• 한국동물학회지
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• 제15권1호
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• pp.15-21
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• 1972

두 케이스의 자궁암 조직을 배양하여 그들의 염색체를 구룹별로 분석한 결과는 아래와 같다. 1. 종족세포의 염색체수가 한 경우는 46이었고, 다른 한 환자에서는 60으로서 저3배성을 나타내었다. 2. 후자의 핵형을 구룹별로 분석한 결과, 구룹간의 염색체 분포는 non-random인 것으로 나타났다.

• 한국발생생물학회지:발생과생식
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• 제17권4호
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• pp.477-482
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• 2013

Science in the 21st century does not consider participants' welfare, safety and human rights in clinical studies, but modern science puts economic profits in its priority. This leads to a growing concern about social responsibility and professionalism ethics of companies, sponsors and scientists. Specifically, there is no way to control conflicts of participants' welfare with economic profits, leading to simply relying on individual ethics, social responsibilities and audit. This paper helps relevant agencies and people involved understand conflict of interest. Also this study presents the guidelines as well as independence, autonomy, ethical imagination and phronesis required for scientists.

• Diabetes and Metabolism Journal
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• 제42권6호
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• pp.465-471
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• 2018

My professional journey to understand the glucose homeostasis began in the 1990s, starting from cloning of the promoter region of glucose transporter type 2 (GLUT2) gene that led us to establish research foundation of my group. When I was a graduate student, I simply thought that hyperglycemia, a typical clinical manifestation of type 2 diabetes mellitus (T2DM), could be caused by a defect in the glucose transport system in the body. Thus, if a molecular mechanism controlling glucose transport system could be understood, treatment of T2DM could be possible. In the early 70s, hyperglycemia was thought to develop primarily due to a defect in the muscle and adipose tissue; thus, muscle/adipose tissue type glucose transporter (GLUT4) became a major research interest in the diabetology. However, glucose utilization occurs not only in muscle/adipose tissue but also in liver and brain. Thus, I was interested in the hepatic glucose transport system, where glucose storage and release are the most actively occurring.

• Journal of Species Research
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• 제6권spc호
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• pp.26-37
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• 2017

Rotifers collected from various terrestrial and aquatic habitats such as mosses on trees or rocks, tree barks, wet mosses and wet leaf litter at streams, and dry leaf litter at four different locations in Korea, were investigated. Thirteen species belonging to nine genera in five families of monogonont and bdelloid rotifers were identified: Bryceella perpusilla Wilts, Martinez Arbizu and Ahlrichs, 2010, Collotheca ornata (Ehrenberg, 1830), Habrotrocha flava Bryce, 1915, H. pusilla (Bryce, 1893), Macrotrachela aculeata Milne, 1886, M. plicata (Bryce, 1892), Mniobia montium Murray, 1911, M. tentans Donner, 1949, Notommata cyrtopus Gosse, 1886, Philodina lepta Wulfert, 1951, P. tranquilla Wulfert, 1942, Pleuretra hystrix $Barto{\check{s}}$, 1950 and Proalinopsis caudatus (Collins, 1873). All these rotifers are new to Korea, and B. perpusilla, H. flava, M. montium, P. caudatus, P. hystrix and P. lepta are new to Asia as well. Of interest, the present study is the first to record B. perpusilla outside its type locality. In addition, P. lepta has previously been recorded from only three European countries.

• Bulletin of the Korean Chemical Society
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• 제32권2호
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• pp.620-624
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• 2011

In recent years, the study of self-assembly peptide used in drug delivery system has been attracted great interest from scientists. In the category are self-assembly peptides in the structure either with one hydrophobic surface and another hydrophilic or a hydrophobic head and a hydrophilic tail. Here, we focus on a novel designed peptide EYK with double amphiphilic surfaces, investigating on the capability of peptide as a carrier for hydrophobic compound model pyrene. The fluorescence data presented the dynamic process of the transfer, showing that the pyrene was in the crystalline form in peptide solution, and molecularly migrated from its peptide encapsulations into the membrane bilayers when the peptide-pyrene suspension was mixed with liposome vesicles. The results indicated that the peptide EYK could stabilize hydrophobic pyrene in aqueous solution and delivered it into EPC liposome as a potential carrier.

• BMB Reports
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• 제40권2호
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• pp.286-289
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• 2007

Despite considerable interest in the biologic processes of regeneration and stem cell activation, little is known about the genes involved in these transformative events. In a Hydra littoralis model of regeneration, we employed a rapid shotgun suppression subtractive hybridization strategy to identify genes that are uniquely expressed in regenerating tissue. With an adaptor-PCR based technique, 16 candidate transcripts were identified, 15 were confirmed unique to mRNA isolated from hydra undergoing regeneration. Of these, 6 were undescribed in GenBank and allied expressed sequence tag (EST) databases (GenBank + EMBL + DDBJ + PDB and the Hydra EST database). BLAST analysis of these sequences identified remarkably similar sequences in anonymous ESTs found in a wide variety of animal species.

• Anatomy and Cell Biology
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• 제57권2호
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• pp.271-277
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• 2024

Human dentition is unique to individuals and helps in identification of individuals in forensic odontology. This study proposes to study the manually ground sections of single rooted teeth using digital methods for dental age estimation. To assess the dentinal translucency from the scanned digital images of manually ground section of teeth using commercially available image edition software. Corroborating the root dentinal translucency length and region of interest (ROI) of translucency zone in pixels (as a marker of dental age) with the chronological age of the subject, as stratified by different age groups. Twenty single-rooted extracted teeth from 20 patients each from 6 groups divided as per age. Manual sectioning of the teeth followed by scanning the sections was done. Root area in pixels and ROI of translucency zone were measured. From the observed values, translucency length percentage (TLP) and percentage of ROI in pixels (TPP) was calculated and tabulated. Pearson's correlation coefficients were obtained for age with TLP and TPP. Positive correlation existed between age and TLP and also between age and TPP. With the obtained data, multilinear regression equations for specific age groups based on 10-year intervals were derived. By a step-down analysis method, age was estimated with an average error of around ±7.9 years. This study gives a novel method for age-estimation that can be applied in real-time forensic sciences.

• 한국치위생학회지
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• 제12권6호
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• pp.1221-1231
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• 2012

Objectives : The purpose of this study was to examine the oral health behavior and examine closely the connection factor and plans oral health promotion. Methods : This survey was conducted on 370 high school students in Kyunggi-do Suwon from November 21 to 23, 2011. 352 questionnaires were collected and analyzed. The collected data was analyzed using the statistical package SPSS WIN 15.0 using frequency, mean and standard deviation analysis, T-test, one-way ANOVA and Duncan's test correlation analysis. Results : The results state that 73.3% of students believe brushing teeth is very important and 26.7% of the students method of tooth brushing is up and down. for correct teeth brushing, they think choosing a brush is important(70.7%) also their brush shapes were uneven form(44.3%) and flat form(43.5%). 31.4% of students are using an oral hygiene device and 31.4% of students had received oral health education. 42.7% of female students get information about oral health from their dental clinics. 24.8% of male students receive information on oral health from parents and relatives. They think the best educator for oral health education will be a Dental hygienist(46.5%), or Dentist(48.0%). we found that a correlation between oral health interest, importance, knowledge and condition effect each other(p<.001). It means that if students have high oral health interest, oral care importance and oral health knowledge which can improve their oral health condition. Conclusions : The results of this study state that we need continuous oral health education systems and prevention programs to raise awareness among students and for the improvement of their oral health.

• 대한화장품학회지
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• 제30권3호
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• pp.385-388
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• 2004

최근에 천연성분의 화장품 응용에 대한 관심이 높아지고 식물에 함유하고 있는 피토에스트로겐(Phytoestrogen)의 항노화 물질 연구가 중요해지고 있다. 태국 식물 Pueraria mirifica 추출물을 $4\%$ 함유한 크림제제(PM 크림)를 추출물 성분이 제외된 플라시보 크림과 비교하여 총 30명 여성을 대상으로 16주간 임상시험을 수행하였다. 피부 모사판을 제작하여 주름 측정을 하였고, 피부 탄력과 보습을 기기 평가하였다. 특히 피부 탄력도는 placebo 크림 사용군 대비 추출물 함유 크림 사용군이 통계적으로 유의하게 탄력도가 증가하였다. 주름이나 보습평가는 특이할 만한 결과를 나타내지는 못했다. Pueraria mirifiaca는 피부 탄력 개선을 주는 항노화 화장품 개발에 응용될 수 있을 것이라 기대된다.

• 한국과학교육학회지
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• 제21권2호
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• pp.357-384
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• 2001

본 논문에서는 통합과학교육에 관한 이론적 방향과 실제적 교수 학습방안을 연계성 있게 제시하여 과학교사들의 통합과학교육에 관한 이해를 도움과 동시에 통합과학 수업 보조자료를 개발하여 실제수업에 활용할 수 있도록 하였다. 이를 위해 공통과학 교과내용 중 통합 과학적 성격이 특히 강한 에너지 단원을 대상으로 통합과학 교수 학습 방안을 모색하였는데, 이것은 이전 논문에서 구성한 '통합과학교육의 방향별 에너지 교수 학습 전략' 을 바탕으로 하고 여기에 각 방향별 특징에 적합한 수업 모형을 적용한 것이다. 즉, 지식내용중심의 통합은 물리, 화학, 생물, 지구과학의 지식을 통합하기 위해서 '에너지의 여행' 을 주제로 선정하고 ' 개방된 발견학습' 수업모형을 적용하여 개념과 탐구관련 중심으로 모색하였다. 사회문제중심의 통합은 과학관련 사회문제를 해결하기 위하여 '에너지의 미래'를 주제로 선정하고 '발생학습' 수업모형을 적용하여 학습자의 인지과정을 중심으로 모색하였다. 개인흥미중심의 통합은 과학과 개인흥미의 통합을 위하여 '에너지의 변신' 을 주제로 선정하고 '프로젝트' 수업모형을 적용하여 학습자의 흥미나 관심분야를 중심으로 모색하였다. 이상과 같은 방향에 따른 통합과학 교수 학습 방안은 다음과 같은 순서에 의해 모색되었다. 먼저, 각 주제별로 다루어야할 통합과학적 교수 학습 내용을 구성하고, 이를 바탕으로 각각의 주제를 통합적으로 수업하기 위한 통합과학적 수업 절차를 설계하였다. 그리고 작성한 수업 절차에 따라 실제 통합과학 수업에서 적용할 수 있는 통합과학적 수업 지도안을 작성하였다. 이상의 연구는 21세기를 대비한 통합과학교육의 방향정립과 교재, 교사, 학생을 고려한 종합적인 통합과학교육 프로그램 개발에 활용될 수 있을 것으로 생각된다.