A micropapillary variant of urothelial carcinoma (MPC) is a distinct entity with an aggressive clinical course. It has a micropapillary configuration resembling that of ovarian papillary serous carcinoma. Its cytologic features have rarely been reported. We report a case of MPC detected by urine cytology. A woman aged 93 years presented with a chief complaint of macroscopic hematuria. Cytology of her voided urine showed clusters of malignant cells in a micropapillary configuration. Each tumor cell had a vacuolated cytoplasm, a high nuclear:cytoplasmic ratio, and irregular hyperchromatic nuclei. An ureteroscopic examination revealed exophytic sessile papillary masses extending from the left lateral wall to the anterolateral wall of the urinary bladder. A transurethral resection of the tumor was carried out. The tumor was characterized by delicate papillae with a thin, well-developed fibrovascular stromal core and numerous secondary micropapillae lined with small cuboidal cells containing uniform low- to intermediate-grade nuclei and occasional intracytoplasmic mucinous inclusions. These tumor cells infiltrated the muscle layers of the bladder, and lymphatic tumor emboli were frequently seen. Recognizing that the presence of MPC components in urinary cytology is important for distinguishing this lesion from low-grade papillary lesions and high-grade urothelial carcinomas can result in early detection and earlier treatment for an improved treatment outcome.
KIM, JEONG DONG;AHN, SANGJOON;LEE, YONG DEOK;PARK, CHANG JE
Nuclear Engineering and Technology
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v.47
no.3
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pp.380-387
/
2015
A lead slowing-down spectrometer (LSDS) system is a promising nondestructive assay technique that enables a quantitative measurement of the isotopic contents of major fissile isotopes in spent nuclear fuel and its pyroprocessing counterparts, such as $^{235}U$, $^{239}Pu$, $^{241}Pu$, and, potentially, minor actinides. The LSDS system currently under development at the Korea Atomic Energy Research Institute (Daejeon, Korea) is planned to utilize a high-flux ($>10^{12}n/cm^2{\cdot}s$) neutron source comprised of a high-energy (30 MeV)/high-current (~2 A) electron beam and a heavy metal target, which results in a very intense and complex radiation field for the facility, thus demanding structural shielding to guarantee the safety. Optimization of the structural shielding design was conducted using MCNPX for neutron dose rate evaluation of several representative hypothetical designs. In order to satisfy the construction cost and neutron attenuation capability of the facility, while simultaneously achieving the aimed dose rate limit (< $0.06{\mu}Sv/h$), a few shielding materials [high-density polyethylene (HDPE)eBorax, $B_4C$, and $Li_2CO_3$] were considered for the main neutron absorber layer, which is encapsulated within the double-sided concrete wall. The MCNP simulation indicated that HDPE-Borax is the most efficient among the aforementioned candidate materials, and the combined thickness of the shielding layers should exceed 100 cm to satisfy the dose limit on the outside surface of the shielding wall of the facility when limiting the thickness of the HDPE-Borax intermediate layer to below 5 cm. However, the shielding wall must include the instrumentation and installation holes for the LSDS system. The radiation leakage through the holes was substantially mitigated by adopting a zigzag-shape with concrete covers on both sides. The suggested optimized design of the shielding structure satisfies the dose rate limit and can be used for the construction of a facility in the near future.
Journal of the Korean Society of Manufacturing Process Engineers
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v.18
no.1
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pp.59-64
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2019
In recent years, the HP-CRTM method, which has the ability to produce carbon fiber-reinforce plastic composites at high speeds, has come into the spotlight in the automotive parts industry, which demands high productivity. Multi-axial carbon fabric, an intermediate material used in this HP-CRTM molding process, consists of layered fibers without crimp, which makes it better in terms of tensile and shear strength than the original woven fabrics. The NCF (non-crimp fabric) can form the layers of the carbon fiber, which have different longitudinal and lateral directions, and ${\pm}{\theta}$ degrees, depending on the product's properties. In this research, preforms were made with carbon fibers of ${\pm}45^{\circ}$ and $0/90^{\circ}$, which were lamination structures under seven different conditions, in order to create the optimal laminated structure for automobile reinforcement center floor tunnels. Carbon fiber composites were created using each of the seven differently laminated preforms, and polyurethane was used as the base material. The specimens were manufactured in accordance with the ASTM D3039 standards, and the effect of the NCF lamination structure on the mechanical properties was confirmed by a tensile test.
Alloy 617 is a Ni-base superalloy and a candidate material for the intermediate heat exchanger (IHX) of a very high temperature gas reactor (VHTR) which is one of the next generation nuclear reactors under development. The high operating temperature of VHTR enables various applications such as mass production of hydrogen with high energy efficiency. Alloy 617 has good creep resistance and phase stability at high temperatures in an air environment. However, it was reported that the mechanical properties decreased at a high temperature in an impure helium environment. In this study, high-temperature corrosion tests were carried out at $850^{\circ}C-950^{\circ}C$ in a helium environment containing the impurity gases $H_2$, CO, and $CH_4$, in order to examine the corrosion behavior of Alloy 617. Until 250 h, Alloy 617 specimens showed a parabolic oxidation behavior at all temperatures. The activation energy for oxidation in helium environment was 154 kJ/mol. The SEM and EDS results elucidated a Cr-rich surface oxide layer, Al-rich internal oxides and depletion of grain boundary carbides. The thickness and depths of degraded layers also showed a parabolic relationship with time. A normal grain growth was observed in the Cr-rich surface oxide layer. When corrosion tests were conducted in a pure helium environment, the oxidation was suppressed drastically. It was elucidated that minor impurity gases in the helium would have detrimental effects on the high-temperature corrosion behavior of Alloy 617 for the VHTR application.
Journal of the Korea Society of Computer and Information
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v.28
no.3
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pp.1-9
/
2023
In this paper, we identify the factors that hinder the application of quantum computing technology to solve meaningful real-world problems, and suggest related research trends and directions. To this end, we summarize the basic knowledge of quantum mechanics from the perspective of computer science, which is necessary to understand the difficulties in applying quantum computing technology, and analyze the currently commercialized quantum computers and quantum programming layers from the literature. Through an analysis of the current status and utilization of cloud-based commercial quantum computing services, we identify four factors that currently hinder the practical application of quantum computing: high barriers to entry for quantum computer programming, constraints on noisy intermediate-scale quantum computers, a still-growing open source ecosystem, and difficulties in simulating realistic problem sizes, and suggest trends and directions for related research. In doing so, it is expected to contribute to laying the groundwork for practical applications of quantum computing technology.
To realize the U-healthcare system, the mobile patient monitoring system is of the essence. In this monitoring system, a patient's real-time data on biometrics and location must be transferred to predeterminate destination server ceaselessly. As the number of mobile patients increases steadily or mobile patients are moving into some specific area, the load balancing solution to real-time data congestion problem is needed. In this paper, we propose a new mobile patient monitoring system with Torus topology where three layers are connected hierarchically and the intermediate layer takes charge of priority-based load balancing. For the formalized design and verification of proposed system, we describe the overall structure with connectivity among its components and implement major components in pseudo-code by adopting a system specification-based approach. This approach makes the design and verification of our mobile patient monitoring system more flexible and accurate.
Journal of the Korean Society for Marine Environment & Energy
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v.10
no.3
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pp.155-166
/
2007
We carried out a study on the marine environment, such as water temperature, salinity, density and chlorophyll ${\alpha}$, and the distribution of phytoplankton community, such as species composition, dominant species and standing crops in the Southwestern Sea of Korea during early summer 2005. According to the analysis of a T-S diagram, three characteristics of water masses were identified. We classified them into Korean and Chinese coastal water, the cold water and the oceanic water. The first was characterized by high temperature and low salinity in the surface layer influenced by river run offs from China and Korea, the second by low temperature and salinity in bottom layer originated from the bottom cold water of the Yellow Sea, and the third by high temperature and high salinity influenced by Tsushima warm currents. The internal discontinuous layer among them was formed at the intermediate depth (about $10{\sim}20\;m$ layer). And the thermal front appeared in the central parts between Tsushima warm currents and Korean and Chinese coastal waters in the Southwestern Sea of Korea. Chlorophyll ${\alpha}$ concentration was high values in the Korean coastal waters and sub-surface layers. But It was low concentration in the Tsushima warm currents regions. The $Chl-{\alpha}$ maximum layers appeared in the sub-surface layer below thermocline. The phytoplankton community in the surface and stratified layers was composed of a total of 40 species belonging to 26 genera. Dominant species were 2 diatoms, Paralia sulcata, Skeletonema costatum and a dinoflagellate, Scripsiella trochoidea. Standing crops of phytoplankton in the surface layer were very low with cell density ranging from 5 to $3.8\;{\times}\;10^3\;cells/L$. Diatoms were controlled by the expanded low salinity coastal waters of the low salinity with high concentrations of nutrients. Otherwise phytoflagellates were dominant in the high temperature regions where the Tsushima warm currents approches the Southwestern Sea of Korea in early summer.
This study intended to compare the productive performance of three different layer raising systems; conventional cage (CC), barn (BR) and aviary (AV). The AV is welfare bestowed housing that allows free locomotion for birds within the BR. The BR allows bird's free locomotion inside BR but without multilevel structures. Both pullets and cockerels were housed together in both AV and BR, but only pullets in CC. Seventeen weeks old Lohmann Brown Lite (n = 800) pullets were housed in AV during this study. The same age layer pullets were simultaneously assigned to either at CC or BR to compare egg production performance with AV. The duration of experiment was 40 weeks (from 21st to 60th week). There were no remarkable differences in egg production, hen day egg production (HDEP) and average egg weight among three rearing systems. First 20 weeks (phase-1) average HDEP (%) of AV, CC, and BR were 85.9, 88.8, 87.1 and average egg weights (g) were 57.5, 59.9, and 56.9 respectively. Those of the remaining 20 weeks (phase-2) were 87.1, 87.9, 85.5 and 64.2, 63.0 62.1, respectively. Daily feed intakes (122 g, 110 g, 125 g); feed conversion ratio (2.4, 2.1, 2.5) and daily egg mass (53.9 g, 54.4 g, 52.8 g) data from AV, CC, and BR were not influenced significantly by the respective raising systems. Daily feed intake of layers in both AV (124 g) and BR (127 g) tended to be higher than that in CC (113 g) during phase-2. Overall, exterior egg quality (dirty and cracked eggs) in both phases was superior in BR compared with AV and CC, whereas CC generated intermediate results. This study indicated that the HDEP per se in AV and BR were not significantly different from that in CC. The study implied that the facility depreciation cost for AV and cost for increased feed intake in AV compared to CC are believed to be critical to evaluate the cost effectiveness of egg production in AV.
Recently 5G technology is one of the technologies that has been receiving much positive responses from users as it is integrated with virtual technology. However, 5G's security issues have not been fully resolved and more security is soon required. In this paper, an approach technique is proposed as a probability-based hierarchy to provide personal privacy for 5G-based IoT users more safely. The proposed technique is aimed at not exposing the privacy of IoT users to third parties by using two random keys created personally by IoT users. In order to satisfy both safety and efficiency, the proposed technology divides the privacy of IoT users into two layers. In the first stage, IoT users will control access to intermediate media using anonymous keys generated by IoT users, and in the second stage, information of IoT users registered with servers will be darkened and replicated. The proposed technique has improved the accuracy of the privacy protection of IoT users as they assign weights to layered information after layering users' privacy information on a probabilistic basis.
Lee, Ju Myeong;Baek, Seung Beom;Lee, Kang Hoon;Kim, Jo Soon;Jeong, Jin Hoon
International Journal of Highway Engineering
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v.19
no.3
/
pp.31-43
/
2017
PURPOSES : The objective of this study is to verify the effect of fiber grid reinforcement on the long-term performance of asphalt pavement overlaid on old concrete pavement by performing field investigation, laboratory test, and finite element analysis. METHODS : The reflection cracking, roughness, and rutting of fiber grid reinforced overlay sections and ordinary overlay sections were compared. Cores were obtained from both the fiber grid reinforced and ordinary sections to measure bonding shear strength between the asphalt intermediate and asphalt overlay layers. Fracture energy, displacement after yield, shear stiffnesses of the cores were also obtained by analyzing the test results. Finite element analysis was performed using the test results to validate the effect of the fiber grid reinforcement on long-term performance of asphalt pavement overlaid on the old concrete pavement. The fatigue cracking and reflection-cracking were predicted for three cases: 1) fiber grid was not used; 2) glass fiber grid was used; 3) carbon fiber grid was used. RESULTS : The reflection-cracking ratio of fiber grid reinforced sections was much smaller than that of ordinary sections. The fiber grid reinforcement also showed reduction effect on rutting while that on roughness was not clear. The reflection-cracking was not affected by traffic volume but by slab deformation and joint movement caused by temperature variation. The bonding shear strength of the fiber grid reinforced sections was larger than that of the ordinary sections. The fracture energy, displacement after yield, and shear stiffnesses of the cores of the fiber grid reinforced sections were also larger than those of the ordinary sections. Finite element analysis results showed that fatigue cracking of glass or carbon fiber grid reinforced pavement was much smaller than that of ordinary pavement. Carbon fiber grid reinforcement showed larger effect in elongating the fatigue life of the ordinary overlay pavement compared to glass fiber grid reinforcement. The binder type of the overlay layer also affected the fatigue life. The fiber grid reinforcement resisted reflection-cracking and the carbon fiber grid showed the greater effect. CONCLUSIONS :The results of field investigation, laboratory test, and finite element analysis showed that the fiber grid reinforcement had a better effect on improving long-term performance of asphalt pavement overlaid on the old concrete pavement.
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