• 한국정밀공학회지
• /
• 제32권8호
• /
• pp.693-698
• /
• 2015

Recently, the quality of products after the corresponding machining processes were scrutinized in the interest of maintaining a high product-quality standard. The structure and stability of machine tools are important for the prediction of product quality. A structural analysis needs to be carried out to achieve the stable design of machine tools before the initial design stage in the manufacturing process of a precision product. In this study, a structural analysis was carried out using a finite element analysis (FEA) simulation to obtain the design stability of the main parts of a grinding machine. The sizes and locations of both the maximum stress and deformation in consideration of the cutting force of the chuck, tail stock, and bearing of the grinding machine were analyzed. Finally the grinding machine was successfully developed.

• Journal of Pharmaceutical Investigation
• /
• 제40권spc호
• /
• pp.97-102
• /
• 2010

A novel surface-attached solid dispersion is designed to improve the solubility and oral bioavailability of poorly water-soluble drugs without crystalline change. Accordingly, it draws increasing interest because of excellent stability and no pollution for accomplishing enhanced solubility and bioavailability, which have recently been highlighted in connection with a number of higher value-added poorly water-soluble drugs. In addition, excellent stability can be attained when the poorly water-soluble drugs are not dissolved but dispersed in water and provide no crystallinity change. This solid dispersion is given by means of attaching the dissolved carriers such as hydrophilic polymer and surfactant to the surface of dispersed drug particles followed by changing the hydrophobic drug to hydrophilic form. The aim of the present review is to outline the preparation, physicochemical property and bioavailability of novel surface-attached solid dispersion with improved solubility and bioavailability of poorly water-soluble drugs without crystalline change.

• 대한토목학회논문집
• /
• 제14권5호
• /
• pp.1253-1263
• /
• 1994

수평흐름에 의한 제체내의 비정상침투류를 실험을 통하여 구명한 것으로 흐름의 속도와 수위의 변동에 따른 제체내에서의 침투류영향을 고려하므로써 하천제방의 안정성증대에 목적을 두었다. 실험은 투수계수가 서로 다른 3가지 모델($K_1=3.52{\times}10^{-1}cm/sec$, $K_2=1.94{\times}10^{-1}cm/sec$, $K_3=4.19{\times}10^{-2}cm/sec$)에 대하여, 각기 흐름의 속도를 60, 70, 80, 90 cm/sec로 변화시키고 동시에 수위를 상승 또는 하강시키는 방법으로 제체내에 발생하는 수위변화를 실험을 통하여 분석하였다. 분석결과 제체내의 침투현상은 제체의 투수계수가 크고, 흐름의 속도가 작을수록 유속의 변화에 따른 영향을 많이 받음을 알 수 있으며, 제외지 수위의 상승과 강하에 따른 배면부 및 표면부에서의 수위가 유속의 영향에 따라 변화함을 알 수 있다.

• 한국추진공학회:학술대회논문집
• /
• 한국추진공학회 2007년도 제29회 추계학술대회논문집
• /
• pp.119-122
• /
• 2007

본 연구에서는 가스발생기의 연소 안정 특성을 파악하기 위해 실험적 방법을 적용하였다. 액체산소와 Jet A-1을 추진제로 사용하며 연료 과농 상태에서 작동하는 실험 가스발생기는 연소실 축 방향 공진 모드에 결합된 1200 Hz 대역의 고주파 연소불안정을 겪었다. 이 연소불안정의 발생 유무는 연소실 출구부의 음향 경계 조건과 화염의 열 발생 축 방향 위치에 매우 민감하게 반응하였다. 결과적으로 단일 분사기 노즐 크기 증가에 의한 화염의 축 방향 길이 증가는 연소안정성을 확연하게 향상시켰다.

• 한국표면공학회:학술대회논문집
• /
• 한국표면공학회 2018년도 춘계학술대회 논문집
• /
• pp.56-56
• /
• 2018

Transparent conductive oxides (TCOs) have attracted attention due to their high electrical conductivity and optical transparency in the visible region. Consequently, TCOs have been widely used as electrode materials in various electronic devices such as flat panel displays and solar cells. Previous studies on TCOs focused on their electrical and optical performances; there have been numerous attempts to improve these properties, such as chemical doping and crystallinity enhancement. Recently, due to rapidly increasing demand for flexible electronics, the academic interest in the mechanical stability of materials has come to the fore as a major issue. In particular, long-term stability under bending is a crucial requirement for flexible electrodes; however, research on this feature is still in the nascent stage. Hydrogen-incorporated amorphous In-Sn-O (a-ITO) thin films were fabricated by introducing hydrogen gas during deposition. The hydrogen concentration in the film was determined by secondary ion mass spectrometry and was found to vary from $4.7{\times}10^{20}$ to $8.1{\times}10^{20}cm^{-3}$ with increasing $H_2$ flow rate. The mechanical stability of the a-ITO thin films dramatically improved because of hydrogen incorporation, without any observable degradation in their electrical or optical properties. With increasing hydrogen concentration, the compressive residual stress gradually decreased and the subgap absorption at around 3.1 eV was suppressed. Considering that the residual stress and subgap absorption mainly originated from defects, hydrogen may be a promising candidate for defect passivation in flexible electronics.

• 한국공작기계학회:학술대회논문집
• /
• 한국공작기계학회 2005년도 춘계학술대회 논문집
• /
• pp.48-53
• /
• 2005

The world, coming into the 21st century, is preparing a new revolution called a knowledge-based society after the industrial society. The interest of the world is concentrated on information technology, nano-technology and biotechnology. In particular, the nano-technology of which study was originally started from an alternative for overcoming semiconductor micro-technology. It can be applied to most industry subject such as electronics, information and communication, machinery, chemistry, bioengineering, energy, etc. They are emerging into the technology that can change civilization of human beings. Specially, ultra precision machining is quickly applied to nano-technology in the field of machinery. Lately, with rapid development of electronics industry and optic industry, there are needs for super precision finishing of various core parts required in such related apparatuses. This paper handles stability of a super precision micro cutting machine that is a core unit of such a super precision finisher, and analyzes the results depending on the hinge type and material change, using FEM analysis. By reviewing the stability, it is possible to achieve the effect of basic data collection for unit control and to reduce trials and errors in unit design and manufacturing.

• Bulletin of the Korean Chemical Society
• /
• 제30권1호
• /
• pp.57-60
• /
• 2009

Alcohol oxidase catalyzes the oxidation of short lines alcohol to aldehyde. In this study, alcohol oxidase from Hansenula polymorpha (HpAOD) was induced by addition of 0.5% methanol as the carbon source and purified to electrophoretic homogeneity by column chromatographies. The purified HpAOD was immobilized with DEAE-cellulose particles and its biochemical properties were compared with those of free enzyme. The substrate specificity and the optimum pH of immobilized enzyme were similar to those of free enzyme. On the other hand, the Km values of free and immobilized enzymes for ethanol were 6.66 and 14.65 mM, respectively. The optimum temperature for free enzyme was ${50^{\circ}C}$, whereas that for immobilized enzyme was ${65^{\circ}C}$. Immobilized enzyme showed high stability against long storage. Immobilized enzyme was also tested for the enzymatic determination of ethanol by the colorimetric method. We detected 1 mg/liter ethanol ($1{\times}10^{-4}$% ethanol) by 2,6- dichloroindophenol system. Therefore, the present study demonstrated that immobilized HpAOD has high substrate specificity toward ethanol and storage stability, which may be of considerable interest for alcohol biosensor and industrial application.

• 서비스연구
• /
• 제5권2호
• /
• pp.35-49
• /
• 2015

본 연구는 금리추세에 따른 국내손해보험회사들의 자산운용 실태를 분석하여 문제점을 도출하고, 자산운용전략에 대한 방향을 제안하고자 2009년~2014년까지의 자료를 바탕으로 연구하였다. 손해보험회사들의 자산현황 및 운용자산 내역, 자산배분실태, 유가증권 내역, 총자산수익률을 시계열 분석하였으며, 금리 주가와 총자산수익률의 상관관계 분석을 실시하였다. 연구결과는 안전자산인 국공특수채의 비중은 증가한 반면에 Credit물인 금융회사채 및 위험자산인 주식의 비중은 감소하여 수익성 보다 안정성 위주로 자산운용을 하고 있었다. 금리하락 추세에 따라 총자산수익률도 같이 하락하고 있었으며, 주가지수 추이와 총자산수익률 추이는 일치하지 않았다. 금리와 총자산수익률 간에는 높은 양(+)의 상관계수가 산출되었지만, KOSPI 주가지수와 총자산수익률 간에는 상관계수가 음(-)으로 나타났다.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2011년도 제40회 동계학술대회 초록집
• /
• pp.252-253
• /
• 2011

ZnO-based thin film transistors (TFTs) are of great interest for application in next generation flat panel displays. Most research has been based on amorphous indium-gallium-zinc-oxide (IGZO) TFTs, rather than single binary oxides, such as ZnO, due to the reproducibility, uniformity, and surface smoothness of the IGZO active channel layer. However, recently, intrinsic ZnO-TFTs have been investigated, and TFT- arrayss have been demonstrated as prototypes of flat-panel displays and electronic circuits. However, ZnO thin films have some significant problems for application as an active channel layer of TFTs; it was easy to change the electrical properties of the i-ZnO thin films under external conditions. The variable electrical properties lead to unstable TFTs device characteristics under bias stress and/or temperature. In order to obtain higher performance and more stable ZnO-based TFTs, HZO thin film was used as an active channel layer. It was expected that HZO-TFTs would have more stable electrical characteristics under gate bias stress conditions because the binding energy of Hf-O is greater than that of Zn-O. For deposition of HZO thin films, Hf would be substituted with Zn, and then Hf could be suppressed to generate oxygen vacancies. In this study, the fabrication of the oxide-based TFTs with HZO active channel layer was reported with excellent stability. Application of HZO thin films as an active channel layer improved the TFT device performance and bias stability, as compared to i-ZnO TFTs. The excellent negative bias temperature stress (NBTS) stability of the device was analyzed using the HZO and i-ZnO TFTs transfer curves acquired at a high temperature (473 K).

• Korean Membrane Journal
• /
• 제8권1호
• /
• pp.58-66
• /
• 2006

The ${\beta}-glucosidase$ from olive fruit is of particular interest compared to the ones from other sources because it has shown to have high specifity to convert the oleuropein into dialdehydes, which have antibacterial activity and are of high interest for their application in the food and pharmaceutical fields. The enzyme is not yet commercially available and advanced clean and safe technologies for its purification able to maintain the functional stability are foreseen. The purification of this protein from fruit extracts has been already tempted by electrophoresis but either enzyme deactivation or high background with unclear profiles occurred. In this work, fruit extracts obtained from the ripening stage that showed the highest enzyme activity have been processed by diafiltration and ultrafiltration. Asymmetric membranes made of polyamide or polysulphone having 50 and 30 kDa molecular weight cut-off, respectively, were tested for the diafiltration process. Ultrafiltration membranes made of polyethersulfone with 4 kDa molecular weight cut-off were used to concentrate the dia-filtered permeate solutions. The efficiency of the separation processes was evaluated byenzyme activity tests using the hydrolysis of p-D-nitrophenyl-${\beta}$-D-glucopyranoside (pNPGlc) as reaction model. Qualitative and quantitative electrophoresis were applied to analyze the composition of protein solution before and after the membrane separation; in addition dot blot and western blot analyses were applied to verify the presence of ${\beta}-glucosidase$ in the processed fractions. The overall results showed that the ${\beta}-glucosidase$ functional stability was preserved during the membrane operations and the removal of 20 kDa proteins allowed to increase the specific activity of the enzyme of about 52% compared to the one present in the initial fruit extract.