• Proceedings of the Korean Geotechical Society Conference
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• 2004.03b
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• pp.839-846
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• 2004

The objective of this study is the evaluation of the tunneling effect on the groundwater-surface water interaction. The designed tunnel line is laid beneath the Gapo-cheon, which runs throughout study area. And, the pre-evaluation of the tunnel-influence on the Gapo-cheon is urgently needed. However, it is very difficult to find out the similar domestic and/or foreign cases. In this study, we would exclude the numerical modeling technique with insufficient data. Instead of the evaluation of the tunneling effect on the groundwater-surface water interaction with the numerical modeling, we monitored the flow rate of surface water at various point. We measured the flow rate of surface water at 5 points. With the results of surface flow, we can conclude that 39% of flow rate in Gapo-cheon is contributed by the groundwater discharge, as baseflow.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.9
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• pp.1269-1275
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• 2015

Turbine-generator torsional response is caused by interaction between electrical transient air-gap torque and mechanical characteristics of turbine-generator shafts. There are various factors that affects torsional interaction such as fault, circuit breaker switching and generator mal-synchronizing, etc. Fortunately, we can easily simulate above torsional interaction phenomena by using ElectroMagnetic Transient Program (EMTP). However, conventional EMTP shows the incomplete response of super- synchronous torsional mode since it does not consider turbine blade section. Therefore, in this paper, we introduced mechanical-electrical analogy for detailed modeling of turbine-generator shaft system including low pressure turbine blade section. In addition, we derived the natural frequencies of modeled turbine-generator shaft system including turbine blade section and analyzed the characteristics of mechanical torque response at shaft coupling and turbine blade root area according to power system balanced/unbalanced faults.

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2317-2325
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• 2014

P-glycoprotein (P-gp) is a member of the ATP-Binding Cassette transporter superfamily and mediates transmembrane efflux of many drugs. Since it is involved in multi-drug resistance activity in various cancer cells, the development of P-gp inhibitor is one of the major concerns in anticancer therapy. Human P-gp protein has at least two "functional" drug binding sites that are called "H" site and "R" site, hence it has multi-binding-specificities. Though the amino acid residues that constitute in drug binding pockets have been proposed by previous experimental evidences, the shapes and the binding poses are not revealed clearly yet. In this study, human P-gp structure was built by homology modeling with available crystal structure of mouse P-gp as a template and docking simulations were performed with inhibitors such as verapamil, hoechst33342, and rhodamine123 to construct the interaction between human P-gp and its inhibitors. The docking simulations were performed 500 times for each inhibitor, and then the interaction frequency of the amino acids at the binding poses was analyzed. With the analysis results, we proposed highly contributing residues that constitute binding pockets of the human P-gp for the inhibitors. Using the highly contributing residues, we proposed the locations and the shapes of verapamil binding site and "R" site, and suggested the possible position of "H" site.

• Proceeding of EDISON Challenge
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• 2016.03a
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• pp.90-95
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• 2016

Heat Shock 70kDa Protein 1-Like(HSPA1L)는 Heat-shock protein70(HSP70) family에 속하는 chaperone protein으로 polypeptide folding, assembly, protein degradation 등 다양한 biological processes에 관여하고 있다. HSPA1L은 human methyltransferase-like protein 21A(METTL21A)에 의해 lysine residue에 methylation이 일어나게 되는데, 암세포에서 일반적인 HSPA1L은 주로 세포질에서 발견되는 반면 methylated HSPA1L의 경우 주로 핵에서 발견이 됨으로써 HSPA1L methylation이 암 세포 성장에 중요할 역할을 할 것이라 추측되며 anti-cancer drug target으로 주목 받고 있다. 하지만 현재 HSPA1L의 구조가 부분적으로만 밝혀져 있어 HSPA1L와 METTL21A가 어떤 residue들이 interaction 하여 binding을 하는지에 대해서 아직 밝혀 지지 않았다. 이로 인해 anti-cancer drug target으로서의 연구에 제한이 있다. 이번 연구에서는 homology modeling(Galaxy-TBM, Galaxy-refine)을 통해 HSPA1L 전체 구조를 밝혀 낸 후, HSPA1L 와 METTL21A를 protein-protein docking을 통해 binding pose 예측을 하였다. 이러한 binding pose를 protein interaction analysis하여 HSPA1L과 METTL21A binding에 관여하는 중요 residue들을 밝혀 냈다. 이러한 structural information은 methylated HSPA1L와 암 세포 성장간의 연관성, 더 나아가 anti-cancer drug 개발로 까지도 이어 질 수 있을 것이라 생각한다.

• Coupled systems mechanics
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• v.3 no.4
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• pp.367-384
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• 2014

The study deals with the physical modeling of a typical single storeyed building frame resting on pile foundation and embedded in cohesive soil mass using the finite element based software SAP-IV. Two groups of piles comprising two and three piles, with series and parallel arrangement thereof, are considered. The slab provided at top and bottom of the frame along with the pile cap is idealized as four noded and two dimensional thin shell elements. The beams and columns of the frame, and piles are modeled using two noded one dimensional beam-column element. The soil is modeled using closely spaced discrete linear springs. A parametric study is carried out to investigate the effect of various parameters of the pile foundation, such as spacing in a group and number of piles in a group, on the response of superstructure. The response considered includes the displacement at the top of the frame and bending moment in columns. The soil-structure interaction effect is found to increase the displacement in the range of 38 -133% and to increase the absolute maximum positive and negative moments in the column in the range of 2-12% and 2-11%. The effect of the soil- structure interaction is observed to be significant for the type of foundation and soil considered in this study. The results obtained are compared further with those of Chore et al. (2010), wherein different idealizations were used for modeling the superstructure frame and sub-structure elements (foundation). While fair agreement is observed in the results in either study, the trend of the results obtained in both studies is also same.

• Korean Journal of Computational Design and Engineering
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• v.15 no.2
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• pp.136-143
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• 2010

Realistic Modeling is to maximize the reality of the environment in which perception is made by virtual environment or remote control using two or more senses of human. Especially, the field of haptic rendering, which provides reality through interaction of visual and tactual sense in realistic model, has brought attention. Haptic rendering calculates the force caused by model deformation during interaction with a virtual model and returns it to the user. Deformable model in the haptic rendering has more complexity than a rigid body because the deformation is calculated inside as well as the outside the model. For this model, Gibson suggested the 3D ChainMail algorithm using volumetric data. However, in case of the deformable model with non-homogeneous materials, there were some discordances between visual and tactual sense information when calculating the force-feedback in real time. Therefore, we propose an algorithm for the Volume Haptic Rendering of non-homogeneous deformable object that reflects the force-feedback consistently in real time, depending on visual information (the amount of deformation), without any post-processing.

• Structural Engineering and Mechanics
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• v.30 no.6
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• pp.665-678
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• 2008

The beams components subjected to the loading such as axial, bending and cyclic thermal loads were studied in this research. The used constitutive equations are those of elasto-plasticity coupled to ductile and/or creep damage. The nonlinear kinematic hardening behavior was considered in elastoplasticity modeling. The unified damage law proposed for ductile failure and fatigue by the author of Sermage et al. (2000) and Kachanov's creep damage model applied to cyclic creep and low cycle fatigue of beams. Based on the results of the analysis, the shakedown limit loads were determined through the calculation of the residual strains developed in the beam analysis. The iterative technique determines the shakedown limit load in an iterative manner by performing a series of full coupled elastic-plastic and continuum damage cyclic loading modeling. The maximum load carrying capacity of the beam can withstand, were determined and imposed on the Bree's interaction diagram. Comparison between the shakedown diagrams generated by or without creep and/or ductile damage for the loading patterns was presented.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2014.06a
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• pp.36-37
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• 2014

It is necessary to develop highly sophisticated Modeling & Simulation (M&S) system for the scientific investigation of marine accident causes and for the systematic reproduction of accidental damage procedure. To ensure an accurate and reasonable prediction of marine accidental causes, such as collision, grounding and flooding, full-scale ship M&S simulations would be the best approach using hydrocode, such as LS-DYNA code, with its Fluid-Structure Interaction (FSI) analysis technique. The objectivity of this paper is to present three full-scale ship collision, grounding and flooding simulation results of marine accidents, and to show the possibility of the scientific investigation of marine accident causes using highly sophisticated M&S system.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.67-74
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• 2008

The regional-scale transient groundwater-river interaction model is developed to gain a better understanding of the regional-scale relationships and interactions between groundwater and river system and quantify the residual river flow after groundwater abstraction from the aquifers with climate variability in the Waimea Plains, New Zealand. The effect of groundwater abstraction and climate variability on river flows is evaluated by calculating river flows at the downstream area for three different drought years (a 1 in 10 drought year, 1 in 20 drought year, and 1 in 24 drought year) and an average year with metered water abstraction data. The effect of future water demand (50 year projection) on river flows is also evaluated. A significant increase in the occurrence of zero flow, or very low flow of 100 L/sec at the downstream area is predicted due to large groundwater abstraction increase with climate variability. Modeling results shows the necessity of establishing dynamic cutback scenarios of water usage to users over the period of drought conditions considering different climate variability from current allocation limit to reduce the occurrence of low flow conditions at the downstream area.

• Wind and Structures
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• v.6 no.3
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• pp.209-220
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• 2003

A tornado changes its wind speed and direction rapidly; therefore, it is difficult to study the effects of a tornado on buildings in a wind tunnel. In this work, the status of the tornado-structure interaction is surveyed by numerical simulation. Various models of the tornado wind field found in literature are surveyed. Three-dimensional computer modeling work using the turbulence model based on large eddy simulation is presented. The effect of tornado on a cubic building is considered for this study. The Navier-Stokes (NS) equations are approximated by finite difference method, and solved by a semi-implicit procedure. The force coefficients are plotted in time to study the effect of the Rankine-Combined Vortex Model. Some flow visualizations are also reported to understand the flow behavior around the cube.