• 한국환경보건학회지
• /
• 제35권3호
• /
• pp.214-219
• /
• 2009

This study examined the removal efficiency of the nitrogen and phosphorus in order to compensate for the combined process of ATAD(Autothermal Thermophilic Aaerobic Digestion) and EGSB(Expended Granular Sludge Bed), which are treatment methods for livestock wastewater, by introducing SBR(Sequencing Batch Reactor) as post-treatment process. The analysis on the treatment efficiency of each operation mode showed that, in the case of T-N, the treatment efficiency were 67.1% and 74.2% for Run-1 and Run-2, respectively, and in the case of T-P, the values were 71.2 and 74.1, respectively, which are indicating that the treatment efficacy is higher in the condition of Run-1, in which the time period of Anoxic and Aerobic segments were increased. In addition, the result of analyzing removal characteristics of nitrogen and phosphorus by Influx load showed that removal efficiency of nitrogen was better in the case of high influx load than in the case of low influx load. Regardless of Influx load, phosphorus showed constant influx concentration, so that removal efficiency of phosphorus was influenced littler by Influx load than that of nitrogen. This study also fed methanol as an external carbon source and performed experiment to induce denitrification under anoxic condition by using nitrate among nitrogen compounds of SBR reactor, and the results showed that intermittent feeding was more effective in Nitrogen Removal than composite feeding.

• 산업식품공학
• /
• 제13권4호
• /
• pp.243-250
• /
• 2009

프라바스타틴 나트륨은 HMG-CoA(3-hydroxy-3-methylglutaryl coenzyme A) 환원효소 저해제로서, 콜레스테롤 생합성의 초기 율속단계(rate-limiting step)에 작용하여 메 발로네이트(mevalonate)의 합성을 저해하는 광범위한 고지혈증 치료제이다. 본 연구에서는 효율적 발효와 고품질의 정제를 통한 생산성 향상을 위해 수행하였다. 프라바스타틴 나트륨의 경쟁력있는 생산성 향상을 위하여 Streptomyces carbophilus KCCM 10370을 UV 돌연변이 처리하여 프라바스타틴 나트륨의 생산량을 약 45배 향상시키는 S. carbophilus K-212(KCCM 10370) 선별하였다. 생산성을 극대화시키기 위하여 콤팩틴 나트륨의 연속식 투입이 회분식 투입보다 생산량이 24%, 전환율 4.3%로 향상 되었으며, 본배양에서 콤팩틴 나트륨의 농도를 연속적으로 투입하여 0.1%(w/v) 이하로 유지시켜 프라바스타틴 나트륨의 생산량이 0.49%, 전환율 70%로 확인하였다. 발효가 종료된 후 배양액을 Diaion HP20 수지 컬럼, 분배(Partition), 그리고 ODS(Octa-Decylsilyl Silicagel) 수지 컬럼 크로마토 그래피를 하여 유럽약전기준(EP)에 적합한 순도 99.7% 이상, 70~72%의 수율이었다. 프라바스타틴 나트륨을 적외부스펙트럼측정법, 자외부스펙트럼측정법, 수소핵자기공명스펙트럼측정법 및 탄소핵자기공명스펙트럼측정법으로 분석한 결과 유럽약전기준(EP)과 일치하였다.

• KSBB Journal
• /
• 제19권5호
• /
• pp.410-414
• /
• 2004

Fed-batch cultures of Enterococcus faecalis RKY1 were performed to maximize the L(+)-Iactic acid concentration in the bioreactor. The highest lactic acid concentration was obtained at around 225 g/L by intermittent feeding the concentrated glucose media containing 500 g/L of glucose and 15 g/L (or 75 g/L) of yeast extract. However, in all fed-batch cultures, volumetric productivities of lactic acid gradually decreased due to the inhibitory effect of lactic acid produced during the fermentation. The highest value of lactic acid concentration obtained in this work corresponded to around 1.5-fold increase compared with conventional batch fermentation.

• 대한수의학회지
• /
• 제49권4호
• /
• pp.365-368
• /
• 2009

A six-year-old female cocker spaniel presented with recurring episodes of pelvic limb weakness and intermittent seizures. Laboratory analysis revealed marked hypoglycemia and an elevated serum insulin concentration. A pancreatic beta-cell tumor at stage III ($T_1N_1M_1$) was diagnosed based on serial blood glucose and insulin measurements along with diagnostic imaging. The patient survived for 140 days after diagnosis with medical management, including frequent feeding and prednisolone therapy. On necropsy, necrosis and masses in the peripancreatic omentum and liver were found; pancreatic beta-cell neoplasia with metastasis to the liver was confirmed by histopathologic examination. This case reports hyper-insulinism in a dog presenting with hypoglycemic seizures.

• 대한유전성대사질환학회지
• /
• 제2권1호
• /
• pp.7-11
• /
• 2002

저자들은 잘 교정되지 않는 대사성 산혈증을 주소로 내원한 3세된 남아와 원인 모르는 기면과 구토로 5차례 입원했던 과거력을 가진 8세된 남아 형제가 유기산 분석에서 isovalerylglycine의 현저한 증가를 보여 만성 간헐형의 isovaleric acidemia로 진단된 예와 탄뎀질량분석검사에서 isovaleric acidemia로 진단되어 조기치료하고 있는 예를 경험하였기에 보고하는 바이다.

• Journal of Chest Surgery
• /
• 제27권6호
• /
• pp.489-493
• /
• 1994

Our patient was a 2.3 kg, male of 33 weeks gestation and spontaneous vaginal delivery. Copious salivary secretion, mild aspiration pneumonia episode due to tracheoesophageal fistula and intermittent cyanotic appearance due to hypoxia were noted shortly after birth. Head up position, frequent upper pouch suction, and adequate fluid and antibiotic therapy were done in incubator. Combined Chest and abdominal film was revealed gas in the stomach and an haziness in right chest with mediastinal shift to the right side. Esophagogram revealed markedly dilated proximal esophagus as blind pouch, and Two dimensional echocardiography showed the Ventricular Septal Defect. The conclusion was congenital esophageal atresia with tracheoesophageal fistula, Vogt-Gross type C, Waterston Risk Category B. Surgical correction with Beardmore anastomosis was performed extrapleurally through 3rd rib bed after the cannulation of umbilical vein and preliminary gastrostomy. The fistula was closed by triple ligation and the upper pouch was then brought down to the presenting surface of the lower esophageal segment that incised, and end to side anastomosis was underwent using interrupt suture placed through the full thickness of both upper pouch and lower esophageal segment. The postoperative patient was well tolerated and recovered uneventfully, permitted feeding on 7th postoperative day after esophagogram.

• International Journal of Computer Science & Network Security
• /
• 제22권4호
• /
• pp.1-12
• /
• 2022

In order to overcome the power fluctuation issues in photovoltaic (PV) smart grid-connected systems and the inverter nonlinearity model problem, an adaptive backstepping command-filter and a double second order generalized Integrators (DSOGI) controller are designed in order to tune the AC current and the DC-link voltage from the DC side. Firstly, we propose to present the filter mathematical model throughout the PV system, at that juncture the backstepping control law is applied in order to control it, Moreover the command filter is bounded to the controller aiming to exclude the backstepping controller differential increase. Additionally, The adaptive law uses Lyapunov stability criterion. Its task is to estimate the uncertain parameters in the smart grid-connected inverter. A DSOGI is added to stabilize the grid currents and eliminate undesirable harmonics meanwhile feeding maximum power generated from PV to the point of common coupling (PCC). Then, guaranteeing a dynamic effective response even under very unbalanced loads and/or intermittent climate changes. Finally, the simulation results will be established using MATLAB/SIMULINK proving that the presented approach can control surely the smart grid-connected system.

• Journal of Nutrition and Health
• /
• 제7권4호
• /
• pp.1-5
• /
• 1974

이유(離乳)한 40마리의 Albino쥐에게 고단백(高蛋白)과 저단백(低蛋白) 사료(館料)를 간격(間隔)을 달리하여 교대(交代)로 급여(給與)하였을때 성장률(成長率), 사료효율(飼料效率), 단백질(驚白質) 효율(效率), 간장(肝臟)과 내장(內臟)의 무게, 단백질(蛋白質) 소화율(消化率), 질소균형(塞素均衡) 등(等)을 조사(調査)하였는데 그 결과(結果)를 요약(要約)하면 다음과 같다. 1. 1일(1日) 간격(間隔)으로 고단백질(高蛋白質)과 저단백질사료(低蛋白質飼料)를 교대(交代)로 급여(給與)한 B구(區)는 중단백질사료(中蛋白質飼料)를 매일(每日) 투여(給與)한 A구(區)와 성장률(成長率), 사료요구율(飼料要求率)에 아무런 효과(差異)가 없었다. 그러나 2일(日) 또는 3일간(日間) 저단백질(低蛋白質) 사료(飼料)를 급여(給與)한 다음 하루동안 고단백질(高蛋白質) 사료(飼料)를 급여(給與)하여도 중단백질(中蛋白質) 사료(飼料)를 매일(每日) 투여(給與)한 구(區)와 동일(同一)한 성장률(成長率)을 가져오지 못하였다. 2. 각구간(各區間) 단백질(蛋白質) 효율(效率)에는 아무런 유의차(有意差)가 없었다. 3. 간중(肝重)은 체중(體重)에 비례(比例)하였으나 장중(腸重) 및 장장(腸長)은 각구(各區)간 차이(差異)가 없었다. 4. 각구간(各區間) 단백질(蛋白質)의 소화율(消化率)에는 유의차(有意差)가 없었으나 요중(尿中) 실소(室素) 배설(排懲)은 B, C, D 구(區)가 모두 A구(區)에 비(比)해 유의적(有意的)으로 컸으며 질소(窒素) 섭취량(攝取量)에 대(對)한 체내(體內) 섭취량(攝取量)도 질소(窒素) 섭취량(攝取量)이 많은 구(區)가 떨어졌다.

• 한국미생물·생명공학회지
• /
• 제20권1호
• /
• pp.73-78
• /
• 1992

Tryptophanase를 이용하여 트립토판 합성시 인돌의 효소활성 저해를 억제하기 위하여 유가식 조업, 유기용매 이상계의 사용, 그리고 cyclodextrin의 첨가등에 대하여 연구하였다. 효소 농도가 0.5mg/ml일때 인돌 농도 0.4mM 부근에서 트립토판 생성이 가장 빨랐으며 그 이상에서는 효소활성이 심한 저해를 받았다. 초기 인돌 농도가 20mM일 때는 27시간 반응후 인돌의 전환율이 20인데 비하여 반응기내 인돌 농도를 5mM 이하로 유가식 조업을 하였을 때 전환율이 80%로 향상되었다.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제32권3호
• /
• pp.242-245
• /
• 2010

Pierre Robin sequence (PRS) describes the clinical triad of micro- and/or retrognathia, glossoptosis and cleft soft palate. Glossopexy has been demonstrated to be an effective treatment in selected cases of obstruction caused by glossoptosis (generally 6 to 10 months of glossopexy period). If radiofrequency therapy (RF) can reduce tongue volume in PRS, it will be helpful in early releasing of the glossopexy. Two-dayold patient showed a PRS triad. Intermittent cyanosis, respiratory difficulty and feeding problems were also observed. The respiration was not improved and prolonged intubation increased the possibility of respiratory complications like pneumonia. The surgical intervention- glossopexy and RF was done 20 days after birth. We applied RF combined with conventional glossopexy and could get successful results while reducing the overall treatment time to 6 weeks. The follow-up until 12 months after birth was uneventful. Considering that early recovery is highly beneficial to PRS patients by reducing risks associated with glossopexy and low energy RF application is very simple and low risk to patient, our combination therapy should be considered for the treatment of airway problem related to PRS.