worm not hot and sweetness as rainy season, cool and sour as autumm, and cold and bitterness as winter. 4 conditions can be classified more detail, because the changes of the seasons are continuous. In the action mechanisms, Gardeniae Fructus reduces Heat of Insufficency Type(虛熱) of the upper class of medicinal herbs(上焦), and Rhel Rhizoma reduces Exessive Heat(實熱) of the under class of them(下焦). The assay methods for four groups medicines can be developed in three ways according to the indicators as follows. First, by the indicator which defines cold-acting medicine(寒性藥) such as Rhei Rhizoma, Coptidis Rhizoma, Scutellariae Radix, Gardeniae Fructus and is differentiated clearly from Hot-acting medicine(熱性藥) at the same time. Second, when the medicines are classified into another four groups as Drugs for Dispelling Internal Cold(溫裏藥), Drugs for Relieving Exterior Syndrome(解表藥), Drugs for Dispelling Phlegm(祛痰藥), Drugs for Regulatings Ki Flow(理氣藥), by the indicator which satisfies each group and is differentiated from other groups, at the same time. Third, by the indicator which has to be defined for each medicinal herb for four classification, individually.

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Outcome of Inhaler Withdrawal in Patients Receiving Triple Therapy for COPD

  • Kim, Sae Ahm;Lee, Ji-Hyun;Kim, Eun-Kyung;Kim, Tae-Hyung;Kim, Woo Jin;Lee, Jin Hwa;Yoon, Ho Il;Baek, Seunghee;Lee, Jae Seung;Oh, Yeon-Mok;Lee, Sang-Do
    • Tuberculosis and Respiratory Diseases
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    • 제79권1호
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    • pp.22-30
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    • 2016
  • Background: The purpose of this study was to document outcomes following withdrawal of a single inhaler (step-down) in chronic obstructive pulmonary disease (COPD) patients on triple therapy (long-acting muscarinic antagonist and a combination of long-acting ${\beta}2$-agonists and inhaled corticosteroid), which a common treatment strategy in clinical practice. Methods: Through a retrospective observational study, COPD patients receiving triple therapy over 2 years (triple group; n=109) were compared with those who had undergone triple therapy for at least 1 year and subsequently, over 9 months, initiated inhaler withdrawal (step-down group, n=39). The index time was defined as the time of withdrawal in the step-down group and as 1 year after the start of triple therapy in the triple group. Results: Lung function at the index time was superior and the previous exacerbation frequency was lower in the step-down group than in the triple group. Step-down resulted in aggravating disease symptoms, a reduced overall quality of life, decreasing exercise performance, and accelerated forced expiratory volume in 1 second ($FEV_1$) decline ($54.7{\pm}15.7mL/yr$ vs. $10.7{\pm}7.1mL/yr$, p=0.007), but there was no observed increase in the frequency of exacerbations. Conclusion: Withdrawal of a single inhaler during triple therapy in COPD patients should be conducted with caution as it may impair the exercise capacity and quality of life while accelerating $FEV_1$ decline.