• Journal of the Institute of Electronics and Information Engineers
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• v.54 no.8
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• pp.3-11
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• 2017

Research and development are being conducted to apply low-power Bluetooth (BLE) technology to IoT (Internet of Things) applications. The characteristic of this application environment is that many piconets can operate in the same space. Therefore, interference between homogeneous networks is likely to occur. In the BLE data channel, adaptive frequency hopping (AFH) scheme is used among the 37 frequency channels, and the master and the slave communicate while changing the carrier frequency. If there are multiple BLE piconets in the same space, there is a risk of frequency collision and packet errors will occur. In this paper, we analyze the packet collision probability due to cochannel interference in multiple asynchronous BLE piconet environments. Specifically, we analyzed packet collision probability according to the number of concurrently operating BLE piconets with the ratio of connection interval to connection event length as the main parameters. The analysis result can be used to set connection event related parameters for a desired packet collision probability according to the number of users having BLE devices in a given space.

• Corrosion Science and Technology
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• v.11 no.3
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• pp.77-81
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• 2012

Cathodic protection(CP) is widely used as a means of protecting corrosion for not only marine structures like ship hulls and offshore drilling facilities, but also underground structures like buried pipelines and oil storage tanks. The principle of CP is that the anodic dissolution of metal can be protected by supplying electrons to the cathode metal. When unprotected structures are nearby to CP systems, interference problems between unprotected and protected structures may be happened. The stray current interference can accelerate the corrosion of nearby structures. So far many efforts have been made to reduce the interference in the electric railway systems adjacent to the underground metal structures like buried pipelines and gas/oil tanks. During recent few decades the protection technologies against stray current induced corrosion have been significantly improved and a number of techniques have been developed. However, there is very limited information an marine environments. Some complex harbor structures are protected by two cathodic protection systems, i.e. sacrificial anode cathodic protection(SACP) and impressed current cathodic protection(ICCP). In this case, when the protection current from sacrificial anodes returns to the cathode through electrolyte, it passes through nearby other low resistance metal structures. In many cases the stray current of ICCP systems influences the function of SACP. In this study, the risk of stray current from the SACP system to adjacent reinforced concrete structures has been verified through laboratory experiments. Concrete and steel pile structures modeled a part of bridge have been investigated in terms of CP potential and current between the two. The variation of stray current according to the magnitude of ICCP/SACP has been studied to mitigate it and to suggest the proper protection criteria.

• The Korean Journal of Air & Space Law and Policy
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• v.24 no.2
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• pp.3-17
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• 2009

The Rome Convention System (1933, 1952, 1978) which deal the third party lability relating to damage caused by aircraft to third parties on the surface have not been so effective and successful like the Warsaw Convention System. This paper briefs the development of the Rome Convention System and the reasons of their failure which are the low level of the limit of liability and non-parties of major civil aviation states such as the United States, the United Kingdom, Japan, Germany and etc. The Diplomatic Conference hosted by ICAO at Montreal during April 20 to May 2 has successfully produced two Conventions; One is Convention on Compensation for Damage Caused by Aircraft to Third Parties (General Risk Convention), the other is Convention on Compensation for Damage to Third Parties, Resulting from Acts of Unlawful Interference involving Aircraft (Unlawful Interference Convention). The major contents and some problems of these two Conventions are reviewed in comparison with the exisiting Rome Convention System and other legal system. Particularly, the entrance into force of the Unlawful Interference Convention may take some time, at least more than 5 years, due to the realistic problems arising from the operation of International Civil Aviation Fund.

• Toxicological Research
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• v.28 no.2
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• pp.81-91
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• 2012

Many risk factors exist for chemotherapy-induced nausea and vomiting (CINV). This study utilized a multivariate projection technique to identify which risk factors were predictive of CINV in clinical practice. A single-centre, prospective, observational study was conducted from January 2007~July 2010 in Singapore. Patients were on highly (HECs) and moderately emetogenic chemotherapies with/without radiotherapy. Patient demographics and CINV risk factors were documented. Daily recording of CINV events was done using a standardized diary. Principal component (PC) analysis was performed to identify which risk factors could differentiate patients with and without CINV. A total of 710 patients were recruited. Majority were females (67%) and Chinese (84%). Five risk factors were potential CINV predictors: histories of alcohol drinking, chemotherapy-induced nausea, chemotherapy-induced vomiting, fatigue and gender. Period (ex-/current drinkers) and frequency of drinking (social/chronic drinkers) differentiated the CINV endpoints in patients on HECs and anthracycline-based, and XELOX regimens, respectively. Fatigue interference and severity were predictive of CINV in anthracycline-based populations, while the former was predictive in HEC and XELOX populations. PC analysis is a potential technique in analyzing clinical population data, and can provide clinicians with an insight as to what predictors to look out for in the clinical assessment of CINV. We hope that our results will increase the awareness among clinician-scientists regarding the usefulness of this technique in the analysis of clinical data, so that appropriate preventive measures can be taken to improve patients' quality of life.

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• v.2 no.3
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• pp.210-218
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• 2021

Recently, pest-resistant living modified (LM) crops developed using RNA interference (RNAi) technology have been imported into South Korea. However, the potential adverse effects of unintentionally released RNAi-based LM crops on non-target species have not yet been reported. Coccinella septempunctata, which feeds on aphids, is an important natural enemy insect which can be exposed to the double-stranded RNA (dsRNA) produced by RNAi-based LM plants. To assess the risk of ingestion of Snf7 dsRNA by C. septempunctata, we first identified the species through morphological analysis of collected insects. A method for species identification at the gene level was developed using a specific C. septempunctata 12S rRNA. Furthermore, an experimental model was devised to assess the risk of Snf7 dsRNA ingestion in C. septempunctata. Snf7 dsRNA was mass-purified using an effective dsRNA synthesis method and its presence in C. septempunctata was confirmed after treatment with purified Snf7 dsRNA. Finally, the survival rate, development time, and dry weight of Snf7 dsRNA-treated C. septempunctata were compared with those of GFP and vATPase A dsRNA control treatments, and no risk was found. This study illustrates an effective Snf7 dsRNA synthesis method, as well as a high-concentration domestic insect risk assessment method which uses dsRNA to assess the risk of unintentional released of LM organisms against non-target species.

• Journal of the Korean Institute of Gas
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• v.15 no.2
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• pp.40-46
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• 2011

The purpose of CBA(cost-benefit analysis) in risk assessment is to show whether the benefits of implementing additional risk reduction methods(RRMs) derived through risk assessment outweigh its costs and it is proper to implement the methods. In this paper CBA has been conducted in order to select the most effective and reasonable RRM as implementing the RRM derived after QRA for the high pressure urban gas pipelines. As conducting QRA again by applying the derived RRMs, No. 10 measure which includes pipeline corrosion monitoring, MOV(motor operated valve) installation and the method to protect pipeline damage caused by third-party mechanical interference has showed the highest risk reduction effect. Also it has been considered to be reasonably practicable by conducting CBA and then is selected as the most effective and reasonable RRM on the objects of this paper.

• Journal of Plant Biotechnology
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• v.46 no.3
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• pp.205-216
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• 2019

Since the RNA interference (RNAi) had been discovered in many organisms, small non-coding RNA-mediated gene silencing technology, including RNAi have been widely applied to analysis of gene function, as well as crop improvement. Despite the usefulness of RNAi technology, RNAi transgenic crops have various potential environmental risks, including off-target and non-target effects. In this study, we developed methods that can be effectively applied to environmental risk assessment of RNAi transgenic crops and verified these methods in 35S::dsRNAi_eGFP rice transgenic plant we generated. Off-target genes, which can be non-specifically suppressed by the expression of dsRNAi_eGFP, were predicted by using the published web tool, pssRNAit, and verified by comparing their expressions between wild-type (WT) and 35S::dsRNAi_eGFP transgenic rice. Also, we verified the non-target effects of the 35S:: dsRNAi_eGFP plant by evaluating horizontal and vertical transfer of small interfering RNAs (siRNAs) produced in the 35S::dsRNAi_eGFP plant into neighboring WT rice and rhizosphere microorganisms, respectively. Our results suggested that the methods we developed, could be widely applied to various RNAi transgenic crops for their environmental risk assessment.

• Journal of the Korean Institute of Gas
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• v.18 no.3
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• pp.60-66
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• 2014

In this study, the overseas failure frequency data of the high-pressure gas pipeline were investigated to apply QRA of high-pressure gas pipeline. The typical overseas failure frequency data of high-pressure gas pipeline are DOT of United States, EGIG of Europe, and UKOPA of United Kingdom (UK). Comparative analysis of these data was shown that EGIG data was suitable for the situation in Korea. In order to apply QRA of high-pressure gas pipeline, non-linear regression analysis using the failure frequency data in the report of EGIG 8th was performed. In the future, intensive researches are required for the external interference because about 50% of the failure frequency of all incidents is the external interference, and for combining of domestic and overseas data.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2813-2818
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• 2012

Background: Considerable evidence suggests that metadherin (MTDH) is a potentially crucial mediator of tumor malignancy and an important therapeutic target for simultaneously enhancing chemotherapy efficacy and reducing metastasis risk. Inhibition of MTDH expression by RNA interference has been shown in several previous research, but silencing MTDH expression by microRNA (miRNA) interference in breast cancer has not been established. In the present study, we investigated the role of MTDH-miRNA in down-regulation of proliferation, motility and migration of breast carcinoma cells. Methods: Expression vectors of recombinant plasmids expressing artificial MTDH miRNA were constructed and transfected to knockdown MTDH expression in MDA-MB-231 breast cancer cells. Expression of MTDH mRNA and protein was detected by RT-PCR and Western blot, respectively. MTT assays were conducted to determine proliferation, and wound healing assays and transwell migration experiments for cell motility and migration. Results: Transfection of recombinant a plasmid of pcDNA-MTDH-miR-4 significantly suppressed the MTDH mRNA and protein levels more than 69% in MDA-MB-231 breast cancer cells. This knockdown significantly inhibited proliferation, motility and migration as compared with controls. Conclusions: MTDH-miRNA may play an important role in down-regulating proliferation, motility and migration in breast cancer cells, and should be considered as a potential small molecule inhibitor therapeutic targeting strategy for the future.

• Journal of the Korean Institute of Gas
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• v.4 no.3 s.11
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• pp.26-32
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• 2000

Because of the continuous growth of energy consumption, and also the tendency to site power lines and pipelines along the same routes, the close proximity of high voltage structures and metallic pipelines has become more and more frequent. Moreover, normal steady state and fault currents become higher as electric networks increase in size and power Therefore, there has been and still is a growing concern(safety of people marking contact with pipeline, risk of damage to the pipeline coating, the metal and equipment connected to pipeline, especially cathodic protection system) about possible hazards resulting from the influence of high voltage power system on metallic structures(gas pipeline, oil pipeline and water pipeline etc.). Therefore, we analyze the interference problems when the gas pipeline is buried with power cable in the same submarine tunnel. This paper present the results of the study about interference mechanism, AC corrosion limitation of safety voltage and analysis of induction voltage.